Published in Cell Rep on May 09, 2014
TZAP: A telomere-associated protein involved in telomere length control. Science (2017) 2.06
Functional characterization of the TERRA transcriptome at damaged telomeres. Nat Commun (2014) 1.16
Complex interactions between the DNA-damage response and mammalian telomeres. Nat Struct Mol Biol (2015) 0.97
Stop pulling my strings - what telomeres taught us about the DNA damage response. Nat Rev Mol Cell Biol (2016) 0.93
Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity. Front Genet (2015) 0.88
PHF11 promotes DSB resection, ATR signaling, and HR. Genes Dev (2017) 0.81
Mitosis, double strand break repair, and telomeres: a view from the end: how telomeres and the DNA damage response cooperate during mitosis to maintain genome stability. Bioessays (2014) 0.78
TeloPIN: a database of telomeric proteins interaction network in mammalian cells. Database (Oxford) (2015) 0.77
The telomeric DNA damage response occurs in the absence of chromatin decompaction. Genes Dev (2017) 0.76
A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response. Biomolecules (2015) 0.76
Identification of TTAGGG-binding proteins in Neurospora crassa, a fungus with vertebrate-like telomere repeats. BMC Genomics (2015) 0.76
How do telomeres and NHEJ coexist? Mol Cell Oncol (2014) 0.75
DNA Replication Origins and Fork Progression at Mammalian Telomeres. Genes (Basel) (2017) 0.75
Guarding chromosomes from oxidative DNA damage to the very end. Acta Biochim Biophys Sin (Shanghai) (2016) 0.75
Collaboration of MLLT1/ENL, Polycomb and ATM for transcription and genome integrity. Nucleus (2016) 0.75
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature (2001) 19.67
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature (2001) 19.54
Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature (2000) 18.26
Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev (2005) 15.19
Restoration of p53 function leads to tumour regression in vivo. Nature (2007) 12.62
A DNA damage checkpoint response in telomere-initiated senescence. Nature (2003) 12.55
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell (2001) 11.39
Telomere reduction in human colorectal carcinoma and with ageing. Nature (1990) 11.24
Role of histone H2A ubiquitination in Polycomb silencing. Nature (2004) 9.48
DNA damage foci at dysfunctional telomeres. Curr Biol (2003) 9.08
A telomerase component is defective in the human disease dyskeratosis congenita. Nature (1999) 7.91
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature (2000) 7.28
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature (2007) 6.82
ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Mol Cell (2008) 6.60
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell (2004) 6.48
Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells. Nat Cell Biol (2007) 6.30
Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol Cell (2005) 6.29
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell (1999) 5.93
Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. Dev Cell (2004) 5.72
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat Cell Biol (2005) 5.49
POT1 as a terminal transducer of TRF1 telomere length control. Nature (2003) 5.43
53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature (2008) 5.11
Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres. Proc Natl Acad Sci U S A (2010) 4.73
Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination. Mol Cell (2010) 4.69
Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC. Nat Genet (2004) 4.63
The CRAPome: a contaminant repository for affinity purification-mass spectrometry data. Nat Methods (2013) 4.34
In situ analyses of genome instability in breast cancer. Nat Genet (2004) 4.32
Identification of human Rap1: implications for telomere evolution. Cell (2000) 4.06
53BP1 regulates DSB repair using Rif1 to control 5' end resection. Science (2013) 4.00
Dyskeratosis congenita in all its forms. Br J Haematol (2000) 3.89
Mouse centric and pericentric satellite repeats form distinct functional heterochromatin. J Cell Biol (2004) 3.65
Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat Genet (2003) 3.64
A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Mol Cell (2013) 3.55
Purification of proteins associated with specific genomic Loci. Cell (2009) 3.53
ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells. Genome Res (2010) 3.46
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. Proc Natl Acad Sci U S A (2010) 3.31
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining. Nat Struct Mol Biol (2010) 3.27
Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b. EMBO J (2006) 3.21
Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination. Nat Struct Mol Biol (2013) 3.18
RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection. Mol Cell (2013) 3.05
Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching. Science (2013) 3.02
TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes. Blood (2008) 3.02
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol (2012) 2.99
PaxDb, a database of protein abundance averages across all three domains of life. Mol Cell Proteomics (2012) 2.93
Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat Genet (2001) 2.92
Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis. Clin Cancer Res (2004) 2.84
POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia. Nat Genet (2013) 2.62
RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling. Cell (2012) 2.60
A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity. Cancer Res (2004) 2.55
Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair. Cell (2011) 2.50
Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase. Curr Biol (2006) 2.36
Telomere dysfunction and fusion during the progression of chronic lymphocytic leukemia: evidence for a telomere crisis. Blood (2010) 2.16
Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres. Nat Struct Mol Biol (2010) 2.04
Prime, repair, restore: the active role of chromatin in the DNA damage response. Mol Cell (2012) 2.04
The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair. Curr Biol (2006) 1.95
TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex. Nat Genet (2004) 1.91
MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres. Genes Dev (2006) 1.81
Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity. Cell (2012) 1.78
Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells. Mol Cell (2013) 1.78
BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery. J Neurosci (2010) 1.76
BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair. J Cell Biol (2010) 1.74
Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions. EMBO J (2012) 1.71
Telomere uncapping and alternative lengthening of telomeres. Mech Ageing Dev (2007) 1.68
Dyskeratosis congenita, stem cells and telomeres. Biochim Biophys Acta (2009) 1.62
Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2. Mol Cell Biol (2009) 1.60
A two-step mechanism for TRF2-mediated chromosome-end protection. Nature (2013) 1.55
BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair. Mol Cell Biol (2011) 1.52
DNA-damage response and repair activities at uncapped telomeres depend on RNF8. Nat Cell Biol (2011) 1.49
A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase. Cell Cycle (2012) 1.46
A WD-repeat protein stabilizes ORC binding to chromatin. Mol Cell (2010) 1.38
Telomeres and telomerase: implications for cancer and aging. Radiat Res (2001) 1.34
Clustered DNA damage induced by gamma radiation in human fibroblasts (HF19), hamster (V79-4) cells and plasmid DNA is revealed as Fpg and Nth sensitive sites. Nucleic Acids Res (2002) 1.33
Role of polycomb proteins Ring1A and Ring1B in the epigenetic regulation of gene expression. Int J Dev Biol (2009) 1.29
The mre11 complex and the response to dysfunctional telomeres. Mol Cell Biol (2009) 1.22
An anticlastogenic function for the Polycomb Group gene Bmi1. Proc Natl Acad Sci U S A (2011) 1.17
Function of Apollo (SNM1B) at telomere highlighted by a splice variant identified in a patient with Hoyeraal-Hreidarsson syndrome. Proc Natl Acad Sci U S A (2010) 1.12
Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks. Oncogene (2004) 1.12
The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening. EMBO J (2013) 1.07
Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing. J Biol Chem (2012) 0.96
Telomeric damage in early stage of chronic lymphocytic leukemia correlates with shelterin dysregulation. Blood (2011) 0.92
A child with severe form of dyskeratosis congenita and TINF2 mutation of shelterin complex. Pediatr Blood Cancer (2010) 0.86
Mutant dyskerin ends relationship with telomerase. Science (1999) 0.83
Keeping telomerase in its place. Nat Med (2002) 0.82
High levels of telomere dysfunction bestow a selective disadvantage during the progression of human oral squamous cell carcinoma. Cancer Res (2003) 0.81
Increased alternative lengthening of telomere phenotypes of telomerase-negative immortal cells upon trichostatin--a treatment. Anticancer Res (2013) 0.79
Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell (2013) 3.91
TZAP: A telomere-associated protein involved in telomere length control. Science (2017) 2.06
ERdj3 is an endoplasmic reticulum degradation factor for mutant glucocerebrosidase variants linked to Gaucher's disease. Chem Biol (2014) 1.52
Product binding enforces the genomic specificity of a yeast polycomb repressive complex. Cell (2014) 0.97
Monoclonal 1- and 3-Phosphohistidine Antibodies: New Tools to Study Histidine Phosphorylation. Cell (2015) 0.88
Co-opting the Fanconi anemia genomic stability pathway enables herpesvirus DNA synthesis and productive growth. Mol Cell (2014) 0.83
Census 2: isobaric labeling data analysis. Bioinformatics (2014) 0.80
Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation. Cell (2016) 0.78
The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity. Cell Metab (2015) 0.78
The Pallbearer E3 ligase promotes actin remodeling via RAC in efferocytosis by degrading the ribosomal protein S6. Dev Cell (2014) 0.78
A ribonuclease coordinates siRNA amplification and mRNA cleavage during RNAi. Cell (2015) 0.78
Intracellular Action of a Secreted Peptide Required for Fungal Virulence. Cell Host Microbe (2016) 0.77
Noncanoncial signal recognition particle RNAs in a major eukaryotic phylum revealed by purification of SRP from the human pathogen Cryptococcus neoformans. Nucleic Acids Res (2015) 0.75
Glycolytic Enzymes Coalesce in G Bodies under Hypoxic Stress. Cell Rep (2017) 0.75