Published in Genes Dev on March 01, 1988
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Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature (1995) 9.84
Promotion of trophoblast stem cell proliferation by FGF4. Science (1998) 8.02
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Cardiac malformation in neonatal mice lacking connexin43. Science (1995) 5.51
Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Cell (1993) 5.12
The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell (1996) 5.10
Liver organogenesis promoted by endothelial cells prior to vascular function. Science (2001) 4.90
Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes. Science (1989) 4.43
Notch1 is required for the coordinate segmentation of somites. Development (1995) 4.33
HNF-3 beta is essential for node and notochord formation in mouse development. Cell (1994) 4.08
A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nat Genet (1993) 3.99
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development (2000) 3.91
FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. Dev Cell (2001) 3.73
flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors. Development (1993) 3.66
Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development (1997) 3.66
A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis. Cell (1997) 3.65
Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion. Nat Genet (1997) 3.64
Inducible expression of an hsp68-lacZ hybrid gene in transgenic mice. Development (1989) 3.61
Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation. Genes Dev (2000) 3.47
Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism. Neuron (2001) 3.42
Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2. Science (1995) 3.37
Essential role of Mash-2 in extraembryonic development. Nature (1994) 3.36
Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene. Cell (1985) 3.30
Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon. Dev Biol (1999) 3.29
The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins. Development (1993) 3.22
A gene trap approach in mouse embryonic stem cells: the lacZ reported is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice. Genes Dev (1992) 3.17
The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells. EMBO J (1995) 3.16
Conservation of the Notch signalling pathway in mammalian neurogenesis. Development (1997) 3.13
fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation. Genes Dev (1994) 3.02
Inactivation of the mouse Huntington's disease gene homolog Hdh. Science (1995) 2.96
Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development (1998) 2.94
Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat Med (1996) 2.94
Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells. Nature (1989) 2.91
The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature (2000) 2.78
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev (1998) 2.72
tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors. Oncogene (1992) 2.68
Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development (1998) 2.67
Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice. Hum Mol Genet (2000) 2.67
Long-term reconstitution of the mouse hematopoietic system by embryonic stem cell-derived fetal liver. Proc Natl Acad Sci U S A (1991) 2.66
Multiple developmental roles of VEGF suggested by a LacZ-tagged allele. Dev Biol (1999) 2.59
Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium. Proc Natl Acad Sci U S A (2001) 2.56
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Degree of methylation of transgenes is dependent on gamete of origin. Nature (1987) 2.52
Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death. Cell (1993) 2.52
A Study of the Action of a Filtrable Staphylococcal Toxin on the Kidneys of Normal Rabbits. Am J Pathol (1934) 2.50
Differences in DNA methylation during oogenesis and spermatogenesis and their persistence during early embryogenesis in the mouse. Genes Dev (1987) 2.49
Genomic imprinting of Mash2, a mouse gene required for trophoblast development. Nat Genet (1995) 2.46
The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis. Development (1999) 2.46
High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene. Mol Cell Biol (1989) 2.45
Gli1 can rescue the in vivo function of Gli2. Development (2001) 2.43
Cell lineage-specific undermethylation of mouse repetitive DNA. Nature (1984) 2.43
Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-beta. Nature (1997) 2.42
Investigation of the fate of 4-5 day post-coitum mouse inner cell mass cells by blastocyst injection. J Embryol Exp Morphol (1979) 2.38
Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo. Development (1992) 2.35
Isolation and characterization of a novel trophoblast-specific cDNA in the mouse. Genes Dev (1988) 2.33
Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum. Development (1994) 2.33
Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia. Nat Genet (1996) 2.32
Non-injection methods for the production of embryonic stem cell-embryo chimaeras. Nature (1993) 2.27
Genetic ablation: targeted expression of a toxin gene causes microphthalmia in transgenic mice. Science (1987) 2.27
The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum. Cell (1992) 2.27
Regulation of a transcription factor network required for differentiation and metabolism. Science (1998) 2.22
Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse. Hum Mol Genet (1999) 2.20
A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain. Development (1996) 2.12
The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo. Genes Dev (2001) 2.04
A transgene containing lacZ inserted into the dystonia locus is expressed in neural tube. Nature (1988) 2.02
Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles. Curr Biol (1998) 2.02
Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: a role for FGFR1 in morphogenetic movement through the primitive streak. Development (1997) 2.01
Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox. Science (1991) 2.01
Establishment and chimera analysis of 129/SvEv- and C57BL/6-derived mouse embryonic stem cell lines. Biotechniques (2000) 1.99
The mouse Engrailed-1 gene and ventral limb patterning. Nature (1996) 1.98
A mouse cerberus/Dan-related gene family. Dev Biol (1999) 1.97
Retrovirus transduction: segregation of the viral transforming function and the herpes simplex virus tk gene in infectious Friend spleen focus-forming virus thymidine kinase vectors. Mol Cell Biol (1983) 1.94
The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis. Development (1998) 1.85
Fate mapping of the mouse midbrain-hindbrain constriction using a site-specific recombination system. Curr Biol (1998) 1.83
Rom-1 is required for rod photoreceptor viability and the regulation of disk morphogenesis. Nat Genet (2000) 1.80
Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function. Development (1997) 1.79
Dynamic expression of the murine Achaete-Scute homologue Mash-1 in the developing nervous system. Mech Dev (1993) 1.79
Comparative chromosome mapping of a conserved homoeo box region in mouse and human. Nature (1985) 1.77
Genetic regulation of stem cell origins in the mouse embryo. Clin Genet (2005) 1.76
Expression patterns of the homeo box-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development. Genes Dev (1988) 1.75
Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos. Cell (1985) 1.73
Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse. Curr Biol (1999) 1.73
Retrovirus transduction: generation of infectious retroviruses expressing dominant and selectable genes is associated with in vivo recombination and deletion events. Mol Cell Biol (1983) 1.72
Mash2 acts cell autonomously in mouse spongiotrophoblast development. Dev Biol (1997) 1.71
Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR beta. Genes Dev (2001) 1.70
Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. Genes Dev (1998) 1.65
Expression analysis of a Notch homologue in the mouse embryo. Dev Biol (1992) 1.61
Alteration of limb and brain patterning in early mouse embryos by ultrasound-guided injection of Shh-expressing cells. Mech Dev (1998) 1.61
The mouse dystonia musculorum gene is a neural isoform of bullous pemphigoid antigen 1. Nat Genet (1995) 1.60
Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and -independent mechanisms. Development (1999) 1.52
Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouse Engrailed-2 mutants. Development (1994) 1.51
The HD mutation causes progressive lethal neurological disease in mice expressing reduced levels of huntingtin. Hum Mol Genet (2001) 1.49
FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. Genes Dev (2001) 1.47