Programmed necrosis in the cross talk of cell death and inflammation.

Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis. Cell Metab (2016) 1.39

TNF biology, pathogenic mechanisms and emerging therapeutic strategies. Nat Rev Rheumatol (2015) 1.10

A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis. Cell Death Dis (2015) 1.02

RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus. Cell Host Microbe (2016) 1.02

Dying cells actively regulate adaptive immune responses. Nat Rev Immunol (2017) 0.94

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis. Cell Res (2016) 0.92

Necroptosis: The Trojan horse in cell autonomous antiviral host defense. Virology (2015) 0.91

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature (2016) 0.90

Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it. Cell Death Differ (2015) 0.90

Manipulation of apoptosis and necroptosis signaling by herpesviruses. Med Microbiol Immunol (2015) 0.88

Necroptosis Promotes Staphylococcus aureus Clearance by Inhibiting Excessive Inflammatory Signaling. Cell Rep (2016) 0.87

An outline of necrosome triggers. Cell Mol Life Sci (2016) 0.86

The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages. J Immunol (2015) 0.86

Autophagy in renal diseases. Pediatr Nephrol (2015) 0.85

Knockdown of RIPK1 Markedly Exacerbates Murine Immune-Mediated Liver Injury through Massive Apoptosis of Hepatocytes, Independent of Necroptosis and Inhibition of NF-κB. J Immunol (2016) 0.83

Regulation of RIPK3- and RHIM-dependent Necroptosis by the Proteasome. J Biol Chem (2016) 0.82

Bacillus thuringiensis Crystal Protein Cry6Aa Triggers Caenorhabditis elegans Necrosis Pathway Mediated by Aspartic Protease (ASP-1). PLoS Pathog (2016) 0.81

Death in the fast lane: what's next for necroptosis? FEBS J (2015) 0.80

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis. Immunity (2016) 0.79

Controlled detonation: Evolution of necroptosis in pathogen defense. Immunol Cell Biol (2016) 0.79

Deletion of FADD in macrophages and granulocytes results in RIP3- and MyD88-dependent systemic inflammation. PLoS One (2015) 0.79

Caspase Inhibition Prevents Tumor Necrosis Factor-α-Induced Apoptosis and Promotes Necrotic Cell Death in Mouse Hepatocytes in Vivo and in Vitro. Am J Pathol (2016) 0.78

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome. Nat Commun (2017) 0.78

Border Security: The Role of RIPK3 in Epithelium Homeostasis. Front Cell Dev Biol (2016) 0.77

Key roles of necroptotic factors in promoting tumor growth. Oncotarget (2016) 0.77

Necroptosis-independent signaling by the RIP kinases in inflammation. Cell Mol Life Sci (2016) 0.77

Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death. PLoS Pathog (2016) 0.76

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases. Immunol Rev (2017) 0.75

RIPK1 and PGAM5 Control Leishmania Replication through Distinct Mechanisms. J Immunol (2016) 0.75

Activation of cell-surface proteases promotes necroptosis, inflammation and cell migration. Cell Res (2016) 0.75

Heat shock protein 90 regulates necroptosis by modulating multiple signaling effectors. Cell Death Dis (2016) 0.75

RIPK3 in cell death and inflammation: the good, the bad, and the ugly. Immunol Rev (2017) 0.75

Oxidative Burst-Dependent NETosis Is Implicated in the Resolution of Necrosis-Associated Sterile Inflammation. Front Immunol (2016) 0.75

Induction of necroptotic cell death by viral activation of the RIG-I or STING pathway. Cell Death Differ (2017) 0.75

Cell-Extrinsic TNF Collaborates with TRIF Signaling To Promote Yersinia-Induced Apoptosis. J Immunol (2016) 0.75

Necroptosis: A new way of dying? Cancer Biol Ther (2016) 0.75

NEMO regulates a cell death switch in TNF signaling by inhibiting recruitment of RIPK3 to the cell death-inducing complex II. Cell Death Dis (2016) 0.75

Cold-inducible RNA-binding protein through TLR4 signaling induces mitochondrial DNA fragmentation and regulates macrophage cell death after trauma. Cell Death Dis (2017) 0.75

Distinct Kinase-Independent Role of RIPK3 in CD11c(+) Mononuclear Phagocytes in Cytokine-Induced Tissue Repair. Cell Rep (2017) 0.75

Participation of Necroptosis in the Host Response to Acute Bacterial Pneumonia. J Innate Immun (2017) 0.75

An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client. Mol Cell Proteomics (2016) 0.75

EnsemblCompara GeneTrees: Complete, duplication-aware phylogenetic trees in vertebrates. Genome Res (2008) 12.72

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell (2009) 11.36

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell (2009) 11.26

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell (2003) 11.07

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol (2008) 10.39

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science (2009) 9.29

Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol (2008) 9.24

How dying cells alert the immune system to danger. Nat Rev Immunol (2008) 8.63

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature (2005) 8.51

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol (2000) 8.49

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell (2007) 8.48

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell (2007) 7.74

Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell (2008) 7.61

The death domain kinase RIP mediates the TNF-induced NF-kappaB signal. Immunity (1998) 7.35

Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell (2006) 7.32

TNF-alpha induces two distinct caspase-8 activation pathways. Cell (2008) 6.81

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. Nat Cell Biol (2009) 6.62

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell (2012) 6.56

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature (2011) 6.31

Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity (1997) 6.15

Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]. Nat Cell Biol (2006) 6.11

RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature (2011) 6.03

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell (2008) 5.89

RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol (2004) 5.74

Induction of apoptosis in mature T cells by tumour necrosis factor. Nature (1995) 5.26

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell (2007) 5.09

Macrophage death and defective inflammation resolution in atherosclerosis. Nat Rev Immunol (2009) 5.03

Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment. Annu Rev Immunol (1999) 4.97

Linear ubiquitination prevents inflammation and regulates immune signalling. Nature (2011) 4.85

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell (2011) 4.78

Mincle is an ITAM-coupled activating receptor that senses damaged cells. Nat Immunol (2008) 4.66

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice. Genes Dev (2000) 4.51

The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol Cell (2011) 4.43

Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev (1999) 4.39

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell (2012) 4.37

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell (2012) 4.29

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature (2011) 4.14

Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4. Mol Cell Biol (2004) 4.05

Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature (2009) 3.93

X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling. Nat Genet (2001) 3.86

Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature (2011) 3.86

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex. Nature (2011) 3.77

A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science (2000) 3.72

Virus inhibition of RIP3-dependent necrosis. Cell Host Microbe (2010) 3.70

A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. J Biol Chem (2003) 3.70

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature (2012) 3.67

Human caspases: activation, specificity, and regulation. J Biol Chem (2009) 3.67

Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation. Immunity (2000) 3.61

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis. Nature (2011) 3.61

NEMO/IKK gamma-deficient mice model incontinentia pigmenti. Mol Cell (2000) 3.60

RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome. Immunity (2011) 3.53

Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3. Mol Cell (2014) 3.52

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation. Immunity (2012) 3.51

TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature (2002) 3.48

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1. Nature (2012) 3.40

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis. Nat Cell Biol (2013) 3.29

Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles. Immunity (2004) 3.26

Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell (2014) 3.25

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis. Proc Natl Acad Sci U S A (2012) 3.24

DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA. Cell Host Microbe (2012) 3.23

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature (2011) 3.17

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity (2013) 3.15

The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity (2011) 3.10

NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling. Mol Cell Biol (2001) 3.02

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome. Nat Immunol (2012) 2.94

Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation. Cell (2014) 2.71

TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species. Cell (2013) 2.71

Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti. Mol Cell (2000) 2.70

Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis. Dev Cell (2001) 2.68

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway. Proc Natl Acad Sci U S A (2011) 2.64

RIPK1 is not essential for TNFR1-induced activation of NF-kappaB. Cell Death Differ (2009) 2.59

Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2. Nat Cell Biol (2004) 2.58

Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome. Immunity (2012) 2.58

Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif. J Immunol (2005) 2.57

Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury. Kidney Int (2012) 2.55

Mechanisms of necroptosis in T cells. J Exp Med (2011) 2.51

Necrostatin: a potentially novel cardioprotective agent? Cardiovasc Drugs Ther (2007) 2.50

Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation. J Biol Chem (2005) 2.41

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8. J Exp Med (2008) 2.40

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death. Cell Res (2013) 2.38

Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency. Nat Immunol (2012) 2.38

Caspase 8 inhibits programmed necrosis by processing CYLD. Nat Cell Biol (2011) 2.37

Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5. Cell (2012) 2.34

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates. Cell Rep (2014) 2.34

Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain. Cell Signal (2007) 2.30

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis. Cell Res (2013) 2.26

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production. Cell Death Differ (2010) 2.26

Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium. Nat Immunol (2012) 2.25

Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. J Biol Chem (2013) 2.24

Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis. Science (2014) 2.23

Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis. Proc Natl Acad Sci U S A (2010) 2.20

RIP3, a novel apoptosis-inducing kinase. J Biol Chem (1999) 2.15

Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling. Curr Biol (2007) 2.15

PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan. Nat Immunol (2006) 2.12

Heme oxygenase-1 affords protection against noncerebral forms of severe malaria. Proc Natl Acad Sci U S A (2009) 2.11

Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis. Arthritis Rheum (2007) 2.10

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2013) 2.10

RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3. Cell (2014) 2.06

Survival function of the FADD-CASPASE-8-cFLIP(L) complex. Cell Rep (2012) 2.06

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature (2014) 2.03

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell (2012) 4.29

Biological function of fucosylation in cancer biology. J Biochem (2008) 1.91

Fucosylated haptoglobin is a novel marker for pancreatic cancer: a detailed analysis of the oligosaccharide structure and a possible mechanism for fucosylation. Int J Cancer (2006) 1.82

Detection of necrosis by release of lactate dehydrogenase activity. Methods Mol Biol (2013) 1.34

A novel core fucose-specific lectin from the mushroom Pholiota squarrosa. J Biol Chem (2012) 1.03

Fucosylated haptoglobin is a novel type of cancer biomarker linked to the prognosis after an operation in colorectal cancer. Cancer (2011) 0.98

Clinical application of a lectin-antibody ELISA to measure fucosylated haptoglobin in sera of patients with pancreatic cancer. Clin Chem Lab Med (2010) 0.98

Enhanced epithelial-mesenchymal transition-like phenotype in N-acetylglucosaminyltransferase V transgenic mouse skin promotes wound healing. J Biol Chem (2011) 0.93

A secreted type of beta1,6 N-acetylglucosaminyltransferase V (GnT-V), a novel angiogenesis inducer, is regulated by gamma-secretase. FASEB J (2006) 0.92

Identification of an inducible factor secreted by pancreatic cancer cell lines that stimulates the production of fucosylated haptoglobin in hepatoma cells. Biochem Biophys Res Commun (2008) 0.88

Glycomic analyses of glycoproteins in bile and serum during rat hepatocarcinogenesis. J Proteome Res (2010) 0.84

Analysis of polarized secretion of fucosylated alpha-fetoprotein in HepG2 cells. J Proteome Res (2012) 0.81

Identification of a novel type of CA19-9 carrier in human bile and sera of cancer patients: an implication of the involvement in nonsecretory exocytosis. J Proteome Res (2010) 0.81

Identification of fucosylated haptoglobin as a novel tumor marker for pancreatic cancer and its possible application for a clinical diagnostic test. Methods Enzymol (2010) 0.80

Mutation of GDP-mannose-4,6-dehydratase in colorectal cancer metastasis. PLoS One (2013) 0.80

Overexpression of α1,6-fucosyltransferase in hepatoma enhances expression of Golgi phosphoprotein 2 in a fucosylation-independent manner. Int J Oncol (2011) 0.79

N-Acetylglucosaminyltransferase V regulates TGF-β response in hepatic stellate cells and the progression of steatohepatitis. Glycobiology (2012) 0.78

High levels of E4-PHA-reactive oligosaccharides: potential as marker for cells with characteristics of hepatic progenitor cells. Glycoconj J (2009) 0.77

Whole-body imaging of tumor cells by azaelectrocyclization: visualization of metastasis dependence on glycan structure. Bioorg Med Chem (2013) 0.76

Preparation of branched cyclomaltoheptaose with 3-O-α-L-fucopyranosyl-α-D-mannopyranose and changes in fucosylation of HCT116 cells treated with the fucose-modified cyclomaltoheptaose. Carbohydr Res (2013) 0.75