Cigarette smoke induces bronchoconstrictor hyperresponsiveness to substance P and inactivates airway neutral endopeptidase in the guinea pig. Possible role of free radicals.

PubWeight™: 1.29‹?› | Rank: Top 10%

🔗 View Article (PMC 329734)

Published in J Clin Invest on September 01, 1989

Authors

D J Dusser1, T D Djokic, D B Borson, J A Nadel

Author Affiliations

1: Cardiovascular Research Institute, University of California, San Francisco 94143-0130.

Articles citing this

Epidemiologic evidence for asthma and exposure to air toxics: linkages between occupational, indoor, and community air pollution research. Environ Health Perspect (2002) 2.66

CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung. Proc Natl Acad Sci U S A (1991) 1.47

Hypertonic saline increases vascular permeability in the rat trachea by producing neurogenic inflammation. J Clin Invest (1990) 1.27

Effects of cigarette smoke on epithelial cells of the respiratory tract. Thorax (1994) 1.13

Neurogenic inflammation: with additional discussion of central and perceptual integration of nonneurogenic inflammation. Environ Health Perspect (1997) 1.08

Brain-derived neurotrophic factor in cigarette smoke-induced airway hyperreactivity. Am J Respir Cell Mol Biol (2013) 1.03

Decreased neutral endopeptidases: possible role in inflammatory diseases of airways. Lung (1990) 1.00

Metalloelastase in lungs and alveolar macrophages is modulated by extracellular substance P in mice. Am J Physiol Lung Cell Mol Physiol (2008) 0.93

Retracted Gastrin-releasing peptide blockade as a broad-spectrum anti-inflammatory therapy for asthma. Proc Natl Acad Sci U S A (2011) 0.91

Expression of functional NK1 receptors in human alveolar macrophages: superoxide anion production, cytokine release and involvement of NF-kappaB pathway. Br J Pharmacol (2005) 0.91

Effects of chronic airway inflammation on the activity and enzymatic inactivation of neuropeptides in guinea pig lungs. J Clin Invest (1994) 0.90

Angiotensin peptides and lung cancer. Curr Cancer Drug Targets (2011) 0.89

CD10/NEP in non-small cell lung carcinomas. Relationship to cellular proliferation. J Clin Invest (1994) 0.88

Effects of epithelium removal on relaxation of airway smooth muscle induced by vasoactive intestinal peptide and electrical field stimulation. Br J Pharmacol (1990) 0.86

Decreased neprilysin and pulmonary vascular remodeling in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 0.85

Ruthenium red, but not capsazepine reduces plasma extravasation by cigarette smoke in rat airways. Br J Pharmacol (1993) 0.85

Functional effects of phosphoramidon and captopril on exogenous neuropeptides in human nasal mucosa. Eur Arch Otorhinolaryngol (1995) 0.85

Adipose-derived stromal cell therapy affects lung inflammation and tracheal responsiveness in guinea pig model of COPD. PLoS One (2014) 0.82

The upper respiratory tract: mucous membrane irritation. Environ Health Perspect (1991) 0.81

Airway inflammation and hypersensitivity induced by chronic smoking. Respir Physiol Neurobiol (2011) 0.80

Soluble recombinant neutral endopeptidase (CD10) as a potential antiinflammatory agent. Inflammation (1998) 0.79

Experimental animal models for COPD: a methodological review. Tob Induc Dis (2017) 0.77

Role of neprilysin in airway inflammation induced by diesel exhaust emissions. Res Rep Health Eff Inst (2011) 0.77

Clearing the air. Smoking and incident asthma in adults. Am J Respir Crit Care Med (2015) 0.76

Substance p regulates environmental tobacco smoke-enhanced tracheal smooth muscle responsiveness in mice. J Allergy (Cairo) (2012) 0.76

Involvement of hydroxyl radicals in neurogenic airway plasma exudation and bronchoconstriction in guinea-pigs in vivo. Br J Pharmacol (1996) 0.76

Bronchial responses to substance P after antigen challenge in the guinea-pig: in vivo and in vitro studies. Mediators Inflamm (1992) 0.75

Acute changes in sputum collected from exposed human subjects in mining conditions. Inhal Toxicol (2010) 0.75

Long-term neprilysin inhibition - implications for ARNIs. Nat Rev Cardiol (2016) 0.75

Effects of four antitussives on airway neurogenic inflammation in a guinea pig model of chronic cough induced by cigarette smoke exposure. Inflamm Res (2013) 0.75

Articles cited by this

MORTALITY IN RELATION TO SMOKING: TEN YEARS' OBSERVATIONS OF BRITISH DOCTORS. Br Med J (1964) 28.21

Oxygen-dependent microbial killing by phagocytes (first of two parts). N Engl J Med (1978) 11.45

The purification and specificity of a neutral endopeptidase from rabbit kidney brush border. Biochem J (1974) 3.14

Acute effects of inhalation of cigarette smoke on airway conductance. J Appl Physiol (1961) 3.08

Capsaicin-induced desensitization of airway mucosa to cigarette smoke, mechanical and chemical irritants. Nature (1983) 2.57

The metabolism of neuropeptides. The hydrolysis of peptides, including enkephalins, tachykinins and their analogues, by endopeptidase-24.11. Biochem J (1984) 2.56

Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man. Cell Tissue Res (1984) 2.05

Selective oxidation of methionine residues in proteins. Biochemistry (1975) 2.03

Electron-spin resonance study of mainstream and sidestream cigarette smoke: nature of the free radicals in gas-phase smoke and in cigarette tar. Environ Health Perspect (1983) 1.93

High-affinity enkephalin-degrading peptidase in brain is increased after morphine. Nature (1978) 1.87

Potential mediator of inflammation. Phagocyte-derived oxidants suppress the elastase-inhibitory capacity of alpha 1-proteinase inhibitor in vitro. J Clin Invest (1980) 1.85

Neutral metalloendopeptidase in human lung tissue and cultured cells. Am Rev Respir Dis (1985) 1.79

Hydrolysis of substance p and neurotensin by converting enzyme and neutral endopeptidase. Peptides (1984) 1.72

Molecular cloning and amino acid sequence of rat enkephalinase. Biochem Biophys Res Commun (1987) 1.58

Increased nonspecific bronchial reactivity in cigarette smokers with normal lung function. Am Rev Respir Dis (1980) 1.57

Enkephalinase inhibitor potentiates mammalian tachykinin-induced contraction in ferret trachea. J Pharmacol Exp Ther (1987) 1.48

Cigarette smoke-induced airway oedema due to activation of capsaicin-sensitive vagal afferents and substance P release. Neuroscience (1983) 1.40

Purification and specificity of a membrane-bound metalloendopeptidase from bovine pituitaries. Biochemistry (1981) 1.37

The effect of cigarette smoke from the mother on bronchial responsiveness and severity of symptoms in children with asthma. J Allergy Clin Immunol (1986) 1.36

Enkephalinase inhibitor potentiates substance P- and electrically induced contraction in ferret trachea. J Appl Physiol (1985) (1987) 1.31

Enkephalinase inhibitors potentiate substance P-induced secretion of 35SO4-macromolecules from ferret trachea. Exp Lung Res (1987) 1.31

Neutral endopeptidase-like enzyme controls the contractile activity of substance P in guinea pig lung. J Clin Invest (1987) 1.24

Neutral endopeptidase and neurogenic inflammation in rats with respiratory infections. J Appl Physiol (1985) (1989) 1.21

Airway neutral endopeptidase-like enzyme modulates tachykinin-induced bronchoconstriction in vivo. J Appl Physiol (1985) (1988) 1.19

Neutral endopeptidase inhibitors potentiate substance P- and capsaicin-induced cough in awake guinea pigs. J Clin Invest (1988) 1.13

Enkephalinase: selective peptide inhibitors. Life Sci (1981) 1.12

The effect of passive smoking on pulmonary function and nonspecific bronchial responsiveness in a population-based sample of children and young adults. Am Rev Respir Dis (1987) 1.12

Substance P-induced bronchoconstriction in the guinea pig. Enhancement by inhibitors of neutral metalloendopeptidase and angiotensin-converting enzyme. Am Rev Respir Dis (1988) 1.10

Free radical pathology: inactivation of human alpha-1-proteinase inhibitor by products from the reaction of nitrogen dioxide with hydrogen peroxide and the etiology of emphysema. Biochem Biophys Res Commun (1982) 1.02

Inhibitors of neutral endopeptidase potentiate electrically and capsaicin-induced noncholinergic contraction in guinea pig bronchi. J Pharmacol Exp Ther (1989) 1.01

Respiratory tract infections increase susceptibility to neurogenic inflammation in the rat trachea. Am Rev Respir Dis (1988) 1.00

Neuropeptides degranulate serous cells of ferret tracheal glands. Am J Physiol (1986) 1.00

Parental smoking in childhood asthma. Ann Allergy (1974) 1.00

Enkephalin dipeptidyl carboxypeptidase (enkephalinase) activity: selective radioassay, properties, and regional distribution in human brain. J Neurochem (1982) 0.99

Mechanisms of substance P-induced contraction of rabbit airway smooth muscle. J Appl Physiol Respir Environ Exerc Physiol (1984) 0.98

Irreversible inhibition of monoamine oxidase by some components of cigarette smoke. Life Sci (1987) 0.96

Inactivation of human alpha-1-proteinase inhibitor by gas-phase cigarette smoke. Biochem Biophys Res Commun (1984) 0.91

Enkephalinase activity in rat peripheral organs. Eur J Pharmacol (1981) 0.91

Inhibition of cigarette smoke-induced oedema in the nasal mucosa by capsaicin pretreatment and a substance P antagonist. Naunyn Schmiedebergs Arch Pharmacol (1984) 0.90

Inhibition of bleomycin-induced DNA breakage by superoxide dismutase. Cancer Res (1981) 0.84

Characterization of two distinct transglutaminases of murine bone marrow-derived macrophages: effects of exposure of viable cells to cigarette smoke on enzyme activity. J Leukoc Biol (1987) 0.78

Articles by these authors

Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection. Am Rev Respir Dis (1976) 6.26

Bronchial hyperreactivity. Am Rev Respir Dis (1980) 4.77

Role of autonomic nervous system and the cough reflex in the increased responsiveness of airways in patients with obstructive airway disease. J Clin Invest (1967) 3.09

New method for perfusing bronchial arteries: histamine bronchoconstriction and apnea. J Appl Physiol (1966) 2.98

Epidermal growth factor system regulates mucin production in airways. Proc Natl Acad Sci U S A (1999) 2.57

Lower threshold and greater bronchomotor responsiveness of asthmatic subjects to sulfur dioxide. Am Rev Respir Dis (1980) 2.31

Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease. Proc Natl Acad Sci U S A (1997) 2.24

O3-induced change in bronchial reactivity to methacholine and airway inflammation in humans. J Appl Physiol (1985) (1986) 2.16

Characterization of human tracheal epithelial cells transformed by an origin-defective simian virus 40. Proc Natl Acad Sci U S A (1988) 2.15

Interleukin-8: an important chemoattractant in sputum of patients with chronic inflammatory airway diseases. Am J Physiol (1993) 2.14

Effect of histamine, serotonin, and acetylcholine on the peripheral airways. J Appl Physiol (1966) 1.95

Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils. J Immunol (2000) 1.88

IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo. J Immunol (1999) 1.88

Exercise increases sulfur dioxide-induced bronchoconstriction in asthmatic subjects. Am Rev Respir Dis (1981) 1.86

Novel Pseudomonas product stimulates interleukin-8 production in airway epithelial cells in vitro. J Clin Invest (1994) 1.85

Importance of airway inflammation for hyperresponsiveness induced by ozone. Am Rev Respir Dis (1983) 1.85

Bronchial hyperirritability in healthy subjects after exposure to ozone. Am Rev Respir Dis (1978) 1.82

Effect of ganglionic blockade on bronchial reactivity in atopic subjects. Am Rev Respir Dis (1980) 1.81

Molecular cloning and primary structure of human 15-lipoxygenase. Biochem Biophys Res Commun (1988) 1.76

Sympathetic versus parasympathetic nervous regulation of airways in dogs. J Appl Physiol (1971) 1.71

Active transport of Na+ and Cl- across the canine tracheal epithelium in vitro. Am Rev Respir Dis (1975) 1.71

Bronchial hyperresponsiveness in normal subjects during attenuated influenza virus infection. Am Rev Respir Dis (1991) 1.64

Airway hyperresponsiveness induced by platelet-activating factor: role of thromboxane generation. J Pharmacol Exp Ther (1986) 1.62

Activation of epidermal growth factor receptors is responsible for mucin synthesis induced by cigarette smoke. Am J Physiol Lung Cell Mol Physiol (2001) 1.59

Predominant generation of 15-lipoxygenase metabolites of arachidonic acid by epithelial cells from human trachea. Proc Natl Acad Sci U S A (1985) 1.59

Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium. Thorax (2004) 1.57

Resistance to breathing during exercise-induced asthma attacks. Am Rev Respir Dis (1970) 1.55

Relationship of epidermal growth factor receptors to goblet cell production in human bronchi. Am J Respir Crit Care Med (2001) 1.54

Mechanisms by which histamine stimulates rapidly adapting receptors in dog lungs. J Appl Physiol Respir Environ Exerc Physiol (1977) 1.53

IL-13 induces mucin production by stimulating epidermal growth factor receptors and by activating neutrophils. Am J Physiol Lung Cell Mol Physiol (2001) 1.52

Leukotriene B4 induces airway hyperresponsiveness in dogs. J Appl Physiol (1985) (1985) 1.49

Enkephalinase inhibitor potentiates mammalian tachykinin-induced contraction in ferret trachea. J Pharmacol Exp Ther (1987) 1.48

Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases. Eur Respir J (2008) 1.44

Autonomic regulation of the airways. Annu Rev Med (1984) 1.42

Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells. J Clin Invest (1990) 1.42

Substance P and vasoactive intestinal peptide degradation by mast cell tryptase and chymase. J Pharmacol Exp Ther (1988) 1.40

Influenza infection causes airway hyperresponsiveness by decreasing enkephalinase. J Appl Physiol (1985) (1988) 1.33

Physiologic diagnosis of subclinical emphysema. Am Rev Respir Dis (1973) 1.32

Elastic recoil of the lungs in chronic asthmatic patients before and after therapy. J Appl Physiol (1967) 1.32

Enkephalinase inhibitor potentiates substance P- and electrically induced contraction in ferret trachea. J Appl Physiol (1985) (1987) 1.31

Autonomic control of airway smooth muscle and airway secretions. Am Rev Respir Dis (1977) 1.31

Enkephalinase inhibitors potentiate substance P-induced secretion of 35SO4-macromolecules from ferret trachea. Exp Lung Res (1987) 1.31

Virus induces airway hyperresponsiveness to tachykinins: role of neutral endopeptidase. J Appl Physiol (1985) (1989) 1.30

Localization of beta-adrenoreceptors in mammalian lung by light microscopic autoradiography. Nature (1982) 1.30

Effect of the oronasal breathing route on sulfur dioxide-induced bronchoconstriction in exercising asthmatic subjects. Am Rev Respir Dis (1982) 1.27

Control of neurotransmission by prostaglandins in canine trachealis smooth muscle. J Appl Physiol Respir Environ Exerc Physiol (1984) 1.27

Micropipette measurement of airway submucosal gland secretion. Autonomic effects. Am Rev Respir Dis (1980) 1.27

Control of mucus secretion and ion transport in airways. Annu Rev Physiol (1979) 1.27

Hypertonic saline increases vascular permeability in the rat trachea by producing neurogenic inflammation. J Clin Invest (1990) 1.27

Selective generation of leukotriene B4 by tracheal epithelial cells from dogs. Biochem Biophys Res Commun (1983) 1.26

Early diagnosis of chronic pulmonary vascular obstruction. Value of pulmonary function tests. Am J Med (1968) 1.26

Neutrophil depletion inhibits airway hyperresponsiveness induced by ozone exposure. Am Rev Respir Dis (1984) 1.23

Substance P-immunoreactive sensory axons in the rat respiratory tract: a quantitative study of their distribution and role in neurogenic inflammation. J Comp Neurol (1992) 1.22

Pseudomonas stimulates interleukin-8 mRNA expression selectively in airway epithelium, in gland ducts, and in recruited neutrophils. Am J Respir Cell Mol Biol (1994) 1.21

Pulmonary diffusing capacity measured at multiple intervals during a single exhalation in man. J Appl Physiol Respir Environ Exerc Physiol (1977) 1.21

Neutral endopeptidase and neurogenic inflammation in rats with respiratory infections. J Appl Physiol (1985) (1989) 1.21

Airway neutral endopeptidase-like enzyme modulates tachykinin-induced bronchoconstriction in vivo. J Appl Physiol (1985) (1988) 1.19

Fluid transport across the canine tracheal epithelium. J Appl Physiol Respir Environ Exerc Physiol (1980) 1.19

Effect of ozone on bronchial reactivity in atopic and nonatopic subjects. Am Rev Respir Dis (1979) 1.19

Effect of vagal blockade on regulation of breathing in conscious dogs. J Appl Physiol (1970) 1.18

Unusual disease of pulmonary arteries with dyspnea. Structure-function relationships. Am J Med (1966) 1.18

Airway hyperresponsiveness and changes in cell counts in bronchoalveolar lavage after ozone exposure in dogs. Am Rev Respir Dis (1984) 1.18

Dog mastocytoma tryptase: affinity purification, characterization, and amino-terminal sequence. Arch Biochem Biophys (1987) 1.17

Human eosinophils induce mucin production in airway epithelial cells via epidermal growth factor receptor activation. J Immunol (2001) 1.16

Antigen-induced airway hyperresponsiveness and pulmonary inflammation in allergic dogs. J Appl Physiol (1985) (1985) 1.15

Bradykinin stimulates Cl secretion and prostaglandin E2 release by canine tracheal epithelium. Am J Physiol (1985) 1.15

Inhibition of neutral endopeptidase potentiates neurogenic inflammation in the rat trachea. J Appl Physiol (1985) (1989) 1.14

Tracheal submucosal gland serous cells stimulated in vitro with adrenergic and cholinergic agonists. A morphometric study. Cell Tissue Res (1981) 1.14

Neutral endopeptidase inhibitors potentiate substance P- and capsaicin-induced cough in awake guinea pigs. J Clin Invest (1988) 1.13

Randomised double-blind placebo-controlled study of the effect of inhibition of nitric oxide synthesis in bradykinin-induced asthma. Lancet (1996) 1.13

Molecular cloning of dog mast cell tryptase and a related protease: structural evidence of a unique mode of serine protease activation. Biochemistry (1989) 1.13

The effects of sodium substitution and ouabain on ion transport by dog tracheal epithelium. Am Rev Respir Dis (1979) 1.11

Screening tests of pulmonary function. N Engl J Med (1970) 1.11

Neutral endopeptidase and angiotensin converting enzyme inhibitors potentiate kinin-induced contraction of ferret trachea. J Pharmacol Exp Ther (1988) 1.11

Pseudomonas aeruginosa induces MUC5AC production via epidermal growth factor receptor. Eur Respir J (2002) 1.11

Inhibition of antigen-induced airway hyperresponsiveness by a thromboxane synthetase inhibitor (OKY-046) in allergic dogs. Am Rev Respir Dis (1986) 1.09

Proteinase 3, a potent secretagogue in airways, is present in cystic fibrosis sputum. Am J Respir Cell Mol Biol (1999) 1.08

Localization and release of lysozyme from ferret trachea: effects of adrenergic and cholinergic drugs. Cell Tissue Res (1983) 1.08

Proteolytic enzymes and airway diseases. Eur Respir J (1998) 1.08

Micropipette measurement of airway submucosal gland secretion: laryngeal reflex. Am Rev Respir Dis (1980) 1.07

Mast cell chymase. A potent secretagogue for airway gland serous cells. J Immunol (1989) 1.06

Dog tracheal epithelial cells in culture synthesize sulfated macromolecular glycoconjugates and release them from the cell surface upon exposure to extracellular proteinases. Exp Lung Res (1987) 1.04

Mast cell tryptase causes airway smooth muscle hyperresponsiveness in dogs. J Clin Invest (1989) 1.04

Neural regulation of 35SO4-macromolecule secretion from tracheal glands of ferrets. J Appl Physiol Respir Environ Exerc Physiol (1984) 1.04

Relation of epidermal growth factor receptor expression to goblet cell hyperplasia in nasal polyps. J Allergy Clin Immunol (2000) 1.03

Distribution of chymase-containing mast cells in human bronchi. J Histochem Cytochem (1992) 1.03

Effect of alpha-adrenergic stimulation on mucus secretion and on ion transport in cat trachea in vitro. Am Rev Respir Dis (1980) 1.03

Involvement of neurogenic inflammation in antigen-induced bronchoconstriction in guinea pigs. Am J Physiol (1993) 1.03