Published in World J Biol Chem on May 26, 2014
The essential kinase ATR: ensuring faithful duplication of a challenging genome. Nat Rev Mol Cell Biol (2017) 1.38
Characterization of the human NEK7 interactome suggests catalytic and regulatory properties distinct from those of NEK6. J Proteome Res (2014) 0.85
Compound heterozygous NEK1 variants in two siblings with oral-facial-digital syndrome type II (Mohr syndrome). Eur J Hum Genet (2016) 0.77
Human Nek7-interactor RGS2 is required for mitotic spindle organization. Cell Cycle (2015) 0.76
A NIMA-related kinase, CNK4, regulates ciliary stability and length. Mol Biol Cell (2016) 0.76
Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1γ-WAPL Axis in the Mouse. Cell Rep (2016) 0.75
Conserved Ankyrin Repeat Proteins and Their NIMA Kinase Partners Regulate Extracellular Matrix Remodeling and Intracellular Trafficking in Caenorhabditis elegans. Genetics (2016) 0.75
New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing. Proteome Sci (2015) 0.75
NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin. Sci Rep (2017) 0.75
Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation. Cell Rep (2017) 0.75
Use of a special Brazilian red-light emitting railroad worm Luciferase in bioassays of NEK7 protein Kinase and Creatine Kinase. BMC Biochem (2017) 0.75
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet (2000) 336.52
Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res (2003) 103.76
Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol (2007) 8.16
Three-dimensional structure of the armadillo repeat region of beta-catenin. Cell (1997) 7.35
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet (2009) 7.30
Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Proc Natl Acad Sci U S A (2003) 4.47
Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nat Cell Biol (2003) 4.31
C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2. J Cell Biol (1998) 3.72
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene (2003) 3.53
Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell (2012) 2.54
Caught Nek-ing: cilia and centrioles. J Cell Sci (2005) 2.33
Nek6 overexpression antagonizes p53-induced senescence in human cancer cells. Cell Cycle (2010) 2.30
Scc1/Rad21/Mcd1 is required for sister chromatid cohesion and kinetochore function in vertebrate cells. Dev Cell (2001) 2.30
The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis. J Biol Chem (2003) 2.18
Never say never. The NIMA-related protein kinases in mitotic control. Trends Cell Biol (2003) 2.13
A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish. Development (2002) 2.00
NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies. Mol Cell (2013) 1.97
Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction. Cancer Res (2010) 1.90
Mitotic regulation by NIMA-related kinases. Cell Div (2007) 1.88
Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. Genes Dev (2002) 1.87
Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase. Curr Biol (2001) 1.82
A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. J Biol Chem (2003) 1.75
Nek8 regulates the expression and localization of polycystin-1 and polycystin-2. J Am Soc Nephrol (2008) 1.70
Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks. Proc Natl Acad Sci U S A (2010) 1.65
NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1. Biochem J (2000) 1.65
Cell cycle regulation by the NEK family of protein kinases. J Cell Sci (2012) 1.64
Substrate specificity and cell cycle regulation of the Nek2 protein kinase, a potential human homolog of the mitotic regulator NIMA of Aspergillus nidulans. J Biol Chem (1995) 1.61
Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic effects including a progressive polycystic kidney disease in mice. Proc Natl Acad Sci U S A (2000) 1.57
NEK1 mutations cause short-rib polydactyly syndrome type majewski. Am J Hum Genet (2011) 1.56
The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis. Mol Cell Biol (2009) 1.55
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. Nat Cell Biol (2009) 1.55
Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors. Gene (2004) 1.52
Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene. Mol Cell (2001) 1.52
Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans. Cell Growth Differ (1994) 1.51
A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells. EMBO J (1992) 1.49
NIMA-related kinases defective in murine models of polycystic kidney diseases localize to primary cilia and centrosomes. J Am Soc Nephrol (2005) 1.47
A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell. Nucleic Acids Res (2008) 1.47
Structure and regulation of the human Nek2 centrosomal kinase. J Biol Chem (2006) 1.45
A NIMA-related kinase, Fa2p, localizes to a novel site in the proximal cilia of Chlamydomonas and mouse kidney cells. Mol Biol Cell (2004) 1.44
Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins. J Clin Invest (1999) 1.41
High incidence of chromosome 13 deletion in multiple myeloma detected by multiprobe interphase FISH. Blood (2000) 1.39
Nek family of kinases in cell cycle, checkpoint control and cancer. Cell Div (2011) 1.37
Roles of endosomal trafficking in neurite outgrowth and guidance. Trends Cell Biol (2009) 1.35
Rootletin interacts with C-Nap1 and may function as a physical linker between the pair of centrioles/basal bodies in cells. Mol Biol Cell (2005) 1.35
Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5. EMBO J (2011) 1.34
Frequent alterations in the expression of serine/threonine kinases in human cancers. Cancer Res (2006) 1.32
The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. J Cell Sci (2008) 1.32
Polycystic kidney disease: new understanding in the pathogenesis. Int J Biochem Cell Biol (2004) 1.32
Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression. FEBS Lett (2006) 1.27
Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2. Breast Cancer Res (2011) 1.22
Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1. Biochemistry (2003) 1.20
Never-in-mitosis related kinase 1 functions in DNA damage response and checkpoint control. Cell Cycle (2008) 1.18
Active Nercc1 protein kinase concentrates at centrosomes early in mitosis and is necessary for proper spindle assembly. Mol Biol Cell (2005) 1.17
The SONB(NUP98) nucleoporin interacts with the NIMA kinase in Aspergillus nidulans. Genetics (2003) 1.17
Activity of the human centrosomal kinase, Nek2, depends on an unusual leucine zipper dimerization motif. J Biol Chem (1999) 1.16
Integrative approach for differentially overexpressed genes in gastric cancer by combining large-scale gene expression profiling and network analysis. Br J Cancer (2008) 1.16
Nek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responses. J Biol Chem (2002) 1.16
An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9. Mol Cell (2009) 1.12
Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint. Mol Biol Cell (2011) 1.12
Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy. Oncogene (2010) 1.11
A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis. EMBO J (2013) 1.11
Drosophila Nek2 protein kinase knockdown leads to centrosome maturation defects while overexpression causes centrosome fragmentation and cytokinesis failure. Exp Cell Res (2005) 1.10
NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response. Cancer Res (2004) 1.10
Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2. J Biol Chem (2002) 1.08
Retracted Nek6 mediates human cancer cell transformation and is a potential cancer therapeutic target. Mol Cancer Res (2010) 1.05
Protein phosphatase-1alpha regulates centrosome splitting through Nek2. Cancer Res (2007) 1.05
NEK7 is a centrosomal kinase critical for microtubule nucleation. Biochem Biophys Res Commun (2007) 1.03
Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients. Biochem Biophys Res Commun (2006) 1.03
Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation. Cell Cycle (2008) 1.03
Nek1 regulates cell death and mitochondrial membrane permeability through phosphorylation of VDAC1. Cell Cycle (2009) 1.03
Patterns of chromosomal imbalances in parathyroid carcinomas. Am J Pathol (2000) 1.02
Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern. Oncogene (1994) 1.01
Nek3 kinase regulates prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells. Oncogene (2007) 1.01
Dynamic regulation of Oct1 during mitosis by phosphorylation and ubiquitination. PLoS One (2011) 1.00
The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis. Hum Mol Genet (2011) 0.99
Application of multiplexed kinase inhibitor beads to study kinome adaptations in drug-resistant leukemia. PLoS One (2013) 0.99
Quercetin inhibits a large panel of kinases implicated in cancer cell biology. Int J Oncol (2010) 0.98
Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells. J Biol Chem (2004) 0.97
Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of γ-tubulin recruitment to the mitotic centrosome. Curr Biol (2012) 0.97
The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase. Hum Mol Genet (2011) 0.97
Nek1 silencing slows down DNA repair and blocks DNA damage-induced cell cycle arrest. Mutagenesis (2010) 0.96
Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor. Mol Endocrinol (2004) 0.96
Identification and characterization of Nek6 protein kinase, a potential human homolog of NIMA histone H3 kinase. Biochem Biophys Res Commun (2002) 0.96
Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation. Mol Cell Biol (2010) 0.96
Double plant homeodomain (PHD) finger proteins DPF3a and -3b are required as transcriptional co-activators in SWI/SNF complex-dependent activation of NF-κB RelA/p50 heterodimer. J Biol Chem (2012) 0.95
Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling. Proc Natl Acad Sci U S A (2013) 0.95
Differential control of the NIMA-related kinases, Nek6 and Nek7, by serum stimulation. Biochem Biophys Res Commun (2003) 0.95
Quantitative chemical proteomics reveals new potential drug targets in head and neck cancer. Mol Cell Proteomics (2011) 0.95
The expression of Nek7, FoxM1, and Plk1 in gallbladder cancer and their relationships to clinicopathologic features and survival. Clin Transl Oncol (2013) 0.95
The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons. J Cell Sci (2009) 0.94
Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells. J Biol Chem (2010) 0.94
Phosphorylation of high-mobility group protein A2 by Nek2 kinase during the first meiotic division in mouse spermatocytes. Mol Biol Cell (2003) 0.94
Cofactor-dependent specificity of a DEAD-box protein. Proc Natl Acad Sci U S A (2013) 0.92
EHD2 mediates trafficking from the plasma membrane by modulating Rac1 activity. Biochem J (2011) 0.92
NIMA-related kinases 6, 4, and 5 interact with each other to regulate microtubule organization during epidermal cell expansion in Arabidopsis thaliana. Plant J (2011) 0.92
Nek8 mutation causes overexpression of galectin-1, sorcin, and vimentin and accumulation of the major urinary protein in renal cysts of jck mice. Mol Cell Proteomics (2005) 0.91
Protein partners of KCTD proteins provide insights about their functional roles in cell differentiation and vertebrate development. Bioessays (2013) 0.91
Novel protein kinases expressed in human breast cancer. Int J Cancer (1993) 0.91
NEK7 is essential for centriole duplication and centrosomal accumulation of pericentriolar material proteins in interphase cells. J Cell Sci (2011) 0.91