Published in Annu Rev Pharmacol Toxicol on January 01, 2007
The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet (2008) 7.65
Harmonics of circadian gene transcription in mammals. PLoS Genet (2009) 4.97
A circadian gene expression atlas in mammals: implications for biology and medicine. Proc Natl Acad Sci U S A (2014) 4.22
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature (2012) 4.15
JTK_CYCLE: an efficient nonparametric algorithm for detecting rhythmic components in genome-scale data sets. J Biol Rhythms (2010) 3.42
Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver. PLoS Biol (2011) 2.94
REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis. PLoS Biol (2009) 2.76
Sex differences in the expression of hepatic drug metabolizing enzymes. Mol Pharmacol (2009) 2.45
The human circadian metabolome. Proc Natl Acad Sci U S A (2012) 2.04
Healthy clocks, healthy body, healthy mind. Trends Cell Biol (2009) 1.95
Circadian control of the immune system. Nat Rev Immunol (2013) 1.90
Coupling governs entrainment range of circadian clocks. Mol Syst Biol (2010) 1.85
The circadian clock in murine chondrocytes regulates genes controlling key aspects of cartilage homeostasis. Arthritis Rheum (2013) 1.82
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase. Proc Natl Acad Sci U S A (2010) 1.82
Circadian oscillation of nucleotide excision repair in mammalian brain. Proc Natl Acad Sci U S A (2009) 1.72
Regulation of clock-controlled genes in mammals. PLoS One (2009) 1.65
Adrenergic nerves govern circadian leukocyte recruitment to tissues. Immunity (2012) 1.63
High-resolution time course analysis of gene expression from pituitary. Cold Spring Harb Symp Quant Biol (2007) 1.45
Probing the relative importance of molecular oscillations in the circadian clock. Genetics (2008) 1.38
Clock is important for food and circadian regulation of macronutrient absorption in mice. J Lipid Res (2009) 1.36
Loss of cryptochrome reduces cancer risk in p53 mutant mice. Proc Natl Acad Sci U S A (2009) 1.35
Control of skin cancer by the circadian rhythm. Proc Natl Acad Sci U S A (2011) 1.34
Brain-specific rescue of Clock reveals system-driven transcriptional rhythms in peripheral tissue. PLoS Genet (2012) 1.27
E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha. Proc Natl Acad Sci U S A (2010) 1.23
Clock genes, intestinal transport and plasma lipid homeostasis. Trends Endocrinol Metab (2009) 1.21
Circadian clock control of the cellular response to DNA damage. FEBS Lett (2010) 1.20
Circadian rhythm in rest and activity: a biological correlate of quality of life and a predictor of survival in patients with metastatic colorectal cancer. Cancer Res (2009) 1.19
Regulation of nucleotide excision repair activity by transcriptional and post-transcriptional control of the XPA protein. Nucleic Acids Res (2010) 1.19
Tuning the mammalian circadian clock: robust synergy of two loops. PLoS Comput Biol (2011) 1.18
Circadian expression profiles of drug-processing genes and transcription factors in mouse liver. Drug Metab Dispos (2008) 1.17
Determination of reference genes for circadian studies in different tissues and mouse strains. BMC Mol Biol (2010) 1.16
Circadian rhythms influence hematopoietic stem cells. Curr Opin Hematol (2009) 1.12
Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle. Proc Natl Acad Sci U S A (2014) 1.11
The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis. Genes Dev (2014) 1.08
Does the clock make the poison? Circadian variation in response to pesticides. PLoS One (2009) 1.05
The circadian clock components CRY1 and CRY2 are necessary to sustain sex dimorphism in mouse liver metabolism. J Biol Chem (2009) 1.04
Diurnal variation of hepatic antioxidant gene expression in mice. PLoS One (2012) 1.04
An automaton model for the cell cycle. Interface Focus (2010) 1.03
Small molecule modifiers of circadian clocks. Cell Mol Life Sci (2012) 1.03
Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans. Proc Natl Acad Sci U S A (2013) 1.02
Sex differences in circadian timing systems: implications for disease. Front Neuroendocrinol (2013) 0.97
Ras-mediated deregulation of the circadian clock in cancer. PLoS Genet (2014) 0.97
Circadian rhythm and its role in malignancy. J Circadian Rhythms (2010) 0.94
Hepatocyte circadian clock controls acetaminophen bioactivation through NADPH-cytochrome P450 oxidoreductase. Proc Natl Acad Sci U S A (2014) 0.93
The interplay of cis-regulatory elements rules circadian rhythms in mouse liver. PLoS One (2012) 0.93
Mathematical modeling as a tool for planning anticancer therapy. Eur J Pharmacol (2009) 0.92
Disruption of period gene expression alters the inductive effects of dioxin on the AhR signaling pathway in the mouse liver. Toxicol Appl Pharmacol (2008) 0.91
Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal. Drug Metab Rev (2010) 0.90
Translational applications of evaluating physiologic variability in human endotoxemia. J Clin Monit Comput (2012) 0.90
A combined experimental and mathematical approach for molecular-based optimization of irinotecan circadian delivery. PLoS Comput Biol (2011) 0.90
Circadian rhythms in urinary functions: possible roles of circadian clocks? Int Neurourol J (2011) 0.89
The role of melanocortin neuronal pathways in circadian biology: a new homeostatic output involving melanocortin-3 receptors? Obes Rev (2009) 0.89
A microphysiological system model of therapy for liver micrometastases. Exp Biol Med (Maywood) (2014) 0.89
Glucocorticoid efficacy in asthma: is improved tissue remodeling upstream of anti-inflammation. J Investig Med (2010) 0.88
Tumor growth rate determines the timing of optimal chronomodulated treatment schedules. PLoS Comput Biol (2010) 0.88
Daily changes in GT1-7 cell sensitivity to GnRH secretagogues that trigger ovulation. Neuroendocrinology (2009) 0.87
Timing of circadian genes in mammalian tissues. Sci Rep (2014) 0.87
A novel site of adult doublecortin expression: neuropeptide neurons within the suprachiasmatic nucleus circadian clock. BMC Neurosci (2008) 0.86
Materials to clinical devices: technologies for remotely triggered drug delivery. Clin Ther (2012) 0.86
Circadian rhythms have broad implications for understanding brain and behavior. Eur J Neurosci (2014) 0.86
The clock genes period 1 and period 2 mediate diurnal rhythms in dioxin-induced Cyp1A1 expression in the mouse mammary gland and liver. Toxicol Lett (2010) 0.86
A dynamic model for functional mapping of biological rhythms. J Biol Dyn (2011) 0.85
Circadian rhythm of osteocalcin in the maxillomandibular complex. J Dent Res (2009) 0.85
Quantitative genetics of sleep in inbred mice. Dialogues Clin Neurosci (2007) 0.85
Strain- and sex-dependent circadian changes in abcc2 transporter expression: implications for irinotecan chronotolerance in mouse ileum. PLoS One (2011) 0.85
Circadian clock, cancer, and chemotherapy. Biochemistry (2014) 0.85
Circadian clock regulates response to pesticides in Drosophila via conserved Pdp1 pathway. Toxicol Sci (2010) 0.85
Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp. Cancer Cell Int (2015) 0.84
Do rotational shifts affect micturition patterns in real practice? A pilot study in healthy, young female nurses. Int Neurourol J (2014) 0.84
Circadian regulation of intestinal lipid absorption by apolipoprotein AIV involves forkhead transcription factors A2 and O1 and microsomal triglyceride transfer protein. J Biol Chem (2013) 0.83
Circadian signatures in rat liver: from gene expression to pathways. BMC Bioinformatics (2010) 0.83
Circadian clock circuitry in colorectal cancer. World J Gastroenterol (2014) 0.82
An agent-based model of cellular dynamics and circadian variability in human endotoxemia. PLoS One (2013) 0.82
Assessment of the impact of dosing time on the pharmacokinetics/pharmacodynamics of prednisolone. AAPS J (2008) 0.81
Molecular bases of circadian rhythmicity in renal physiology and pathology. Nephrol Dial Transplant (2013) 0.81
Fine-tuning anti-tumor immunotherapies via stochastic simulations. BMC Bioinformatics (2012) 0.81
Circadian gene hClock enhances proliferation and inhibits apoptosis of human colorectal carcinoma cells in vitro and in vivo. Mol Med Rep (2015) 0.80
Regulation of circadian and acute activity levels by the murine suprachiasmatic nuclei. PLoS One (2014) 0.80
Modeling physiologic variability in human endotoxemia. Crit Rev Biomed Eng (2012) 0.80
Genetics and epigenetics of circadian rhythms and their potential roles in neuropsychiatric disorders. Neurosci Bull (2015) 0.79
Coffee and caffeine potentiate the antiamyloidogenic activity of melatonin via inhibition of Aβ oligomerization and modulation of the Tau-mediated pathway in N2a/APP cells. Drug Des Devel Ther (2014) 0.79
Presence of multiple peripheral circadian oscillators in the tissues controlling voiding function in mice. Exp Mol Med (2014) 0.79
Relationship between intensity of night shift work and antioxidant status in blood of nurses. Int Arch Occup Environ Health (2012) 0.79
Functional genomics identify Birc5/survivin as a candidate gene involved in the chronotoxicity of cyclin-dependent kinase inhibitors. Cell Cycle (2014) 0.79
The mammalian clock and chronopharmacology. Bioorg Med Chem Lett (2013) 0.79
Neuroimmunomodulation in unipolar depression: a focus on chronobiology and chronotherapeutics. J Neural Transm (Vienna) (2012) 0.78
Transplantability of a circadian clock to a noncircadian organism. Sci Adv (2015) 0.78
Mammalian Period represses and de-represses transcription by displacing CLOCK-BMAL1 from promoters in a Cryptochrome-dependent manner. Proc Natl Acad Sci U S A (2016) 0.78
Circadian regulators of intestinal lipid absorption. J Lipid Res (2014) 0.78
Impact of chronodisruption during primate pregnancy on the maternal and newborn temperature rhythms. PLoS One (2013) 0.78
Assembly of a comprehensive regulatory network for the mammalian circadian clock: a bioinformatics approach. PLoS One (2015) 0.78
Estimation methods for human circadian phase by use of peripheral tissues. Hypertens Res (2016) 0.77
Deregulated expression of cryptochrome genes in human colorectal cancer. Mol Cancer (2016) 0.77
Electroencephalographic signals synchronize with behaviors and are sexually dimorphic during the light-dark cycle in reproductive frogs. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2013) 0.77
Novel putative mechanisms to link circadian clocks to healthy aging. J Neural Transm (Vienna) (2013) 0.77
Biochemistry that times the day. Biochemistry (2014) 0.77
The expression of melanopsin and clock genes in Xenopus laevis melanophores and their modulation by melatonin. Braz J Med Biol Res (2012) 0.76
Chronomodulated chemotherapy versus conventional chemotherapy for advanced colorectal cancer: a meta-analysis of five randomized controlled trials. Int J Colorectal Dis (2010) 0.76
Effects of restraint stress on the daily rhythm of hydrolysis of adenine nucleotides in rat serum. J Circadian Rhythms (2011) 0.76
Circadian rhythms of fetal liver transcription persist in the absence of canonical circadian clock gene expression rhythms in vivo. PLoS One (2012) 0.76
The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell (2002) 9.92
The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annu Rev Physiol (2010) 6.63
Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells. Cell (2004) 6.44
System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biol (2007) 6.23
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell (2008) 5.68
Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions. Nat Genet (2006) 5.08
Mammalian genes are transcribed with widely different bursting kinetics. Science (2011) 4.08
Integration of microRNA miR-122 in hepatic circadian gene expression. Genes Dev (2009) 3.64
Crosstalk between components of circadian and metabolic cycles in mammals. Cell Metab (2011) 3.31
Rhythms of mammalian body temperature can sustain peripheral circadian clocks. Curr Biol (2002) 3.05
The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification. Cell Metab (2006) 3.00
REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis. PLoS Biol (2009) 2.76
The mammalian circadian timing system: from gene expression to physiology. Chromosoma (2004) 2.67
Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding. Cell (2010) 2.52
PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. Science (2005) 2.29
Properties, entrainment, and physiological functions of mammalian peripheral oscillators. J Biol Rhythms (2006) 2.21
The period length of fibroblast circadian gene expression varies widely among human individuals. PLoS Biol (2005) 2.13
Genome-wide RNA polymerase II profiles and RNA accumulation reveal kinetics of transcription and associated epigenetic changes during diurnal cycles. PLoS Biol (2012) 2.12
The loss of circadian PAR bZip transcription factors results in epilepsy. Genes Dev (2004) 1.92
Cold-inducible RNA-binding protein modulates circadian gene expression posttranscriptionally. Science (2012) 1.91
Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factor. Genes Dev (2008) 1.78
Phosphorylation of CREB Ser142 regulates light-induced phase shifts of the circadian clock. Neuron (2002) 1.72
Blood-borne circadian signal stimulates daily oscillations in actin dynamics and SRF activity. Cell (2013) 1.71
Circadian gene expression is resilient to large fluctuations in overall transcription rates. EMBO J (2008) 1.61
Simulated body temperature rhythms reveal the phase-shifting behavior and plasticity of mammalian circadian oscillators. Genes Dev (2012) 1.48
Impact of behavior on central and peripheral circadian clocks in the common vole Microtus arvalis, a mammal with ultradian rhythms. Proc Natl Acad Sci U S A (2006) 1.40
Physiology. Proteasomes keep the circadian clock ticking. Science (2007) 1.08
Circadian gene expression in cultured cells. Methods Enzymol (2005) 1.07
Proline- and acidic amino acid-rich basic leucine zipper proteins modulate peroxisome proliferator-activated receptor alpha (PPARalpha) activity. Proc Natl Acad Sci U S A (2011) 1.05
Circadian Dbp transcription relies on highly dynamic BMAL1-CLOCK interaction with E boxes and requires the proteasome. Mol Cell (2012) 1.01
Origins and consequences of transcriptional discontinuity. Curr Opin Cell Biol (2011) 0.97
A CLOCK-less clock. Trends Cell Biol (2006) 0.93
Real-time recording of circadian liver gene expression in freely moving mice reveals the phase-setting behavior of hepatocyte clocks. Genes Dev (2013) 0.93
Cardiac hypertrophy, low blood pressure, and low aldosterone levels in mice devoid of the three circadian PAR bZip transcription factors DBP, HLF, and TEF. Am J Physiol Regul Integr Comp Physiol (2010) 0.92
REV-ERBs: more than the sum of the individual parts. Cell Metab (2012) 0.83
Circadian glucose homeostasis requires compensatory interference between brain and liver clocks. Proc Natl Acad Sci U S A (2008) 0.81
Body temperature cycles: gatekeepers of circadian clocks. Cell Cycle (2013) 0.81
Orphan nuclear receptors, molecular clockwork, and the entrainment of peripheral oscillators. Novartis Found Symp (2003) 0.80
CAVIN-3 regulates circadian period length and PER:CRY protein abundance and interactions. EMBO Rep (2012) 0.79
Shedding new light on circadian clocks. Elife (2013) 0.78
Physiology. Feeding the clock. Science (2009) 0.77
Circadian cell-cycle progression: Cracking open the gate. Cell (2010) 0.76
In Vitro Screening for Regulated Transcription Factors with Differential Display of DNA-Binding Proteins (DDDP). CSH Protoc (2008) 0.76
Transcription factor loading: please take my place! Cell (2011) 0.75
Glucocorticoid rhythm renders female mice more daring. Cell (2013) 0.75
The ticking tail: daily oscillations in mRNA poly(A) tail length drive circadian cycles in protein synthesis. Genes Dev (2012) 0.75
Getting Surprising Answers to Unasked Questions. Cell (2017) 0.75
[Circadian metabolism of medicaments: an important Geneva discovery]. Rev Med Suisse (2006) 0.75
Otto Naegeli Award 2002 honors the work of Prof. Walter Wahli. Swiss Med Wkly (2002) 0.75
[The inter-individual variability of circadian period length in human skin cells]. Med Sci (Paris) (2006) 0.75