Published in Proc Natl Acad Sci U S A on August 01, 1989
Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis. Proc Natl Acad Sci U S A (2011) 1.69
Small-molecule CFTR inhibitors slow cyst growth in polycystic kidney disease. J Am Soc Nephrol (2008) 1.56
Determinants of renal volume in autosomal-dominant polycystic kidney disease. Kidney Int (2007) 1.44
Strategies targeting cAMP signaling in the treatment of polycystic kidney disease. J Am Soc Nephrol (2013) 1.33
Cyclic AMP-mediated cyst expansion. Biochim Biophys Acta (2010) 1.21
Cell biology of polycystin-2. Cell Signal (2006) 1.21
Functional expression and apical localization of the cystic fibrosis transmembrane conductance regulator in MDCK I cells. Biochem J (1997) 1.05
In vitro fluid secretion by epithelium from polycystic kidneys. J Clin Invest (1995) 0.98
Function and regulation of TRPP2 at the plasma membrane. Am J Physiol Renal Physiol (2009) 0.97
Rationale for early treatment of polycystic kidney disease. Pediatr Nephrol (2014) 0.91
Anion secretion by the inner medullary collecting duct. Evidence for involvement of the cystic fibrosis transmembrane conductance regulator. J Clin Invest (1995) 0.91
Thiophenecarboxylate suppressor of cyclic nucleotides discovered in a small-molecule screen blocks toxin-induced intestinal fluid secretion. Mol Pharmacol (2008) 0.89
The microenvironmental determinants for kidney epithelial cyst morphogenesis. Eur J Cell Biol (2008) 0.89
Food Restriction Ameliorates the Development of Polycystic Kidney Disease. J Am Soc Nephrol (2015) 0.88
Cilium, centrosome and cell cycle regulation in polycystic kidney disease. Biochim Biophys Acta (2011) 0.85
Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice. Am J Pathol (1995) 0.84
P2 receptors in renal pathophysiology. Purinergic Signal (2009) 0.81
The Treatment of Autosomal Dominant Polycystic Kidney Disease. Dtsch Arztebl Int (2015) 0.80
Polarized Trafficking of AQP2 Revealed in Three Dimensional Epithelial Culture. PLoS One (2015) 0.79
ANKS3 Co-Localises with ANKS6 in Mouse Renal Cilia and Is Associated with Vasopressin Signaling and Apoptosis In Vivo in Mice. PLoS One (2015) 0.78
Inhibition of phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model. Mol Cancer (2012) 0.78
AMP-activated Protein Kinase Suppresses Biosynthesis of Glucosylceramide by Reducing Intracellular Sugar Nucleotides. J Biol Chem (2015) 0.77
Steviol reduces MDCK Cyst formation and growth by inhibiting CFTR channel activity and promoting proteasome-mediated CFTR degradation. PLoS One (2013) 0.76
New Insights into the Molecular Mechanisms Targeting Tubular Channels/Transporters in PKD Development. Kidney Dis (Basel) (2016) 0.75
Heterotrimeric G protein signaling in polycystic kidney disease. Physiol Genomics (2016) 0.75
Clinical Manifestation and Management of ADPKD in Western Countries. Kidney Dis (Basel) (2016) 0.75
VIP17/MAL expression modulates epithelial cyst formation and ciliogenesis. Am J Physiol Cell Physiol (2012) 0.75
Growth of Madin-Darby canine kidney epithelial cell (MDCK) line in hormone-supplemented, serum-free medium. Proc Natl Acad Sci U S A (1979) 2.34
Cyst formation and growth in autosomal dominant polycystic kidney disease. Kidney Int (1987) 2.16
Retention of differentiated properties in an established dog kidney epithelial cell line (MDCK). J Cell Biol (1979) 1.96
Modification of Na and Cl transport in canine tracheal mucosa by prostaglandins. Am J Physiol (1981) 1.45
Active transport of chloride in frog cornea. Am J Physiol (1966) 1.32
Sodium-dependent chloride secretion across rabbit descending colon. Am J Physiol (1983) 1.28
Morphogenetic clonal growth of kidney epithelial cell line MDCK. Anat Rec (1987) 1.26
Fluid transport across the canine tracheal epithelium. J Appl Physiol Respir Environ Exerc Physiol (1980) 1.19
Elevated c-myc protooncogene expression in autosomal recessive polycystic kidney disease. Proc Natl Acad Sci U S A (1987) 1.12
Fluid secretion in isolated proximal straight renal tubules. Effect of human uremic serum. J Clin Invest (1973) 1.08
Activators of protein kinase C inhibit sodium transport in A6 epithelia. Am J Physiol (1986) 1.05
Chemical modification of cell proliferation and fluid secretion in renal cysts. Kidney Int (1989) 1.03
Vasopressin, theophylline, PGE2, and indomethacin on active Na transport in frog skin: studies with microelectrodes. Am J Physiol (1981) 0.98
Basement membrane antigens in renal polycystic disease. Am J Pathol (1988) 0.95
Evidence that prostaglandin E2 stimulates chloride secretion in cultured A6 renal epithelial cells. Am J Physiol (1986) 0.89
Complete response to vasopressin requires epithelial organization in A6 cells in culture. Am J Physiol (1986) 0.86
Coupling of Na-H exchange and Na-K pump activity in cultured rat proximal tubule cells. Am J Physiol (1986) 0.86
Catecholamine-stimulation of Cl- secretion in MDCK cell epithelium. Biochim Biophys Acta (1981) 0.86
Secretory NaCl and volume flow in renal tubules. Am J Physiol (1986) 0.82
Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle. J Biol Chem (1977) 5.16
Effect of vasopressin and cyclic AMP on permeability of isolated collecting tubules. Am J Physiol (1966) 4.19
Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape. Proc Natl Acad Sci U S A (1991) 3.01
Effect of prostaglandin E1 on the permeability response of the isolated collecting tubule to vasopressin, adenosine 3',5'-monophosphate, and theophylline. J Clin Invest (1968) 2.76
cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway. Kidney Int (2000) 2.65
Control of intracellular pH and growth by fibronectin in capillary endothelial cells. J Cell Biol (1990) 2.41
Cyst formation and growth in autosomal dominant polycystic kidney disease. Kidney Int (1987) 2.16
Ultrastructural studies of vasopressin effect on isolated perfused renal collecting tubules of the rabbit. J Cell Biol (1968) 2.06
The nature of transtubular Na and K transport in isolated rabbit renal collecting tubules. J Clin Invest (1970) 1.88
Physical properties of isolated perfused renal tubules and tubular basement membranes. J Clin Invest (1972) 1.86
Effect of cell spreading on cytoplasmic pH in normal and transformed fibroblasts. Proc Natl Acad Sci U S A (1989) 1.81
Exacerbation of familial renal lymphangiomatosis during pregnancy. AJR Am J Roentgenol (1988) 1.75
Multiple integrins share the ability to induce elevation of intracellular pH. Exp Cell Res (1991) 1.67
Effect of vasopressin on electrical resistance of renal cortical collecting tubules. Am J Physiol (1971) 1.65
Acute renal failure with selective medullary injury in the rat. J Clin Invest (1988) 1.62
Paths of transtubular water flow in isolated renal collecting tubules. J Cell Biol (1969) 1.57
The genetics and physiology of polycystic kidney disease. Semin Nephrol (2001) 1.57
Epithelial transport in polycystic kidney disease. Physiol Rev (1998) 1.45
Regulation of renal tubule cell volume in hypotonic media. Am J Physiol (1973) 1.39
Ultrastructure and function of cysts from human adult polycystic kidneys. Kidney Int (1980) 1.34
Adhesion is required for protein kinase C-dependent activation of the Na+/H+ antiporter by platelet-derived growth factor. Proc Natl Acad Sci U S A (1992) 1.34
The cystic fibrosis transmembrane conductance regulator mediates transepithelial fluid secretion by human autosomal dominant polycystic kidney disease epithelium in vitro. Kidney Int (1996) 1.28
Volumetric determination of progression in autosomal dominant polycystic kidney disease by computed tomography. Kidney Int (2000) 1.22
Elevated proto-oncogene expression in polycystic kidneys of the C57BL/6J (cpk) mouse. J Am Soc Nephrol (1991) 1.22
The secretion of fluid by renal cysts from patients with autosomal dominant polycystic kidney disease. N Engl J Med (1993) 1.22
A hereditary model of slowly progressive polycystic kidney disease in the mouse. J Am Soc Nephrol (1991) 1.16
Renal accumulation and excretion of cyclic adenosine monophosphate in a murine model of slowly progressive polycystic kidney disease. Am J Kidney Dis (1997) 1.16
Acquired cystic disease: replacing one kidney disease with another. Kidney Int (1985) 1.15
Immunolocalization of ion transport proteins in human autosomal dominant polycystic kidney epithelial cells. Proc Natl Acad Sci U S A (1996) 1.15
Renal epithelial fluid secretion and cyst growth: the role of cyclic AMP. FASEB J (1989) 1.13
Elevated c-myc protooncogene expression in autosomal recessive polycystic kidney disease. Proc Natl Acad Sci U S A (1987) 1.12
ADH-PGE2 interactions in cortical collecting tubule. I. Depression of sodium transport. Am J Physiol (1981) 1.11
Fluid secretion in isolated proximal straight renal tubules. Effect of human uremic serum. J Clin Invest (1973) 1.08
Polycystin-1 transforms the cAMP growth-responsive phenotype of M-1 cells. Kidney Int (2001) 1.08
Polycystic kidney disease: etiology, pathogenesis, and treatment. Dis Mon (1995) 1.08
Measure of carbon and nitrogen stable isotope ratios in cultured cells. J Am Soc Mass Spectrom (2004) 1.07
The role of computed tomography in the evaluation of adult polycystic kidney disease. Am J Kidney Dis (1981) 1.06
Chloride and fluid secretion by cultured human polycystic kidney cells. Kidney Int (1996) 1.06
Natural history of acquired renal cystic disease in dialysis patients: a prospective longitudinal CT study. AJR Am J Roentgenol (1991) 1.05
Vanadate-stimulated natriuresis. Nature (1978) 1.05
Temperature effect on ADH response of isolated perfused rabbit collecting tubules. Am J Physiol (1980) 1.03
Polycystic kidney disease: a predominance of giant nephrons. Am J Physiol (1983) 1.03
Anion secretion drives fluid secretion by monolayers of cultured human polycystic cells. Am J Physiol (1995) 1.03
Chemical modification of cell proliferation and fluid secretion in renal cysts. Kidney Int (1989) 1.03
C-fos expression is hypersensitive to serum-stimulation in cultured cystic kidney cells from the C57BL/6J-cpk mouse. J Cell Physiol (1992) 1.01
Acute metabolic acidosis augments collecting duct acidification rate in the rat. Am J Physiol (1981) 1.00
Modification of disease progression in rats with inherited polycystic kidney disease. Am J Kidney Dis (1996) 0.99
Calcified renal stones and cyst calcifications in autosomal dominant polycystic kidney disease: clinical and CT study in 84 patients. AJR Am J Roentgenol (1992) 0.99
Isovolumetric regulation of isolated S2 proximal tubules in anisotonic media. J Clin Invest (1986) 0.98
Influence of serum proteins on net fluid reabsorption of isolated proximal tubules. Kidney Int (1972) 0.98
A synthetic peptide derived from glycine-gated Cl- channel induces transepithelial Cl- and fluid secretion. Am J Physiol (1997) 0.97
Liver cysts in autosomal-dominant polycystic kidney disease: clinical and computed tomographic study. AJR Am J Roentgenol (1985) 0.97
Autosomal recessive polycystic kidney disease in a murine model. A gross and microscopic description. Lab Invest (1988) 0.96
Chloride and fluid secretion in polycystic kidney disease. J Am Soc Nephrol (1998) 0.95
Vasopressin: effect on deformability of urinary surface of collecting duct cells. Science (1970) 0.95
In vitro formation and expansion of cysts derived from human renal cortex epithelial cells. Kidney Int (1992) 0.95
cAMP-dependent fluid secretion in rat inner medullary collecting ducts. Am J Physiol Renal Physiol (2001) 0.95
Effect of lovastatin on the development of polycystic kidney disease in the Han:SPRD rat. Am J Kidney Dis (1995) 0.95
The effects of vanadate on the fluxes of sodium and potassium ions through the sodium pump. J Physiol (1980) 0.95
Matrix metalloproteinases and TIMPS in cultured C57BL/6J-cpk kidney tubules. Kidney Int (1996) 0.94
Effect of urea concentration of pelvic fluid on renal concentrating ability. Am J Physiol (1980) 0.94
Electron-probe analysis of cultured cells. Ann N Y Acad Sci (1986) 0.92
Cyst fluid from human autosomal dominant polycystic kidneys promotes cyst formation and expansion by renal epithelial cells in vitro. J Am Soc Nephrol (1992) 0.91
A clinical index to predict survival in acute renal failure patients requiring dialysis. Am J Kidney Dis (1988) 0.91
Localization of overexpressed c-myc mRNA in polycystic kidneys of the cpk mouse. Kidney Int (1992) 0.91
Studies of isolated renal tubules in vitro. Annu Rev Physiol (1978) 0.91
Direct determination of free fatty acid transport across the adipocyte plasma membrane using quantitative fluorescence microscopy. J Biol Chem (1991) 0.90
A synthetic channel-forming peptide induces Cl(-) secretion: modulation by Ca(2+)-dependent K(+) channels. Biochim Biophys Acta (2000) 0.90
CN- secondary ions form by recombination as demonstrated using multi-isotope mass spectrometry of 13C- and 15N-labeled polyglycine. J Am Soc Mass Spectrom (2006) 0.90
[Micropuncture study of urine formation. II. In the non diuretic Psammomys]. Nephron (1969) 0.90
Cellular aspects of renal sodium transport and cell volume regulation. Kidney Int (1976) 0.90
Effect of hypotonic medium on K and Na content of proximal renal tubules. Am J Physiol (1977) 0.89
Carbon dioxide dissociation curve in potassium depletion. Am J Physiol (1967) 0.89
Preparation of individual human diploid fibroblasts and study of ion transport. Am J Physiol (1985) 0.88
Secretory activity and aryl acid content of serum, urine, and cerebrospinal fluid in normal and uremic man. J Lab Clin Med (1975) 0.87
Renal Na,K-ATPase: determinants of inhibition by vanadium. Am J Physiol (1979) 0.87
Mode of water transport in mammalian renal collecting tubules. Fed Proc (1971) 0.86
Technical problems associated with collection of distal tubular fluid in the rat. Yale J Biol Med (1973) 0.86
Coupling of Na-H exchange and Na-K pump activity in cultured rat proximal tubule cells. Am J Physiol (1986) 0.86
Spontaneous subcapsular and perinephric hemorrhage in end-stage kidney disease: clinical and CT findings. AJR Am J Roentgenol (1987) 0.85
Pancreatic zymogen granules differ markedly in protein composition. Science (1986) 0.85
Cyst fluid from a murine model of polycystic kidney disease stimulates fluid secretion, cyclic adenosine monophosphate accumulation, and cell proliferation by Madin-Darby canine kidney cells in vitro. Am J Kidney Dis (1995) 0.85
Electron probe microanalysis of biological soft tissues: principle and technique. Fed Proc (1980) 0.84
Transepithelial water permeability in an in vitro model of renal cysts. J Am Soc Nephrol (1990) 0.84
Methylprednisolone retards the progression of inherited polycystic kidney disease in rodents. Am J Kidney Dis (1995) 0.84
The single nephron preparation--cortical collecting tubules. Yale J Biol Med (1973) 0.83
Effect of parathyroid hormone on phosphate reabsorption in rat distal convolution. Am J Physiol (1978) 0.83
Cellular volume and cytoplasmic gel. Biol Cell (1985) 0.83
Understanding human cystic disease through experimental models. Semin Nephrol (1991) 0.83
Alanine stimulation of passive potassium efflux in hepatocytes is independent of Na(+)-K+ pump activity. Am J Physiol (1990) 0.83
Water diuretic and natriuretic effect of clonidine in the rat. J Pharmacol Exp Ther (1979) 0.83
Coupling of cell volume and membrane potential changes to fluid secretion in a model of renal cysts. Kidney Int (1994) 0.83
Fluorescence analysis of picoliter samples. Anal Biochem (1980) 0.83
Renal medullary concentrating process: an integrative hypothesis. Am J Physiol (1980) 0.83
Ionic transport in individual renal epithelial cells from adult and young rats. Acta Physiol Scand (1986) 0.82
Distal site of action of parathyroid hormone on phosphate reabsorption. Am J Physiol (1975) 0.82
Tubular basement membrane changes in 2-amino-4,5-diphenylthiazole-induced polycystic disease. Kidney Int (1985) 0.82
CT of acquired cystic kidney disease and renal tumors in long-term dialysis patients. AJR Am J Roentgenol (1984) 0.82
Cellular electrolyte and volume changes induced by acidosis in the rabbit proximal straight tubule. J Am Soc Nephrol (1991) 0.81