Published in Structure on September 11, 2014
Necroptosis and its role in inflammation. Nature (2015) 3.01
Necroptosis activation in Alzheimer's disease. Nat Neurosci (2017) 1.38
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death. EMBO J (2016) 1.13
Toxin-induced necroptosis is a major mechanism of Staphylococcus aureus lung damage. PLoS Pathog (2015) 1.11
A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis. Cell Death Dis (2015) 1.02
Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3. Nat Commun (2015) 1.02
Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis. Mol Cell (2016) 1.01
RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury. Cell Death Differ (2016) 0.98
MLKL forms cation channels. Cell Res (2016) 0.92
Molecular crosstalk between apoptosis, necroptosis, and survival signaling. Mol Cell Oncol (2015) 0.91
Necroinflammation in Kidney Disease. J Am Soc Nephrol (2015) 0.86
Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides. J Immunol (2016) 0.82
Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis. Cell Death Dis (2016) 0.82
Therapeutic applications of TRAIL receptor agonists in cancer and beyond. Pharmacol Ther (2015) 0.80
Post-translational control of RIPK3 and MLKL mediated necroptotic cell death. F1000Res (2015) 0.80
The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis. Immunity (2016) 0.79
A motive for killing: effector functions of regulated lytic cell death. Immunol Cell Biol (2016) 0.79
Evolutionary divergence of the necroptosis effector MLKL. Cell Death Differ (2016) 0.79
Identification of a novel cell death-inducing domain reveals that fungal amyloid-controlled programmed cell death is related to necroptosis. Proc Natl Acad Sci U S A (2016) 0.79
Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy. Oncotarget (2016) 0.78
Insane in the membrane: a structural perspective of MLKL function in necroptosis. Immunol Cell Biol (2017) 0.78
DED or alive: assembly and regulation of the death effector domain complexes. Cell Death Dis (2015) 0.77
Analysis of the N-terminal region of human MLKL, as well as two distinct MLKL isoforms, reveals new insights into necroptotic cell death. Biosci Rep (2015) 0.77
On the problem of resonance assignments in solid state NMR of uniformly ¹⁵N,¹³C-labeled proteins. J Magn Reson (2015) 0.76
Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis. Trends Pharmacol Sci (2017) 0.75
Switch for the necroptotic permeation pore. Structure (2014) 0.75
Analyses of Compact Trichinella Kinomes Reveal a MOS-Like Protein Kinase with a Unique N-Terminal Domain. G3 (Bethesda) (2016) 0.75
MLKL channel in necroptosis is octamer formed by tetramers in a dyadic process. Mol Cell Biol (2016) 0.75
Pore-forming toxin-mediated ion dysregulation leads to death receptor-independent necroptosis of lung epithelial cells during bacterial pneumonia. Cell Death Differ (2017) 0.75
Electrophysiologist shows a cation channel function of MLKL. Cell Res (2016) 0.75
Dying to protect: cell death and the control of T-cell homeostasis. Immunol Rev (2017) 0.75
MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis. Proc Natl Acad Sci U S A (2017) 0.75
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J Biomol NMR (1995) 93.94
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer (1972) 35.74
Protein backbone angle restraints from searching a database for chemical shift and sequence homology. J Biomol NMR (1999) 26.99
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell (1997) 24.57
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science (2001) 23.42
Cell death: critical control points. Cell (2004) 22.56
NMR View: A computer program for the visualization and analysis of NMR data. J Biomol NMR (1994) 22.42
Caspases: enemies within. Science (1998) 19.45
Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell (2009) 11.36
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell (2009) 11.26
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science (2009) 9.29
Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol (2008) 9.24
Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol (2010) 9.06
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol (2000) 8.49
Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell (2002) 8.38
TNF-alpha induces two distinct caspase-8 activation pathways. Cell (2008) 6.81
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell (2012) 6.56
Backbone 1H and 15N resonance assignments of the N-terminal SH3 domain of drk in folded and unfolded states using enhanced-sensitivity pulsed field gradient NMR techniques. J Biomol NMR (1994) 6.06
Directed self-assembly of monodisperse phospholipid bilayer Nanodiscs with controlled size. J Am Chem Soc (2004) 5.32
Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. J Exp Med (1998) 4.08
Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis. J Immunol (1988) 3.64
Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis. Nature (2011) 3.61
RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome. Immunity (2011) 3.53
Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3. Mol Cell (2014) 3.52
More than one way to die: apoptosis, necrosis and reactive oxygen damage. Oncogene (1999) 3.42
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis. Nat Cell Biol (2013) 3.29
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity (2013) 3.15
Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids. Nat Struct Mol Biol (2006) 3.14
RIP1, a kinase on the crossroads of a cell's decision to live or die. Cell Death Differ (2007) 2.96
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis. Cell (2013) 2.75
Many stimuli pull the necrotic trigger, an overview. Cell Death Differ (2011) 2.55
Necrosis: a specific form of programmed cell death? Exp Cell Res (2003) 2.47
The lipid composition of rat-liver mitochondria, fluffy layer and microsomes. Biochem J (1962) 2.44
Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death. Cell Res (2013) 2.38
The signal sequence moves through a ribosomal tunnel into a noncytoplasmic aqueous environment at the ER membrane early in translocation. Cell (1993) 2.20
SNARE-mediated lipid mixing depends on the physical state of the vesicles. Biophys J (2005) 1.91
Optimized phospholipid bilayer nanodiscs facilitate high-resolution structure determination of membrane proteins. J Am Chem Soc (2013) 1.90
Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury. Hepatology (2013) 1.73
Direct evidence for membrane pore formation by the apoptotic protein Bax. Biochem Biophys Res Commun (2002) 1.20
Antibacterial membrane attack by a pore-forming intestinal C-type lectin. Nature (2013) 1.17
Solution structure of the Vam7p PX domain. Biochemistry (2002) 1.10
Lipid-protein nanodiscs: possible application in high-resolution NMR investigations of membrane proteins and membrane-active peptides. Biochemistry (Mosc) (2009) 1.08
Reluctance to membrane binding enables accessibility of the synaptobrevin SNARE motif for SNARE complex formation. Proc Natl Acad Sci U S A (2011) 1.04
Enlightening molecular mechanisms through study of protein interactions. J Mol Cell Biol (2012) 0.88
Necrosis is an active and controlled form of programmed cell death. Biochemistry (Mosc) (2002) 0.86