PubRank

Sanford D Markowitz

Author PubWeight™ 199.56‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The consensus coding sequences of human breast and colorectal cancers. Science 2006 60.02
2 The genomic landscapes of human breast and colorectal cancers. Science 2007 38.12
3 Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci U S A 2008 10.52
4 Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet 2004 7.78
5 Heteroplasmic mitochondrial DNA mutations in normal and tumour cells. Nature 2010 4.53
6 Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers. Proc Natl Acad Sci U S A 2008 4.13
7 Detection in fecal DNA of colon cancer-specific methylation of the nonexpressed vimentin gene. J Natl Cancer Inst 2005 3.73
8 Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance. Proc Natl Acad Sci U S A 2011 2.54
9 The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Genes Chromosomes Cancer 2008 2.52
10 Three classes of genes mutated in colorectal cancers with chromosomal instability. Cancer Res 2004 2.51
11 Genetic and epigenetic alterations in colon cancer. Annu Rev Genomics Hum Genet 2002 2.43
12 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. Proc Natl Acad Sci U S A 2004 2.42
13 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis. Proc Natl Acad Sci U S A 2006 2.41
14 Sensitive digital quantification of DNA methylation in clinical samples. Nat Biotechnol 2009 2.34
15 DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination. Sci Signal 2010 2.04
16 SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers. Proc Natl Acad Sci U S A 2003 2.01
17 Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination. J Cell Biol 2006 1.85
18 A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2. Proc Natl Acad Sci U S A 2003 1.84
19 Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. Proc Natl Acad Sci U S A 2008 1.84
20 Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions. Cancer Cell 2013 1.74
21 BCL9 promotes tumor progression by conferring enhanced proliferative, metastatic, and angiogenic properties to cancer cells. Cancer Res 2009 1.74
22 PRL-3 expression in metastatic cancers. Clin Cancer Res 2003 1.73
23 NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer. Cancer Prev Res (Phila) 2008 1.71
24 15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors. Proc Natl Acad Sci U S A 2009 1.65
25 Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps. Clin Cancer Res 2005 1.59
26 Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancers. Cancer Res 2003 1.58
27 Aberrant vimentin methylation is characteristic of upper gastrointestinal pathologies. Cancer Epidemiol Biomarkers Prev 2012 1.57
28 Clinical trial resources on the internet must be designed to reach underrepresented minorities. Cancer J 2007 1.56
29 The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter. J Physiol 2004 1.53
30 Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers. Proc Natl Acad Sci U S A 2009 1.51
31 Aspirin and colon cancer--targeting prevention? N Engl J Med 2007 1.50
32 Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis. J Clin Invest 2014 1.46
33 CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer. Genes Chromosomes Cancer 2006 1.44
34 HLTF gene silencing in human colon cancer. Proc Natl Acad Sci U S A 2002 1.43
35 Infrequent detection of germline allele-specific expression of TGFBR1 in lymphoblasts and tissues of colon cancer patients. Cancer Res 2009 1.38
36 Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T. Proc Natl Acad Sci U S A 2010 1.30
37 Emerging paradigms for the initiation of mucin-type protein O-glycosylation by the polypeptide GalNAc transferase family of glycosyltransferases. J Biol Chem 2011 1.19
38 Allele-specific expression of TGFBR1 in colon cancer patients. Carcinogenesis 2010 1.17
39 Identification of susceptibility genes for cancer in a genome-wide scan: results from the colon neoplasia sibling study. Am J Hum Genet 2008 1.10
40 Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase (HPGD). Sci Transl Med 2014 1.07
41 The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer. Int J Cancer 2008 1.06
42 The microRNAs, MiR-31 and MiR-375, as candidate markers in Barrett's esophageal carcinogenesis. Genes Chromosomes Cancer 2012 1.06
43 Global mutational profiling of formalin-fixed human colon cancers from a pathology archive. Mod Pathol 2012 1.01
44 15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer. Cancer Res 2008 1.00
45 Mutational inactivation of TGFBR2 in microsatellite unstable colon cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming growth factor beta resistant cells. Genes Chromosomes Cancer 2008 0.97
46 NTRK3 is a potential tumor suppressor gene commonly inactivated by epigenetic mechanisms in colorectal cancer. PLoS Genet 2013 0.96
47 Confirmation of linkage to and localization of familial colon cancer risk haplotype on chromosome 9q22. Cancer Res 2010 0.96
48 Genetic variation in 15-hydroxyprostaglandin dehydrogenase and colon cancer susceptibility. PLoS One 2013 0.91
49 H3K4me3 inversely correlates with DNA methylation at a large class of non-CpG-island-containing start sites. Genome Med 2012 0.90
50 Somatic mutations in CCK2R alter receptor activity that promote oncogenic phenotypes. Mol Cancer Res 2012 0.88
51 Is TGFBR1*6A a susceptibility allele for nonsyndromic familial colorectal neoplasia? Cancer Epidemiol Biomarkers Prev 2007 0.88
52 C8orf4 is a transforming growth factor B induced transcript downregulated in metastatic colon cancer. Int J Cancer 2004 0.88
53 Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations. Int J Cancer 2006 0.88
54 An improved method for staining cell colonies in clonogenic assays. Cytotechnology 2007 0.86
55 Colonic 15-PGDH levels are stable across distance and time and are not perturbed by aspirin intervention. Dig Dis Sci 2013 0.83
56 Two Distinct Categories of Focal Deletions in Cancer Genomes. PLoS One 2013 0.82
57 MethyLight droplet digital PCR for detection and absolute quantification of infrequently methylated alleles. Epigenetics 2015 0.82
58 The effectiveness of colonoscopy in reducing mortality from colorectal cancer. Ann Intern Med 2009 0.82
59 Detection of mononucleotide repeat sequence alterations in a large background of normal DNA for screening high-frequency microsatellite instability cancers. Clin Cancer Res 2006 0.79
60 Ugene, a newly identified protein that is commonly overexpressed in cancer and binds uracil DNA glycosylase. Cancer Res 2008 0.79
61 Hereditary colon cancer genes. Methods Mol Biol 2003 0.78
62 Early loss of deleted in colorectal carcinoma gene transcript detected in a group of benign colon adenomas. J Biomed Sci 2002 0.77
63 The molecular pathogenesis of colorectal cancer and its potential application to colorectal cancer screening. Dig Dis Sci 2014 0.76