Published in Nature on May 16, 2007
Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature (2010) 22.04
Origins and Mechanisms of miRNAs and siRNAs. Cell (2009) 20.77
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Mol Cell (2009) 4.57
Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2. Mol Cell (2007) 4.22
Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans. Nat Struct Mol Biol (2010) 4.22
Deadenylation is a widespread effect of miRNA regulation. RNA (2008) 3.98
Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing. Genes Dev (2007) 3.92
MicroRNA regulation by RNA-binding proteins and its implications for cancer. Nat Rev Cancer (2011) 3.91
A parsimonious model for gene regulation by miRNAs. Science (2011) 3.79
miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA. EMBO J (2011) 3.55
Messenger RNA regulation: to translate or to degrade. EMBO J (2008) 3.38
mir-17-92, a cluster of miRNAs in the midst of the cancer network. Int J Biochem Cell Biol (2010) 3.15
p16(INK4a) translation suppressed by miR-24. PLoS One (2008) 3.08
Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells. J Immunol (2008) 2.95
Potential role of miR-9 and miR-223 in recurrent ovarian cancer. Mol Cancer (2008) 2.53
The c-myb proto-oncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells. Blood (2008) 2.34
Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins. EMBO J (2009) 2.32
The mammalian ovary from genesis to revelation. Endocr Rev (2009) 2.31
Estradiol-regulated microRNAs control estradiol response in breast cancer cells. Nucleic Acids Res (2009) 2.27
Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression. RNA (2009) 2.15
Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy reveal the cytoplasmic origination of loaded nuclear RISC in vivo in human cells. Nucleic Acids Res (2008) 2.01
Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation. Nature (2008) 1.85
Multiple independent domains of dGW182 function in miRNA-mediated repression in Drosophila. RNA (2009) 1.80
MicroRNAs and their role in progressive kidney diseases. Clin J Am Soc Nephrol (2009) 1.77
MicroRNA-repressed mRNAs contain 40S but not 60S components. Proc Natl Acad Sci U S A (2008) 1.71
The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing. EMBO J (2013) 1.68
microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells. PLoS One (2009) 1.67
MicroRNA regulation of neural stem cells and neurogenesis. J Neurosci (2010) 1.64
Posttranscriptional control of neuronal development by microRNA networks. Trends Neurosci (2007) 1.56
Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation. Int J Genomics (2014) 1.54
Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway. Proc Natl Acad Sci U S A (2010) 1.52
Perturbation of the P-body component Mov10 inhibits HIV-1 infectivity. PLoS One (2010) 1.51
Mammalian GW182 contains multiple Argonaute-binding sites and functions in microRNA-mediated translational repression. RNA (2009) 1.50
Mechanism of eIF6-mediated inhibition of ribosomal subunit joining. J Biol Chem (2010) 1.44
The complexity of miRNA-mediated repression. Cell Death Differ (2014) 1.44
P body-associated protein Mov10 inhibits HIV-1 replication at multiple stages. J Virol (2010) 1.40
Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies. Proc Natl Acad Sci U S A (2008) 1.35
MicroRNAs can regulate human APP levels. Mol Neurodegener (2008) 1.34
Capped small RNAs and MOV10 in human hepatitis delta virus replication. Nat Struct Mol Biol (2008) 1.34
MicroRNAs: molecular features and role in cancer. Front Biosci (Landmark Ed) (2012) 1.32
Moloney leukemia virus 10 (MOV10) protein inhibits retrovirus replication. J Biol Chem (2010) 1.27
A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like. Mol Cell Biol (2011) 1.26
Eukaryotic initiation factor 6 mediates a continuum between 60S ribosome biogenesis and translation. EMBO Rep (2009) 1.20
Estrogen Regulation of MicroRNA Expression. Curr Genomics (2009) 1.20
p53 activates the PANK1/miRNA-107 gene leading to downregulation of CDK6 and p130 cell cycle proteins. Nucleic Acids Res (2010) 1.19
RISC-target interaction: cleavage and translational suppression. Biochim Biophys Acta (2008) 1.18
How do miRNAs mediate translational repression? Silence (2010) 1.17
MiR-205 silences MED1 in hypoxic primary human trophoblasts. FASEB J (2010) 1.17
An expanded seed sequence definition accounts for full regulation of the hid 3' UTR by bantam miRNA. RNA (2009) 1.17
Computational analysis of miRNA-mediated repression of translation: implications for models of translation initiation inhibition. RNA (2008) 1.17
MOV10 RNA helicase is a potent inhibitor of retrotransposition in cells. PLoS Genet (2012) 1.17
Mixture models and wavelet transforms reveal high confidence RNA-protein interaction sites in MOV10 PAR-CLIP data. Nucleic Acids Res (2012) 1.15
Dual regulation of miRNA biogenesis generates target specificity in neurotrophin-induced protein synthesis. Cell (2012) 1.15
Insect microRNAs: biogenesis, expression profiling and biological functions. Insect Biochem Mol Biol (2012) 1.15
The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications. PLoS Genet (2011) 1.13
Invited review: decoding the microRNA response to hypoxia. Pflugers Arch (2011) 1.12
Shielding the messenger (RNA): microRNA-based anticancer therapies. Pharmacol Ther (2011) 1.12
A role for human Dicer in pre-RISC loading of siRNAs. Nucleic Acids Res (2010) 1.11
The role of positive selection in determining the molecular cause of species differences in disease. BMC Evol Biol (2008) 1.11
Kinetic signatures of microRNA modes of action. RNA (2012) 1.09
Intracellular processing of immunostimulatory CpG-siRNA: Toll-like receptor 9 facilitates siRNA dicing and endosomal escape. J Control Release (2013) 1.07
MicroRNA in the ovary and female reproductive tract. J Anim Sci (2008) 1.07
The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans. EMBO Rep (2011) 1.07
The let-7 microRNA interfaces extensively with the translation machinery to regulate cell differentiation. Cell Cycle (2008) 1.07
The MicroRNA Biology of the Mammalian Nucleus. Mol Ther Nucleic Acids (2014) 1.05
Host restriction factors in retroviral infection: promises in virus-host interaction. Retrovirology (2012) 1.05
Roles of microRNA in plant defense and virus offense interaction. Plant Cell Rep (2008) 1.05
MicroRNAs as Molecular Targets for Cancer Therapy: On the Modulation of MicroRNA Expression. Pharmaceuticals (Basel) (2013) 1.04
MicroRNAs: Meta-controllers of gene expression in synaptic activity emerge as genetic and diagnostic markers of human disease. Pharmacol Ther (2011) 1.03
Regulation of signalling by microRNAs. Biochem Soc Trans (2012) 1.02
Functional characterization of the plasmacytoma variant translocation 1 gene (PVT1) in diabetic nephropathy. PLoS One (2011) 1.02
Translational repression precedes and is required for ZAP-mediated mRNA decay. EMBO J (2012) 1.02
Progress in corneal wound healing. Prog Retin Eye Res (2015) 1.02
Blockade of pachytene piRNA biogenesis reveals a novel requirement for maintaining post-meiotic germline genome integrity. PLoS Genet (2012) 1.00
Role for the MOV10 RNA helicase in polycomb-mediated repression of the INK4a tumor suppressor. Nat Struct Mol Biol (2010) 1.00
Computational analysis of target hub gene repression regulated by multiple and cooperative miRNAs. Nucleic Acids Res (2012) 1.00
Numerical modelling of microRNA-mediated mRNA decay identifies novel mechanism of microRNA controlled mRNA downregulation. Nucleic Acids Res (2010) 0.99
Regulation of divalent metal transporter 1 (DMT1) non-IRE isoform by the microRNA Let-7d in erythroid cells. Haematologica (2010) 0.99
Thinking about RNA? MicroRNAs in the brain. Mamm Genome (2008) 0.98
Functional polymorphisms in the serotonin 1B receptor gene (HTR1B) predict self-reported anger and hostility among young men. Am J Med Genet B Neuropsychiatr Genet (2010) 0.98
Thymic versus induced regulatory T cells - who regulates the regulators? Front Immunol (2013) 0.98
miRNA repression of translation in vitro takes place during 43S ribosomal scanning. Nucleic Acids Res (2012) 0.96
The complexity, function and applications of RNA in circulation. Front Genet (2013) 0.96
Post-transcriptional regulation of cadherin-11 expression by GSK-3 and beta-catenin in prostate and breast cancer cells. PLoS One (2009) 0.95
MicroRNAs and toll-like receptor/interleukin-1 receptor signaling. J Hematol Oncol (2012) 0.95
Uncoupling of lin-14 mRNA and protein repression by nutrient deprivation in Caenorhabditis elegans. RNA (2009) 0.94
Regulation of lin-4 miRNA expression, organismal growth and development by a conserved RNA binding protein in C. elegans. Dev Biol (2010) 0.94
Function and ribosomal localization of aIF6, a translational regulator shared by archaea and eukarya. Nucleic Acids Res (2008) 0.94
miRNAs regulated by estrogens, tamoxifen, and endocrine disruptors and their downstream gene targets. Mol Cell Endocrinol (2015) 0.94
MicroRNA-133 inhibits behavioral aggregation by controlling dopamine synthesis in locusts. PLoS Genet (2014) 0.93
A genome-wide RNAi screen identifies genes regulating the formation of P bodies in C. elegans and their functions in NMD and RNAi. Protein Cell (2011) 0.93
Human UPF1 participates in small RNA-induced mRNA downregulation. Mol Cell Biol (2009) 0.93
Role of Dicer in female fertility. Trends Endocrinol Metab (2009) 0.92
APOBEC3G inhibits microRNA-mediated repression of translation by interfering with the interaction between Argonaute-2 and MOV10. J Biol Chem (2012) 0.92
Role of the RNA-binding protein IMP-2 in muscle cell motility. Mol Cell Biol (2010) 0.91
Ribosomal protein RPS-14 modulates let-7 microRNA function in Caenorhabditis elegans. Dev Biol (2009) 0.90
The panorama of miRNA-mediated mechanisms in mammalian cells. Cell Mol Life Sci (2014) 0.90
Dynamical modeling of microRNA action on the protein translation process. BMC Syst Biol (2010) 0.89
TRIM65 regulates microRNA activity by ubiquitination of TNRC6. Proc Natl Acad Sci U S A (2014) 0.89
Identification of molecular determinants from Moloney leukemia virus 10 homolog (MOV10) protein for virion packaging and anti-HIV-1 activity. J Biol Chem (2011) 0.89
The Microprocessor complex mediates the genesis of microRNAs. Nature (2004) 17.70
The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res (2012) 15.41
Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell (2005) 15.26
Selective blockade of microRNA processing by Lin28. Science (2008) 14.39
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature (2005) 13.44
Long noncoding RNAs with enhancer-like function in human cells. Cell (2010) 13.00
Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol (2009) 11.50
Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell (2005) 9.27
Modulation of microRNA processing and expression through RNA editing by ADAR deaminases. Nat Struct Mol Biol (2005) 7.49
Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science (2007) 7.41
MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet (2004) 6.11
An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. Nature (2005) 5.89
New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34
The Lin28/let-7 axis regulates glucose metabolism. Cell (2011) 4.65
p53 is regulated by the lysine demethylase LSD1. Nature (2007) 4.53
Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells. Nat Struct Mol Biol (2009) 4.41
MicroRNA biogenesis and cancer. Cancer Res (2005) 4.41
Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem (2008) 4.40
An operational definition of epigenetics. Genes Dev (2009) 4.26
Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans. Nat Struct Mol Biol (2010) 4.22
miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts. Cell (2010) 4.07
Activating RNAs associate with Mediator to enhance chromatin architecture and transcription. Nature (2013) 3.98
Retracted A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat Genet (2009) 3.88
EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. Science (2012) 3.74
Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Cell (2005) 3.66
The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms. RNA (2002) 3.62
RNA editing of the microRNA-151 precursor blocks cleavage by the Dicer-TRBP complex. EMBO Rep (2007) 3.40
The imprinted H19 lncRNA antagonizes let-7 microRNAs. Mol Cell (2013) 3.27
Trans-splicing and polyadenylation of let-7 microRNA primary transcripts. RNA (2004) 3.18
Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem Biol (2006) 3.15
Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell (2011) 2.99
Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. Mol Cell (2003) 2.90
A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. Proc Natl Acad Sci U S A (2002) 2.78
A chromatin remodelling complex that loads cohesin onto human chromosomes. Nature (2002) 2.53
Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury. J Am Soc Nephrol (2008) 2.51
MicroRNA assassins: factors that regulate the disappearance of miRNAs. Nat Struct Mol Biol (2010) 2.42
A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway. Nature (2013) 2.34
Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein. Cell (2007) 2.29
Molecular basis for interaction of let-7 microRNAs with Lin28. Cell (2011) 2.28
Functional interplay between histone demethylase and deacetylase enzymes. Mol Cell Biol (2006) 2.20
How does Lin28 let-7 control development and disease? Trends Cell Biol (2012) 2.09
The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase. Nat Struct Mol Biol (2007) 2.05
Loss of DNA replication control is a potent inducer of gene amplification. Science (2010) 2.02
A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein. J Biol Chem (2004) 1.98
The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell (2011) 1.95
Requirement of dimerization for RNA editing activity of adenosine deaminases acting on RNA. J Biol Chem (2003) 1.93
The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions. EMBO J (2007) 1.92
Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II. Mol Cell Biol (2007) 1.89
Autoregulation of microRNA biogenesis by let-7 and Argonaute. Nature (2012) 1.85
Isolation of human NURF: a regulator of Engrailed gene expression. EMBO J (2003) 1.80
Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev Biol (2003) 1.79
Structural basis for ubiquitin recognition by the Otu1 ovarian tumor domain protein. J Biol Chem (2008) 1.75
Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7). RNA (2012) 1.74
Activation of BRCA1/BRCA2-associated helicase BACH1 is required for timely progression through S phase. Mol Cell Biol (2007) 1.72
MicroRNA biogenesis: isolation and characterization of the microprocessor complex. Methods Mol Biol (2006) 1.69
A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. J Biol Chem (2002) 1.67
Post-transcriptional control of DGCR8 expression by the Microprocessor. RNA (2009) 1.67
Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay. RNA (2008) 1.65
Locus control region transcription plays an active role in long-range gene activation. Mol Cell (2006) 1.63
Long noncoding RNAs usher in a new era in the biology of enhancers. Cell (2013) 1.58
MicroRNA gene regulatory pathways in the establishment and maintenance of ESC identity. Cell Stem Cell (2010) 1.53
Long non-coding RNAs and enhancers. Curr Opin Genet Dev (2011) 1.52
LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in Caenorhabditis elegans. Nat Struct Mol Biol (2011) 1.51
Hypoxia-mediated selective mRNA translation by an internal ribosome entry site-independent mechanism. J Biol Chem (2008) 1.51
Functional dissection of the human TNRC6 (GW182-related) family of proteins. Mol Cell Biol (2009) 1.49
Identification of mRNAs associated with alphaCP2-containing RNP complexes. Mol Cell Biol (2003) 1.49
EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator. Mol Microbiol (2004) 1.46
Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes. Proc Natl Acad Sci U S A (2006) 1.44
Regulation of transcription by long noncoding RNAs. Annu Rev Genet (2014) 1.43
MicroRNA biogenesis: regulating the regulators. Crit Rev Biochem Mol Biol (2012) 1.41
Cell cycle regulation of chromatin at an origin of DNA replication. EMBO J (2005) 1.40
Bystander gene activation by a locus control region. EMBO J (2004) 1.38
Regulation of alpha-globin mRNA stability. Exp Biol Med (Maywood) (2003) 1.38
Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation. Nat Commun (2012) 1.35
CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L. Hum Mol Genet (2005) 1.35
Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies. Proc Natl Acad Sci U S A (2008) 1.35
Butyrate increases the efficiency of translation of gamma-globin mRNA. Blood (2004) 1.34
Nonsense mutations in close proximity to the initiation codon fail to trigger full nonsense-mediated mRNA decay. J Biol Chem (2004) 1.33
The KH-domain protein alpha CP has a direct role in mRNA stabilization independent of its cognate binding site. Mol Cell Biol (2003) 1.26
Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae. Mol Cell Biol (2007) 1.26
PHF8 targets histone methylation and RNA polymerase II to activate transcription. Mol Cell Biol (2010) 1.25
Functional analysis of Hes-1 in preadipocytes. Mol Endocrinol (2005) 1.21
Pseudogene-mediated posttranscriptional silencing of HMGA1 can result in insulin resistance and type 2 diabetes. Nat Commun (2010) 1.17
Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest. J Biol Chem (2009) 1.17
A novel set of nuclear localization signals determine distributions of the alphaCP RNA-binding proteins. Mol Cell Biol (2003) 1.16
Recruitment of MLL by HMG-domain protein iBRAF promotes neural differentiation. Nat Cell Biol (2005) 1.15
Argonaute2 expression is post-transcriptionally coupled to microRNA abundance. RNA (2013) 1.15
Jarid2 regulates mouse epidermal stem cell activation and differentiation. EMBO J (2011) 1.14
Noncoding RNAs and enhancers: complications of a long-distance relationship. Trends Genet (2011) 1.13
In vivo association of the stability control protein alphaCP with actively translating mRNAs. Mol Cell Biol (2003) 1.12
Polycomb repressive complex 2-dependent and -independent functions of Jarid2 in transcriptional regulation in Drosophila. Mol Cell Biol (2012) 1.10
Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. Cancer Res (2005) 1.09