Published in Chem Rev on February 01, 2006
Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett (2008) 2.61
The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA. Angew Chem Int Ed Engl (2010) 1.76
The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One (2010) 1.67
A proteome chip approach reveals new DNA damage recognition activities in Escherichia coli. Nat Methods (2007) 1.54
Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools. Chem Res Toxicol (2011) 1.30
Genome dynamics in major bacterial pathogens. FEMS Microbiol Rev (2009) 1.06
Targeting and processing of site-specific DNA interstrand crosslinks. Environ Mol Mutagen (2010) 1.05
Using the bias from flow to elucidate single DNA repair protein sliding and interactions with DNA. Biophys J (2009) 0.93
Investigating the biochemical impact of DNA damage with structure-based probes: abasic sites, photodimers, alkylation adducts, and oxidative lesions. Biochemistry (2009) 0.93
Exocyclic carbons adjacent to the N6 of adenine are targets for oxidation by the Escherichia coli adaptive response protein AlkB. J Am Chem Soc (2012) 0.92
Mechanism of S-oxygenation by a cysteine dioxygenase model complex. J Phys Chem A (2011) 0.90
Imposing function down a (cupin)-barrel: secondary structure and metal stereochemistry in the αKG-dependent oxygenases. Metallomics (2013) 0.89
Chlamydomonas reinhardtii: a convenient model system for the study of DNA repair in photoautotrophic eukaryotes. Curr Genet (2007) 0.86
Genome stability: recent insights in the topoisomerase reverse gyrase and thermophilic DNA alkyltransferase. Extremophiles (2014) 0.85
Quantifying the energetic contributions of desolvation and π-electron density during translesion DNA synthesis. Nucleic Acids Res (2010) 0.85
Quantum mechanics/molecular mechanics study on the oxygen binding and substrate hydroxylation step in AlkB repair enzymes. Chemistry (2013) 0.85
Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage. Carcinogenesis (2013) 0.83
Repair of DNA Alkylation Damage by the Escherichia coli Adaptive Response Protein AlkB as Studied by ESI-TOF Mass Spectrometry. J Nucleic Acids (2010) 0.82
Axial and equatorial ligand effects on biomimetic cysteine dioxygenase model complexes. Org Biomol Chem (2012) 0.81
Exploring the roles of nucleobase desolvation and shape complementarity during the misreplication of O(6)-methylguanine. J Mol Biol (2011) 0.80
Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res (2014) 0.80
Insight into the cooperative DNA binding of the O⁶-alkylguanine DNA alkyltransferase. DNA Repair (Amst) (2014) 0.77
Crystal structure of the RNA demethylase ALKBH5 from zebrafish. FEBS Lett (2014) 0.77
Characterization of a novel DNA glycosylase from S. sahachiroi involved in the reduction and repair of azinomycin B induced DNA damage. Nucleic Acids Res (2015) 0.77
Protein sensing in living cells by molecular rotor-based fluorescence-switchable chemical probes. Chem Sci (2015) 0.77
Mechanistic studies on the application of DNA aptamers as inhibitors of 2-oxoglutarate-dependent oxygenases. J Med Chem (2012) 0.76
A quantum chemical study of repair of O6-methylguanine to guanine by tyrosine: evaluation of the winged helix-turn-helix model. J Mol Model (2009) 0.76
DNA Polymerases ImuC and DinB Are Involved in DNA Alkylation Damage Tolerance in Pseudomonas aeruginosa and Pseudomonas putida. PLoS One (2017) 0.75
Rhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA Damage. J Biol Chem (2016) 0.75
Copper carbenes alkylate guanine chemoselectively through a substrate directed reaction. Chem Sci (2016) 0.75
Instability and decay of the primary structure of DNA. Nature (1993) 25.58
A general method for the covalent labeling of fusion proteins with small molecules in vivo. Nat Biotechnol (2002) 6.77
Structure, Recognition, and Processing of Cisplatin-DNA Adducts. Chem Rev (1999) 5.63
FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes. Crit Rev Biochem Mol Biol (2004) 5.61
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature (2003) 5.49
Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. Nature (2002) 5.47
Geometric and electronic structure/function correlations in non-heme iron enzymes. Chem Rev (2000) 5.44
A new pathway for DNA repair in Escherichia coli. Nature (1977) 5.37
Structure and function of DNA photolyase and cryptochrome blue-light photoreceptors. Chem Rev (2003) 5.17
DNA and its associated processes as targets for cancer therapy. Nat Rev Cancer (2002) 4.69
AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli. Nature (2002) 4.62
Regulation and expression of the adaptive response to alkylating agents. Annu Rev Biochem (1988) 4.32
Alkylation damage in DNA and RNA--repair mechanisms and medical significance. DNA Repair (Amst) (2004) 4.03
A phylogenomic study of DNA repair genes, proteins, and processes. Mutat Res (1999) 3.67
Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA. Nature (2005) 3.67
Reversal of DNA alkylation damage by two human dioxygenases. Proc Natl Acad Sci U S A (2002) 3.62
Structure, function, and inhibition of O6-alkylguanine-DNA alkyltransferase. Prog Nucleic Acid Res Mol Biol (1995) 3.53
Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res (1990) 3.38
Labeling of fusion proteins with synthetic fluorophores in live cells. Proc Natl Acad Sci U S A (2004) 3.11
Repair of O(6)-alkylguanine by alkyltransferases. Mutat Res (2000) 3.05
Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis. Proc Natl Acad Sci U S A (1985) 3.01
Mutagenesis, genotoxicity, and repair of 1-methyladenine, 3-alkylcytosines, 1-methylguanine, and 3-methylthymine in alkB Escherichia coli. Proc Natl Acad Sci U S A (2004) 3.00
Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents. Mutat Res (1990) 2.94
DNA binding and nucleotide flipping by the human DNA repair protein AGT. Nat Struct Mol Biol (2004) 2.86
Repairing DNA-methylation damage. Nat Rev Mol Cell Biol (2004) 2.85
A mechanistic perspective on the chemistry of DNA repair glycosylases. Chem Rev (2003) 2.84
The intracellular signal for induction of resistance to alkylating agents in E. coli. Cell (1986) 2.77
Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction. EMBO J (1982) 2.67
The major human abasic endonuclease: formation, consequences and repair of abasic lesions in DNA. Mutat Res (2001) 2.49
DNA adduct formation from tobacco-specific N-nitrosamines. Mutat Res (1999) 2.41
AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation. Mol Cell (2004) 2.26
Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes. Curr Opin Struct Biol (1999) 2.25
Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB. BMC Genomics (2003) 2.23
Structural basis for the excision repair of alkylation-damaged DNA. Cell (1996) 2.23
DNA Cross-Linking Agents as Antitumor Drugs. Chem Rev (1998) 2.17
Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents. Proc Natl Acad Sci U S A (1990) 2.14
A new gene (alkB) of Escherichia coli that controls sensitivity to methyl methane sulfonate. J Bacteriol (1983) 2.06
Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase. EMBO J (1982) 2.03
AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo. Nat Struct Mol Biol (2005) 1.96
Demethylation of 3-methylthymine in DNA by bacterial and human DNA dioxygenases. J Biol Chem (2004) 1.94
Methylation-induced blocks to in vitro DNA replication. Mutat Res (1985) 1.89
3-methyladenine DNA glycosylases: structure, function, and biological importance. Bioessays (1999) 1.80
Generation of an endogenous DNA-methylating agent by nitrosation in Escherichia coli. J Bacteriol (1996) 1.77
Directed evolution of O6-alkylguanine-DNA alkyltransferase for efficient labeling of fusion proteins with small molecules in vivo. Chem Biol (2003) 1.76
Repair of 3-methylthymine and 1-methylguanine lesions by bacterial and human AlkB proteins. Nucleic Acids Res (2004) 1.75
Nonenzymatic methylation of DNA by S-adenosylmethionine in vitro. Carcinogenesis (1982) 1.68
Defective processing of methylated single-stranded DNA by E. coli AlkB mutants. Genes Dev (2000) 1.68
Dynamic opening of DNA during the enzymatic search for a damaged base. Nat Struct Mol Biol (2004) 1.60
One motif--many different reactions. Nat Struct Biol (2000) 1.59
Recent progress on the Ada response for inducible repair of DNA alkylation damage. Oncogene (2002) 1.59
Functional domains and methyl acceptor sites of the Escherichia coli ada protein. J Biol Chem (1988) 1.58
Crystal structure of a suicidal DNA repair protein: the Ada O6-methylguanine-DNA methyltransferase from E. coli. EMBO J (1994) 1.58
O6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and chemotherapy. Bioessays (2002) 1.58
Substrate specificities of bacterial and human AlkB proteins. Nucleic Acids Res (2004) 1.54
Direct visualization of a DNA glycosylase searching for damage. Chem Biol (2002) 1.53
Minimal methylated substrate and extended substrate range of Escherichia coli AlkB protein, a 1-methyladenine-DNA dioxygenase. J Biol Chem (2003) 1.53
Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding. EMBO J (2000) 1.50
Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma. J Clin Oncol (2002) 1.50
Direct repair of the exocyclic DNA adduct 1,N6-ethenoadenine by the DNA repair AlkB proteins. J Am Chem Soc (2005) 1.50
The selectivity and inhibition of AlkB. J Biol Chem (2003) 1.43
cDNA cloning and chromosomal assignment of the human O6-methylguanine-DNA methyltransferase. cDNA expression in Escherichia coli and gene expression in human cells. J Biol Chem (1990) 1.43
Molecular cloning and functional analysis of a human cDNA encoding an Escherichia coli AlkB homolog, a protein involved in DNA alkylation damage repair. Nucleic Acids Res (1996) 1.41
O2- and alpha-ketoglutarate-dependent tyrosyl radical formation in TauD, an alpha-keto acid-dependent non-heme iron dioxygenase. Biochemistry (2003) 1.41
A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation. Proc Natl Acad Sci U S A (1999) 1.41
Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS). J Mol Biol (2001) 1.41
Structure and transcriptional regulation of the Escherichia coli adaptive response gene aidB. J Bacteriol (1994) 1.40
The role of O6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis. Mutat Res (1985) 1.39
Linear free energy correlations for enzymatic base flipping: how do damaged base pairs facilitate specific recognition? Biochemistry (2004) 1.35
The Escherichia coli AlkB protein protects human cells against alkylation-induced toxicity. J Bacteriol (1994) 1.35
DNA-binding mechanism of O6-alkylguanine-DNA alkyltransferase. Effects of protein and DNA alkylation on complex stability. J Biol Chem (2002) 1.34
Structure and expression of the alkB gene of Escherichia coli related to the repair of alkylated DNA. J Biol Chem (1986) 1.33
How do DNA repair proteins locate damaged bases in the genome? Chem Biol (1997) 1.30
Degradation of the alkylated form of the DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase. Carcinogenesis (2002) 1.29
The mechanism of action of DNA photolyases. Curr Opin Chem Biol (2001) 1.26
The structure of the human AGT protein bound to DNA and its implications for damage detection. J Mol Biol (2005) 1.26
Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase. Nucleic Acids Res (2000) 1.25
Enzyme-catalyzed methyl transfers to thiols: the role of zinc. Curr Opin Chem Biol (1997) 1.22
Molecular cloning and characterization of the alkB gene of Escherichia coli. Mol Gen Genet (1985) 1.22
Repair of DNA methylphosphotriesters through a metalloactivated cysteine nucleophile. Science (1993) 1.20
Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. J Clin Oncol (2000) 1.19
First principles calculations of the tautomers and pK(a) values of 8-oxoguanine: implications for mutagenicity and repair. Chem Res Toxicol (2002) 1.18
Regulatory responses of the adaptive response to alkylation damage: a simple regulon with complex regulatory features. J Bacteriol (2000) 1.17
Preparation and characterization of the native iron(II)-containing DNA repair AlkB protein directly from Escherichia coli. J Am Chem Soc (2004) 1.16
Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase. J Biol Chem (2005) 1.16
The Saccharomyces cerevisiae MGT1 DNA repair methyltransferase gene: its promoter and entire coding sequence, regulation and in vivo biological functions. Nucleic Acids Res (1992) 1.15
Regulation of expression of the ada gene controlling the adaptive response. Interactions with the ada promoter of the Ada protein and RNA polymerase. J Mol Biol (1989) 1.15
Bioinformatic mapping of AlkB homology domains in viruses. BMC Genomics (2005) 1.14
Hyperthermostable protein structure maintained by intra and inter-helix ion-pairs in archaeal O6-methylguanine-DNA methyltransferase. J Mol Biol (1999) 1.12
DNA repair by bacterial AlkB proteins. Res Microbiol (2003) 1.11
Aberrant activity of the DNA repair enzyme AlkB. J Inorg Biochem (2004) 1.10
Alternative reactivity of an alpha-ketoglutarate-dependent iron(II) oxygenase: enzyme self-hydroxylation. J Am Chem Soc (2001) 1.09
Positive and negative regulation of transcription by a cleavage product of Ada protein. J Mol Biol (1990) 1.09
O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145. Biochemistry (2003) 1.09
Purification of the E. coli ogt gene product to homogeneity and its rate of action on O6-methylguanine, O6-ethylguanine and O4-methylthymine in dodecadeoxyribonucleotides. Nucleic Acids Res (1989) 1.08
Methylcobamide:coenzyme M methyltransferase isozymes from Methanosarcina barkeri. Physicochemical characterization, cloning, sequence analysis, and heterologous gene expression. J Biol Chem (1996) 1.08
Repair of O6-methylguanine, O6-ethylguanine, O6-isopropylguanine and O4-methylthymine in synthetic oligodeoxynucleotides by Escherichia coli ada gene O6-alkylguanine-DNA-alkyltransferase. Carcinogenesis (1989) 1.07
Trapping distinct structural states of a protein/DNA interaction through disulfide crosslinking. Chem Biol (2002) 1.07
Regulation of repair of alkylation damage in mammalian genomes. Prog Nucleic Acid Res Mol Biol (1993) 1.06
Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O(6)-alkylguanine-DNA alkyltransferase. Mutat Res (2000) 1.05
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science (2011) 14.29
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science (2011) 13.16
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol (2010) 9.01
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell (2011) 7.37
Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome. Cell (2012) 7.09
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol (2011) 5.96
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell (2012) 4.18
5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nat Neurosci (2011) 4.15
Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming. Cell (2013) 3.13
Gold-catalyzed organic transformations. Chem Rev (2008) 3.06
Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells. PLoS Genet (2011) 2.87
Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett (2008) 2.61
Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA. Nat Chem Biol (2012) 2.45
Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell (2012) 2.39
Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development. Cell Res (2011) 2.36
Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA. Nature (2008) 2.30
Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Cell (2013) 2.16
Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila. Nat Chem Biol (2008) 2.04
Reversible RNA adenosine methylation in biological regulation. Trends Genet (2012) 1.93
Sensitive and specific single-molecule sequencing of 5-hydroxymethylcytosine. Nat Methods (2011) 1.90
An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus. Nat Chem Biol (2006) 1.83
Syntheses of 5-formyl- and 5-carboxyl-dC containing DNA oligos as potential oxidation products of 5-hydroxymethylcytosine in DNA. Org Lett (2011) 1.82
A small molecule enhances RNA interference and promotes microRNA processing. Nat Biotechnol (2008) 1.80
The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA. Angew Chem Int Ed Engl (2010) 1.76
HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis. Proc Natl Acad Sci U S A (2013) 1.70
5-formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription. Nat Struct Mol Biol (2012) 1.67
Tet-assisted bisulfite sequencing of 5-hydroxymethylcytosine. Nat Protoc (2012) 1.66
Brønsted acid catalyzed addition of phenols, carboxylic acids, and tosylamides to simple olefins. Org Lett (2006) 1.63
Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia. Cancer Cell (2012) 1.61
A selective fluorescent probe for carbon monoxide imaging in living cells. Angew Chem Int Ed Engl (2012) 1.55
A proteome chip approach reveals new DNA damage recognition activities in Escherichia coli. Nat Methods (2007) 1.54
Selective fluorescent probes for live-cell monitoring of sulphide. Nat Commun (2011) 1.51
A non-heme iron-mediated chemical demethylation in DNA and RNA. Acc Chem Res (2009) 1.51
Mapping recently identified nucleotide variants in the genome and transcriptome. Nat Biotechnol (2012) 1.51
Direct repair of the exocyclic DNA adduct 1,N6-ethenoadenine by the DNA repair AlkB proteins. J Am Chem Soc (2005) 1.50
The Pseudomonas aeruginosa multidrug efflux regulator MexR uses an oxidation-sensing mechanism. Proc Natl Acad Sci U S A (2008) 1.39
Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA. RNA (2013) 1.37
Mechanism and function of oxidative reversal of DNA and RNA methylation. Annu Rev Biochem (2014) 1.36
Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain. Genome Biol (2014) 1.36
Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase. Nature (2010) 1.36
In the Staphylococcus aureus two-component system sae, the response regulator SaeR binds to a direct repeat sequence and DNA binding requires phosphorylation by the sensor kinase SaeS. J Bacteriol (2010) 1.35
Genome-wide analysis of N1-methyl-adenosine modification in human tRNAs. RNA (2010) 1.33
Intramolecular amide bonds stabilize pili on the surface of bacilli. Proc Natl Acad Sci U S A (2009) 1.31
Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency. Nat Cell Biol (2013) 1.27
The structure of the human AGT protein bound to DNA and its implications for damage detection. J Mol Biol (2005) 1.26
A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in Staphylococcus aureus. Mol Microbiol (2008) 1.25
Enhanced 5-methylcytosine detection in single-molecule, real-time sequencing via Tet1 oxidation. BMC Biol (2013) 1.24
Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins. Nat Struct Mol Biol (2011) 1.23
Crystal structures of the reduced, sulfenic acid, and mixed disulfide forms of SarZ, a redox active global regulator in Staphylococcus aureus. J Biol Chem (2009) 1.21
Potential functional roles of DNA demethylation intermediates. Trends Biochem Sci (2013) 1.21
Efficient functionalization of aromatic C-H bonds catalyzed by gold(III) under mild and solvent-free conditions. J Org Chem (2004) 1.21
Genome-wide DNA hydroxymethylation changes are associated with neurodevelopmental genes in the developing human cerebellum. Hum Mol Genet (2012) 1.21
Quantitative genetic background of the host influences gut microbiomes in chickens. Sci Rep (2013) 1.20
Nucleic acid modifications with epigenetic significance. Curr Opin Chem Biol (2012) 1.20
TET1 plays an essential oncogenic role in MLL-rearranged leukemia. Proc Natl Acad Sci U S A (2013) 1.19
A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination. Nat Struct Mol Biol (2010) 1.18
High-resolution N(6) -methyladenosine (m(6) A) map using photo-crosslinking-assisted m(6) A sequencing. Angew Chem Int Ed Engl (2014) 1.18
Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis. Nat Commun (2013) 1.18
Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance. Proc Natl Acad Sci U S A (2012) 1.18
Golden pigment production and virulence gene expression are affected by metabolisms in Staphylococcus aureus. J Bacteriol (2010) 1.18
Preparation and characterization of the native iron(II)-containing DNA repair AlkB protein directly from Escherichia coli. J Am Chem Soc (2004) 1.16
A general strategy to convert the MerR family proteins into highly sensitive and selective fluorescent biosensors for metal ions. J Am Chem Soc (2004) 1.16
Selective recognition of metal ions by metalloregulatory proteins. Curr Opin Chem Biol (2008) 1.16
Crystal structures of SlyA protein, a master virulence regulator of Salmonella, in free and DNA-bound states. J Biol Chem (2011) 1.15
A silver-catalyzed intramolecular amidation of saturated C--h bonds. Angew Chem Int Ed Engl (2004) 1.15
Oxidative dealkylation DNA repair mediated by the mononuclear non-heme iron AlkB proteins. J Inorg Biochem (2006) 1.15
Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA. Proc Natl Acad Sci U S A (2012) 1.11
Gold(I)-catalyzed intra- and intermolecular hydroamination of unactivated olefins. J Am Chem Soc (2006) 1.11
Aureusimines in Staphylococcus aureus are not involved in virulence. PLoS One (2010) 1.11
FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA. Nat Commun (2013) 1.10
Silver-catalyzed intermolecular amination of C--H groups. Angew Chem Int Ed Engl (2007) 1.10
Pseudomonas aeruginosa OspR is an oxidative stress sensing regulator that affects pigment production, antibiotic resistance and dissemination during infection. Mol Microbiol (2009) 1.09
Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation. Nat Commun (2013) 1.08
Spatiotemporal clustering of the epigenome reveals rules of dynamic gene regulation. Genome Res (2012) 1.08
Genome sequences of wild and domestic bactrian camels. Nat Commun (2012) 1.07
Gold(I)-catalyzed intermolecular addition of phenols and carboxylic acids to olefins. J Am Chem Soc (2005) 1.07
Syntheses of two 5-hydroxymethyl-2'-deoxycytidine phosphoramidites with TBDMS as the 5-hydroxymethyl protecting group and their incorporation into DNA. J Org Chem (2011) 1.07
Capsule anchoring in Bacillus anthracis occurs by a transpeptidation reaction that is inhibited by capsidin. Mol Microbiol (2008) 1.06
Proteome-wide quantification and characterization of oxidation-sensitive cysteines in pathogenic bacteria. Cell Host Microbe (2013) 1.06
Organocatalysis in cross-coupling: DMEDA-catalyzed direct C-H arylation of unactivated benzene. J Am Chem Soc (2010) 1.05
Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2. Proc Natl Acad Sci U S A (2014) 1.04
AirSR, a [2Fe-2S] cluster-containing two-component system, mediates global oxygen sensing and redox signaling in Staphylococcus aureus. J Am Chem Soc (2011) 1.04
Design of an emission ratiometric biosensor from MerR family proteins: a sensitive and selective sensor for Hg2+. J Am Chem Soc (2007) 1.03
Chemical modification-assisted bisulfite sequencing (CAB-Seq) for 5-carboxylcytosine detection in DNA. J Am Chem Soc (2013) 1.03
Dynamic copper(I) imaging in mammalian cells with a genetically encoded fluorescent copper(I) sensor. J Am Chem Soc (2010) 1.03
Probing the structure and function of the Escherichia coli DNA alkylation repair AlkB protein through chemical cross-linking. J Am Chem Soc (2003) 1.01
Nucleic acid oxidation in DNA damage repair and epigenetics. Chem Rev (2014) 1.01
The auxiliary protein complex SaePQ activates the phosphatase activity of sensor kinase SaeS in the SaeRS two-component system of Staphylococcus aureus. Mol Microbiol (2012) 1.00
Interaction of human and bacterial AlkB proteins with DNA as probed through chemical cross-linking studies. Nucleic Acids Res (2004) 1.00
An exceptionally selective lead(II)-regulatory protein from Ralstonia metallidurans: development of a fluorescent lead(II) probe. Angew Chem Int Ed Engl (2005) 1.00
Intramolecular additions of alcohols and carboxylic acids to inert olefins catalyzed by silver(I) triflate. Org Lett (2005) 1.00
Ni-catalyzed mild arylation of alpha-halocarbonyl compounds with arylboronic acids. Org Lett (2007) 0.99
Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing. Nat Commun (2013) 0.99
An Au-catalyzed cyclialkylation of electron-rich arenes with epoxides to prepare 3-chromanols. J Am Chem Soc (2004) 0.98
Expression of multidrug resistance efflux pump gene norA is iron responsive in Staphylococcus aureus. J Bacteriol (2012) 0.98
CcpA mediates proline auxotrophy and is required for Staphylococcus aureus pathogenesis. J Bacteriol (2010) 0.97