Published in Development on May 01, 1995
Notch signaling is essential for vascular morphogenesis in mice. Genes Dev (2000) 6.88
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev (2003) 4.89
Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation. EMBO J (1999) 3.95
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med (2008) 3.64
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells. Genes Dev (2002) 3.55
Lessons on the pathogenesis of aneurysm from heritable conditions. Nature (2011) 2.97
Mice lacking both presenilin genes exhibit early embryonic patterning defects. Genes Dev (1999) 2.90
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc Natl Acad Sci U S A (1999) 2.82
The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures. Genes Dev (2001) 2.74
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development (2007) 2.70
Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Genes Dev (1998) 2.70
Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo. Genes Dev (2002) 2.69
Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways. Proc Natl Acad Sci U S A (2003) 2.69
Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci U S A (2004) 2.66
Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium. Proc Natl Acad Sci U S A (2001) 2.56
Notch signaling is essential for ventricular chamber development. Dev Cell (2007) 2.53
Essential role of endothelial Notch1 in angiogenesis. Circulation (2005) 2.28
Dynamic expression and essential functions of Hes7 in somite segmentation. Genes Dev (2001) 2.26
Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis. Genes Dev (1999) 2.26
The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Genes Dev (2001) 2.15
Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development (2009) 2.10
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev (2003) 2.10
Control of her1 expression during zebrafish somitogenesis by a delta-dependent oscillator and an independent wave-front activity. Genes Dev (2000) 2.09
Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate. J Cell Sci (2010) 2.07
Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol Cell Biol (1998) 1.99
Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling. Mol Cell Biol (2009) 1.97
LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein. Mol Cell Biol (1998) 1.96
Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development (2007) 1.94
Critical role of endothelial Notch1 signaling in postnatal angiogenesis. Circ Res (2006) 1.91
RBP-L, a transcription factor related to RBP-Jkappa. Mol Cell Biol (1997) 1.89
The HAND1 basic helix-loop-helix transcription factor regulates trophoblast differentiation via multiple mechanisms. Mol Cell Biol (2000) 1.80
LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. Genes Dev (2004) 1.76
Neural stem cell self-renewal. Crit Rev Oncol Hematol (2007) 1.76
WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos. Genes Dev (2004) 1.74
Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors. Development (2006) 1.67
Notch1 control of oligodendrocyte differentiation in the spinal cord. J Cell Biol (2002) 1.65
Vertebrate segmentation: from cyclic gene networks to scoliosis. Cell (2011) 1.65
Eph signaling is required for segmentation and differentiation of the somites. Genes Dev (1998) 1.65
Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling. Genes Dev (2004) 1.63
Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C. Mol Cell Biol (1999) 1.61
Retracted Critical role of notch signaling in osteosarcoma invasion and metastasis. Clin Cancer Res (2008) 1.61
The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal. J Biol (2004) 1.61
The role of secondary heart field in cardiac development. Dev Biol (2009) 1.60
Smooth muscle Notch1 mediates neointimal formation after vascular injury. Circulation (2009) 1.58
Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2. Mol Cell Biol (2000) 1.54
Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice. Hepatology (2010) 1.53
A missense mutation in the bovine SLC35A3 gene, encoding a UDP-N-acetylglucosamine transporter, causes complex vertebral malformation. Genome Res (2005) 1.52
Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cord. Neuron (2007) 1.52
Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. J Clin Invest (2011) 1.51
The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments. Genes Dev (2004) 1.46
The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development. Proc Natl Acad Sci U S A (2008) 1.46
Recombination signal sequence-binding protein Jkappa alters mesodermal cell fate decisions by suppressing cardiomyogenesis. Proc Natl Acad Sci U S A (2003) 1.45
Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis. Development (2008) 1.43
Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode. Development (2008) 1.42
Examination of transcriptional networks reveals an important role for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell maintenance. Genome Res (2010) 1.41
Transient inactivation of Notch signaling synchronizes differentiation of neural progenitor cells. Dev Biol (2007) 1.40
Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice. Proc Natl Acad Sci U S A (2009) 1.38
Notch signaling, the segmentation clock, and the patterning of vertebrate somites. J Biol (2009) 1.34
Notch signalling synchronizes the zebrafish segmentation clock but is not needed to create somite boundaries. PLoS Genet (2008) 1.30
Activated Notch1 target genes during embryonic cell differentiation depend on the cellular context and include lineage determinants and inhibitors. PLoS One (2010) 1.30
Transcriptional oscillation of lunatic fringe is essential for somitogenesis. Genes Dev (2003) 1.29
Activity and distribution of paxillin, focal adhesion kinase, and cadherin indicate cooperative roles during zebrafish morphogenesis. Mol Biol Cell (2003) 1.29
Transit-amplifying ductular (oval) cells and their hepatocytic progeny are characterized by a novel and distinctive expression of delta-like protein/preadipocyte factor 1/fetal antigen 1. Am J Pathol (2004) 1.25
Stra13 regulates satellite cell activation by antagonizing Notch signaling. J Cell Biol (2007) 1.24
The bHLH regulator pMesogenin1 is required for maturation and segmentation of paraxial mesoderm. Genes Dev (2000) 1.22
Expression of the mouse cerberus-related gene, Cerr1, suggests a role in anterior neural induction and somitogenesis. Proc Natl Acad Sci U S A (1998) 1.22
Gamma secretase inhibitors of Notch signaling. Onco Targets Ther (2013) 1.21
NOTCHing the bone: insights into multi-functionality. Bone (2009) 1.19
Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. EMBO Rep (2007) 1.17
Notch expression patterns in the retina: An eye on receptor-ligand distribution during angiogenesis. Gene Expr Patterns (2006) 1.15
Role of glycosylation of Notch in development. Semin Cell Dev Biol (2010) 1.10
Asymmetric localization of numb in the chick somite and the influence of myogenic signals. Dev Dyn (2006) 1.09
Canonical Notch signaling is not necessary for prosensory induction in the mouse cochlea: insights from a conditional mutant of RBPjkappa. J Neurosci (2011) 1.09
Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins. J Biol Chem (2012) 1.07
Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation. Genes Dev (2008) 1.06
Notch1 in bone marrow-derived cells mediates cardiac repair after myocardial infarction. Circulation (2011) 1.06
A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling. Proc Natl Acad Sci U S A (2002) 1.05
Cooperative function of deltaC and her7 in anterior segment formation. Dev Biol (2005) 1.04
Periodic repression of Notch pathway genes governs the segmentation of Xenopus embryos. Genes Dev (1999) 1.03
Nas transgenic mouse line allows visualization of Notch pathway activity in vivo. Genesis (2006) 1.03
Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREB. Mol Cell Biol (2006) 1.02
Identification of oscillatory genes in somitogenesis from functional genomic analysis of a human mesenchymal stem cell model. Dev Biol (2007) 1.01
Notch-1 signaling regulates intestinal epithelial barrier function, through interaction with CD4+ T cells, in mice and humans. Gastroenterology (2010) 1.00
Noise-limited frequency signal transmission in gene circuits. Biophys J (2007) 0.99
NOTCH, a new signaling pathway implicated in holoprosencephaly. Hum Mol Genet (2010) 0.98
Transcriptional repression in the Notch pathway: thermodynamic characterization of CSL-MINT (Msx2-interacting nuclear target protein) complexes. J Biol Chem (2011) 0.98
Assignment of the disease locus for lethal congenital contracture syndrome to a restricted region of chromosome 9q34, by genome scan using five affected individuals. Am J Hum Genet (1998) 0.97
Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression. J Biol Chem (2011) 0.96
Jarid2 (Jumonji, AT rich interactive domain 2) regulates NOTCH1 expression via histone modification in the developing heart. J Biol Chem (2011) 0.96
Proteolytic cleavage of Notch: "HIT and RUN". Curr Mol Med (2011) 0.95
Cyclical expression of the Notch/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis. Dev Biol (2009) 0.94
The role of chorionic gonadotropin and Notch1 in implantation. J Assist Reprod Genet (2007) 0.94
Hajdu-Cheney syndrome: a review. Orphanet J Rare Dis (2014) 0.93
BMPs and FGFs target Notch signalling via jagged 2 to regulate tooth morphogenesis and cytodifferentiation. Development (2010) 0.92
Isolation of a murine homologue of the Drosophila neuralized gene, a gene required for axonemal integrity in spermatozoa and terminal maturation of the mammary gland. Mol Cell Biol (2001) 0.91
Possible novel targets for therapeutic angiogenesis. Curr Opin Pharmacol (2008) 0.91
Signaling by FGF4 and FGF8 is required for axial elongation of the mouse embryo. Dev Biol (2012) 0.91
Molecular biology of pancreatic ductal adenocarcinoma progression: aberrant activation of developmental pathways. Prog Mol Biol Transl Sci (2010) 0.91
Rapid identification of homologous recombinants and determination of gene copy number with reference/query pyrosequencing (RQPS). Genome Res (2009) 0.91
MyoD stimulates delta-1 transcription and triggers notch signaling in the Xenopus gastrula. EMBO J (1999) 0.91
Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci U S A (1993) 20.33
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature (1995) 15.15
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature (1995) 9.84
Promotion of trophoblast stem cell proliferation by FGF4. Science (1998) 8.02
Embryonic stem cells alone are able to support fetal development in the mouse. Development (1990) 6.37
Cardiac malformation in neonatal mice lacking connexin43. Science (1995) 5.51
Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1. Science (1998) 5.23
The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell (1996) 5.10
Liver organogenesis promoted by endothelial cells prior to vascular function. Science (2001) 4.90
Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes. Science (1989) 4.43
HNF-3 beta is essential for node and notochord formation in mouse development. Cell (1994) 4.08
FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. Dev Cell (2001) 3.73
flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors. Development (1993) 3.66
A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis. Cell (1997) 3.65
Inducible expression of an hsp68-lacZ hybrid gene in transgenic mice. Development (1989) 3.61
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Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon. Dev Biol (1999) 3.29
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The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells. EMBO J (1995) 3.16
Conservation of the Notch signalling pathway in mammalian neurogenesis. Development (1997) 3.13
fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation. Genes Dev (1994) 3.02
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The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature (2000) 2.78
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Multiple developmental roles of VEGF suggested by a LacZ-tagged allele. Dev Biol (1999) 2.59
Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium. Proc Natl Acad Sci U S A (2001) 2.56
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Differences in DNA methylation during oogenesis and spermatogenesis and their persistence during early embryogenesis in the mouse. Genes Dev (1987) 2.49
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Cell lineage-specific undermethylation of mouse repetitive DNA. Nature (1984) 2.43
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Isolation and characterization of a novel trophoblast-specific cDNA in the mouse. Genes Dev (1988) 2.33
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Genetic ablation: targeted expression of a toxin gene causes microphthalmia in transgenic mice. Science (1987) 2.27
Regulation of a transcription factor network required for differentiation and metabolism. Science (1998) 2.22
A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain. Development (1996) 2.12
The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo. Genes Dev (2001) 2.04
A transgene containing lacZ inserted into the dystonia locus is expressed in neural tube. Nature (1988) 2.02
Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles. Curr Biol (1998) 2.02
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Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox. Science (1991) 2.01
A mouse cerberus/Dan-related gene family. Dev Biol (1999) 1.97
The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis. Development (1998) 1.85
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Rom-1 is required for rod photoreceptor viability and the regulation of disk morphogenesis. Nat Genet (2000) 1.80
Genetic regulation of stem cell origins in the mouse embryo. Clin Genet (2005) 1.76
Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse. Curr Biol (1999) 1.73
Mash2 acts cell autonomously in mouse spongiotrophoblast development. Dev Biol (1997) 1.71
Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR beta. Genes Dev (2001) 1.70
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Age-related cochlear hair cell loss is enhanced in mice lacking copper/zinc superoxide dismutase. Neurobiol Aging (1999) 1.65
Expression analysis of a Notch homologue in the mouse embryo. Dev Biol (1992) 1.61
The mouse dystonia musculorum gene is a neural isoform of bullous pemphigoid antigen 1. Nat Genet (1995) 1.60
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