Lipid storage by adipose tissue macrophages regulates systemic glucose tolerance.

PubWeight™: 0.85‹?›

🔗 View Article (PMC 4137117)

Published in Am J Physiol Endocrinol Metab on July 01, 2014

Authors

Myriam Aouadi1, Pranitha Vangala1, Joseph C Yawe1, Michaela Tencerova1, Sarah M Nicoloro1, Jessica L Cohen1, Yuefei Shen1, Michael P Czech2

Author Affiliations

1: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts.
2: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts Michael.Czech@umassmed.edu Myriam.Aouadi@umassmed.edu Michael.Czech@umassmed.edu.

Articles cited by this

Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22

Macrophages, inflammation, and insulin resistance. Annu Rev Physiol (2010) 11.77

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest (2005) 9.09

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol (2008) 8.43

Inflammatory links between obesity and metabolic disease. J Clin Invest (2011) 6.73

Adipose tissue remodeling and obesity. J Clin Invest (2011) 6.12

PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat Med (2001) 6.09

Lipid-induced insulin resistance: unravelling the mechanism. Lancet (2010) 4.88

Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J Clin Invest (2010) 4.56

Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Mol Cell Biol (2009) 3.96

Angiogenesis modulates adipogenesis and obesity. J Clin Invest (2007) 3.23

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Nature (2009) 3.21

Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice. J Lipid Res (2008) 3.03

Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation. Cell Metab (2013) 2.23

PPARdelta is a very low-density lipoprotein sensor in macrophages. Proc Natl Acad Sci U S A (2003) 2.10

Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes (2011) 1.91

Macrophage infiltration into adipose tissue may promote angiogenesis for adipose tissue remodeling in obesity. Am J Physiol Endocrinol Metab (2008) 1.84

Diabetes and apoptosis: lipotoxicity. Apoptosis (2009) 1.75

The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects. J Clin Invest (1999) 1.72

Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in low density lipoprotein receptor-deficient mice. J Biol Chem (2000) 1.68

Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase. Proc Natl Acad Sci U S A (2003) 1.65

Angiogenesis and development of adipose tissue. Mol Cell Endocrinol (2009) 1.63

CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice. J Lipid Res (2003) 1.54

Transcytosis of lipoprotein lipase across cultured endothelial cells requires both heparan sulfate proteoglycans and the very low density lipoprotein receptor. J Biol Chem (2000) 1.21

Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production. Cell Metab (2013) 1.19

Lack of "immunological fitness" during fasting in metabolically challenged animals. J Lipid Res (2012) 1.08

Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice. Proc Natl Acad Sci U S A (2013) 1.04

Glucan particles for selective delivery of siRNA to phagocytic cells in mice. Biochem J (2011) 1.03

Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue. Diabetes (2011) 0.99

Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 and the intravascular processing of triglyceride-rich lipoproteins. J Intern Med (2012) 0.99

Nrf2, a PPARγ alternative pathway to promote CD36 expression on inflammatory macrophages: implication for malaria. PLoS Pathog (2011) 0.96

Macrophage lipoprotein lipase modulates the development of atherosclerosis but not adiposity. J Lipid Res (2013) 0.85

Articles by these authors

Map4k4 impairs energy metabolism in endothelial cells and promotes insulin resistance in obesity. Am J Physiol Endocrinol Metab (2017) 0.75