Published in PLoS Comput Biol on June 05, 2014
Genotype distribution-based inference of collective effects in genome-wide association studies: insights to age-related macular degeneration disease mechanism. BMC Genomics (2016) 1.41
FHSA-SED: Two-Locus Model Detection for Genome-Wide Association Study with Harmony Search Algorithm. PLoS One (2016) 0.75
An Efficient Stepwise Statistical Test to Identify Multiple Linked Human Genetic Variants Associated with Specific Phenotypic Traits. PLoS One (2015) 0.75
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Complement factor H polymorphism in age-related macular degeneration. Science (2005) 31.10
Genome-wide strategies for detecting multiple loci that influence complex diseases. Nat Genet (2005) 14.88
Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov (2007) 11.46
The mystery of missing heritability: Genetic interactions create phantom heritability. Proc Natl Acad Sci U S A (2012) 11.23
Multiple interval mapping for quantitative trait loci. Genetics (1999) 10.03
Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems. Nat Rev Genet (2008) 9.26
Modular epistasis in yeast metabolism. Nat Genet (2004) 8.64
The mutational load with epistatic gene interactions in fitness. Genetics (1966) 7.75
HTRA1 promoter polymorphism in wet age-related macular degeneration. Science (2006) 7.12
A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation. Genome Res (2001) 6.06
A perspective on epistasis: limits of models displaying no main effect. Am J Hum Genet (2002) 5.63
Bayesian inference of epistatic interactions in case-control studies. Nat Genet (2007) 4.31
Genes that distinguish physiological and pathological angiogenesis. Cancer Cell (2007) 3.35
Detection of gene x gene interactions in genome-wide association studies of human population data. Hum Hered (2007) 2.97
Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate. PLoS Genet (2013) 2.68
Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype. Mol Psychiatry (2008) 2.38
A forest-based approach to identifying gene and gene gene interactions. Proc Natl Acad Sci U S A (2007) 2.36
Will retinal implants restore vision? Science (2002) 2.35
Complement activation and inhibition: a delicate balance. Trends Immunol (2009) 2.22
Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC. Mol Psychiatry (2012) 2.20
Translational mini-review series on complement factor H: genetics and disease associations of human complement factor H. Clin Exp Immunol (2008) 2.19
Selecting SNPs in two-stage analysis of disease association data: a model-free approach. Ann Hum Genet (2000) 2.05
Structural basis for complement factor H linked age-related macular degeneration. J Exp Med (2007) 2.02
INTERSNP: genome-wide interaction analysis guided by a priori information. Bioinformatics (2009) 2.02
A new map of glycosaminoglycan and C3b binding sites on factor H. J Immunol (2008) 1.89
The GABAergic deficit hypothesis of major depressive disorder. Mol Psychiatry (2010) 1.80
Travelling the world of gene-gene interactions. Brief Bioinform (2011) 1.69
A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis. BMC Genomics (2008) 1.64
EPIBLASTER-fast exhaustive two-locus epistasis detection strategy using graphical processing units. Eur J Hum Genet (2010) 1.62
Conditions under which genome-wide association studies will be positively misleading. Genetics (2010) 1.60
The factor H variant associated with age-related macular degeneration (His-384) and the non-disease-associated form bind differentially to C-reactive protein, fibromodulin, DNA, and necrotic cells. J Biol Chem (2007) 1.51
Preservation of ganglion cell layer neurons in age-related macular degeneration. Invest Ophthalmol Vis Sci (2001) 1.47
Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism. J Biol Chem (2007) 1.36
Cellular mechanisms of blood-retinal barrier dysfunction in macular edema. Doc Ophthalmol (1999) 1.31
A complete classification of epistatic two-locus models. BMC Genet (2008) 1.22
A novel statistic for genome-wide interaction analysis. PLoS Genet (2010) 1.19
Evidence for abnormal forward trafficking of AMPA receptors in frontal cortex of elderly patients with schizophrenia. Neuropsychopharmacology (2010) 1.19
Epistatic module detection for case-control studies: a Bayesian model with a Gibbs sampling strategy. PLoS Genet (2009) 1.17
The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation. Mol Biol Cell (2007) 1.12
A cholinergic receptor gene (CHRM2) affects event-related oscillations. Behav Genet (2006) 1.09
A novel method to identify high order gene-gene interactions in genome-wide association studies: gene-based MDR. BMC Bioinformatics (2012) 1.06
Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology. Biochem Soc Trans (2010) 1.05
The role of complement Factor H in age-related macular degeneration: a review. Surv Ophthalmol (2010) 1.04
Detecting disease-associated genotype patterns. BMC Bioinformatics (2009) 1.01
Age-related macular degeneration: activation of innate immunity system via pattern recognition receptors. J Mol Med (Berl) (2008) 0.99
Association of CHRM2 with IQ: converging evidence for a gene influencing intelligence. Behav Genet (2006) 0.99
Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip. Ophthalmology (2011) 0.95
Synergistic effects of genetic variation in nicotinic and muscarinic receptors on visual attention but not working memory. Proc Natl Acad Sci U S A (2009) 0.94
Bipolar disorder: involvement of signaling cascades and AMPA receptor trafficking at synapses. Neuron Glia Biol (2004) 0.92
Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to treatment in patients with major depressive disorder. Eur Arch Psychiatry Clin Neurosci (2011) 0.91
Establishment of a human in vitro model of the outer blood-retinal barrier. J Anat (2007) 0.89
Detecting Genes and Gene-gene Interactions for Age-related Macular Degeneration with a Forest-based Approach. Stat Biopharm Res (2009) 0.88
JAWAMix5: an out-of-core HDF5-based java implementation of whole-genome association studies using mixed models. Bioinformatics (2013) 0.84
Polymorphisms in the GRIA1 gene region in psychotic bipolar disorder. Am J Med Genet B Neuropsychiatr Genet (2009) 0.83
Disparate cholinergic currents in rat principal trigeminal sensory nucleus neurons mediated by M1 and M2 receptors: a possible mechanism for selective gating of afferent sensory neurotransmission. Eur J Neurosci (2006) 0.82
Interactions of histidine-rich glycoprotein with immunoglobulins and proteins of the complement system. Mol Immunol (2009) 0.80
Neurotransmission and bipolar disorder: a systematic family-based association study. Am J Med Genet B Neuropsychiatr Genet (2008) 0.79
Differential roles of transcriptional mediator complex subunits Crsp34/Med27, Crsp150/Med14 and Trap100/Med24 during zebrafish retinal development. Genetics (2006) 0.78