Published in Cell on May 15, 1992
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. Genes Dev (2008) 4.38
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev (1998) 3.46
Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol Cell Biol (1998) 3.09
Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion. J Cell Biol (1993) 2.95
Signal transduction by the Wnt family of ligands. Biochem J (1998) 2.66
The role of Axin2 in calvarial morphogenesis and craniosynostosis. Development (2005) 2.63
Ancient deuterostome origins of vertebrate brain signalling centres. Nature (2012) 2.36
Wnt-mediated self-renewal of neural stem/progenitor cells. Proc Natl Acad Sci U S A (2008) 2.15
Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord. Genes Dev (2002) 2.01
FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals. EMBO J (2003) 1.85
Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon. Proc Natl Acad Sci U S A (1994) 1.54
Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor gene. Proc Natl Acad Sci U S A (1993) 1.54
The alpha catalytic subunit of protein kinase CK2 is required for mouse embryonic development. Mol Cell Biol (2007) 1.52
Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway. Cell Stem Cell (2009) 1.51
Modulation of mouse neural crest cell motility by N-cadherin and connexin 43 gap junctions. J Cell Biol (2001) 1.38
Impaired neural development caused by inducible expression of Axin in transgenic mice. Mech Dev (2006) 1.32
Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase. Mol Cell Biol (2011) 1.31
Intraflagellar transport protein 172 is essential for primary cilia formation and plays a vital role in patterning the mammalian brain. Dev Biol (2008) 1.30
Ontogeny-recapitulating generation and tissue integration of ES cell-derived Purkinje cells. Nat Neurosci (2010) 1.26
Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development. Dev Dyn (2011) 1.24
TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors. Dev Biol (2007) 1.22
Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain. EMBO J (2001) 1.17
Gene targeting of CK2 catalytic subunits. Mol Cell Biochem (2008) 1.12
WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum. Development (2012) 1.12
Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells. Proc Natl Acad Sci U S A (2013) 1.12
Spatial analysis of expression patterns predicts genetic interactions at the mid-hindbrain boundary. PLoS Comput Biol (2009) 1.03
Wnt-1-inducing factor-1: a novel G/C box-binding transcription factor regulating the expression of Wnt-1 during neuroectodermal differentiation. Mol Cell Biol (1993) 1.03
A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. Elife (2013) 0.99
Candidate gene screen in the red flour beetle Tribolium reveals six3 as ancient regulator of anterior median head and central complex development. PLoS Genet (2011) 0.99
Manipulating gene activity in Wnt1-expressing precursors of neural epithelial and neural crest cells. Dev Dyn (2010) 0.99
Neurotrophic activity of the Antennapedia homeodomain depends on its specific DNA-binding properties. Proc Natl Acad Sci U S A (1993) 0.99
Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: evidence from targeted mutations. Proc Natl Acad Sci U S A (1997) 0.98
spiel ohne grenzen/pou2 is required during establishment of the zebrafish midbrain-hindbrain boundary organizer. Development (2001) 0.98
The cephalic neural crest exerts a critical effect on forebrain and midbrain development. Proc Natl Acad Sci U S A (2006) 0.96
Wnt signaling is regulated by endoplasmic reticulum retention. PLoS One (2009) 0.95
Glycogen synthase kinase 3β and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage. Stem Cells (2012) 0.93
Cloning and developmental expression of mouse pygopus 2, a putative Wnt signaling component. Genomics (2004) 0.93
En1 and Wnt signaling in midbrain dopaminergic neuronal development. Neural Dev (2011) 0.92
Genes, lineages and the neural crest: a speculative review. Philos Trans R Soc Lond B Biol Sci (2000) 0.92
Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries. Dev Biol (2006) 0.92
Wnt1 expression temporally allocates upper rhombic lip progenitors and defines their terminal cell fate in the cerebellum. Mol Cell Neurosci (2011) 0.91
Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation. Mol Cell Biol (2011) 0.91
DNA affinity cleaving analysis of homeodomain-DNA interaction: identification of homeodomain consensus sites in genomic DNA. Proc Natl Acad Sci U S A (1994) 0.90
Postnatal isoform switch and protein localization of LEF1 and TCF7L2 transcription factors in cortical, thalamic, and mesencephalic regions of the adult mouse brain. Brain Struct Funct (2012) 0.89
Pattern formation during development of the embryonic cerebellum. Front Neuroanat (2012) 0.88
Fluorescence-activated cell sorting of EGFP-labeled neural crest cells from murine embryonic craniofacial tissue. J Biomed Biotechnol (2005) 0.88
Development and function of the midbrain dopamine system: what we know and what we need to. Genes Brain Behav (2015) 0.87
The swaying mouse as a model of osteogenesis imperfecta caused by WNT1 mutations. Hum Mol Genet (2014) 0.87
Dynamic temporal requirement of Wnt1 in midbrain dopamine neuron development. Development (2013) 0.86
WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation. PLoS One (2013) 0.86
Cellular commitment in the developing cerebellum. Front Cell Neurosci (2015) 0.86
Wnt/beta-catenin signaling in cerebral cortical development. Organogenesis (2008) 0.85
Differentiation of human induced pluripotent stem cells to mature functional Purkinje neurons. Sci Rep (2015) 0.84
Cellular programming and reprogramming: sculpting cell fate for the production of dopamine neurons for cell therapy. Stem Cells Int (2012) 0.83
Genetic dissection of midbrain dopamine neuron development in vivo. Dev Biol (2012) 0.83
Wnt3a promotes hippocampal neurogenesis by shortening cell cycle duration of neural progenitor cells. Cell Mol Neurobiol (2010) 0.83
Wnt/β-catenin signalling is active in a highly dynamic pattern during development of the mouse cerebellum. PLoS One (2011) 0.83
Desire, disease, and the origins of the dopaminergic system. Schizophr Bull (2008) 0.83
Shh and Gli3 regulate formation of the telencephalic-diencephalic junction and suppress an isthmus-like signaling source in the forebrain. Dev Biol (2011) 0.82
Oncogenic role of engrailed-2 (en-2) in prostate cancer cell growth and survival. Transl Oncogenomics (2008) 0.82
Directed midbrain and spinal cord neurogenesis from pluripotent stem cells to model development and disease in a dish. Front Neurosci (2014) 0.82
In vivo expression of ephrinA5-Fc in mice results in cephalic neural crest agenesis and craniofacial abnormalities. Mol Cells (2014) 0.81
β-catenin is required in the neural crest and mesencephalon for pituitary gland organogenesis. BMC Dev Biol (2016) 0.81
Midbrain dopaminergic development in vivo and in vitro from embryonic stem cells. J Anat (2005) 0.81
Variation in WNT7A is unlikely to be a cause of familial congenital talipes equinovarus. BMC Med Genet (2008) 0.81
A bi-modal function of Wnt signalling directs an FGF activity gradient to spatially regulate neuronal differentiation in the midbrain. Development (2013) 0.80
Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription. Proc Natl Acad Sci U S A (2016) 0.78
A knock-in allele of En1 expressing dre recombinase. Genesis (2016) 0.77
AP-2δ is a crucial transcriptional regulator of the posterior midbrain. PLoS One (2011) 0.77
Expression and functional analysis of the Wnt/beta-catenin induced mir-135a-2 locus in embryonic forebrain development. Neural Dev (2016) 0.77
Immortalization of neuronal progenitors using SV40 large T antigen and differentiation towards dopaminergic neurons. J Cell Mol Med (2012) 0.76
Osterix is required for cranial neural crest-derived craniofacial bone formation. Biochem Biophys Res Commun (2013) 0.76
Linking respiratory rhythm generation to segmentation of the vertebrate hindbrain. Pflugers Arch (2003) 0.76
Dissecting the role of Wnt signaling and its interactions with FGF signaling during midbrain neurogenesis. Neurogenesis (Austin) (2015) 0.75
Lrp5/6 are required for cerebellar development and for suppressing TH expression in Purkinje cells via β-catenin. Mol Brain (2016) 0.75
Engrailed homeoproteins in visual system development. Cell Mol Life Sci (2014) 0.75
Identification of the 187 bp EphA7 Genomic DNA as the Dorsal Midline-Specific Enhancer of the Diencephalon and Mesencephalon. Mol Cells (2015) 0.75
Mouse IDGenes: a reference database for genetic interactions in the developing mouse brain. Database (Oxford) (2014) 0.75
Ldb1 Is Essential for the Development of Isthmic Organizer and Midbrain Dopaminergic Neurons. Stem Cells Dev (2016) 0.75
Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain. PLoS Biol (2017) 0.75
The Role of MicroRNAs in Cerebellar Development and Autism Spectrum Disorder During Embryogenesis. Mol Neurobiol (2016) 0.75
Asymmetrically deployed Actomyosin-based contractility generates a boundary between developing leg segments in Drosophila. Dev Biol (2017) 0.75
Specific and spatial labeling of P0-Cre versus Wnt1-Cre in cranial neural crest in early mouse embryos. Genesis (2017) 0.75
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature (1992) 25.54
Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science (1993) 14.91
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell (1991) 14.89
p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature (1999) 13.21
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev (2000) 11.49
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell (1990) 10.99
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature (1995) 8.68
Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature (1992) 8.16
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature (1997) 8.04
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell (1993) 7.41
Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. Nature (1993) 6.75
Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines. Nature (1984) 6.54
Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. Nat Genet (1996) 6.06
p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science (1995) 6.01
A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development (1999) 5.85
Impaired energy homeostasis in C/EBP alpha knockout mice. Science (1995) 5.68
Sonic hedgehog signaling is essential for hair development. Curr Biol (1998) 5.58
Chromosome engineering in mice. Nature (1995) 5.48
Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Cell (1993) 5.12
Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev (1996) 4.94
Increased bone formation in osteocalcin-deficient mice. Nature (1996) 4.91
The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature (1999) 4.74
Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector. Nature (1986) 4.73
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science (1998) 4.72
Requirement for Wnt3 in vertebrate axis formation. Nat Genet (1999) 4.68
Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell (2001) 4.61
Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes. Science (1989) 4.43
Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice. Nature (2001) 4.41
In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene (1993) 4.03
A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nat Genet (1993) 3.99
Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development (1996) 3.91
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development (2000) 3.91
Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Nat Genet (1993) 3.85
BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev (1995) 3.84
Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells. Nature (1991) 3.83
Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev (1994) 3.77
Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development (1997) 3.66
Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion. Nat Genet (1997) 3.64
A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes Dev (1993) 3.60
Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc Natl Acad Sci U S A (1993) 3.57
Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice. Nature (1992) 3.54
Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation. Genes Dev (2000) 3.47
Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis. Cell (1989) 3.42
Gene targeting in embryonic stem cells. Methods Enzymol (1993) 3.41
Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2. Science (1995) 3.37
Essential role of Mash-2 in extraembryonic development. Nature (1994) 3.36
Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev (2000) 3.30
Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene. Cell (1985) 3.30
Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. Nat Genet (1995) 3.29
Cancer predisposition caused by elevated mitotic recombination in Bloom mice. Nat Genet (2000) 3.28
Target frequency and integration pattern for insertion and replacement vectors in embryonic stem cells. Mol Cell Biol (1991) 3.25
A gene trap approach in mouse embryonic stem cells: the lacZ reported is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice. Genes Dev (1992) 3.17
Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation. EMBO J (1998) 3.12
Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. Proc Natl Acad Sci U S A (1999) 3.06
Genomic DNA microextraction: a method to screen numerous samples. Anal Biochem (1992) 3.05
Noggin is a mesenchymally derived stimulator of hair-follicle induction. Nat Cell Biol (1999) 2.99
Multiple defects and perinatal death in mice deficient in follistatin. Nature (1995) 2.96
Inactivation of the mouse Huntington's disease gene homolog Hdh. Science (1995) 2.96
Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development (1998) 2.94
Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat Med (1996) 2.94
Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell (2001) 2.84
The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature (2000) 2.78
The length of homology required for gene targeting in embryonic stem cells. Mol Cell Biol (1991) 2.75
Mouse ENU mutagenesis. Hum Mol Genet (1999) 2.72
Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells. Proc Natl Acad Sci U S A (1998) 2.71
Functional analysis of activins during mammalian development. Nature (1995) 2.71
Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice. Hum Mol Genet (2000) 2.67
The tumor suppressor p53. Biochim Biophys Acta (1993) 2.65
Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell (1993) 2.62
Different phenotypes for mice deficient in either activins or activin receptor type II. Nature (1995) 2.62
Congenital heart disease in mice deficient for the DiGeorge syndrome region. Nature (1999) 2.60
Genetic background alters the spectrum of tumors that develop in p53-deficient mice. FASEB J (1993) 2.57
Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death. Cell (1993) 2.52
A Study of the Action of a Filtrable Staphylococcal Toxin on the Kidneys of Normal Rabbits. Am J Pathol (1934) 2.50
Genomic imprinting of Mash2, a mouse gene required for trophoblast development. Nat Genet (1995) 2.46
Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments. Cell (1993) 2.45
Disruption of muscle architecture and myocardial degeneration in mice lacking desmin. J Cell Biol (1996) 2.44
Gli1 can rescue the in vivo function of Gli2. Development (2001) 2.43
Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. Genes Dev (1995) 2.41
A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice. Nature (1987) 2.33
Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum. Development (1994) 2.33
Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia. Nat Genet (1996) 2.32
Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. Nat Genet (1998) 2.32
Gene targeting yields a CD18-mutant mouse for study of inflammation. J Immunol (1993) 2.32
Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Proc Natl Acad Sci U S A (1995) 2.27
Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients. Lancet (1998) 2.26
Clinical and pharmacological properties of ivermectin in rabbits and guinea pigs. Vet Rec (1992) 2.21
Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse. Hum Mol Genet (1999) 2.20
Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance. Oncogene (1994) 2.20
Effects of genetic background on tumorigenesis in p53-deficient mice. Mol Carcinog (1995) 2.18
The paired-like homeo box gene MHox is required for early events of skeletogenesis in multiple lineages. Genes Dev (1995) 2.07
Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev (1998) 2.02
Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderm-inducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis. Development (1991) 2.02
Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis. Proc Natl Acad Sci U S A (1998) 2.00
Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev (1994) 1.99
Establishment and chimera analysis of 129/SvEv- and C57BL/6-derived mouse embryonic stem cell lines. Biotechniques (2000) 1.99
The mouse Engrailed-1 gene and ventral limb patterning. Nature (1996) 1.98
Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev (1990) 1.97