TeloPIN: a database of telomeric proteins interaction network in mammalian cells.

A higher-order entity formed by the flexible assembly of RAP1 with TRF2. Nucleic Acids Res (2016) 0.79

Translin and Trax differentially regulate telomere-associated transcript homeostasis. Oncotarget (2016) 0.76

Fast gapped-read alignment with Bowtie 2. Nat Methods (2012) 83.79

Model-based analysis of ChIP-Seq (MACS). Genome Biol (2008) 51.63

Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev (2005) 15.19

Switching and signaling at the telomere. Cell (2001) 11.25

How shelterin protects mammalian telomeres. Annu Rev Genet (2008) 11.20

Pot1, the putative telomere end-binding protein in fission yeast and humans. Science (2001) 6.95

X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions. Nat Genet (1998) 6.82

Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science (2007) 6.33

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet (1997) 4.95

TIN2, a new regulator of telomere length in human cells. Nat Genet (1999) 4.66

Telomeres: protecting chromosomes against genome instability. Nat Rev Mol Cell Biol (2010) 4.23

TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. Nature (2007) 4.23

Identification of human Rap1: implications for telomere evolution. Cell (2000) 4.06

Purification of proteins associated with specific genomic Loci. Cell (2009) 3.53

How telomeres are replicated. Nat Rev Mol Cell Biol (2007) 3.27

Telomeric localization of TRF2, a novel human telobox protein. Nat Genet (1997) 3.23

Telomere length, stem cells and aging. Nat Chem Biol (2007) 3.10

Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J Biol Chem (2004) 2.76

TRF1 is a dimer and bends telomeric DNA. EMBO J (1997) 2.64

TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres. Mol Cell (2009) 2.60

Syndromes of telomere shortening. Annu Rev Genomics Hum Genet (2009) 2.60

T-loops and the origin of telomeres. Nat Rev Mol Cell Biol (2004) 2.54

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity. Nature (2012) 2.33

TPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in mice. Dev Cell (2010) 2.24

TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. Nature (2011) 2.17

The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase. Nucleic Acids Res (2010) 2.05

Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells. Nature (2011) 2.03

Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation. Cell (2013) 1.79

Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites. Nat Cell Biol (2010) 1.69

The telomerase database. Nucleic Acids Res (2007) 1.69

The telosome/shelterin complex and its functions. Genome Biol (2008) 1.57

How shelterin solves the telomere end-protection problem. Cold Spring Harb Symp Quant Biol (2011) 1.51

TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs. Nat Struct Mol Biol (2009) 1.51

Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nat Cell Biol (2010) 1.47

Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging. EMBO J (2005) 1.38

RAP1 protects from obesity through its extratelomeric role regulating gene expression. Cell Rep (2013) 1.31

Human telomeric proteins occupy selective interstitial sites. Cell Res (2011) 1.30

Nontelomeric role for Rap1 in regulating metabolism and protecting against obesity. Cell Rep (2013) 1.25

The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats. Cell Res (2011) 1.25

TERRA transcripts are bound by a complex array of RNA-binding proteins. Nat Commun (2010) 1.19

Nontelomeric TRF2-REST interaction modulates neuronal gene silencing and fate of tumor and stem cells. Curr Biol (2008) 1.14

The role of telomere biology in cancer. Annu Rev Pathol (2012) 1.13

TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells. Nat Cell Biol (2013) 1.12

Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. Mol Cell Proteomics (2010) 1.12

Inside the mammalian telomere interactome: regulation and regulatory activities of telomeres. Crit Rev Eukaryot Gene Expr (2006) 1.11

Telomere length in Hutchinson-Gilford progeria syndrome. Mech Ageing Dev (2009) 1.10

Short telomeres: from dyskeratosis congenita to sporadic aplastic anemia and malignancy. Transl Res (2013) 1.08

PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres. Mol Biol Cell (2006) 1.07

Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1. Nucleic Acids Res (2008) 1.06

A quantitative telomeric chromatin isolation protocol identifies different telomeric states. Nat Commun (2013) 1.04

HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment. EMBO J (2013) 1.04

Newborn screening for 3-methylcrotonyl-CoA carboxylase deficiency: population heterogeneity of MCCA and MCCB mutations and impact on risk assessment. Hum Mutat (2006) 1.01

Telomere-binding factors and general DNA repair. Nat Genet (2005) 0.99

Telomere biology in aging and cancer. J Am Geriatr Soc (2005) 0.98

Isolation of chromatin from dysfunctional telomeres reveals an important role for Ring1b in NHEJ-mediated chromosome fusions. Cell Rep (2014) 0.95

A three-state model for the regulation of telomerase by TERRA and hnRNPA1. Nucleic Acids Res (2013) 0.92

Quantitative interaction screen of telomeric repeat-containing RNA reveals novel TERRA regulators. Genome Res (2013) 0.91

Akt regulates TPP1 homodimerization and telomere protection. Aging Cell (2013) 0.88

Subtelomeric CTCF and cohesin binding site organization using improved subtelomere assemblies and a novel annotation pipeline. Genome Res (2014) 0.88

The telomere-associated homeobox-containing protein TAH1/HMBOX1 participates in telomere maintenance in ALT cells. J Cell Sci (2013) 0.79