Published in Trends Cell Biol on May 01, 2003
Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol (2007) 8.16
Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. PLoS Biol (2006) 5.44
The vertebrate primary cilium in development, homeostasis, and disease. Cell (2009) 5.29
Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote. BMC Genomics (2004) 3.68
Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi. BMC Genomics (2005) 2.66
Intraflagellar transport protein 27 is a small G protein involved in cell-cycle control. Curr Biol (2007) 2.15
Cilia and the cell cycle? J Cell Biol (2005) 1.94
Mitotic regulation by NIMA-related kinases. Cell Div (2007) 1.88
Cell cycle regulation by the NEK family of protein kinases. J Cell Sci (2012) 1.64
The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis. Mol Cell Biol (2009) 1.55
Systematic deletion and mitotic localization of the nuclear pore complex proteins of Aspergillus nidulans. Mol Biol Cell (2006) 1.48
A NIMA-related kinase, Fa2p, localizes to a novel site in the proximal cilia of Chlamydomonas and mouse kidney cells. Mol Biol Cell (2004) 1.44
Recruitment of NIMA kinase shows that maturation of the S. pombe spindle-pole body occurs over consecutive cell cycles and reveals a role for NIMA in modulating SIN activity. Genes Dev (2004) 1.41
Forward genetic analysis of the apicomplexan cell division cycle in Toxoplasma gondii. PLoS Pathog (2008) 1.38
Nek family of kinases in cell cycle, checkpoint control and cancer. Cell Div (2011) 1.37
Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5. EMBO J (2011) 1.34
The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. J Cell Sci (2008) 1.32
Mitosis, not just open or closed. Eukaryot Cell (2007) 1.27
The NIMA-family kinase, Nek1 affects the stability of centrosomes and ciliogenesis. BMC Cell Biol (2008) 1.23
Never-in-mitosis related kinase 1 functions in DNA damage response and checkpoint control. Cell Cycle (2008) 1.18
Active Nercc1 protein kinase concentrates at centrosomes early in mitosis and is necessary for proper spindle assembly. Mol Biol Cell (2005) 1.17
The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology. Genome Biol (2011) 1.14
Inhibition of Aurora-B kinase activity by poly(ADP-ribosyl)ation in response to DNA damage. Proc Natl Acad Sci U S A (2005) 1.05
Nek1 regulates cell death and mitochondrial membrane permeability through phosphorylation of VDAC1. Cell Cycle (2009) 1.03
Searching for gold beyond mitosis: Mining intracellular membrane traffic in Aspergillus nidulans. Cell Logist (2012) 0.99
The Toxoplasma gondii centrosome is the platform for internal daughter budding as revealed by a Nek1 kinase mutant. J Cell Sci (2013) 0.99
Gene expression profiles of different clinical stages of colorectal carcinoma: toward a molecular genetic understanding of tumor progression. Int J Colorectal Dis (2005) 0.98
Phylogenetic analysis of the Neks reveals early diversification of ciliary-cell cycle kinases. PLoS One (2007) 0.98
Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression. J Cell Biol (2015) 0.98
Loss of the ciliary kinase Nek8 causes left-right asymmetry defects. J Am Soc Nephrol (2013) 0.97
Global analysis of serine-threonine protein kinase genes in Neurospora crassa. Eukaryot Cell (2011) 0.97
Defects in ciliary localization of Nek8 is associated with cystogenesis. Pediatr Nephrol (2008) 0.96
Cdk1, Plks, Auroras, and Neks: the mitotic bodyguards. Adv Exp Med Biol (2008) 0.96
The cell adhesion gene PVRL3 is associated with congenital ocular defects. Hum Genet (2011) 0.96
Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability. Mol Cancer (2011) 0.96
Molecular machinery of signal transduction and cell cycle regulation in Plasmodium. Mol Biochem Parasitol (2009) 0.95
The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons. J Cell Sci (2009) 0.94
Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis. J Cell Biol (2015) 0.93
Structural analysis of the regulation of the DYNLL/LC8 binding to Nek9 by phosphorylation. J Biol Chem (2013) 0.91
"Stop Ne(c)king around": How interactomics contributes to functionally characterize Nek family kinases. World J Biol Chem (2014) 0.91
Nek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: a mechanism for aneuploidy in cancer. Exp Mol Pathol (2009) 0.90
Copy number suppressors of the Aspergillus nidulans nimA1 mitotic kinase display distinctive and highly dynamic cell cycle-regulated locations. Eukaryot Cell (2008) 0.89
Phosphorylation of AIB1 at mitosis is regulated by CDK1/CYCLIN B. PLoS One (2011) 0.89
The genome of Spironucleus salmonicida highlights a fish pathogen adapted to fluctuating environments. PLoS Genet (2014) 0.89
HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus. Nat Commun (2015) 0.88
Nek9 regulates spindle organization and cell cycle progression during mouse oocyte meiosis and its location in early embryo mitosis. Cell Cycle (2012) 0.87
Regulation of mitosis by the NIMA kinase involves TINA and its newly discovered partner, An-WDR8, at spindle pole bodies. Mol Biol Cell (2013) 0.87
Kinome analysis of receptor-induced phosphorylation in human natural killer cells. PLoS One (2012) 0.87
Potential link between the NIMA mitotic kinase and nuclear membrane fission during mitotic exit in Aspergillus nidulans. Eukaryot Cell (2004) 0.87
An inhibitory role of NEK6 in TGFβ/Smad signaling pathway. BMB Rep (2015) 0.86
Abnormal expression of Nek2 in pancreatic ductal adenocarcinoma: a novel marker for prognosis. Int J Clin Exp Pathol (2014) 0.86
DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9. J Biol Chem (2011) 0.84
CPDadh: a new peptidase family homologous to the cysteine protease domain in bacterial MARTX toxins. Protein Sci (2009) 0.84
Dissecting the M phase-specific phosphorylation of serine-proline or threonine-proline motifs. Mol Biol Cell (2010) 0.82
NIMA-related kinases regulate directional cell growth and organ development through microtubule function in Arabidopsis thaliana. Plant Signal Behav (2012) 0.82
KSHV reactivation and novel implications of protein isomerization on lytic switch control. Viruses (2015) 0.81
The Drosophila protein kinase LK6 is regulated by ERK and phosphorylates the eukaryotic initiation factor eIF4E in vivo. Biochem J (2005) 0.79
The Dual Nature of Nek9 in Adenovirus Replication. J Virol (2015) 0.77
Cell cycle regulation by checkpoints. Methods Mol Biol (2014) 0.77
Structure, function, and evolution of plant NIMA-related kinases: implication for phosphorylation-dependent microtubule regulation. J Plant Res (2015) 0.77
Insights into dynamic mitotic chromatin organization through the NIMA kinase suppressor SonC, a chromatin-associated protein involved in the DNA damage response. Genetics (2013) 0.76
A NIMA-related kinase, CNK4, regulates ciliary stability and length. Mol Biol Cell (2016) 0.76
Human Nek7-interactor RGS2 is required for mitotic spindle organization. Cell Cycle (2015) 0.76
Nek7 is overexpressed in hepatocellular carcinoma and promotes hepatocellular carcinoma cell proliferation in vitro and in vivo. Oncotarget (2016) 0.76
Tumor antigen analysis in neuroblastoma by serological interrogation of bioinformatic data. Cancer Sci (2010) 0.76
NEK2 serves as a prognostic biomarker for hepatocellular carcinoma. Int J Oncol (2017) 0.75
Expression of Nek1 during kidney development and cyst formation in multiple nephron segments in the Nek1-deficient kat2J mouse model of polycystic kidney disease. J Biomed Sci (2014) 0.75
New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing. Proteome Sci (2015) 0.75
Nek2 siRNA therapy using a portal venous port-catheter system for liver metastasis in pancreatic cancer. Cancer Sci (2016) 0.75
NEK8 regulates DNA damage-induced RAD51 foci formation and replication fork protection. Cell Cycle (2016) 0.75
Protein tyrosine phosphatases in the human genome. Cell (2004) 8.09
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr Biol (2004) 7.59
Evolution of protein kinase signaling from yeast to man. Trends Biochem Sci (2002) 5.28
Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem (2007) 4.60
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. Proc Natl Acad Sci U S A (2004) 4.13
Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. Cancer Cell (2003) 3.87
PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell (2012) 3.83
PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone. J Cell Biol (2002) 3.51
Reconstruction of cellular signalling networks and analysis of their properties. Nat Rev Mol Cell Biol (2005) 3.46
Structure-based prediction of protein-protein interactions on a genome-wide scale. Nature (2012) 3.37
Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation. Nat Immunol (2002) 3.32
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol Cell Biol (2005) 3.25
TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Cancer Res (2009) 2.96
Kinomics: methods for deciphering the kinome. Nat Methods (2005) 2.94
Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains. Cell (2005) 2.88
Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase. Mol Cell (2003) 2.69
The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Mol Cell (2002) 2.64
Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins. EMBO J (2007) 2.59
The mouse kinome: discovery and comparative genomics of all mouse protein kinases. Proc Natl Acad Sci U S A (2004) 2.50
Autoregulation and homodimerization are involved in the activation of the plant steroid receptor BRI1. Dev Cell (2005) 2.48
Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes. Proc Natl Acad Sci U S A (2002) 2.28
Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature (2003) 2.28
Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15
CtIP links DNA double-strand break sensing to resection. Mol Cell (2009) 2.11
SMK-1, an essential regulator of DAF-16-mediated longevity. Cell (2006) 2.10
Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases. J Cell Sci (2003) 2.10
Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. J Biol Chem (2002) 2.08
Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways. Proc Natl Acad Sci U S A (2005) 1.85
Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis. Mol Cell Biol (2006) 1.82
Cyclin-dependent kinases: a family portrait. Nat Cell Biol (2009) 1.80
The regulatory crosstalk between kinases and proteases in cancer. Nat Rev Cancer (2010) 1.80
Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors. Cell Cycle (2010) 1.74
Microarray and cDNA sequence analysis of transcription during nerve-dependent limb regeneration. BMC Biol (2009) 1.74
EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas). Nat Cell Biol (2002) 1.72
Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension. J Cell Biol (2002) 1.72
A conserved ubiquitination pathway determines longevity in response to diet restriction. Nature (2009) 1.71
The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. Mol Cell (2009) 1.64
Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival. Cancer Cell (2006) 1.62
Degradation of activated protein kinases by ubiquitination. Annu Rev Biochem (2009) 1.61
Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism. Cell Res (2013) 1.59
Nuclear translocation of caspase-3 is dependent on its proteolytic activation and recognition of a substrate-like protein(s). J Biol Chem (2004) 1.50
Rapid activation of ATM on DNA flanking double-strand breaks. Nat Cell Biol (2007) 1.49
Wnt-independent beta-catenin transactivation in tumor development. Cell Cycle (2004) 1.47
Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. Chem Biol (2003) 1.47
Critical roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balance. Cell Metab (2006) 1.44
Protein kinase signaling networks in cancer. Curr Opin Genet Dev (2010) 1.41
c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis. Mol Cell (2007) 1.40
Fitting WWP-1 in the dietary restriction network. Cell Cycle (2015) 1.39
Roles of Chk1 in cell biology and cancer therapy. Int J Cancer (2013) 1.37
Structural basis for high-affinity peptide inhibition of human Pin1. ACS Chem Biol (2007) 1.36
The Schizosaccharomyces pombe aurora-related kinase Ark1 interacts with the inner centromere protein Pic1 and mediates chromosome segregation and cytokinesis. Mol Biol Cell (2002) 1.33
Real-time imaging reveals that noninvasive mammary epithelial acini can contain motile cells. J Cell Biol (2007) 1.32
Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro. Mol Cell Biol (2002) 1.31
c-Abl phosphorylates Dok1 to promote filopodia during cell spreading. J Cell Biol (2004) 1.26
A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster. EMBO Rep (2003) 1.24
Ubiquitin ligase activity of TFIIH and the transcriptional response to DNA damage. Mol Cell (2005) 1.22
Minichromosome maintenance proteins interact with checkpoint and recombination proteins to promote s-phase genome stability. Mol Cell Biol (2008) 1.21
Cancer-associated loss-of-function mutations implicate DAPK3 as a tumor-suppressing kinase. Cancer Res (2011) 1.21
RING domain dimerization is essential for RNF4 function. Biochem J (2010) 1.20
Suppressors of Bir1p (Survivin) identify roles for the chromosomal passenger protein Pic1p (INCENP) and the replication initiation factor Psf2p in chromosome segregation. Mol Cell Biol (2005) 1.20
Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins identified through a string search. J Biol Chem (2012) 1.19
Proteasome inhibitor drugs on the rise. Cancer Res (2006) 1.16
Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint. Mol Cell Biol (2006) 1.15
Focal adhesion kinase is not required for integrin function or viability in Drosophila. Development (2004) 1.14
MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress. Mol Cell Biol (2006) 1.12
Tuberous sclerosis and insulin resistance. Unlikely bedfellows reveal a TORrid affair. Cell Cycle (2005) 1.09
Instructive role of aPKCzeta subcellular localization in the assembly of adherens junctions in neural progenitors. Proc Natl Acad Sci U S A (2007) 1.08
Genic regions of a large salamander genome contain long introns and novel genes. BMC Genomics (2009) 1.06
Viral E3 ubiquitin ligase-mediated degradation of a cellular E3: viral mimicry of a cellular phosphorylation mark targets the RNF8 FHA domain. Mol Cell (2012) 1.06
Mitotic regulation of ribosomal S6 kinase 1 involves Ser/Thr, Pro phosphorylation of consensus and non-consensus sites by Cdc2. J Biol Chem (2003) 1.00
A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association. Mol Cell Biol (2005) 1.00
Signal transduction. Unexpected mediators of protein phosphorylation. Science (2004) 0.99
Structural maintenance of chromosomes (SMC) proteins, a family of conserved ATPases. Genome Biol (2002) 0.96
Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesis. Proc Natl Acad Sci U S A (2010) 0.96
Turning the replication checkpoint on and off. Cell Cycle (2006) 0.94
The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination. J Biol Chem (2012) 0.93
Retrotransposon long interspersed nucleotide element-1 (LINE-1) is activated during salamander limb regeneration. Dev Growth Differ (2012) 0.91
Regulation of the Chlamydomonas cell cycle by a stable, chromatin-associated retinoblastoma tumor suppressor complex. Plant Cell (2010) 0.91
PI-3 kinase activity is necessary for ERK1/2-induced disruption of mammary epithelial architecture. Breast Cancer Res (2009) 0.90
Meeting at mitosis: cell cycle-specific regulation of c-Src by RPTPalpha. Sci STKE (2002) 0.89
Critical role of T-loop and H-motif phosphorylation in the regulation of S6 kinase 1 by the tuberous sclerosis complex. J Biol Chem (2004) 0.88
Monitoring ATM kinase activity in living cells. DNA Repair (Amst) (2007) 0.87
Possible involvement of caspase-7 in cell cycle progression at mitosis. Genes Cells (2008) 0.86
The transcriptional coactivators p/CIP and SRC-1 control insulin resistance through IRS1 in obesity models. PLoS One (2012) 0.85
The structure of the membrane distal phosphatase domain of RPTPalpha reveals interdomain flexibility and an SH2 domain interaction region. Biochemistry (2003) 0.85
Psy2 targets the PP4 family phosphatase Pph3 to dephosphorylate Mth1 and repress glucose transporter gene expression. Mol Cell Biol (2013) 0.83
Genetic and cellular mechanisms of oncogenesis. Curr Opin Genet Dev (2010) 0.83
Activation of germline-specific genes is required for limb regeneration in the Mexican axolotl. Dev Biol (2012) 0.83
Mitotic phosphorylation rescues Abl from F-actin-mediated inhibition. J Biol Chem (2005) 0.82
Phosphoproteomics finds its timing. Nat Biotechnol (2004) 0.80
Identification of MAPK substrates by expression screening with solid-phase phosphorylation. Methods Mol Biol (2004) 0.77
Meeting report: targeting the kinome--20 years of tyrosine kinase inhibitor research in Basel. Sci STKE (2007) 0.76
Tony Hunter: kinase king. Interview by Ruth Williams. J Cell Biol (2008) 0.75
PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis. Cell (2014) 0.75