Published in PLoS Genet on September 23, 2010
Detecting epistasis in human complex traits. Nat Rev Genet (2014) 1.61
Genotype distribution-based inference of collective effects in genome-wide association studies: insights to age-related macular degeneration disease mechanism. BMC Genomics (2016) 1.41
Improved statistics for genome-wide interaction analysis. PLoS Genet (2012) 1.33
Knowledge-driven analysis identifies a gene-gene interaction affecting high-density lipoprotein cholesterol levels in multi-ethnic populations. PLoS Genet (2012) 1.31
Gene-based testing of interactions in association studies of quantitative traits. PLoS Genet (2013) 1.23
Ultrahigh-dimensional variable selection method for whole-genome gene-gene interaction analysis. BMC Bioinformatics (2012) 1.04
Association analysis of frost tolerance in rye using candidate genes and phenotypic data from controlled, semi-controlled, and field phenotyping platforms. BMC Plant Biol (2011) 0.96
iLOCi: a SNP interaction prioritization technique for detecting epistasis in genome-wide association studies. BMC Genomics (2012) 0.90
Characterisation of genome-wide association epistasis signals for serum uric acid in human population isolates. PLoS One (2011) 0.89
Genome-wide eQTLs and heritability for gene expression traits in unrelated individuals. BMC Genomics (2014) 0.84
Abundant local interactions in the 4p16.1 region suggest functional mechanisms underlying SLC2A9 associations with human serum uric acid. Hum Mol Genet (2014) 0.83
Modeling haplotype-haplotype interactions in case-control genetic association studies. Front Genet (2012) 0.82
AprioriGWAS, a new pattern mining strategy for detecting genetic variants associated with disease through interaction effects. PLoS Comput Biol (2014) 0.80
Allele-specific network reveals combinatorial interaction that transcends small effects in psoriasis GWAS. PLoS Comput Biol (2014) 0.80
Genome-wide gene-gene interaction analysis for next-generation sequencing. Eur J Hum Genet (2015) 0.79
Investigating the Role of Gene-Gene Interactions in TB Susceptibility. PLoS One (2015) 0.79
An Exploration of the Role of MicroRNAs in Psoriasis: A Systematic Review of the Literature. Medicine (Baltimore) (2015) 0.78
Functional Regression Models for Epistasis Analysis of Multiple Quantitative Traits. PLoS Genet (2016) 0.78
Epistatic effects on abdominal fat content in chickens: results from a genome-wide SNP-SNP interaction analysis. PLoS One (2013) 0.77
From interaction to co-association --a Fisher r-to-z transformation-based simple statistic for real world genome-wide association study. PLoS One (2013) 0.77
Biological knowledge-driven analysis of epistasis in human GWAS with application to lipid traits. Methods Mol Biol (2015) 0.76
Filter-free exhaustive odds ratio-based genome-wide interaction approach pinpoints evidence for interaction in the HLA region in psoriasis. BMC Genet (2015) 0.75
To control false positives in gene-gene interaction analysis: two novel conditional entropy-based approaches. PLoS One (2013) 0.75
KNN-MDR: a learning approach for improving interactions mapping performances in genome wide association studies. BMC Bioinformatics (2017) 0.75
A Novel Test for Detecting SNP-SNP Interactions in Case-Only Trio Studies. Genetics (2016) 0.75
Genome-Wide Analysis of Gene-Gene and Gene-Environment Interactions Using Closed-Form Wald Tests. Genet Epidemiol (2015) 0.75
The impact of genotype calling errors on family-based studies. Sci Rep (2016) 0.75
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A (2009) 54.68
KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res (1999) 40.62
Genetic mapping in human disease. Science (2008) 15.12
Human genetic variation and its contribution to complex traits. Nat Rev Genet (2009) 12.11
Detecting gene-gene interactions that underlie human diseases. Nat Rev Genet (2009) 12.07
Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity (Edinb) (2005) 9.85
A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet (2006) 9.56
Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems. Nat Rev Genet (2008) 9.26
Non-hierarchical logistic models and case-only designs for assessing susceptibility in population-based case-control studies. Stat Med (1994) 6.50
MicroRNA target site polymorphisms and human disease. Trends Genet (2008) 5.32
A complete enumeration and classification of two-locus disease models. Hum Hered (2000) 4.45
Genes, environment and the value of prospective cohort studies. Nat Rev Genet (2006) 4.33
Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. Am J Hum Genet (2006) 4.22
Gene-environment interaction in genome-wide association studies. Am J Epidemiol (2008) 3.96
Test for interaction between two unlinked loci. Am J Hum Genet (2006) 3.88
Distinctive patterns of microRNA expression in primary muscular disorders. Proc Natl Acad Sci U S A (2007) 3.72
A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis. Nat Genet (2003) 3.52
Traversing the conceptual divide between biological and statistical epistasis: systems biology and a more modern synthesis. Bioessays (2005) 3.47
Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein. Am J Hum Genet (2008) 3.27
Modeling quantitative trait Loci and interpretation of models. Genetics (2005) 3.15
Using biological networks to search for interacting loci in genome-wide association studies. Eur J Hum Genet (2009) 2.68
A unified model for functional and statistical epistasis and its application in quantitative trait Loci analysis. Genetics (2007) 2.47
Case-only design to measure gene-gene interaction. Epidemiology (1999) 2.30
Invited commentary: from genome-wide association studies to gene-environment-wide interaction studies--challenges and opportunities. Am J Epidemiol (2008) 2.20
Interactions in epidemiology: relevance, identification, and estimation. Epidemiology (2009) 2.10
Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients. Rheumatol Int (2008) 2.09
Gene-environment interaction: definitions and study designs. Prev Med (1997) 2.04
A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis. BMC Genomics (2008) 1.64
Epidemiologic and genetic approaches in the study of gene-environment interaction: an overview of available methods. Epidemiol Rev (1998) 1.38
Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic stroke. Ann Neurol (2005) 1.36
Allelic association studies of genome wide association data can reveal errors in marker position assignments. BMC Genet (2007) 1.09
The semaphorin 7A receptor Plexin C1 is lost during melanoma metastasis. Am J Dermatopathol (2009) 1.08
The challenge of detecting epistasis (G x G interactions): Genetic Analysis Workshop 16. Genet Epidemiol (2009) 0.99
Locality of global stochastic interaction in directed acyclic networks. Neural Comput (2002) 0.82
[Association study of NOTCH4 gene polymorphisms with schizophrenia and mood disorders in mixed pedigrees]. Yi Chuan (2005) 0.78
Analysis of a promoter polymorphism in the SMDF neuregulin 1 isoform in Schizophrenia. Neuropsychobiology (2009) 0.77
Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med (2013) 24.88
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med (2004) 22.96
Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I. Arthritis Rheum (2008) 13.08
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat Genet (2009) 5.75
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet (2011) 5.56
Test for interaction between two unlinked loci. Am J Hum Genet (2006) 3.88
Epigenomic analysis of multilineage differentiation of human embryonic stem cells. Cell (2013) 3.81
Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis. N Engl J Med (2013) 3.81
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Nat Genet (2010) 3.58
Efficacy and safety of adalimumab in patients with ankylosing spondylitis: results of a multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum (2006) 3.51
Multiple transporters associated with malaria parasite responses to chloroquine and quinine. Mol Microbiol (2003) 3.26
Gene and pathway-based second-wave analysis of genome-wide association studies. Eur J Hum Genet (2010) 3.03
Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nat Genet (2013) 2.87
Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet (2011) 2.54
The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA. Genes Dev (2011) 2.53
Protective effect of hydroxychloroquine on renal damage in patients with lupus nephritis: LXV, data from a multiethnic US cohort. Arthritis Rheum (2009) 2.50
Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease. PLoS Genet (2010) 2.44
Electronic monitoring of oral therapies in ethnically diverse and economically disadvantaged patients with rheumatoid arthritis: consequences of low adherence. Arthritis Rheum (2013) 2.42
The impact of tumor necrosis factor α inhibitors on radiographic progression in ankylosing spondylitis. Arthritis Rheum (2013) 2.40
A multiethnic, multicenter cohort of patients with systemic lupus erythematosus (SLE) as a model for the study of ethnic disparities in SLE. Arthritis Rheum (2007) 2.24
Highly transparent and conductive ZnO: Al thin films from a low temperature aqueous solution approach. Adv Mater (2013) 2.21
The concept of axial spondyloarthritis: joint statement of the spondyloarthritis research and treatment network and the Assessment of SpondyloArthritis international Society in response to the US Food and Drug Administration's comments and concerns. Arthritis Rheumatol (2014) 2.14
The effect of single nucleotide polymorphism identification strategies on estimates of linkage disequilibrium. Mol Biol Evol (2003) 1.93
Short leukocyte telomere length predicts risk of diabetes in american indians: the strong heart family study. Diabetes (2013) 1.91
Association studies for next-generation sequencing. Genome Res (2011) 1.89
Major histocompatibility complex (MHC) class II alleles, haplotypes and epitopes which confer susceptibility or protection in systemic sclerosis: analyses in 1300 Caucasian, African-American and Hispanic cases and 1000 controls. Ann Rheum Dis (2009) 1.84
The pluripotent genome in three dimensions is shaped around pluripotency factors. Nature (2013) 1.82
Meta-analysis of the prognostic value of circulating tumor cells in breast cancer. Clin Cancer Res (2012) 1.79
Genome-wide gene and pathway analysis. Eur J Hum Genet (2010) 1.79
Discovery of Ca2+-relevant and differentiation-associated genes downregulated in esophageal squamous cell carcinoma using cDNA microarray. Oncogene (2004) 1.77
Systemic lupus erythematosus in a multiethnic US cohort (LUMINA). XXIII. Baseline predictors of vascular events. Arthritis Rheum (2004) 1.75
Resolution of anaphase bridges in cancer cells. Chromosoma (2004) 1.72
Effect of hydroxychloroquine on the survival of patients with systemic lupus erythematosus: data from LUMINA, a multiethnic US cohort (LUMINA L). Ann Rheum Dis (2007) 1.69
An entropy-based genome-wide transmission/disequilibrium test. Hum Genet (2007) 1.65
Family-based association studies for next-generation sequencing. Am J Hum Genet (2012) 1.65
Systemic lupus erythematosus in three ethnic groups: XVI. Association of hydroxychloroquine use with reduced risk of damage accrual. Arthritis Rheum (2005) 1.64
Klinefelter's syndrome (47,XXY) in male systemic lupus erythematosus patients: support for the notion of a gene-dose effect from the X chromosome. Arthritis Rheum (2008) 1.64
New population-based reference values for spinal mobility measures based on the 2009-2010 National Health and Nutrition Examination Survey. Arthritis Rheumatol (2014) 1.64
End-stage renal disease in African Americans with lupus nephritis is associated with APOL1. Arthritis Rheumatol (2014) 1.62
Present Y chromosomes reveal the ancestry of Emperor CAO Cao of 1800 years ago. J Hum Genet (2011) 1.61
Presence of the human leukocyte antigen class II gene DRB1*1101 predicts interferon gamma levels and disease recurrence in melanoma patients. Ann Surg Oncol (2002) 1.57
The clinical relevance of autoantibodies in scleroderma. Arthritis Res Ther (2003) 1.56
Henoch-Schönlein purpura with hypocomplementemia. Pediatr Nephrol (2012) 1.54
Systemic lupus erythematosus in a multiethnic US cohort: XLIII. The significance of thrombocytopenia as a prognostic factor. Arthritis Rheum (2007) 1.51
Predictors of interstitial lung disease in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohort. Arthritis Res Ther (2010) 1.50
Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. PLoS Genet (2011) 1.49
Are there gender differences in severity of ankylosing spondylitis? Results from the PSOAS cohort. Ann Rheum Dis (2006) 1.47
An entropy-based statistic for genomewide association studies. Am J Hum Genet (2005) 1.47
Unique mitochondrial genome architecture in unicellular relatives of animals. Proc Natl Acad Sci U S A (2003) 1.47
Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer. Cancer Res (2010) 1.45
Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus. Arthritis Rheum (2009) 1.43
Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study. Am J Hum Genet (2010) 1.43
Perceived functioning has ethnic-specific associations in systemic sclerosis: another dimension of personalized medicine. J Rheumatol (2009) 1.42
Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis. Ann Rheum Dis (2009) 1.42
Hepatitis C seroconversion in methadone maintenance treatment programs in Wuhan, China. Addiction (2015) 1.42
Association between testing for human immunodeficiency virus and changes in risk behaviors among injecting drug users in southern China. Sex Transm Dis (2009) 1.41
Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus. Ann Rheum Dis (2011) 1.41
Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study. Am J Hum Genet (2012) 1.41
Systemic sclerosis and lupus: points in an interferon-mediated continuum. Arthritis Rheum (2010) 1.40
An oncogenic isoform of HER2 associated with locally disseminated breast cancer and trastuzumab resistance. Mol Cancer Ther (2009) 1.39
Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies. Medicine (Baltimore) (2006) 1.39
Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations. J Autoimmun (2009) 1.38
IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus. Ann Rheum Dis (2011) 1.38
HLA-DPB1 and DPB2 are genetic loci for systemic sclerosis: a genome-wide association study in Koreans with replication in North Americans. Arthritis Rheum (2009) 1.36
Current status of outcome measure development for clinical trials in systemic sclerosis. Report from OMERACT 6. J Rheumatol (2003) 1.36
Intracoronary administration of cardiac stem cells in mice: a new, improved technique for cell therapy in murine models. Basic Res Cardiol (2011) 1.36
Tumor-infiltrating lymphocyte grade in primary melanomas is independently associated with melanoma-specific survival in the population-based genes, environment and melanoma study. J Clin Oncol (2013) 1.36
Systemic lupus erythematosus in a multiethnic lupus cohort (LUMINA). XVII. Predictors of self-reported health-related quality of life early in the disease course. Arthritis Rheum (2004) 1.35
Proteomic analysis of tumor necrosis factor-alpha resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype. Breast Cancer Res (2008) 1.35
Time to renal disease and end-stage renal disease in PROFILE: a multiethnic lupus cohort. PLoS Med (2006) 1.34
Pulmonary involvement in systemic sclerosis: associations with genetic, serologic, sociodemographic, and behavioral factors. Arthritis Rheum (2007) 1.33
Differential regulation of lipopolysaccharide-induced monocyte matrix metalloproteinase (MMP)-1 and MMP-9 by p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases. J Immunol (2003) 1.32
Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling. J Cell Biol (2008) 1.32
Sinorhizobium meliloti ExoR and ExoS proteins regulate both succinoglycan and flagellum production. J Bacteriol (2004) 1.31
Treatment adherence in patients with rheumatoid arthritis and systemic lupus erythematosus. Clin Rheumatol (2008) 1.29
Anti-diabetic action of Punica granatum flower extract: activation of PPAR-gamma and identification of an active component. Toxicol Appl Pharmacol (2005) 1.27
Risk factors for functional limitations in patients with long-standing ankylosing spondylitis. Arthritis Rheum (2005) 1.26
Functional linear models for association analysis of quantitative traits. Genet Epidemiol (2013) 1.26
Integrated analysis of mutations, miRNA and mRNA expression in glioblastoma. BMC Syst Biol (2010) 1.26
Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines. Arthritis Rheum (2009) 1.24
Zebrafish sp7:EGFP: a transgenic for studying otic vesicle formation, skeletogenesis, and bone regeneration. Genesis (2010) 1.23
Anti-IL-17 receptor antibody AMG 827 leads to rapid clinical response in subjects with moderate to severe psoriasis: results from a phase I, randomized, placebo-controlled trial. J Invest Dermatol (2012) 1.23
Punica granatum flower extract, a potent alpha-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats. J Ethnopharmacol (2005) 1.23
A polymorphism within IL21R confers risk for systemic lupus erythematosus. Arthritis Rheum (2009) 1.23
Randomly distributed crossovers may generate block-like patterns of linkage disequilibrium: an act of genetic drift. Hum Genet (2003) 1.23
Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations. Arthritis Res Ther (2009) 1.22
A proteome reference map and proteomic analysis of Bifidobacterium longum NCC2705. Mol Cell Proteomics (2006) 1.22
Novel multiplex technology for diagnostic characterization of rheumatoid arthritis. Arthritis Res Ther (2011) 1.21
Relationship of arterial stiffness and early mild diastolic heart failure in general middle and aged population. Eur Heart J (2010) 1.21
Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor. Arterioscler Thromb Vasc Biol (2012) 1.21