Published in Nature on March 09, 2014
Intrinsic Age-Dependent Changes and Cell-Cell Contacts Regulate Nephron Progenitor Lifespan. Dev Cell (2015) 2.25
Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause. Cell (2016) 1.59
Human haematopoietic stem cell lineage commitment is a continuous process. Nat Cell Biol (2017) 1.52
Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status. Cell Rep (2015) 1.51
The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Sci Signal (2015) 1.44
RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML. Cell Stem Cell (2016) 1.42
Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells. Cell (2016) 1.42
Hematopoietic stem cells: concepts, definitions, and the new reality. Blood (2015) 1.30
Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells. Cell Stem Cell (2015) 1.04
Ribosome profiling reveals a cell-type-specific translational landscape in brain tumors. J Neurosci (2014) 0.99
Cellular differences in protein synthesis regulate tissue homeostasis. Cell (2014) 0.97
IP3 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice. Blood (2015) 0.96
Ribosomopathies: how a common root can cause a tree of pathologies. Dis Model Mech (2015) 0.95
p53, a translational regulator: contribution to its tumour-suppressor activity. Oncogene (2015) 0.88
Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9. Nat Med (2016) 0.88
Stem cell function and stress response are controlled by protein synthesis. Nature (2016) 0.87
RNA-guided isomerization of uridine to pseudouridine--pseudouridylation. RNA Biol (2014) 0.87
Human keratinocytes have two interconvertible modes of proliferation. Nat Cell Biol (2015) 0.85
Proteome complexity and the forces that drive proteome imbalance. Nature (2016) 0.84
Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes. Leukemia (2015) 0.83
The transcription factor Foxm1 is essential for the quiescence and maintenance of hematopoietic stem cells. Nat Immunol (2015) 0.83
Dynamic Regulation of a Ribosome Rescue Pathway in Erythroid Cells and Platelets. Cell Rep (2016) 0.83
Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation. Cell Stem Cell (2015) 0.82
Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes. Haematologica (2015) 0.82
Ubiquitin-Dependent Regulation of Stem Cell Biology. Trends Cell Biol (2017) 0.81
Translation from unconventional 5' start sites drives tumour initiation. Nature (2017) 0.80
The chromatin regulator Brpf1 regulates embryo development and cell proliferation. J Biol Chem (2015) 0.80
Stress-induced inhibition of translation independently of eIF2α phosphorylation. J Cell Sci (2015) 0.80
Regulation and consequences of monocytosis. Immunol Rev (2014) 0.79
Dense transcript profiling in single cells by image correlation decoding. Nat Methods (2016) 0.79
Translational activation maintains germline tissue homeostasis during adulthood. Worm (2015) 0.79
The DHX33 RNA Helicase Promotes mRNA Translation Initiation. Mol Cell Biol (2015) 0.78
Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2. Proc Natl Acad Sci U S A (2016) 0.78
mTOR complex 1 activity is required to maintain the canonical endocytic recycling pathway against lysosomal delivery. J Biol Chem (2017) 0.77
Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature (2017) 0.77
The Role of PTEN in Myeloid Malignancies. Hematol Rep (2015) 0.77
Role of the small subunit processome in the maintenance of pluripotent stem cells. Genes Dev (2015) 0.77
Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction. Cell Res (2015) 0.77
CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo. PLoS Pathog (2017) 0.77
The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs. Genes Dev (2016) 0.76
Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines. Stem Cell Reports (2016) 0.76
CD99 is a therapeutic target on disease stem cells in myeloid malignancies. Sci Transl Med (2017) 0.76
Stem cells: Valine starvation leads to a hungry niche. Nature (2016) 0.75
Tailor made protein synthesis for HSCs. Cell Stem Cell (2014) 0.75
Short-course rapamycin treatment enables engraftment of immunogenic gene-engineered bone marrow under low-dose irradiation to permit long-term immunological tolerance. Stem Cell Res Ther (2017) 0.75
Expression Profiling of Ribosome Biogenesis Factors Reveals Nucleolin as a Novel Potential Marker to Predict Outcome in AML Patients. PLoS One (2017) 0.75
Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447. Oncotarget (2016) 0.75
Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions. J Exp Med (2017) 0.75
Therapeutic dosages of aspirin counteract the IL-6 induced pro-tumorigenic effects by slowing down the ribosome biogenesis rate. Oncotarget (2016) 0.75
Local TNFR1 Signaling Licenses Murine Neutrophils for Increased TLR-Dependent Cytokine and Eicosanoid Production. J Immunol (2017) 0.75
Role of the mammalian target of rapamycin pathway in lentiviral vector transduction of hematopoietic stem cells. Curr Opin Hematol (2015) 0.75
Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function. Cell Rep (2017) 0.75
IP3 3-kinase B prevents bone marrow failure. Oncotarget (2015) 0.75
Induction of the 5S RNP-Mdm2-p53 ribosomal stress pathway delays the initiation but fails to eradicate established murine acute myeloid leukemia. Leukemia (2016) 0.75
Society for Pediatric Research 2015 Young Investigator Award: genetics of human hematopoiesis-what patients can teach us about blood cell production. Pediatr Res (2015) 0.75
The Ribosome Biogenesis Protein Nol9 Is Essential for Definitive Hematopoiesis and Pancreas Morphogenesis in Zebrafish. PLoS Genet (2015) 0.75
Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations. EMBO Mol Med (2017) 0.75
Oncogenic PTEN functions and models in T-cell malignancies. Oncogene (2015) 0.75
RNA-binding proteins in mouse male germline stem cells: a mammalian perspective. Cell Regen (Lond) (2016) 0.75
Effects of physiological and synthetic IAP antagonism on c-IAP-dependent signaling. Oncogene (2015) 0.75
Mechanism and Function of Angiogenin in Hematopoietic Malignancy. (2015) 0.75
Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer. Cell (2017) 0.75
Somatic stem cell differentiation is regulated by PI3K/Tor signaling in response to local cues. Development (2016) 0.75
Fli-1 overexpression in erythroleukemic cells promotes erythroid de-differentiation while Spi-1/PU.1 exerts the opposite effect. Int J Oncol (2017) 0.75
Translation is actively regulated during the differentiation of CD8(+) effector T cells. Nat Immunol (2017) 0.75
Autophagy is a signature of a signaling network that maintains hematopoietic stem cells. PLoS One (2017) 0.75
The Growing Toolbox for Protein Synthesis Studies. Trends Biochem Sci (2017) 0.75
Autogenous Control of 5'TOP mRNA Stability by 40S Ribosomes. Mol Cell (2017) 0.75
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell (2005) 24.00
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature (2006) 11.86
Regulation of translation initiation by FRAP/mTOR. Genes Dev (2001) 9.40
Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans (2006) 7.69
PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature (2006) 7.35
Does the ribosome translate cancer? Nat Rev Cancer (2003) 6.89
Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85. Cell (1984) 6.81
PUROMYCIN INHIBITION OF PROTEIN SYNTHESIS: INCORPORATION OF PUROMYCIN INTO PEPTIDE CHAINS. Proc Natl Acad Sci U S A (1964) 5.72
The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature (2012) 5.61
Ribosomopathies: human disorders of ribosome dysfunction. Blood (2010) 4.43
SUnSET, a nonradioactive method to monitor protein synthesis. Nat Methods (2009) 4.12
Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell (2010) 3.79
Cyclophosphamide/granulocyte colony-stimulating factor induces hematopoietic stem cells to proliferate prior to mobilization. Proc Natl Acad Sci U S A (1997) 3.74
Activation of mTORC2 by association with the ribosome. Cell (2011) 3.38
Fluorescence visualization of newly synthesized proteins in mammalian cells. Angew Chem Int Ed Engl (2006) 2.96
Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency. Nature (2008) 2.95
Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo. Proc Natl Acad Sci U S A (2002) 2.74
Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family. Blood (2008) 2.68
Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute. Development (2004) 2.54
SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors. Cell Stem Cell (2013) 2.47
Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation. Nature (2008) 2.47
Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression. Cell Stem Cell (2012) 2.15
Ex vivo expansion of human hematopoietic stem and progenitor cells. Blood (2011) 2.12
RPN-6 determines C. elegans longevity under proteotoxic stress conditions. Nature (2012) 2.11
mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell Stem Cell (2012) 2.06
Imaging 26S proteasome activity and inhibition in living mice. Nat Med (2003) 2.04
Defective ribosome assembly in Shwachman-Diamond syndrome. Blood (2011) 1.97
mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion. Cell Stem Cell (2010) 1.82
Increased proteasome activity in human embryonic stem cells is regulated by PSMD11. Nature (2012) 1.75
Mechanisms that regulate stem cell aging and life span. Cell Stem Cell (2013) 1.73
Translational control in cancer etiology. Cold Spring Harb Perspect Biol (2013) 1.71
Imaging protein synthesis in cells and tissues with an alkyne analog of puromycin. Proc Natl Acad Sci U S A (2011) 1.65
L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway. Blood (2012) 1.61
Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways. Nat Med (2012) 1.58
A general approach to detect protein expression in vivo using fluorescent puromycin conjugates. Chem Biol (2004) 1.45
The p53 tumor suppressor causes congenital malformations in Rpl24-deficient mice and promotes their survival. Mol Cell Biol (2009) 1.40
Toward an understanding of the physiological function of Mammalian stem cells. Dev Cell (2005) 1.35
Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia. Blood (2011) 1.28
The role of p53 in ribosomopathies. Semin Hematol (2011) 1.17
Congenital disorders of ribosome biogenesis and bone marrow failure. Biol Blood Marrow Transplant (2009) 0.95
The ribosome-related protein, SBDS, is critical for normal erythropoiesis. Blood (2011) 0.85
The bone marrow niche for haematopoietic stem cells. Nature (2014) 5.06
Lens regeneration using endogenous stem cells with gain of visual function. Nature (2016) 1.56