Chronic metformin treatment improves post-stroke angiogenesis and recovery after experimental stroke.

PubWeight™: 0.92‹?›

🔗 View Article (PMC 4061245)

Published in Eur J Neurosci on March 21, 2014

Authors

Venugopal R Venna1, Jun Li, Matthew D Hammond, Nickolas S Mancini, Louise D McCullough

Author Affiliations

1: Department of Neuroscience, University of Connecticut Health Center, Farmington, CT, USA.

Articles citing this

Obesity and Cancer: An Angiogenic and Inflammatory Link. Microcirculation (2016) 0.84

Targeting the nNOS/peroxynitrite/calpain system to confer neuroprotection and aid functional recovery in a mouse model of TBI. Brain Res (2015) 0.82

Metformin attenuates hyperoxia-induced lung injury in neonatal rats by reducing the inflammatory response. Am J Physiol Lung Cell Mol Physiol (2015) 0.80

Neuropharmacological Actions of Metformin in Stroke. Curr Neuropharmacol (2015) 0.77

A dual role for AMP-activated protein kinase (AMPK) during neonatal hypoxic-ischaemic brain injury in mice. J Neurochem (2015) 0.77

Activating Endogenous Neural Precursor Cells Using Metformin Leads to Neural Repair and Functional Recovery in a Model of Childhood Brain Injury. Stem Cell Reports (2015) 0.77

Metformin in the diabetic brain: friend or foe? Ann Transl Med (2014) 0.77

Effects of metformin treatment on glioma-induced brain edema. Am J Transl Res (2016) 0.75

Small Vessels, Big Role: Renal Microcirculation and Progression of Renal Injury. Hypertension (2017) 0.75

Electroacupuncture preconditioning attenuates ischemic brain injury by activation of the adenosine monophosphate-activated protein kinase signaling pathway. Neural Regen Res (2015) 0.75

Sex differences in outcomes after stroke among patients with low total cholesterol levels: a large hospital-based prospective study. Biol Sex Differ (2016) 0.75

Pharmacological Modulation of Functional Phenotypes of Microglia in Neurodegenerative Diseases. Front Aging Neurosci (2017) 0.75

Multiparity improves outcomes after cerebral ischemia in female mice despite features of increased metabovascular risk. Proc Natl Acad Sci U S A (2017) 0.75

To Use or Not to Use Metformin in Cerebral Ischemia: A Review of the Application of Metformin in Stroke Rodents. Stroke Res Treat (2017) 0.75

Articles cited by this

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet (1998) 34.34

Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest (2001) 23.21

Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care (2008) 21.05

Preventing stroke: saving lives around the world. Lancet Neurol (2007) 6.55

Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res (2005) 4.38

Cellular and molecular mechanisms of metformin: an overview. Clin Sci (Lond) (2012) 4.04

Plasticity during stroke recovery: from synapse to behaviour. Nat Rev Neurosci (2009) 4.03

AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress. J Biol Chem (2003) 3.02

Metformin use and mortality among patients with diabetes and atherothrombosis. Arch Intern Med (2010) 2.52

Chronic behavioral testing after focal ischemia in the mouse: functional recovery and the effects of gender. Exp Neurol (2004) 2.30

Stroke declines from third to fourth leading cause of death in the United States: historical perspective and challenges ahead. Stroke (2011) 2.23

Neurogenesis, angiogenesis, and MRI indices of functional recovery from stroke. Stroke (2007) 2.22

AMP-activated protein kinase signaling stimulates VEGF expression and angiogenesis in skeletal muscle. Circ Res (2005) 2.06

The adhesive removal test: a sensitive method to assess sensorimotor deficits in mice. Nat Protoc (2009) 1.87

Non-invasive mapping of corticofugal fibres from multiple motor areas--relevance to stroke recovery. Brain (2006) 1.85

Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat. Am J Pathol (1993) 1.77

Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. Cell Stem Cell (2012) 1.74

Post-stroke plastic reorganisation in the adult brain. Lancet Neurol (2003) 1.72

Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide. Pharmacol Rep (2010) 1.56

Determining stroke's rank as a cause of death using multicause mortality data. Stroke (2012) 1.53

Middle cerebral artery occlusion model in rodents: methods and potential pitfalls. J Biomed Biotechnol (2011) 1.46

Angiogenesis after stroke is correlated with increased numbers of macrophages: the clean-up hypothesis. J Cereb Blood Flow Metab (2001) 1.35

Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1. J Neurosci (2008) 1.33

Early exclusive use of the affected forelimb after moderate transient focal ischemia in rats : functional and anatomic outcome. Stroke (2000) 1.28

Angiogenesis: a harmonized target for recovery after stroke. Stroke (2012) 1.22

Resolution of stroke deficits following contralateral grafts of conditionally immortal neuroepithelial stem cells. Stroke (2001) 1.22

Effects of metformin in experimental stroke. Stroke (2010) 1.19

The heterogeneous temporal evolution of focal ischemic neuronal damage in the rat. Acta Neuropathol (1993) 1.16

Preservation and modulation of specific left hemisphere regions is vital for treated recovery from anomia in stroke. J Neurosci (2010) 1.14

Metformin inhibits inflammatory response via AMPK-PTEN pathway in vascular smooth muscle cells. Biochem Biophys Res Commun (2012) 1.11

Secondary reduction in the apparent diffusion coefficient of water, increase in cerebral blood volume, and delayed neuronal death after middle cerebral artery occlusion and early reperfusion in the rat. J Cereb Blood Flow Metab (1999) 1.06

Application of magnetic resonance to animal models of cerebral ischemia. J Magn Reson Imaging (2001) 1.06

Vascularization pattern after ischemic stroke is different in control versus diabetic rats: relevance to stroke recovery. Stroke (2013) 1.05

NF-κB contributes to the detrimental effects of social isolation after experimental stroke. Acta Neuropathol (2012) 1.01

Border zone neovascularization in cerebral ischemic infarct. Folia Neuropathol (1999) 1.00

Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthase. J Biol Chem (2010) 0.98

Chronic in vivo imaging shows no evidence of dendritic plasticity or functional remapping in the contralesional cortex after stroke. Cereb Cortex (2012) 0.94

Metformin increases phagocytosis and acidifies lysosomal/endosomal compartments in AMPK-dependent manner in rat primary microglia. Naunyn Schmiedebergs Arch Pharmacol (2009) 0.92

Deficits in auditory, cognitive, and motor processing following reversible middle cerebral artery occlusion in mice. Exp Neurol (2012) 0.91

Exploration of beneficial and deleterious effects of inflammation in stroke: dynamics of inflammation cells. Philos Trans A Math Phys Eng Sci (2009) 0.90

Exofocal dopaminergic degeneration as antidepressant target in mouse model of poststroke depression. Biol Psychiatry (2012) 0.90

Preconditioning induces sustained neuroprotection by downregulation of adenosine 5'-monophosphate-activated protein kinase. Neuroscience (2011) 0.88

Rejuvenating regeneration: metformin activates endogenous adult stem cells. Cell Cycle (2012) 0.86

New striatal neurons form projections to substantia nigra in adult rat brain after stroke. Neurobiol Dis (2011) 0.85

Insulin sensitizing drugs increase the endogenous dopaminergic tone in obese insulin-resistant women with polycystic ovary syndrome. J Endocrinol (2005) 0.82

Neuroprotection of lipoic acid treatment promotes angiogenesis and reduces the glial scar formation after brain injury. Neuroscience (2012) 0.82

An old drug for new ideas: metformin promotes adult neurogenesis and spatial memory formation. Cell Stem Cell (2012) 0.82

Metabolic and haemodynamic effects of metformin in patients with type 2 diabetes mellitus and hypertension. Diabetes Obes Metab (2001) 0.82

Clinical efficacy of metformin against insulin resistance parameters: sinking the iceberg. Drugs (1999) 0.81

Performance and training standards for endovascular acute ischemic stroke treatment. Neurology (2012) 0.80

Differential response in choice reaction time following apomorphine based on prior dopaminergic treatment. Acta Neurol Scand (2004) 0.76

Articles by these authors

(truncated to the top 100)

The diploid genome sequence of an Asian individual. Nature (2008) 46.29

The sequence and de novo assembly of the giant panda genome. Nature (2009) 15.76

The genome of the cucumber, Cucumis sativus L. Nat Genet (2009) 8.19

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02

An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people. Science (2012) 7.94

The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67

Echinococcosis. Lancet (2003) 6.83

Population analysis of large copy number variants and hotspots of human genetic disease. Am J Hum Genet (2009) 6.79

A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science (2004) 6.62

Clinical findings in 111 cases of influenza A (H7N9) virus infection. N Engl J Med (2013) 5.38

A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms. Nature (2004) 5.24

Resequencing of 31 wild and cultivated soybean genomes identifies patterns of genetic diversity and selection. Nat Genet (2010) 5.20

An Aboriginal Australian genome reveals separate human dispersals into Asia. Science (2011) 4.84

Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region. Science (2006) 4.38

Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood (2010) 4.33

A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells. Nat Immunol (2008) 4.28

Targeted genome modification of crop plants using a CRISPR-Cas system. Nat Biotechnol (2013) 4.19

KaKs_Calculator: calculating Ka and Ks through model selection and model averaging. Genomics Proteomics Bioinformatics (2006) 4.15

[Human natural infection of Plasmodium knowlesi]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi (2006) 3.99

Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J. Nature (2007) 3.91

Detectable clonal mosaicism from birth to old age and its relationship to cancer. Nat Genet (2012) 3.68

A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature (2009) 3.63

The role of geography in human adaptation. PLoS Genet (2009) 3.41

Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science (2013) 3.40

Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development. Nat Med (2008) 3.33

Randomized phase III trial of induction chemotherapy with docetaxel, cisplatin, and fluorouracil followed by surgery versus up-front surgery in locally advanced resectable oral squamous cell carcinoma. J Clin Oncol (2012) 3.08

Immediate intraportal transplantation of human bone marrow mesenchymal stem cells prevents death from fulminant hepatic failure in pigs. Hepatology (2012) 3.04

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. N Engl J Med (2015) 3.00

Mouse transcriptome: neutral evolution of 'non-coding' complementary DNAs. Nature (2004) 3.00

Genome-wide measurement of RNA folding energies. Mol Cell (2012) 2.85

A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair. J Immunol (2007) 2.77

Concepts in immunology and diagnosis of hydatid disease. Clin Microbiol Rev (2003) 2.77

IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections. Hepatology (2015) 2.76

Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study. Hum Mol Genet (2008) 2.71

Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science (2009) 2.68

Brain anatomical network and intelligence. PLoS Comput Biol (2009) 2.68

Surveillance of demographic characteristics and health behaviors among adult cancer survivors--Behavioral Risk Factor Surveillance System, United States, 2009. MMWR Surveill Summ (2012) 2.57

Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain. Biol Psychiatry (2004) 2.53

The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest (2009) 2.52

Hop is an unusual homeobox gene that modulates cardiac development. Cell (2002) 2.52

Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases. Science (2011) 2.52

Guidelines for the prevention of stroke in women: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke (2014) 2.50

Gender-specific gene expression in post-mortem human brain: localization to sex chromosomes. Neuropsychopharmacology (2004) 2.48

Basis set exchange: a community database for computational sciences. J Chem Inf Model (2007) 2.37

Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice. Arthritis Rheum (2011) 2.33

Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation. J Clin Invest (2014) 2.31

Chronic behavioral testing after focal ischemia in the mouse: functional recovery and the effects of gender. Exp Neurol (2004) 2.30

West Nile virus. Lancet Neurol (2007) 2.26

Parathyroid hormone signaling through low-density lipoprotein-related protein 6. Genes Dev (2008) 2.22

The effect of lidocaine on early postoperative cognitive dysfunction after coronary artery bypass surgery. Anesth Analg (2002) 2.20

Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. Biochem Biophys Res Commun (2005) 2.18

A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal. FASEB J (2006) 2.17

Prognostic nomogram for intrahepatic cholangiocarcinoma after partial hepatectomy. J Clin Oncol (2013) 2.16

Association between crystals and cartilage degeneration in the ankle. J Rheumatol (2008) 2.15

Meta-analysis added power to identify variants in FTO associated with type 2 diabetes and obesity in the Asian population. Obesity (Silver Spring) (2010) 2.15

IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid-derived suppressor cells. J Immunol (2010) 2.12

TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets. J Clin Invest (2012) 2.10

Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1. Sci Transl Med (2011) 2.10

High rate of chimeric gene origination by retroposition in plant genomes. Plant Cell (2006) 2.08

Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier. J Immunol (2006) 2.06

IgT, a primitive immunoglobulin class specialized in mucosal immunity. Nat Immunol (2010) 2.03

Arsenic and fluoride exposure in drinking water: children's IQ and growth in Shanyin county, Shanxi province, China. Environ Health Perspect (2007) 2.03

Early millet use in northern China. Proc Natl Acad Sci U S A (2012) 2.01

Characterizing the admixed African ancestry of African Americans. Genome Biol (2009) 2.01

Growth of epitaxial nanowires at the junctions of nanowalls. Science (2003) 1.99

Single-atom catalysis of CO oxidation using Pt1/FeOx. Nat Chem (2011) 1.98

IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program. J Biol Chem (2002) 1.94

Phenotypic clustering in MPZ mutations. Brain (2004) 1.94

Genomic analysis of the immune gene repertoire of amphioxus reveals extraordinary innate complexity and diversity. Genome Res (2008) 1.92

TTC, fluoro-Jade B and NeuN staining confirm evolving phases of infarction induced by middle cerebral artery occlusion. J Neurosci Methods (2009) 1.86

The White test: a new dye test for intraoperative detection of bile leakage during major liver resection. Arch Surg (2008) 1.86

Isolated coronary artery bypass graft combined with bone marrow mononuclear cells delivered through a graft vessel for patients with previous myocardial infarction and chronic heart failure: a single-center, randomized, double-blind, placebo-controlled clinical trial. J Am Coll Cardiol (2011) 1.85

Overexpression of astrocyte elevated gene-1 (AEG-1) is associated with esophageal squamous cell carcinoma (ESCC) progression and pathogenesis. Carcinogenesis (2009) 1.85

Molecular engineering of DNA: molecular beacons. Angew Chem Int Ed Engl (2009) 1.84

Identification and mechanism of ABA receptor antagonism. Nat Struct Mol Biol (2010) 1.83

Sam68 up-regulation correlates with, and its down-regulation inhibits, proliferation and tumourigenicity of breast cancer cells. J Pathol (2010) 1.82

Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase. J Biol Chem (2004) 1.80

Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3. Nat Immunol (2010) 1.77

Complete genome sequence of Paenibacillus polymyxa SC2, a strain of plant growth-promoting Rhizobacterium with broad-spectrum antimicrobial activity. J Bacteriol (2010) 1.76

The effects of cardiopulmonary bypass on the number of cerebral microemboli and the incidence of cognitive dysfunction after coronary artery bypass graft surgery. Anesth Analg (2009) 1.74

Environment. Building a "green" railway in China. Science (2007) 1.73

Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication. J Cell Biol (2005) 1.73

Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction? Circulation (2008) 1.72

Pathways to ischemic neuronal cell death: are sex differences relevant? J Transl Med (2008) 1.71

Shortened internodal length of dermal myelinated nerve fibres in Charcot-Marie-Tooth disease type 1A. Brain (2009) 1.70

Pivotal advance: peritoneal cavity B-1 B cells have phagocytic and microbicidal capacities and present phagocytosed antigen to CD4+ T cells. J Leukoc Biol (2011) 1.67

Acute stroke management in the elderly. Cerebrovasc Dis (2006) 1.67

Neuroprotective effects of adenosine monophosphate-activated protein kinase inhibition and gene deletion in stroke. Stroke (2007) 1.67

Isolation and analyses of genes preferentially expressed during early cotton fiber development by subtractive PCR and cDNA array. Nucleic Acids Res (2003) 1.67

Influenza H7N9 and H9N2 viruses: coexistence in poultry linked to human H7N9 infection and genome characteristics. J Virol (2014) 1.67

Digital gene expression for non-model organisms. Genome Res (2011) 1.66

G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation. J Immunol (2009) 1.65

Size control of gold nanocrystals in citrate reduction: the third role of citrate. J Am Chem Soc (2007) 1.65

Structural basis for molecular recognition of folic acid by folate receptors. Nature (2013) 1.62

Hierarchical generalized linear models for multiple groups of rare and common variants: jointly estimating group and individual-variant effects. PLoS Genet (2011) 1.61

MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-κB/IκBα negative feedback loop. J Clin Invest (2011) 1.60

Whole-genome sequencing reveals untapped genetic potential in Africa's indigenous cereal crop sorghum. Nat Commun (2013) 1.60

Genetic diversity and phylogenetic analysis of glycoprotein 5 of PRRSV isolates in mainland China from 1996 to 2006: coexistence of two NA-subgenotypes with great diversity. Vet Microbiol (2007) 1.60

Inhibition of Sca-1-positive skeletal stem cell recruitment by alendronate blunts the anabolic effects of parathyroid hormone on bone remodeling. Cell Stem Cell (2010) 1.60

Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients. Clin Cancer Res (2009) 1.59