Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer.

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Published in J Clin Oncol on June 01, 2009

Authors

Sao Jiralerspong1, Shana L Palla, Sharon H Giordano, Funda Meric-Bernstam, Cornelia Liedtke, Chad M Barnett, Limin Hsu, Mien-Chie Hung, Gabriel N Hortobagyi, Ana M Gonzalez-Angulo

Author Affiliations

1: Department of Breast Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, 77030-4009, USA.

Associated clinical trials:

Neoadjuvant Letrozole Plus Metformin vs Letrozole Plus Placebo for ER-positive Postmenopausal Breast Cancer | NCT01589367

The MetNET-2 Trial (MetNET-2) | NCT02823691

The Effects of Neoadjuvant Metformin on Tumour Cell Proliferation and Tumour Progression in Pancreatic Ductal Adenocarcinoma (Metformin 001) | NCT02978547

Metformin, Neo-adjuvant Temozolomide and Hypo- Accelerated Radiotherapy Followed by Adjuvant TMZ in Patients With GBM | NCT02780024

Metformin Pharmacology in Human Cancers: A Proof of Principle Study | NCT03477162

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