Published in Sci Signal on April 14, 2015
L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia. Am J Cancer Res (2015) 0.95
Comprehensive Proteomic Analysis of Human Erythropoiesis. Cell Rep (2016) 0.82
Milk--A Nutrient System of Mammalian Evolution Promoting mTORC1-Dependent Translation. Int J Mol Sci (2015) 0.80
Perspective: The Potential Role of Essential Amino Acids and the Mechanistic Target of Rapamycin Complex 1 (mTORC1) Pathway in the Pathogenesis of Child Stunting. Adv Nutr (2016) 0.77
Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals. Science (2017) 0.76
Amino acid uptake in erythropoiesis. Sci Signal (2015) 0.75
Amino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells. J Clin Invest (2017) 0.75
The Promotion of Erythropoiesis via the Regulation of Reactive Oxygen Species by Lactic Acid. Sci Rep (2017) 0.75
NIH Image to ImageJ: 25 years of image analysis. Nat Methods (2012) 84.41
Multiplex genome engineering using CRISPR/Cas systems. Science (2013) 55.53
mTOR signaling in growth control and disease. Cell (2012) 29.21
Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling. Science (2009) 20.75
Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell (2000) 17.44
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell (2003) 15.12
Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell (2009) 14.51
Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol (2009) 13.89
Hematopoiesis: an evolving paradigm for stem cell biology. Cell (2008) 11.95
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest (2007) 9.33
Multiple upstream AUG codons mediate translational control of GCN4. Cell (1986) 8.48
Bidirectional transport of amino acids regulates mTOR and autophagy. Cell (2009) 7.88
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science (2011) 7.55
Evidence for translational regulation of the activator of general amino acid control in yeast. Proc Natl Acad Sci U S A (1984) 7.23
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc Natl Acad Sci U S A (2004) 7.03
Essential role for Nix in autophagic maturation of erythroid cells. Nature (2008) 6.49
A unifying model for mTORC1-mediated regulation of mRNA translation. Nature (2012) 6.44
The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature (2012) 5.61
Vertebrate genome evolution and the zebrafish gene map. Nat Genet (1998) 5.16
NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci U S A (2007) 5.14
Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system. Blood (2003) 4.91
DISTINCT MEDIATING SYSTEMS FOR THE TRANSPORT OF NEUTRAL AMINO ACIDS BY THE EHRLICH CELL. J Biol Chem (1963) 3.88
The autistic neuron: troubled translation? Cell (2008) 3.81
The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. EMBO J (2010) 3.76
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell (2012) 3.38
Model for the regulation of mRNA translation applied to haemoglobin synthesis. Nature (1974) 3.37
Amino acid signalling upstream of mTOR. Nat Rev Mol Cell Biol (2013) 3.36
The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Mol Cell Biol (2002) 3.22
Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature (2012) 3.13
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output. Nat Cell Biol (2013) 3.11
Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Mol Cell (2009) 3.05
Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells. Genes Dev (1999) 3.02
Mitoferrin is essential for erythroid iron assimilation. Nature (2006) 2.99
Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain. Mol Cell (2000) 2.75
mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin. Science (2013) 2.71
An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Science (2013) 2.71
Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. EMBO J (2001) 2.62
Amino acid transport across mammalian intestinal and renal epithelia. Physiol Rev (2008) 2.38
Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat Immunol (2013) 2.37
Leucyl-tRNA synthetase controls TORC1 via the EGO complex. Mol Cell (2012) 2.37
Regulation of protein synthesis by the heme-regulated eIF2alpha kinase: relevance to anemias. Blood (2007) 2.33
Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo. Cancer Cell (2011) 2.24
Regulation of translation elongation factor-2 by insulin via a rapamycin-sensitive signalling pathway. EMBO J (1996) 2.20
Characterization of genomic deletion efficiency mediated by clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells. J Biol Chem (2014) 2.18
Altered translation of GATA1 in Diamond-Blackfan anemia. Nat Med (2014) 2.11
The zebrafish organizer requires chordino. Nature (1997) 2.06
mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell Stem Cell (2012) 2.06
Ribosome profiling: new views of translation, from single codons to genome scale. Nat Rev Genet (2014) 2.04
mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell Metab (2013) 1.91
Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia. Nat Med (2013) 1.89
A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin. Mol Cell Biol (2004) 1.88
Haematopoietic stem cells require a highly regulated protein synthesis rate. Nature (2014) 1.86
T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. Cancer Cell (2010) 1.85
Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo. Blood (2011) 1.79
Molecular identification of spadetail: regulation of zebrafish trunk and tail mesoderm formation by T-box genes. Development (1998) 1.77
L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway. Blood (2012) 1.61
A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression. PLoS Biol (2010) 1.58
Coordinated regulation of protein synthesis and degradation by mTORC1. Nature (2014) 1.51
Retention and loss of amino acid biosynthetic pathways based on analysis of whole-genome sequences. Eukaryot Cell (2006) 1.50
Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation. Blood (2011) 1.50
Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes. Blood (2011) 1.43
Distinct perturbation of the translatome by the antidiabetic drug metformin. Proc Natl Acad Sci U S A (2012) 1.43
Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency. Nat Genet (2003) 1.40
Dietary L-leucine improves the anemia in a mouse model for Diamond-Blackfan anemia. Blood (2012) 1.39
Identification of LAT4, a novel amino acid transporter with system L activity. J Biol Chem (2005) 1.36
Iron and porphyrin trafficking in heme biogenesis. J Biol Chem (2010) 1.34
Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. J Biol Chem (2003) 1.34
Friend erythroleukemia revisited. Blood (2000) 1.26
Alteration of vimentin intermediate filament expression during differentiation of human hemopoietic cells. EMBO J (1983) 1.22
Cohesin proteins promote ribosomal RNA production and protein translation in yeast and human cells. PLoS Genet (2012) 1.17
Beta thalassemia and translation of globin messenger RNA. Proc Natl Acad Sci U S A (1971) 1.16
The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption. Cell Metab (2013) 1.14
EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2. J Biol Chem (2009) 1.13
Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq. Genome Res (2012) 1.13
SATB2 augments ΔNp63α in head and neck squamous cell carcinoma. EMBO Rep (2010) 1.11
Successful treatment of a Diamond-Blackfan anemia patient with amino acid leucine. Haematologica (2007) 1.11
Control of hematopoietic stem cell emergence by antagonistic functions of ribosomal protein paralogs. Dev Cell (2013) 1.11
Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts. Nature (2012) 1.09
mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis. Development (2014) 1.08
Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet (2013) 1.07
Snx3 regulates recycling of the transferrin receptor and iron assimilation. Cell Metab (2013) 1.06
Amino acid transporter LAT3 is required for podocyte development and function. J Am Soc Nephrol (2009) 1.06
Marrow failure: a window into ribosome biology. Blood (2014) 1.06
Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia. Blood (2012) 1.05
HIF2α acts as an mTORC1 activator through the amino acid carrier SLC7A5. Mol Cell (2012) 1.05
Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression. Cancer Res (2011) 1.05
An amino acid shuffle activates mTORC1. Cell (2009) 1.01
Gadd34 requirement for normal hemoglobin synthesis. Mol Cell Biol (2006) 0.99
TMEM14C is required for erythroid mitochondrial heme metabolism. J Clin Invest (2014) 0.96
High frequency of ribosomal protein gene deletions in Italian Diamond-Blackfan anemia patients detected by multiplex ligation-dependent probe amplification assay. Haematologica (2012) 0.96
mTOR regulates cellular iron homeostasis through tristetraprolin. Cell Metab (2012) 0.95
Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis. Dev Biol (2012) 0.94
Heme transport and erythropoiesis. Curr Opin Chem Biol (2013) 0.94
Vimentin downregulation is an inherent feature of murine erythropoiesis and occurs independently of lineage. Development (1990) 0.93
mTOR regulates brain morphogenesis by mediating GSK3 signaling. Development (2014) 0.93
L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-independent way. Br J Haematol (2014) 0.86
Depletion of hemoglobin and carbonic anhydrase from erythrocyte cytosolic samples by preparative clear native electrophoresis. Nat Protoc (2011) 0.86
Macrocytic anemia and mitochondriopathy resulting from a defect in sideroflexin 4. Am J Hum Genet (2013) 0.86
mTOR inhibition and erythropoiesis: microcytosis or anaemia? Nephrol Dial Transplant (2011) 0.86
Defects of protein production in erythroid cells revealed in a zebrafish Diamond-Blackfan anemia model for mutation in RPS19. Cell Death Dis (2014) 0.84