Published in Oncotarget on August 30, 2016
Cancer's Achilles' Heel: Apoptosis and Necroptosis to the Rescue. Int J Mol Sci (2016) 0.76
The National Cancer Institute ALMANAC: A Comprehensive Screening Resource for the Detection of Anticancer Drug Pairs with Enhanced Therapeutic Activity. Cancer Res (2017) 0.75
Exploitation of necroptosis for treatment of caspase-compromised cancers. Oncol Lett (2017) 0.75
Hallmarks of cancer: the next generation. Cell (2011) 140.01
The hallmarks of cancer. Cell (2000) 113.05
Immunity, inflammation, and cancer. Cell (2010) 28.27
The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet (2010) 15.87
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature (2004) 12.41
Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Science (1996) 12.23
Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell (2009) 11.36
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell (2009) 11.26
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell (2003) 11.07
Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science (2004) 10.77
Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med (2006) 10.54
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ (2008) 10.45
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol (2010) 9.59
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science (2009) 9.29
Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol (2008) 9.24
Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol (2010) 9.06
Regulation and function of IKK and IKK-related kinases. Sci STKE (2006) 8.98
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol (2000) 8.49
Interferons, immunity and cancer immunoediting. Nat Rev Immunol (2006) 8.23
Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell (2008) 7.61
The death domain kinase RIP mediates the TNF-induced NF-kappaB signal. Immunity (1998) 7.35
Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell (2006) 7.32
TNF-alpha induces two distinct caspase-8 activation pathways. Cell (2008) 6.81
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell (2012) 6.56
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature (2011) 6.31
RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature (2011) 6.03
cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell (2008) 5.89
The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell (2006) 5.18
Autophagic programmed cell death by selective catalase degradation. Proc Natl Acad Sci U S A (2006) 4.81
cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell (2011) 4.78
Cell death. N Engl J Med (2009) 4.75
Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Cell (2006) 4.43
Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev (1999) 4.39
The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell (2012) 4.37
Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death. J Exp Med (2005) 4.32
The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell (2012) 4.29
Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. J Exp Med (1998) 4.08
Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature (2009) 3.93
Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature (2011) 3.86
Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes Dev (2003) 3.79
Clearance of apoptotic cells: getting rid of the corpses. Mol Cell (2004) 3.64
Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis. Nature (2011) 3.61
Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3. Mol Cell (2014) 3.52
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis. Nat Cell Biol (2013) 3.29
Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis. Proc Natl Acad Sci U S A (2012) 3.24
Necroptosis: the release of damage-associated molecular patterns and its physiological relevance. Immunity (2013) 3.22
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis. Sci Signal (2010) 3.20
FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature (2011) 3.17
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity (2013) 3.15
The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity (2011) 3.10
Necroptosis and its role in inflammation. Nature (2015) 3.01
Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE. J Exp Med (2008) 2.97
Apoptosis and necrosis: detection, discrimination and phagocytosis. Methods (2008) 2.93
A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. EMBO J (1998) 2.82
Immunogenic death of colon cancer cells treated with oxaliplatin. Oncogene (2009) 2.74
F-actin is an evolutionarily conserved damage-associated molecular pattern recognized by DNGR-1, a receptor for dead cells. Immunity (2012) 2.72
Necroptosis. N Engl J Med (2014) 2.71
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ (2014) 2.66
Crosstalk between apoptosis, necrosis and autophagy. Biochim Biophys Acta (2013) 2.61
Necroptosis: a specialized pathway of programmed necrosis. Cell (2008) 2.61
Many stimuli pull the necrotic trigger, an overview. Cell Death Differ (2011) 2.55
FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells. Proc Natl Acad Sci U S A (2008) 2.52
Mechanisms of necroptosis in T cells. J Exp Med (2011) 2.51
Beginnings of a good apoptotic meal: the find-me and eat-me signaling pathways. Immunity (2011) 2.47
Caspase inhibitors promote alternative cell death pathways. Sci STKE (2006) 2.44
Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells. Nature (2016) 2.43
Biological functions of microRNAs: a review. J Physiol Biochem (2010) 2.38
Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death. Cell Res (2013) 2.38
Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums. J Exp Med (2010) 2.38
Caspase 8 inhibits programmed necrosis by processing CYLD. Nat Cell Biol (2011) 2.37
MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates. Cell Rep (2014) 2.34
Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features. Cell Death Differ (2009) 2.33
Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain. Cell Signal (2007) 2.30
cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production. Cell Death Differ (2010) 2.26
Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. J Biol Chem (2013) 2.24
Antigen-mediated T cell expansion regulated by parallel pathways of death. Proc Natl Acad Sci U S A (2008) 2.20
Dendritic cells: understanding immunogenicity. Eur J Immunol (2007) 2.13
RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8⁺ T cells. Science (2015) 2.09
Programmed necrosis: backup to and competitor with apoptosis in the immune system. Nat Immunol (2011) 2.09
A role for FADD in T cell activation and development. Immunity (1998) 2.09
Survival function of the FADD-CASPASE-8-cFLIP(L) complex. Cell Rep (2012) 2.06
Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling. Mol Biol Cell (2002) 2.05
Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment. J Cell Biol (2009) 2.02
Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance. J Clin Invest (2010) 1.97
Shikonin circumvents cancer drug resistance by induction of a necroptotic death. Mol Cancer Ther (2007) 1.90
The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments. Immunity (2012) 1.89
RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis. Cell (2014) 1.88
NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling. Mol Cell (2015) 1.80
The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocation and localizes to mitochondria. FEBS Lett (2000) 1.80
The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis. Nat Immunol (2015) 1.77
Drug insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms. Nat Clin Pract Oncol (2006) 1.73
TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation. Cell Death Differ (2012) 1.72
Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis. EMBO Mol Med (2012) 1.68
Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis. Proc Natl Acad Sci U S A (2010) 1.67
Widespread mitochondrial depletion via mitophagy does not compromise necroptosis. Cell Rep (2013) 1.59
Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation. J Biol Chem (2009) 1.56
Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase. Cell Death Differ (2012) 1.53
Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production. Mol Biol Cell (2003) 1.47
Rapid, noninflammatory and PS-dependent phagocytic clearance of necrotic cells. Cell Death Differ (2003) 1.44
A role of RIP3-mediated macrophage necrosis in atherosclerosis development. Cell Rep (2013) 1.44