Published in World J Gastroenterol on April 21, 2014
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Thyroxine differentially modulates the peripheral clock: lessons from the human hair follicle. PLoS One (2015) 0.77
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GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways. J Hematol Oncol (2016) 0.76
Case-control study of candidate gene methylation and adenomatous polyp formation. Int J Colorectal Dis (2016) 0.75
Carcinogenic effects of circadian disruption: an epigenetic viewpoint. Chin J Cancer (2015) 0.75
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The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell (2008) 6.44
Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells. Cell (2004) 6.44
The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell (2002) 6.05
Control mechanism of the circadian clock for timing of cell division in vivo. Science (2003) 5.92
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell (2008) 5.68
Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science (2009) 5.35
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science (2009) 5.30
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Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell (2001) 4.61
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Circadian rhythms: mechanisms and therapeutic implications. Annu Rev Pharmacol Toxicol (2007) 3.19
Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803. J Clin Oncol (2009) 2.94
Night-shift work and risk of colorectal cancer in the nurses' health study. J Natl Cancer Inst (2003) 2.87
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Circadian clock control by SUMOylation of BMAL1. Science (2005) 2.30
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Host circadian clock as a control point in tumor progression. J Natl Cancer Inst (2002) 2.21
Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex. Proc Natl Acad Sci U S A (2002) 2.04
The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. Genes Dev (2002) 2.02
The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers. J Clin Invest (2008) 1.95
Timing to perfection: the biology of central and peripheral circadian clocks. Neuron (2012) 1.91
Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex. Proc Natl Acad Sci U S A (2005) 1.91
Physiological regulation of [beta]-catenin stability by Tcf3 and CK1epsilon. J Cell Biol (2001) 1.80
Nuclear hormone receptors for heme: REV-ERBalpha and REV-ERBbeta are ligand-regulated components of the mammalian clock. Mol Endocrinol (2008) 1.77
SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging. Cell (2013) 1.71
Tumor suppression by the mammalian Period genes. Cancer Causes Control (2006) 1.69
Regulation of clock-controlled genes in mammals. PLoS One (2009) 1.65
Over-expression of circadian clock gene Bmal1 affects proliferation and the canonical Wnt pathway in NIH-3T3 cells. Cell Biochem Funct (2012) 1.57
Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex. Mol Cell Biol (2008) 1.52
Riding tandem: circadian clocks and the cell cycle. Cell (2007) 1.49
Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation. PLoS One (2010) 1.44
Global co-distribution of light at night (LAN) and cancers of prostate, colon, and lung in men. Chronobiol Int (2009) 1.40
Nuclear translocation of beta-catenin in colorectal cancer. Br J Cancer (2000) 1.38
Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress. J Biol Chem (2010) 1.37
Role of aryl hydrocarbon receptor in cancer. Biochim Biophys Acta (2013) 1.37
Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2. J Mol Cell Cardiol (2003) 1.34
SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. J Biol Chem (2009) 1.33
WNT signaling and lymphocyte development. Cell (2002) 1.32
Circadian proteins in the regulation of cell cycle and genotoxic stress responses. Trends Cell Biol (2007) 1.30
Nuclear receptor Rev-erbalpha: a heme receptor that coordinates circadian rhythm and metabolism. Nucl Recept Signal (2010) 1.27
Regulation of genes of the circadian clock in human colon cancer: reduced period-1 and dihydropyrimidine dehydrogenase transcription correlates in high-grade tumors. Cancer Res (2007) 1.24
Circadian clock genes as modulators of sensitivity to genotoxic stress. Cell Cycle (2005) 1.20
Rhythmic changes in colonic motility are regulated by period genes. Am J Physiol Gastrointest Liver Physiol (2009) 1.17
Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. Cell Metab (2013) 1.16
Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest. Genome Biol (2008) 1.15
Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis. J Cell Biol (2009) 1.15
Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control. J Biol Chem (2009) 1.14
O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination. Cell Metab (2013) 1.14
Correlated downregulation of estrogen receptor beta and the circadian clock gene Per1 in human colorectal cancer. Mol Carcinog (2009) 1.14
Expression of circadian genes correlates with liver metastasis and outcomes in colorectal cancer. Oncol Rep (2011) 1.12
The crosstalk between physiology and circadian clock proteins. Chronobiol Int (2009) 1.12
Peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of Embelin on colon carcinogenesis. Cancer Res (2009) 1.11
Implications of circadian clocks for the rhythmic delivery of cancer therapeutics. Adv Drug Deliv Rev (2007) 1.11
The circadian clock gene Per1 suppresses cancer cell proliferation and tumor growth at specific times of day. Chronobiol Int (2009) 1.11
Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription. J Biol Chem (2009) 1.08
Epigenetic silencing of peroxisome proliferator-activated receptor γ is a biomarker for colorectal cancer progression and adverse patients' outcome. PLoS One (2010) 1.08
Clock gene expression levels and relationship with clinical and pathological features in colorectal cancer patients. Chronobiol Int (2011) 1.08
The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway. FASEB J (2012) 1.07
Circadian clock-controlled intestinal expression of the multidrug-resistance gene mdr1a in mice. Gastroenterology (2008) 1.06
Period 2 mutation accelerates ApcMin/+ tumorigenesis. Mol Cancer Res (2008) 1.05
The circadian clock components CRY1 and CRY2 are necessary to sustain sex dimorphism in mouse liver metabolism. J Biol Chem (2009) 1.04
Alternative splicing yields novel BMAL2 variants: tissue distribution and functional characterization. Am J Physiol Cell Physiol (2002) 1.04
Low level microsatellite instability may be associated with reduced cancer specific survival in sporadic stage C colorectal carcinoma. Gut (2005) 1.02
Clock genes and clock-controlled genes in the regulation of metabolic rhythms. Chronobiol Int (2012) 1.02
Role of biological rhythms in gastrointestinal health and disease. Rev Endocr Metab Disord (2009) 1.00
Circadian proteins and genotoxic stress response. Circ Res (2010) 0.99
The circadian clock circuitry and the AHR signaling pathway in physiology and pathology. Biochem Pharmacol (2013) 0.96
Clock genes and cancer. Integr Cancer Ther (2009) 0.96
Src-mediated aryl hydrocarbon and epidermal growth factor receptor cross talk stimulates colon cancer cell proliferation. Am J Physiol Gastrointest Liver Physiol (2012) 0.94
Cathepsin B and cathepsin D expression in the progression of colorectal adenoma to carcinoma. Cancer Lett (2004) 0.94
Microsatellite instability in colorectal cancer and association with thymidylate synthase and dihydropyrimidine dehydrogenase expression. BMC Cancer (2009) 0.94
Mutations in the circadian gene CLOCK in colorectal cancer. Mol Cancer Res (2010) 0.93
Effects of the biological clock gene Bmal1 on tumour growth and anti-cancer drug activity. J Biochem (2010) 0.93
Expression of Cathepsin B and L antigen and activity is associated with early colorectal cancer progression. Eur J Cancer (2004) 0.93
Reduced expression of PER3 is associated with incidence and development of colon cancer. Ann Surg Oncol (2012) 0.92
Circadian clock manipulation for cancer prevention and control and the relief of cancer symptoms. Integr Cancer Ther (2009) 0.92
A common origin: signaling similarities in the regulation of the circadian clock and DNA damage responses. Biol Pharm Bull (2010) 0.92
Role of clock genes in gastrointestinal motility. Am J Physiol Gastrointest Liver Physiol (2010) 0.92
ARNTL2 and SERPINE1: potential biomarkers for tumor aggressiveness in colorectal cancer. J Cancer Res Clin Oncol (2011) 0.91
Beta-catenin induces beta-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice. J Biochem (2008) 0.90
Plasminogen activator inhibitor-1 as a potential marker for the malignancy of colorectal cancer. Br J Cancer (2005) 0.89
Circadian time-dependent tumor suppressor function of period genes. Integr Cancer Ther (2009) 0.89
Interplay between SOX9, β-catenin and PPARγ activation in colorectal cancer. Biochim Biophys Acta (2013) 0.89
An association between clock genes and clock-controlled cell cycle genes in murine colorectal tumors. Int J Cancer (2012) 0.88
Expression of clock genes in patients with colorectal cancer. Int J Biol Markers (2013) 0.86
Plasminogen activator inhibitor-1 and the circadian clock in metabolic disorders. Clin Exp Hypertens (2009) 0.86
Discoveries of rhythms in human biological functions: a historical review. Chronobiol Int (2009) 0.86
Association of the clock genes polymorphisms with colorectal cancer susceptibility. J Surg Oncol (2013) 0.85
Cryptochrome 1 overexpression correlates with tumor progression and poor prognosis in patients with colorectal cancer. PLoS One (2013) 0.85
Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2. Toxicol In Vitro (2011) 0.85
Expression of circadian clock gene human Period2 (hPer2) in human colorectal carcinoma. World J Surg Oncol (2011) 0.85
Temporal gradient in the clock gene and cell-cycle checkpoint kinase Wee1 expression along the gut. Chronobiol Int (2009) 0.83