Published in FEBS Lett on February 20, 2014
Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res (2014) 0.80
Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation. IUCrJ (2014) 0.75
Update: Mechanisms Underlying N(6)-Methyladenosine Modification of Eukaryotic mRNA. Trends Genet (2016) 0.75
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet (2007) 14.99
Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet (2007) 13.62
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (2007) 9.86
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature (2012) 7.00
Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell (2012) 6.99
Dioxygen activation at mononuclear nonheme iron active sites: enzymes, models, and intermediates. Chem Rev (2004) 6.11
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol (2011) 5.96
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature (2003) 5.49
Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. Nature (2002) 5.47
Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity (2005) 5.23
AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli. Nature (2002) 4.62
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell (2012) 4.18
Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. RNA (1997) 2.89
Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett (2008) 2.61
An expression vector tailored for large-scale, high-throughput purification of recombinant proteins. Protein Expr Purif (2006) 2.58
Grand challenge commentary: RNA epigenetics? Nat Chem Biol (2010) 2.33
IME4, a gene that mediates MAT and nutritional control of meiosis in Saccharomyces cerevisiae. Mol Cell Biol (1992) 2.31
Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA. Nature (2008) 2.30
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. EMBO J (2006) 2.27
Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB. Nature (2006) 2.24
Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB. BMC Genomics (2003) 2.23
Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature (2010) 2.04
Localization of N6-methyladenosine in the Rous sarcoma virus genome. J Mol Biol (1977) 1.77
The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA. Angew Chem Int Ed Engl (2010) 1.76
Prevalence of loss-of-function FTO mutations in lean and obese individuals. Diabetes (2009) 1.54
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA. Nat Commun (2011) 1.52
A non-heme iron-mediated chemical demethylation in DNA and RNA. Acc Chem Res (2009) 1.51
Direct reversal of DNA alkylation damage. Chem Rev (2006) 1.22
FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA. Nat Commun (2013) 1.10
Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification. J Biol Chem (2011) 0.95
Crystallization and preliminary X-ray diffraction of the RNA demethylase ALKBH5. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.76