Published in Cells on October 11, 2013
Potentials of single-cell biology in identification and validation of disease biomarkers. J Cell Mol Med (2016) 0.77
Altered microRNA profiles in plasma exosomes from mesial temporal lobe epilepsy with hippocampal sclerosis. Oncotarget (2016) 0.75
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet (2000) 336.52
Genomic expression programs in the response of yeast cells to environmental changes. Mol Biol Cell (2000) 36.09
Functional discovery via a compendium of expression profiles. Cell (2000) 31.39
Transcriptional regulatory code of a eukaryotic genome. Nature (2004) 27.21
A synthetic oscillatory network of transcriptional regulators. Nature (2000) 24.58
Construction of a genetic toggle switch in Escherichia coli. Nature (2000) 24.02
BioGRID: a general repository for interaction datasets. Nucleic Acids Res (2006) 22.41
SGD: Saccharomyces Genome Database. Nucleic Acids Res (1998) 20.26
Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Res (2003) 14.79
Network-based classification of breast cancer metastasis. Mol Syst Biol (2007) 12.18
Foundations for engineering biology. Nature (2005) 11.22
Computational systems biology. Nature (2002) 10.33
Biological robustness. Nat Rev Genet (2004) 9.98
Significance analysis of time course microarray experiments. Proc Natl Acad Sci U S A (2005) 8.65
Analysis of optimality in natural and perturbed metabolic networks. Proc Natl Acad Sci U S A (2002) 8.41
It's a noisy business! Genetic regulation at the nanomolar scale. Trends Genet (1999) 7.09
A synthetic multicellular system for programmed pattern formation. Nature (2005) 6.93
A fast, robust and tunable synthetic gene oscillator. Nature (2008) 6.85
Robustness of cellular functions. Cell (2004) 6.65
Engineered gene circuits. Nature (2002) 6.25
Reverse engineering of biological complexity. Science (2002) 6.06
The YEASTRACT database: a tool for the analysis of transcription regulatory associations in Saccharomyces cerevisiae. Nucleic Acids Res (2006) 4.53
Robust, tunable biological oscillations from interlinked positive and negative feedback loops. Science (2008) 4.45
A tunable synthetic mammalian oscillator. Nature (2009) 4.33
Predicting disease genes using protein-protein interactions. J Med Genet (2006) 4.10
Diversity-based, model-guided construction of synthetic gene networks with predicted functions. Nat Biotechnol (2009) 3.86
The model organism as a system: integrating 'omics' data sets. Nat Rev Mol Cell Biol (2006) 3.69
A predictive model for transcriptional control of physiology in a free living cell. Cell (2007) 3.35
Software for systems biology: from tools to integrated platforms. Nat Rev Genet (2011) 2.42
Cancer as a robust system: implications for anticancer therapy. Nat Rev Cancer (2004) 2.28
Systems metabolic engineering of Escherichia coli for L-threonine production. Mol Syst Biol (2007) 2.18
A genome-scale computational study of the interplay between transcriptional regulation and metabolism. Mol Syst Biol (2007) 2.15
Entrainment of a population of synthetic genetic oscillators. Science (2011) 1.66
Formulating genome-scale kinetic models in the post-genome era. Mol Syst Biol (2008) 1.64
Computational reconstruction of transcriptional regulatory modules of the yeast cell cycle. BMC Bioinformatics (2006) 1.47
Evolutionary optimization with data collocation for reverse engineering of biological networks. Bioinformatics (2004) 1.47
Quantitative characterization of the transcriptional regulatory network in the yeast cell cycle. Bioinformatics (2004) 1.43
Advances in synthetic biology: on the path from prototypes to applications. Curr Opin Biotechnol (2005) 1.41
Application of systems biology for bioprocess development. Trends Biotechnol (2008) 1.30
Discovering functions and revealing mechanisms at molecular level from biological networks. Proteomics (2007) 1.29
Metabolite essentiality elucidates robustness of Escherichia coli metabolism. Proc Natl Acad Sci U S A (2007) 1.26
Identification of transcription factor cooperativity via stochastic system model. Bioinformatics (2006) 1.25
Robustness analysis and tuning of synthetic gene networks. Bioinformatics (2007) 1.24
Integrated cellular network of transcription regulations and protein-protein interactions. BMC Syst Biol (2010) 1.20
Quantitative inference of dynamic regulatory pathways via microarray data. BMC Bioinformatics (2005) 1.20
Robust synchronization control scheme of a population of nonlinear stochastic synthetic genetic oscillators under intrinsic and extrinsic molecular noise via quorum sensing. BMC Syst Biol (2012) 1.17
A new measure of the robustness of biochemical networks. Bioinformatics (2005) 1.13
Identifying regulatory targets of cell cycle transcription factors using gene expression and ChIP-chip data. BMC Bioinformatics (2007) 1.09
Construction of a cancer-perturbed protein-protein interaction network for discovery of apoptosis drug targets. BMC Syst Biol (2008) 1.07
Efficient classification of complete parameter regions based on semidefinite programming. BMC Bioinformatics (2007) 1.06
Dynamic modeling of cis-regulatory circuits and gene expression prediction via cross-gene identification. BMC Bioinformatics (2005) 1.05
On the attenuation and amplification of molecular noise in genetic regulatory networks. BMC Bioinformatics (2006) 1.04
A network-based biomarker approach for molecular investigation and diagnosis of lung cancer. BMC Med Genomics (2011) 1.01
On the robust circuit design schemes of biochemical networks: steady-state approach. IEEE Trans Biomed Circuits Syst (2007) 0.97
Robust H infinity-stabilization design in gene networks under stochastic molecular noises: fuzzy-interpolation approach. IEEE Trans Syst Man Cybern B Cybern (2008) 0.95
GA-based Design Algorithms for the Robust Synthetic Genetic Oscillators with Prescribed Amplitude, Period and Phase. Gene Regul Syst Bio (2010) 0.95
Robust synthetic biology design: stochastic game theory approach. Bioinformatics (2009) 0.94
A systematic design method for robust synthetic biology to satisfy design specifications. BMC Syst Biol (2009) 0.94
A systems biology approach to construct the gene regulatory network of systemic inflammation via microarray and databases mining. BMC Med Genomics (2008) 0.94
Global screening of potential Candida albicans biofilm-related transcription factors via network comparison. BMC Bioinformatics (2010) 0.93
Robust engineered circuit design principles for stochastic biochemical networks with parameter uncertainties and disturbances. IEEE Trans Biomed Circuits Syst (2008) 0.91
Robust design of biological circuits: evolutionary systems biology approach. J Biomed Biotechnol (2011) 0.91
Identifying functional mechanisms of gene and protein regulatory networks in response to a broader range of environmental stresses. Comp Funct Genomics (2010) 0.90
Engineering a native homoethanol pathway in Escherichia coli B for ethanol production. Biotechnol Lett (2007) 0.89
New measurement methods of network robustness and response ability via microarray data. PLoS One (2013) 0.86
Identification of infection- and defense-related genes via a dynamic host-pathogen interaction network using a Candida albicans-zebrafish infection model. J Innate Immun (2013) 0.84
Analysing microarray data in drug discovery using systems biology. Expert Opin Drug Discov (2007) 0.83
On the estimation of robustness and filtering ability of dynamic biochemical networks under process delays, internal parametric perturbations and external disturbances. Math Biosci (2009) 0.83
Robust synthetic gene network design via library-based search method. Bioinformatics (2011) 0.83
Construction and clarification of dynamic gene regulatory network of cancer cell cycle via microarray data. Cancer Inform (2007) 0.81
Constructing gene regulatory networks for long term photosynthetic light acclimation in Arabidopsis thaliana. BMC Bioinformatics (2011) 0.81
Integrating scientific cultures. Mol Syst Biol (2007) 0.80
On the increase in network robustness and decrease in network response ability during the aging process: a systems biology approach via microarray data. IEEE/ACM Trans Comput Biol Bioinform (2013) 0.79
On the calculation of signal transduction ability of signaling transduction pathways in intracellular communication: systematic approach. Bioinformatics (2012) 0.79
Prediction of phenotype-associated genes via a cellular network approach: a Candida albicans infection case study. PLoS One (2012) 0.78
A Unifying Mathematical Framework for Genetic Robustness, Environmental Robustness, Network Robustness and their Tradeoff on Phenotype Robustness in Biological Networks Part II: Ecological Networks. Evol Bioinform Online (2013) 0.78
A Unifying Mathematical Framework for Genetic Robustness, Environmental Robustness, Network Robustness and their Trade-offs on Phenotype Robustness in Biological Networks. Part III: Synthetic Gene Networks in Synthetic Biology. Evol Bioinform Online (2013) 0.78
A Unifying Mathematical Framework for Genetic Robustness, Environmental Robustness, Network Robustness and their Trade-off on Phenotype Robustness in Biological Networks Part I: Gene Regulatory Networks in Systems and Evolutionary Biology. Evol Bioinform Online (2013) 0.78
Multiobjective H2/H∞ synthetic gene network design based on promoter libraries. Math Biosci (2011) 0.78
Robust model matching control of immune systems under environmental disturbances: dynamic game approach. J Theor Biol (2008) 0.78