Published in Development on July 01, 1998
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol Cell Biol (2006) 3.29
THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia. Nat Genet (2008) 3.19
Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1. Proc Natl Acad Sci U S A (2000) 2.73
Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube. Cell (2012) 2.54
Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development. Genes Dev (2003) 2.12
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Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. Genes Dev (2002) 2.10
A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev (2002) 2.09
Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features. Proc Natl Acad Sci U S A (2003) 1.98
The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev (2007) 1.87
Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle. Genes Dev (2004) 1.84
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Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus. Genes Dev (1999) 1.79
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The primary cilium at the crossroads of mammalian hedgehog signaling. Curr Top Dev Biol (2008) 1.75
Anorectal malformations caused by defects in sonic hedgehog signaling. Am J Pathol (2001) 1.72
Gli proteins and the control of spinal-cord patterning. EMBO Rep (2003) 1.68
A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube. Genes Dev (2005) 1.68
Human GLI3 intragenic conserved non-coding sequences are tissue-specific enhancers. PLoS One (2007) 1.68
Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition. Genes Dev (2005) 1.65
Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors. Development (2010) 1.65
Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis. J Clin Invest (2015) 1.59
Mediator modulates Gli3-dependent Sonic hedgehog signaling. Mol Cell Biol (2006) 1.58
Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development. Dev Biol (2008) 1.48
Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube. Development (2011) 1.48
Turning heads: development of vertebrate branchiomotor neurons. Dev Dyn (2004) 1.46
Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specification. Genes Dev (2002) 1.46
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The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization. Development (2009) 1.41
Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus. Mol Cell Biol (2005) 1.39
Hippi is essential for node cilia assembly and Sonic hedgehog signaling. Dev Biol (2006) 1.37
Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development. Mol Cell Biol (2005) 1.31
Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells. Cancer Res (2007) 1.30
Cooperative requirement of the Gli proteins in neurogenesis. Development (2005) 1.25
Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning. Genes Dev (2012) 1.24
Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome. Dis Model Mech (2010) 1.18
Roles for Hedgehog signaling in adult organ homeostasis and repair. Development (2014) 1.17
The relationship between sonic Hedgehog signaling, cilia, and neural tube defects. Birth Defects Res A Clin Mol Teratol (2010) 1.16
Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway. Hum Mol Genet (2009) 1.16
Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain. Curr Opin Genet Dev (2010) 1.10
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GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells. PLoS One (2009) 1.09
Activation of Erk by sonic hedgehog independent of canonical hedgehog signalling. Int J Biochem Cell Biol (2010) 1.07
The teratogenic effects of prenatal ethanol exposure are exacerbated by Sonic Hedgehog or GLI2 haploinsufficiency in the mouse. PLoS One (2014) 1.05
Three-dimensional micro-MRI analysis of cerebral artery development in mouse embryos. Magn Reson Med (2009) 1.04
The transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes. Blood (2005) 1.04
Establishment and characterization of immortalized Gli-null mouse embryonic fibroblast cell lines. BMC Cell Biol (2008) 1.04
Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity. Development (2011) 1.03
Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels. Circ Res (2011) 1.01
GLI2-specific transcriptional activation of the bone morphogenetic protein/activin antagonist follistatin in human epidermal cells. J Biol Chem (2008) 0.97
Gli function is essential for motor neuron induction in zebrafish. Dev Biol (2005) 0.94
Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development. Development (2010) 0.93
Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia. Mol Cell Biol (2006) 0.93
Current perspectives on the genetic causes of neural tube defects. Neurogenetics (2006) 0.92
Direct and indirect requirements of Shh/Gli signaling in early pituitary development. Dev Biol (2010) 0.92
Molecular mechanisms involved in progesterone receptor regulation of uterine function. J Steroid Biochem Mol Biol (2006) 0.92
Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling. Genes Dev (2014) 0.91
Floor plate-derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord. Development (2013) 0.91
Redundant and differential roles of transcription factors Gli1 and Gli2 in the development of mouse fetal Leydig cells. Biol Reprod (2011) 0.90
The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice. Mol Cell Biol (2003) 0.90
Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programs. Hum Mol Genet (2011) 0.90
Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia. Sci Transl Med (2015) 0.89
Odontogenic keratocysts arise from quiescent epithelial rests and are associated with deregulated hedgehog signaling in mice and humans. Am J Pathol (2006) 0.88
Holoprosencephaly: signaling interactions between the brain and the face, the environment and the genes, and the phenotypic variability in animal models and humans. Wiley Interdiscip Rev Dev Biol (2014) 0.88
Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling. Dev Biol (2012) 0.87
Nodal signaling is required for closure of the anterior neural tube in zebrafish. BMC Dev Biol (2007) 0.87
Mouse thalamic differentiation: gli-dependent pattern and gli-independent prepattern. Front Neurosci (2012) 0.87
A central region of Gli2 regulates its localization to the primary cilium and transcriptional activity. J Cell Sci (2014) 0.87
Temporal deletion of Arl13b reveals that a mispatterned neural tube corrects cell fate over time. Development (2012) 0.87
An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth. Nat Commun (2014) 0.87
Transcriptional regulation of graded Hedgehog signaling. Semin Cell Dev Biol (2014) 0.86
Ascl1/Mash1 is a novel target of Gli2 during Gli2-induced neurogenesis in P19 EC cells. PLoS One (2011) 0.86
What are those cilia doing in the neural tube? Cilia (2012) 0.85
Visualization of Gli activity in craniofacial tissues of hedgehog-pathway reporter transgenic zebrafish. PLoS One (2010) 0.84
Patterning the limb before and after SHH signalling. J Anat (2003) 0.84
The cellular and molecular etiology of the craniofacial defects in the avian ciliopathic mutant talpid2. Development (2014) 0.84
Stabilization of speckle-type POZ protein (Spop) by Daz interacting protein 1 (Dzip1) is essential for Gli turnover and the proper output of Hedgehog signaling. J Biol Chem (2013) 0.83
Specific requirement of Gli transcription factors in Hedgehog-mediated intestinal development. J Biol Chem (2013) 0.83
Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling. PLoS One (2012) 0.83
Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development. Dev Biol (2014) 0.83
Zebrafish cyclin-dependent protein kinase-like 1 (zcdkl1): identification and functional characterization. Int J Mol Sci (2011) 0.82
The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function. J Cell Sci (2015) 0.82
Mouse limbs expressing only the Gli3 repressor resemble those of Sonic hedgehog mutants. Dev Biol (2013) 0.82
The zebrafish tailbud contains two independent populations of midline progenitor cells that maintain long-term germ layer plasticity and differentiate in response to local signaling cues. Development (2015) 0.81
T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressor. PLoS One (2015) 0.81
A revised model of Xenopus dorsal midline development: differential and separable requirements for Notch and Shh signaling. Dev Biol (2011) 0.81
A potential role of alternative splicing in the regulation of the transcriptional activity of human GLI2 in gonadal tissues. BMC Mol Biol (2006) 0.81
Targeting stem cell behavior in desmoid tumors (aggressive fibromatosis) by inhibiting hedgehog signaling. Neoplasia (2013) 0.81
A systems-based approach to investigate dose- and time-dependent methylmercury-induced gene expression response in C57BL/6 mouse embryos undergoing neurulation. Birth Defects Res B Dev Reprod Toxicol (2010) 0.81
Pax3 synergizes with Gli2 and Zic1 in transactivating the Myf5 epaxial somite enhancer. Dev Biol (2013) 0.81
Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish. Biol Open (2013) 0.80
Selection Based on FOXA2 Expression Is Not Sufficient to Enrich for Dopamine Neurons From Human Pluripotent Stem Cells. Stem Cells Transl Med (2014) 0.78
GLI-2 modulates retroviral gene expression. J Virol (2001) 0.78
Regulation of Hedgehog signaling by ubiquitination. Front Biol (Beijing) (2015) 0.78
Arsenic inhibits hedgehog signaling during P19 cell differentiation. Toxicol Appl Pharmacol (2014) 0.77
Kif3a controls murine nephron number via GLI3 repressor, cell survival, and gene expression in a lineage-specific manner. PLoS One (2013) 0.76
INPP5E regulates phosphoinositide-dependent cilia transition zone function. J Cell Biol (2016) 0.76
Optochemical dissection of T-box gene-dependent medial floor plate development. ACS Chem Biol (2015) 0.76
Foxa2 mediates critical functions of prechordal plate in patterning and morphogenesis and is cell autonomously required for early ventral endoderm morphogenesis. Biol Open (2012) 0.76
Suppressor of Fused chaperones Gli proteins to generate transcriptional responses to Sonic Hedgehog signaling. Mol Cell Biol (2016) 0.75
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