Heritable genome editing in C. elegans via a CRISPR-Cas9 system.

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Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell (2013) 13.37

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CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein Cell (2015) 7.80

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Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins. Genome Res (2014) 3.31

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Heritable gene knockout in Caenorhabditis elegans by direct injection of Cas9-sgRNA ribonucleoproteins. Genetics (2013) 2.44

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Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases. Genome Res (2013) 2.28

Precise and heritable genome editing in evolutionarily diverse nematodes using TALENs and CRISPR/Cas9 to engineer insertions and deletions. Genetics (2013) 2.22

Condensin-driven remodelling of X chromosome topology during dosage compensation. Nature (2015) 2.15

Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9. Proc Natl Acad Sci U S A (2013) 2.13

Targeted mutagenesis in rice using CRISPR-Cas system. Cell Res (2013) 2.00

Somatic mosaicism and allele complexity induced by CRISPR/Cas9 RNA injections in mouse zygotes. Dev Biol (2014) 1.96

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Efficient gene disruption in diverse strains of Toxoplasma gondii using CRISPR/CAS9. MBio (2014) 1.61

A co-CRISPR strategy for efficient genome editing in Caenorhabditis elegans. Genetics (2014) 1.60

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High-throughput genome editing and phenotyping facilitated by high resolution melting curve analysis. PLoS One (2014) 1.60

Dramatic enhancement of genome editing by CRISPR/Cas9 through improved guide RNA design. Genetics (2015) 1.52

Efficient genome editing in Caenorhabditis elegans by CRISPR-targeted homologous recombination. Nucleic Acids Res (2013) 1.49

Tissue expression pattern of PMK-2 p38 MAPK is established by the miR-58 family in C. elegans. PLoS Genet (2015) 1.47

The CRISPR/Cas9 System Facilitates Clearance of the Intrahepatic HBV Templates In Vivo. Mol Ther Nucleic Acids (2014) 1.46

Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells. Cell Res (2014) 1.45

Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing. Nat Biotechnol (2014) 1.43

Repurposing CRISPR/Cas9 for in situ functional assays. Genes Dev (2013) 1.41

Oligonucleotide-based targeted gene editing in C. elegans via the CRISPR/Cas9 system. Cell Res (2014) 1.39

Rapid and precise engineering of the Caenorhabditis elegans genome with lethal mutation co-conversion and inactivation of NHEJ repair. Genetics (2014) 1.38

Validation of microinjection methods for generating knockout mice by CRISPR/Cas-mediated genome engineering. Sci Rep (2014) 1.38

A CRISPR/Cas9 toolkit for multiplex genome editing in plants. BMC Plant Biol (2014) 1.37

Enhanced specificity and efficiency of the CRISPR/Cas9 system with optimized sgRNA parameters in Drosophila. Cell Rep (2014) 1.35

Streamlined Genome Engineering with a Self-Excising Drug Selection Cassette. Genetics (2015) 1.33

Genome editing in rice and wheat using the CRISPR/Cas system. Nat Protoc (2014) 1.33

Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells. Nat Commun (2014) 1.31

Random and targeted transgene insertion in Caenorhabditis elegans using a modified Mos1 transposon. Nat Methods (2014) 1.29

Efficient chromosomal gene modification with CRISPR/cas9 and PCR-based homologous recombination donors in cultured Drosophila cells. Nucleic Acids Res (2014) 1.23

Visualization of specific DNA sequences in living mouse embryonic stem cells with a programmable fluorescent CRISPR/Cas system. Nucleus (2014) 1.20

Comparison of non-canonical PAMs for CRISPR/Cas9-mediated DNA cleavage in human cells. Sci Rep (2014) 1.19

Targeted mutagenesis using CRISPR/Cas system in medaka. Biol Open (2014) 1.18

CCR5 gene disruption via lentiviral vectors expressing Cas9 and single guided RNA renders cells resistant to HIV-1 infection. PLoS One (2014) 1.16

Safeguarding CRISPR-Cas9 gene drives in yeast. Nat Biotechnol (2015) 1.14

Dual sgRNA-directed gene knockout using CRISPR/Cas9 technology in Caenorhabditis elegans. Sci Rep (2014) 1.12

CRISPRseek: a bioconductor package to identify target-specific guide RNAs for CRISPR-Cas9 genome-editing systems. PLoS One (2014) 1.11

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CRISPR/Cas9-mediated genome engineering and the promise of designer flies on demand. Fly (Austin) (2013) 1.10

Characterization of Staphylococcus aureus Cas9: a smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications. Genome Biol (2015) 1.10

Targeted genome engineering techniques in Drosophila. Methods (2014) 1.09

Efficient and heritable gene targeting in tilapia by CRISPR/Cas9. Genetics (2014) 1.08

Gene inactivation using the CRISPR/Cas9 system in the nematode Pristionchus pacificus. Dev Genes Evol (2014) 1.05

The Opisthorchis viverrini genome provides insights into life in the bile duct. Nat Commun (2014) 1.01

Efficient Genome Editing in Clostridium cellulolyticum via CRISPR-Cas9 Nickase. Appl Environ Microbiol (2015) 1.01

CRISPR/Cas9 mediated multiplex genome editing and heritable mutagenesis of BmKu70 in Bombyx mori. Sci Rep (2014) 1.00

CRISPR/Cas9-mediated gene knock-down in post-mitotic neurons. PLoS One (2014) 1.00

CRISPR/Cas-mediated targeted mutagenesis in Daphnia magna. PLoS One (2014) 0.99

Generation of inheritable and "transgene clean" targeted genome-modified rice in later generations using the CRISPR/Cas9 system. Sci Rep (2015) 0.98

Exciting prospects for precise engineering of Caenorhabditis elegans genomes with CRISPR/Cas9. Genetics (2013) 0.97

CRISPR-Cas: an efficient tool for genome engineering of virulent bacteriophages. Nucleic Acids Res (2014) 0.96

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Efficient gene targeting in golden Syrian hamsters by the CRISPR/Cas9 system. PLoS One (2014) 0.96

RNA-guided nucleases: a new era for engineering the genomes of model and nonmodel organisms. Genetics (2013) 0.95

Heritable/conditional genome editing in C. elegans using a CRISPR-Cas9 feeding system. Cell Res (2014) 0.94

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Cut site selection by the two nuclease domains of the Cas9 RNA-guided endonuclease. J Biol Chem (2014) 0.93

Efficient and versatile CRISPR engineering of human neurons in culture to model neurological disorders. Wellcome Open Res (2016) 0.92

Generation of multi-gene knockout rabbits using the Cas9/gRNA system. Cell Regen (Lond) (2014) 0.92

TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome. Nat Cell Biol (2015) 0.91

CRISPR/Cas9-mediated gene knockout in the ascidian Ciona intestinalis. Dev Growth Differ (2014) 0.91

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Tissue-specific genome editing in Ciona embryos by CRISPR/Cas9. Development (2014) 0.90

CRISPR/cas9, a novel genomic tool to knock down microRNA in vitro and in vivo. Sci Rep (2016) 0.90

Cas9 Variants Expand the Target Repertoire in Caenorhabditis elegans. Genetics (2015) 0.90

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Detailed phenotypic and molecular analyses of genetically modified mice generated by CRISPR-Cas9-mediated editing. PLoS One (2015) 0.89

Genetic and genomic tools for the marine annelid Platynereis dumerilii. Genetics (2014) 0.88

Regulation of structure and function of sarcomeric actin filaments in striated muscle of the nematode Caenorhabditis elegans. Anat Rec (Hoboken) (2014) 0.87

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Transgenesis in Strongyloides and related parasitic nematodes: historical perspectives, current functional genomic applications and progress towards gene disruption and editing. Parasitology (2016) 0.87

Modeling Disease In Vivo With CRISPR/Cas9. Trends Mol Med (2015) 0.87

A geminivirus-based guide RNA delivery system for CRISPR/Cas9 mediated plant genome editing. Sci Rep (2015) 0.86

Patterns of CRISPR/Cas9 activity in plants, animals and microbes. Plant Biotechnol J (2016) 0.85

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