Published in Angew Chem Int Ed Engl on November 15, 2010
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol (2011) 5.96
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell (2012) 4.18
Grand challenge commentary: RNA epigenetics? Nat Chem Biol (2010) 2.33
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA. Nat Commun (2011) 1.52
Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. Nat Chem Biol (2012) 1.41
RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation. Genes Dev (2015) 1.29
Cellular dynamics of RNA modification. Acc Chem Res (2011) 1.28
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy. Proc Natl Acad Sci U S A (2014) 1.19
N6-methyl-adenosine modification in messenger and long non-coding RNA. Trends Biochem Sci (2013) 1.13
Transfer RNA methytransferases and their corresponding modifications in budding yeast and humans: activities, predications, and potential roles in human health. DNA Cell Biol (2011) 1.07
Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature (2014) 1.01
Nucleic acid oxidation in DNA damage repair and epigenetics. Chem Rev (2014) 1.01
Optimal translational termination requires C4 lysyl hydroxylation of eRF1. Mol Cell (2014) 0.99
tRNA modifications regulate translation during cellular stress. FEBS Lett (2014) 0.98
NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation. EMBO J (2016) 0.96
Archaeal Elp3 catalyzes tRNA wobble uridine modification at C5 via a radical mechanism. Nat Chem Biol (2014) 0.95
Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification. J Biol Chem (2011) 0.95
A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α. EMBO Mol Med (2013) 0.94
The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond. J Biol Chem (2015) 0.92
Sprouts of RNA epigenetics: the discovery of mammalian RNA demethylases. RNA Biol (2013) 0.90
Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation. J Biol Chem (2014) 0.89
Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases. J Biol Chem (2015) 0.89
DNA repair by reversal of DNA damage. Cold Spring Harb Perspect Biol (2013) 0.88
Roles of Trm9- and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA. Nucleic Acids Res (2011) 0.87
Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation. Nucleic Acids Res (2014) 0.83
Human ALKBH4 interacts with proteins associated with transcription. PLoS One (2012) 0.83
Spectroscopic and magnetic studies of wild-type and mutant forms of the Fe(II)- and 2-oxoglutarate-dependent decarboxylase ALKBH4. Biochem J (2011) 0.82
Insights into molecular plasticity in protein complexes from Trm9-Trm112 tRNA modifying enzyme crystal structure. Nucleic Acids Res (2015) 0.80
The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage. Nucleic Acids Res (2012) 0.80
Schizosaccharomyces pombe Ofd2 is a nuclear 2-oxoglutarate and iron dependent dioxygenase interacting with histones. PLoS One (2011) 0.80
Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res (2014) 0.80
Synthesis of a FTO inhibitor with anticonvulsant activity. ACS Chem Neurosci (2014) 0.79
Implications for damage recognition during Dpo4-mediated mutagenic bypass of m1G and m3C lesions. Structure (2011) 0.79
The atomic resolution structure of human AlkB homolog 7 (ALKBH7), a key protein for programmed necrosis and fat metabolism. J Biol Chem (2014) 0.78
The epitranscriptome in modulating spatiotemporal RNA translation in neuronal post-synaptic function. Front Cell Neurosci (2015) 0.77
Crystal structure of the RNA demethylase ALKBH5 from zebrafish. FEBS Lett (2014) 0.77
Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities. PLoS One (2014) 0.77
Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins. DNA Repair (Amst) (2015) 0.77
Characterization of a Trypanosoma brucei Alkb homolog capable of repairing alkylated DNA. Exp Parasitol (2012) 0.76
Modifying the maker: Oxygenases target ribosome biology. Translation (Austin) (2015) 0.75
Chemical Proteomic Profiling of Human Methyltransferases. J Am Chem Soc (2016) 0.75
ALKBHs-facilitated RNA modifications and de-modifications. DNA Repair (Amst) (2016) 0.75
Trm112, a Protein Activator of Methyltransferases Modifying Actors of the Eukaryotic Translational Apparatus. Biomolecules (2017) 0.75
Reversible RNA modifications in meiosis and pluripotency. Nat Methods (2016) 0.75
ALKBH1 is an RNA dioxygenase responsible for cytoplasmic and mitochondrial tRNA modifications. Nucleic Acids Res (2017) 0.75
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97
Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet (2007) 13.62
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (2007) 9.86
Inactivation of the Fto gene protects from obesity. Nature (2009) 5.61
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature (2003) 5.49
Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. Nature (2002) 5.47
AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli. Nature (2002) 4.62
Expanding chemical biology of 2-oxoglutarate oxygenases. Nat Chem Biol (2008) 4.52
The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases. Genome Biol (2001) 4.39
Reversal of DNA alkylation damage by two human dioxygenases. Proc Natl Acad Sci U S A (2002) 3.62
Trm9-catalyzed tRNA modifications link translation to the DNA damage response. Mol Cell (2007) 2.94
Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett (2008) 2.61
Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA. EMBO J (2006) 2.52
AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation. Mol Cell (2004) 2.26
Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB. BMC Genomics (2003) 2.23
Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation. Mamm Genome (1999) 1.92
Novel methyltransferase for modified uridine residues at the wobble position of tRNA. Mol Cell Biol (2003) 1.86
Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival. Mol Cell Biol (2010) 1.53
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression. Cancer Res (2009) 1.42
Direct reversal of DNA alkylation damage. Chem Rev (2006) 1.22
Bioinformatic mapping of AlkB homology domains in viruses. BMC Genomics (2005) 1.14
It's a mod mod tRNA world. Nat Chem Biol (2008) 0.91
Chemical structure of a new modified nucleoside located in the anticodon of Bombyx mori glycine tRNA2. J Biochem (1988) 0.91
Abnormal codon recognition of glycyl-tRNA from the posterior silk glands of Bombyx mori. J Biochem (1980) 0.84
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science (2011) 14.29
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science (2011) 13.16
Structures of the bacterial ribosome at 3.5 A resolution. Science (2005) 12.63
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol (2010) 9.01
The first metal-organic framework (MOF) of Imazethapyr and its SHG, piezoelectric and ferroelectric properties. Dalton Trans (2008) 8.86
Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell (2008) 7.93
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell (2011) 7.37
Revealing global regulatory features of mammalian alternative splicing using a quantitative microarray platform. Mol Cell (2004) 7.32
Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome. Cell (2012) 7.09
Hydrogen-bonded ferroelectrics based on metal-organic coordination. J Am Chem Soc (2009) 6.69
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol (2011) 5.96
Exploration of essential gene functions via titratable promoter alleles. Cell (2004) 5.21
Probing microRNAs with microarrays: tissue specificity and functional inference. RNA (2004) 4.91
Supramolecular bola-like ferroelectric: 4-methoxyanilinium tetrafluoroborate-18-crown-6. J Am Chem Soc (2011) 4.73
An evolutionarily conserved mechanism for controlling the efficiency of protein translation. Cell (2010) 4.45
Diisopropylammonium chloride: a ferroelectric organic salt with a high phase transition temperature and practical utilization level of spontaneous polarization. Adv Mater (2011) 4.30
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell (2012) 4.18
High-definition macromolecular composition of yeast RNA-processing complexes. Mol Cell (2004) 4.18
5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nat Neurosci (2011) 4.15
Tissue-specific differences in human transfer RNA expression. PLoS Genet (2006) 4.10
Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming. Cell (2013) 3.13
Improved virological outcomes in British Columbia concomitant with decreasing incidence of HIV type 1 drug resistance detection. Clin Infect Dis (2010) 3.12
A panoramic view of yeast noncoding RNA processing. Cell (2003) 3.11
Gold-catalyzed organic transformations. Chem Rev (2008) 3.06
Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. Nature (2012) 2.98
A multiferroic perdeutero metal-organic framework. Angew Chem Int Ed Engl (2011) 2.88
DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke. Cell (2010) 2.87
Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells. PLoS Genet (2011) 2.87
Basis for structural diversity in homologous RNAs. Science (2004) 2.70
Crystal structure of the specificity domain of ribonuclease P. Nature (2003) 2.69
Net primary production of Chinese croplands from 1950 to 1999. Ecol Appl (2007) 2.61
Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett (2008) 2.61
Structural basis for mRNA and tRNA positioning on the ribosome. Proc Natl Acad Sci U S A (2006) 2.55
Structural basis for aminoglycoside inhibition of bacterial ribosome recycling. Nat Struct Mol Biol (2007) 2.54
Innate immune and chemically triggered oxidative stress modifies translational fidelity. Nature (2009) 2.50
Selective charging of tRNA isoacceptors induced by amino-acid starvation. EMBO Rep (2005) 2.48
Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA. Nat Chem Biol (2012) 2.45
Structure of a bacterial ribonuclease P holoenzyme in complex with tRNA. Nature (2010) 2.40
Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell (2012) 2.39
Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development. Cell Res (2011) 2.36
Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA. Nature (2008) 2.30
Leucine-tRNA initiates at CUG start codons for protein synthesis and presentation by MHC class I. Science (2012) 2.30
Alternative splicing of conserved exons is frequently species-specific in human and mouse. Trends Genet (2005) 2.26
Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T cells. J Biol Chem (2009) 2.18
Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Cell (2013) 2.16
Genome-wide analysis of mouse transcripts using exon microarrays and factor graphs. Nat Genet (2005) 2.15
Crystal structure of the RNA component of bacterial ribonuclease P. Nature (2005) 2.10
tRNA over-expression in breast cancer and functional consequences. Nucleic Acids Res (2009) 2.08
Diversity of tRNA genes in eukaryotes. Nucleic Acids Res (2006) 2.05
Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila. Nat Chem Biol (2008) 2.04
Nascent peptide in the ribosome exit tunnel affects functional properties of the A-site of the peptidyl transferase center. Mol Cell (2011) 1.96
Reversible RNA adenosine methylation in biological regulation. Trends Genet (2012) 1.93
Sensitive and specific single-molecule sequencing of 5-hydroxymethylcytosine. Nat Methods (2011) 1.90
RNA catalyses nuclear pre-mRNA splicing. Nature (2013) 1.86
Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells. J Biol Chem (2006) 1.86
An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus. Nat Chem Biol (2006) 1.83
IKK mediates ischemia-induced neuronal death. Nat Med (2005) 1.83
Syntheses of 5-formyl- and 5-carboxyl-dC containing DNA oligos as potential oxidation products of 5-hydroxymethylcytosine in DNA. Org Lett (2011) 1.82
Functional coordination of alternative splicing in the mammalian central nervous system. Genome Biol (2007) 1.80
Exploring the regulation of tRNA distribution on the genomic scale. J Mol Biol (2004) 1.80
A small molecule enhances RNA interference and promotes microRNA processing. Nat Biotechnol (2008) 1.80
Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation. J Biol Chem (2007) 1.78
Vascular gene expression in nonneoplastic and malignant brain. Am J Pathol (2004) 1.71
HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis. Proc Natl Acad Sci U S A (2013) 1.70
Single-molecule studies highlight conformational heterogeneity in the early folding steps of a large ribozyme. Proc Natl Acad Sci U S A (2004) 1.69
5-formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription. Nat Struct Mol Biol (2012) 1.67
Gene expression profiling in a renal cell carcinoma cell line: dissecting VHL and hypoxia-dependent pathways. Mol Cancer Res (2003) 1.67
Tet-assisted bisulfite sequencing of 5-hydroxymethylcytosine. Nat Protoc (2012) 1.66
Increased ectonucleotidase expression and activity in regulatory T cells of patients with head and neck cancer. Clin Cancer Res (2009) 1.66
Identification of recognition residues for ligation-based detection and quantitation of pseudouridine and N6-methyladenosine. Nucleic Acids Res (2007) 1.66
Azide-bridged one-dimensional Mn(III) polymers: effects of side group of Schiff base ligands on structure and magnetism. Inorg Chem (2007) 1.65
Statistical resynchronization and Bayesian detection of periodically expressed genes. Nucleic Acids Res (2004) 1.64
Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2p. J Biol Chem (2009) 1.64
Brønsted acid catalyzed addition of phenols, carboxylic acids, and tosylamides to simple olefins. Org Lett (2006) 1.63
The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol (2002) 1.61
Patterns of exon-intron architecture variation of genes in eukaryotic genomes. BMC Genomics (2009) 1.61
Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia. Cancer Cell (2012) 1.61
Diisopropylammonium bromide is a high-temperature molecular ferroelectric crystal. Science (2013) 1.61
Specificity of Distalless repression and limb primordia development by abdominal Hox proteins. Dev Cell (2002) 1.61
Nuclear factor-kappaB contributes to infarction after permanent focal ischemia. Stroke (2004) 1.58
X-ray crystal structures of the WT and a hyper-accurate ribosome from Escherichia coli. Proc Natl Acad Sci U S A (2003) 1.58
A role for tRNA modifications in genome structure and codon usage. Cell (2012) 1.57
Polymorphism of antigen MPT64 in Mycobacterium tuberculosis strains. J Clin Microbiol (2013) 1.56
Real-time RNA profiling within a single bacterium. Proc Natl Acad Sci U S A (2005) 1.56