Androgen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone/muscle, metabolic syndrome and neuron/immune systems: lessons learned from mice lacking AR in specific cells.

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Published in Nucl Recept Signal on August 19, 2013

Authors

Chawnshang Chang1, Shuyuan Yeh1, Soo Ok Lee1, Ta-Min Chang1

Author Affiliations

1: George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, and the Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA (CC, SY, SOL, T-MC) and Sex Hormone Research Center, China Medical University/Hospital, Taichung, Taiwan (CC).

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Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature (2002) 8.77

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell (1998) 8.10

Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem (2004) 7.91

Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J Clin Invest (2000) 6.84

Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A (2003) 6.82

Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev (2002) 6.38

An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nat Genet (1998) 5.95

Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig. Endocrinology (1959) 5.37

Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell (2002) 5.01

Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. Genes Dev (2007) 4.97

Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med (2002) 4.69

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Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization. J Biol Chem (2002) 4.52

Multiple organ failure. Pathophysiology and potential future therapy. Ann Surg (1992) 4.50

A transgenic mouse line that retains Cre recombinase activity in mature oocytes irrespective of the cre transgene transmission. Biochem Biophys Res Commun (1997) 4.47

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature (1979) 4.08

Androgen receptor (AR) coregulators: an overview. Endocr Rev (2002) 4.01

Molecular cloning of human and rat complementary DNA encoding androgen receptors. Science (1988) 3.96

Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab (2007) 3.69

Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. Proc Natl Acad Sci U S A (1996) 3.56

The conversion of testosterone to 5-alpha-androstan-17-beta-ol-3-one by rat prostate in vivo and in vitro. J Biol Chem (1968) 3.54

Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex. Endocr Rev (2007) 3.54

The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Res (1994) 3.52

Analysis of Fgf8 gene function in vertebrate development. Cold Spring Harb Symp Quant Biol (1997) 3.51

A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. Proc Natl Acad Sci U S A (2004) 3.48

Cloning of human androgen receptor complementary DNA and localization to the X chromosome. Science (1988) 3.40

Maternally expressed PGK-Cre transgene as a tool for early and uniform activation of the Cre site-specific recombinase. Transgenic Res (1998) 3.36

Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. Cell Metab (2006) 3.34

A gender gap in autoimmunity. Science (1999) 3.33

T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination. Proc Natl Acad Sci U S A (1995) 3.21

X-linked gene for testicular feminization in the mouse. Nature (1970) 3.19

Obesity-related derangements in metabolic regulation. Annu Rev Biochem (2006) 3.14

Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues. Proc Natl Acad Sci U S A (2002) 3.08

DMP1-targeted Cre expression in odontoblasts and osteocytes. J Dent Res (2007) 3.07

Positive selection of natural autoreactive B cells. Science (1999) 2.91

A brain-liver circuit regulates glucose homeostasis. Cell Metab (2005) 2.83

The cytomegalovirus enhancer: a pan-active control element in transgenic mice. Mol Cell Biol (1990) 2.80

Testosterone dose-response relationships in healthy young men. Am J Physiol Endocrinol Metab (2001) 2.79

Hirsutism. Lancet (1997) 2.74

Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J Biol Chem (2007) 2.73

Postinjury multiple organ failure: a bimodal phenomenon. J Trauma (1996) 2.69

Gonadal hormones determine sensitivity to central leptin and insulin. Diabetes (2006) 2.62

Selective retention of dihydrotestosterone by prostatic nuclei. Nature (1968) 2.60

Promotion of bladder cancer development and progression by androgen receptor signals. J Natl Cancer Inst (2007) 2.59

Characterization and expression of a cDNA encoding the human androgen receptor. Proc Natl Acad Sci U S A (1989) 2.49

Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle. J Clin Endocrinol Metab (2004) 2.47

Site- and time-specific gene targeting in the mouse. Methods (2001) 2.42

The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest (2005) 2.40

Lilly lecture 2003: the struggle for mastery in insulin action: from triumvirate to republic. Diabetes (2004) 2.39

Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors. Proc Natl Acad Sci U S A (1988) 2.39

Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest (2004) 2.34

Role of the liver in the control of carbohydrate and lipid homeostasis. Diabetes Metab (2004) 2.33

Overfeeding rapidly induces leptin and insulin resistance. Diabetes (2001) 2.32

Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids. Development (2004) 2.30

The androgen receptor governs the execution, but not programming, of male sexual and territorial behaviors. Neuron (2010) 2.26

The androgen receptor gene mutations database (ARDB): 2004 update. Hum Mutat (2004) 2.25

Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem (2000) 2.18

Expression and activity of osteoblast-targeted Cre recombinase transgenes in murine skeletal tissues. Int J Dev Biol (2004) 2.15

The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions. Mol Endocrinol (2002) 2.12

Gene targeting restricted to mouse striated muscle lineage. Nucleic Acids Res (1999) 2.11

X-linked recessive bulbospinal neuronopathy. A clinicopathological study. Brain (1989) 2.10

Androgens and bone. Endocr Rev (2004) 2.06

The intranuclear binding of testosterone and 5-alpha-androstan-17-beta-ol-3-one by rat prostate. J Biol Chem (1968) 1.98

The cellular fate of glucose and its relevance in type 2 diabetes. Endocr Rev (2004) 1.98

PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a). Proc Natl Acad Sci U S A (2008) 1.92

Critical role for hypothalamic mTOR activity in energy balance. Cell Metab (2009) 1.90

Review of major adverse effects of androgen-deprivation therapy in men with prostate cancer. Cancer (2009) 1.90

Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. J Clin Invest (2004) 1.88

Long polyglutamine tracts in the androgen receptor are associated with reduced trans-activation, impaired sperm production, and male infertility. J Clin Endocrinol Metab (1997) 1.88

ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor. Nat Med (2007) 1.87

The androgen receptor gene mutations database: 2012 update. Hum Mutat (2012) 1.84

Differential sensitivity to central leptin and insulin in male and female rats. Diabetes (2003) 1.80

Selective expression of an aP2/Fatty Acid Binding Protein 4-Cre transgene in non-adipogenic tissues during embryonic development. Transgenic Res (2006) 1.78

Obesity and androgens: facts and perspectives. Fertil Steril (2006) 1.78

Mutation of the androgen receptor causes oncogenic transformation of the prostate. Proc Natl Acad Sci U S A (2005) 1.73

CXCR2 deficiency confers impaired neutrophil recruitment and increased susceptibility during Toxoplasma gondii infection. J Immunol (2001) 1.73

Suppressive function of androgen receptor in bone resorption. Proc Natl Acad Sci U S A (2003) 1.72

Identification and characterization of a promoter cassette conferring adipocyte-specific gene expression. Endocrinology (2010) 1.71

Androgen receptor-mediated inhibition of cutaneous wound healing. J Clin Invest (2002) 1.70

Androgen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in model. J Clin Invest (2006) 1.67

Androgen signaling in myocytes contributes to the maintenance of muscle mass and fiber type regulation but not to muscle strength or fatigue. Endocrinology (2009) 1.66

Tissue-specific effects of central leptin on the expression of genes involved in lipid metabolism in liver and white adipose tissue. Endocrinology (2007) 1.64

Cloning, structure and expression of a cDNA encoding the human androgen receptor. Biochem Biophys Res Commun (1988) 1.64

Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-alpha expression. J Clin Invest (2009) 1.62

Interactions between androgen and estrogen receptors and the effects on their transactivational properties. Mol Cell Endocrinol (2000) 1.62

Transgenic rescue of insulin receptor-deficient mice. J Clin Invest (2004) 1.57

Androgen receptor null male mice develop late-onset obesity caused by decreased energy expenditure and lipolytic activity but show normal insulin sensitivity with high adiponectin secretion. Diabetes (2005) 1.57

Androgen receptors in thymic epithelium modulate thymus size and thymocyte development. Endocrinology (2001) 1.53

Brain masculinization requires androgen receptor function. Proc Natl Acad Sci U S A (2004) 1.51

Sex steroids and insulin resistance. Clin Sci (Lond) (2002) 1.47

CREB-binding protein in androgen receptor-mediated signaling. Proc Natl Acad Sci U S A (1998) 1.47

Minireview: nutrient sensing and the regulation of insulin action and energy balance. Endocrinology (2003) 1.47

The influence of the gonads and adrenal glands on the immune response to skin grafts. Transplantation (1969) 1.46

Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice. FASEB J (2008) 1.46

Endocrinologic control of the development and activity of the human sebaceous gland. J Invest Dermatol (1974) 1.42

The role of estrogen receptors and androgen receptors in sex steroid regulation of B lymphopoiesis. J Immunol (1998) 1.40

A frameshift mutation destabilizes androgen receptor messenger RNA in the Tfm mouse. Mol Endocrinol (1991) 1.39