Published in J Nutr on November 01, 2003
Choline: critical role during fetal development and dietary requirements in adults. Annu Rev Nutr (2006) 2.83
Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains. FASEB J (2006) 2.07
Importance of methyl donors during reproduction. Am J Clin Nutr (2008) 1.62
Diethanolamine alters neurogenesis and induces apoptosis in fetal mouse hippocampus. FASEB J (2006) 1.47
Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes. FASEB J (2007) 1.42
Prenatal choline supplementation mitigates the adverse effects of prenatal alcohol exposure on development in rats. Neurotoxicol Teratol (2009) 1.30
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Maternal nutritional status, C(1) metabolism and offspring DNA methylation: a review of current evidence in human subjects. Proc Nutr Soc (2011) 1.25
Choline deficiency alters global histone methylation and epigenetic marking at the Re1 site of the calbindin 1 gene. FASEB J (2009) 1.21
Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA methylation of their genes in rat fetal liver and brain. J Biol Chem (2008) 1.21
DNA methylation impacts on learning and memory in aging. Neurobiol Aging (2007) 1.20
Prenatal choline availability modulates hippocampal neurogenesis and neurogenic responses to enriching experiences in adult female rats. Eur J Neurosci (2007) 1.16
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Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus. Proc Natl Acad Sci U S A (2010) 1.09
Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine. Arterioscler Thromb Vasc Biol (2014) 1.08
Maternal dietary choline availability alters the balance of netrin-1 and DCC neuronal migration proteins in fetal mouse brain hippocampus. Brain Res Dev Brain Res (2005) 1.06
Research review: maternal prenatal distress and poor nutrition - mutually influencing risk factors affecting infant neurocognitive development. J Child Psychol Psychiatry (2012) 1.04
Gene response elements, genetic polymorphisms and epigenetics influence the human dietary requirement for choline. IUBMB Life (2007) 1.03
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Nutrigenomics and metabolomics will change clinical nutrition and public health practice: insights from studies on dietary requirements for choline. Am J Clin Nutr (2007) 1.01
Early second trimester maternal plasma choline and betaine are related to measures of early cognitive development in term infants. PLoS One (2012) 1.00
Gestational choline supplementation normalized fetal alcohol-induced alterations in histone modifications, DNA methylation, and proopiomelanocortin (POMC) gene expression in β-endorphin-producing POMC neurons of the hypothalamus. Alcohol Clin Exp Res (2013) 1.00
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Choline intake during pregnancy and child cognition at age 7 years. Am J Epidemiol (2013) 0.94
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What choline metabolism can tell us about the underlying mechanisms of fetal alcohol spectrum disorders. Mol Neurobiol (2011) 0.90
Dietary docosahexaenoic acid supplementation modulates hippocampal development in the Pemt-/- mouse. J Biol Chem (2009) 0.90
Choline nutrition programs brain development via DNA and histone methylation. Cent Nerv Syst Agents Med Chem (2012) 0.89
The supply of choline is important for fetal progenitor cells. Semin Cell Dev Biol (2011) 0.87
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Water maze experience and prenatal choline supplementation differentially promote long-term hippocampal recovery from seizures in adulthood. Hippocampus (2010) 0.83
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Diet-gene interactions underlie metabolic individuality and influence brain development: implications for clinical practice derived from studies on choline metabolism. Ann Nutr Metab (2012) 0.81
Diethanolamine alters proliferation and choline metabolism in mouse neural precursor cells. Toxicol Sci (2007) 0.81
Neuroprotective actions of perinatal choline nutrition. Clin Chem Lab Med (2013) 0.80
Supplemental dietary choline during development exerts antidepressant-like effects in adult female rats. Brain Res (2012) 0.80
Postnatal choline levels mediate cognitive deficits in a rat model of schizophrenia. Pharmacol Biochem Behav (2012) 0.80
Methyl donor deficiency affects fetal programming of gastric ghrelin cell organization and function in the rat. Am J Pathol (2009) 0.78
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Dose response effects of dermally applied diethanolamine on neurogenesis in fetal mouse hippocampus and potential exposure of humans. Toxicol Sci (2008) 0.76
Maternal dietary intake of choline in mice regulates development of the cerebral cortex in the offspring. FASEB J (2015) 0.76
High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring. Hum Mol Genet (2017) 0.75
Plasma 1-carbon metabolites and academic achievement in 15-yr-old adolescents. FASEB J (2016) 0.75
Combined Supplementation of Choline and Docosahexaenoic Acid during Pregnancy Enhances Neurodevelopment of Fetal Hippocampus. Neurol Res Int (2017) 0.75
Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood. Brain Res (2011) 0.75
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Postnatal choline supplementation selectively attenuates hippocampal microRNA alterations associated with developmental alcohol exposure. Alcohol (2017) 0.75
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Perinatal choline supplementation increases the threshold for chunking in spatial memory. Neuroreport (1997) 1.44
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Common genetic polymorphisms affect the human requirement for the nutrient choline. FASEB J (2006) 1.88
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Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. Proc Natl Acad Sci U S A (2005) 1.73
Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study. Am J Clin Nutr (2006) 1.71
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Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load. Am J Clin Nutr (2005) 1.66
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Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency. FASEB J (2003) 1.59
Diethanolamine induces hepatic choline deficiency in mice. Toxicol Sci (2002) 1.57
Choline- and betaine-defined diets for use in clinical research and for the management of trimethylaminuria. J Am Diet Assoc (2004) 1.53
Choline metabolism and risk of breast cancer in a population-based study. FASEB J (2008) 1.51
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Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study. BMC Cardiovasc Disord (2007) 1.47
Elevated serum creatine phosphokinase in choline-deficient humans: mechanistic studies in C2C12 mouse myoblasts. Am J Clin Nutr (2004) 1.46
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Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes. FASEB J (2007) 1.42
Perturbations in choline metabolism cause neural tube defects in mouse embryos in vitro. FASEB J (2002) 1.41
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Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas. J Biol Chem (2011) 1.40
Choline availability modulates human neuroblastoma cell proliferation and alters the methylation of the promoter region of the cyclin-dependent kinase inhibitor 3 gene. J Neurochem (2004) 1.40
Phosphatidylethanolamine-N-methyltransferase activity and dietary choline regulate liver-plasma lipid flux and essential fatty acid metabolism in mice. J Nutr (2003) 1.36
Folic acid deficiency during late gestation decreases progenitor cell proliferation and increases apoptosis in fetal mouse brain. J Nutr (2004) 1.35
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Choline deficiency alters global histone methylation and epigenetic marking at the Re1 site of the calbindin 1 gene. FASEB J (2009) 1.21
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Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline. FASEB J (2010) 1.18
Choline deficiency increases lymphocyte apoptosis and DNA damage in humans. Am J Clin Nutr (2006) 1.18
Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Curr Opin Gastroenterol (2012) 1.17
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The association between betaine and choline intakes and the plasma concentrations of homocysteine in women. Am J Clin Nutr (2007) 1.16
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Ad libitum choline intake in healthy individuals meets or exceeds the proposed adequate intake level. J Nutr (2005) 1.10
Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus. Proc Natl Acad Sci U S A (2010) 1.09
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Maternal dietary choline availability alters the balance of netrin-1 and DCC neuronal migration proteins in fetal mouse brain hippocampus. Brain Res Dev Brain Res (2005) 1.06
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Computer-assisted teaching of nutritional anemias and diabetes to first-year medical students. Am J Clin Nutr (2002) 0.98
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Deficiency in methionine, tryptophan, isoleucine, or choline induces apoptosis in cultured cells. J Nutr (2002) 0.95
The evolution of Nutrition in Medicine, a computer-assisted nutrition curriculum. Am J Clin Nutr (2006) 0.95
Deletion of the Pemt gene increases progenitor cell mitosis, DNA and protein methylation and decreases calretinin expression in embryonic day 17 mouse hippocampus. Brain Res Dev Brain Res (2004) 0.94
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Conjugated linoleic acid supplementation for twelve weeks increases lean body mass in obese humans. J Nutr (2007) 0.94
Inadequate intake of nutrients essential for neurodevelopment in children with fetal alcohol spectrum disorders (FASD). Neurotoxicol Teratol (2013) 0.92
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The epigenetic effects of a high prenatal folate intake in male mouse fetuses exposed in utero to arsenic. Toxicol Appl Pharmacol (2012) 0.91
Docosahexaenoic acid in plasma phosphatidylcholine may be a potential marker for in vivo phosphatidylethanolamine N-methyltransferase activity in humans. Am J Clin Nutr (2011) 0.91
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Choline and betaine intake and the risk of colorectal cancer in men. Cancer Epidemiol Biomarkers Prev (2010) 0.90
Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res (2013) 0.90
Adapting the contents of computer-based instruction based on knowledge tests maintains effectiveness of nutrition education. Am J Clin Nutr (2003) 0.88
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