Published in Nucleic Acids Res on February 21, 2014
Long-range looping of a locus control region drives tissue-specific chromatin packing within a multigene cluster. Nucleic Acids Res (2016) 0.75
Expression of Placental Members of the Human Growth Hormone Gene Family Is Increased in Response to Sequential Inhibition of DNA Methylation and Histone Deacetylation. Biores Open Access (2015) 0.75
An integrated encyclopedia of DNA elements in the human genome. Nature (2012) 64.73
Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. Cell (2007) 16.66
A user's guide to the encyclopedia of DNA elements (ENCODE). PLoS Biol (2011) 16.53
CTCF: master weaver of the genome. Cell (2009) 15.09
Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions. Nature (2008) 10.95
The protein CTCF is required for the enhancer blocking activity of vertebrate insulators. Cell (1999) 9.74
Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains. Genome Res (2008) 7.41
Epigenetic modifications and human disease. Nat Biotechnol (2010) 7.29
Architectural protein subclasses shape 3D organization of genomes during lineage commitment. Cell (2013) 6.37
CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. Genes Dev (2006) 6.32
We gather together: insulators and genome organization. Curr Opin Genet Dev (2007) 5.81
CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across species. Mol Cell (2004) 5.51
Remote control of gene transcription. Hum Mol Genet (2005) 4.80
Locus control regions. Blood (2002) 4.41
Selective cleavage of human DNA: RecA-assisted restriction endonuclease (RARE) cleavage. Science (1991) 3.87
Highly efficient modification of bacterial artificial chromosomes (BACs) using novel shuttle vectors containing the R6Kgamma origin of replication. Genome Res (2002) 3.61
DNase-seq: a high-resolution technique for mapping active gene regulatory elements across the genome from mammalian cells. Cold Spring Harb Protoc (2010) 3.54
CTCF and cohesin: linking gene regulatory elements with their targets. Cell (2013) 2.53
Multiple interactions between regulatory regions are required to stabilize an active chromatin hub. Genes Dev (2004) 2.17
The human growth hormone locus: nucleotide sequence, biology, and evolution. Genomics (1989) 2.17
Enhancer and promoter interactions-long distance calls. Curr Opin Genet Dev (2011) 1.88
The human growth hormone gene family: structure and evolution of the chromosomal locus. Nucleic Acids Res (1983) 1.81
A defined locus control region determinant links chromatin domain acetylation with long-range gene activation. Mol Cell (2002) 1.70
Specific sites in the C terminus of CTCF interact with the SA2 subunit of the cohesin complex and are required for cohesin-dependent insulation activity. Mol Cell Biol (2011) 1.68
The human growth hormone gene is regulated by a multicomponent locus control region. Mol Cell Biol (1995) 1.54
Targeted recruitment of histone acetyltransferase activity to a locus control region. J Biol Chem (2000) 1.40
Beta-globin regulation and long-range interactions. Adv Genet (2008) 1.31
Patterns of histone acetylation suggest dual pathways for gene activation by a bifunctional locus control region. EMBO J (2000) 1.28
Pit-1 binding sites at the somatotrope-specific DNase I hypersensitive sites I, II of the human growth hormone locus control region are essential for in vivo hGH-N gene activation. J Biol Chem (1999) 1.27
The human growth hormone gene cluster locus control region supports position-independent pituitary- and placenta-specific expression in the transgenic mouse. J Biol Chem (2000) 1.25
Chromatin domains, insulators, and the regulation of gene expression. Biochim Biophys Acta (2012) 1.11
Epigenetic modifications at the human growth hormone locus predict distinct roles for histone acetylation and methylation in placental gene activation. Mol Endocrinol (2004) 1.08
Characterization and histologic localization of human growth hormone-variant gene expression in the placenta. J Clin Invest (1989) 1.05
The human placental lactogen genes: structure, function, evolution and transcriptional regulation. Endocr Rev (1991) 1.04
Epigenetic activation of the human growth hormone gene cluster during placental cytotrophoblast differentiation. Mol Cell Biol (2007) 1.03
The juxtaposition of a promoter with a locus control region transcriptional domain activates gene expression. EMBO Rep (2008) 1.00
Surveying the epigenomic landscape, one base at a time. Genome Biol (2012) 0.99
CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the β-globin locus. Nucleic Acids Res (2012) 0.98
Pituitary-specific repression of placental members of the human growth hormone gene family. A possible mechanism for locus regulation. J Biol Chem (1993) 0.97
An initiator element is required for maximal human chorionic somatomammotropin gene promoter and enhancer function. J Biol Chem (1995) 0.97
Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. J Biol Chem (1997) 0.95
Chromatin loop formation in the β-globin locus and its role in globin gene transcription. Mol Cells (2012) 0.94
DNase I hypersensitive site II of the human growth hormone locus control region mediates an essential and distinct long-range enhancer function. J Biol Chem (2012) 0.89
POU1F1-mediated activation of hGH-N by deoxyribonuclease I hypersensitive site II of the human growth hormone locus control region. J Mol Biol (2011) 0.86
MicroRNA silencing through RISC recruitment of eIF6. Nature (2007) 4.37
miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts. Cell (2010) 4.07
The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms. RNA (2002) 3.62
Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay. RNA (2008) 1.65
Locus control region transcription plays an active role in long-range gene activation. Mol Cell (2006) 1.63
Hypoxia-mediated selective mRNA translation by an internal ribosome entry site-independent mechanism. J Biol Chem (2008) 1.51
Identification of mRNAs associated with alphaCP2-containing RNP complexes. Mol Cell Biol (2003) 1.49
Bystander gene activation by a locus control region. EMBO J (2004) 1.38
Regulation of alpha-globin mRNA stability. Exp Biol Med (Maywood) (2003) 1.38
Butyrate increases the efficiency of translation of gamma-globin mRNA. Blood (2004) 1.34
Nonsense mutations in close proximity to the initiation codon fail to trigger full nonsense-mediated mRNA decay. J Biol Chem (2004) 1.33
Vitamin D-binding protein influences total circulating levels of 1,25-dihydroxyvitamin D3 but does not directly modulate the bioactive levels of the hormone in vivo. Endocrinology (2008) 1.26
The KH-domain protein alpha CP has a direct role in mRNA stabilization independent of its cognate binding site. Mol Cell Biol (2003) 1.26
Pseudogene-mediated posttranscriptional silencing of HMGA1 can result in insulin resistance and type 2 diabetes. Nat Commun (2010) 1.17
Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest. J Biol Chem (2009) 1.17
A novel set of nuclear localization signals determine distributions of the alphaCP RNA-binding proteins. Mol Cell Biol (2003) 1.16
In vivo association of the stability control protein alphaCP with actively translating mRNAs. Mol Cell Biol (2003) 1.12
Neurobeachin is essential for neuromuscular synaptic transmission. J Neurosci (2004) 1.08
Epigenetic modifications at the human growth hormone locus predict distinct roles for histone acetylation and methylation in placental gene activation. Mol Endocrinol (2004) 1.08
Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations. Nucleic Acids Res (2011) 1.03
129X1/SvJ mouse strain has a novel defect in inflammatory cell recruitment. J Immunol (2002) 1.03
Epigenetic activation of the human growth hormone gene cluster during placental cytotrophoblast differentiation. Mol Cell Biol (2007) 1.03
The juxtaposition of a promoter with a locus control region transcriptional domain activates gene expression. EMBO Rep (2008) 1.00
Neurobeachin regulates neurotransmitter receptor trafficking to synapses. J Cell Biol (2012) 0.97
Targeting a KH-domain protein with RNA decoys. RNA (2002) 0.97
The 3' untranslated region complex involved in stabilization of human alpha-globin mRNA assembles in the nucleus and serves an independent role as a splice enhancer. Mol Cell Biol (2007) 0.96
Specification of unique Pit-1 activity in the hGH locus control region. Proc Natl Acad Sci U S A (2002) 0.95
Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1α-mediated mRNA transcription and continuous protein synthesis. FASEB J (2012) 0.94
An RNA-independent linkage of noncoding transcription to long-range enhancer function. Mol Cell Biol (2012) 0.91
Activation of the human GH gene cluster: roles for targeted chromatin modification. Trends Endocrinol Metab (2003) 0.91
Neutrophil recruitment to the lung in both C5a- and CXCL1-induced alveolitis is impaired in vitamin D-binding protein-deficient mice. J Immunol (2013) 0.91
A cell type-restricted mRNA surveillance pathway triggered by ribosome extension into the 3' untranslated region. Nat Struct Mol Biol (2007) 0.91
Haploinsufficiency of the autism candidate gene Neurobeachin induces autism-like behaviors and affects cellular and molecular processes of synaptic plasticity in mice. Neurobiol Dis (2012) 0.90
αCP Poly(C) binding proteins act as global regulators of alternative polyadenylation. Mol Cell Biol (2013) 0.90
An RNA-protein complex links enhanced nuclear 3' processing with cytoplasmic mRNA stabilization. EMBO J (2011) 0.90
Shared stabilization functions of pyrimidine-rich determinants in the erythroid 15-lipoxygenase and alpha-globin mRNAs. Mol Cell Biol (2006) 0.89
DNase I hypersensitive site II of the human growth hormone locus control region mediates an essential and distinct long-range enhancer function. J Biol Chem (2012) 0.89
A single base difference between Pit-1 binding sites at the hGH promoter and locus control region specifies distinct Pit-1 conformations and functions. Mol Cell Biol (2006) 0.89
Synapse associated protein 102 (SAP102) binds the C-terminal part of the scaffolding protein neurobeachin. PLoS One (2012) 0.88
Distinct chromatin configurations regulate the initiation and the maintenance of hGH gene expression. Mol Cell Biol (2013) 0.85
Tissue-specific chromatin modifications at a multigene locus generate asymmetric transcriptional interactions. Mol Cell Biol (2006) 0.85
The role of the hGH locus control region in somatotrope restriction of hGH-N gene expression. Mol Endocrinol (2011) 0.83
Research resource: T-antigen transformation of pituitary cells captures three novel cell lines in the Pit-1 lineage. Mol Endocrinol (2010) 0.82
Cytoplasmic poly(A) binding protein C4 serves a critical role in erythroid differentiation. Mol Cell Biol (2014) 0.81
An intronic locus control region plays an essential role in the establishment of an autonomous hepatic chromatin domain for the human vitamin D-binding protein gene. Mol Cell Biol (2007) 0.80
The poly(rC)-binding protein alphaCP2 is a noncanonical factor in X. laevis cytoplasmic polyadenylation. RNA (2011) 0.80
Identification of a secondary promoter within the human B cell receptor component gene hCD79b. J Biol Chem (2013) 0.79
Too much PABP, too little translation. J Clin Invest (2010) 0.78
The human vitamin D-binding protein gene contains locus control determinants sufficient for autonomous activation in hepatic chromatin. Nucleic Acids Res (2006) 0.78
The role of the serum vitamin D binding protein in the actions of the vitamin D analog eldecalcitol (ED-71) on bone and mineral metabolism. Calcif Tissue Int (2013) 0.77
Igbeta(CD79b) mRNA expression in chronic lymphocytic leukaemia cells correlates with immunoglobulin heavy chain gene mutational status but does not serve as an independent predictor of clinical severity. Am J Hematol (2007) 0.75