Diabetes and apoptosis: lipotoxicity.

Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes. PLoS Genet (2010) 3.75

Hepatocyte death: a clear and present danger. Physiol Rev (2010) 2.18

Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. PLoS One (2010) 2.14

Lipid landscapes and pipelines in membrane homeostasis. Nature (2014) 2.09

Enhanced metabolic flexibility associated with elevated adiponectin levels. Am J Pathol (2010) 1.72

Acyl-CoA synthesis, lipid metabolism and lipotoxicity. Biochim Biophys Acta (2009) 1.58

CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis. Am J Physiol Gastrointest Liver Physiol (2010) 1.54

Anthocyanins-rich extract of wild Chinese blueberry protects glucolipotoxicity-induced INS832/13 β-cell against dysfunction and death. J Food Sci Technol (2014) 1.39

Mechanisms of lipotoxicity in NAFLD and clinical implications. J Pediatr Gastroenterol Nutr (2011) 1.35

Developmental programming: impact of prenatal testosterone excess and postnatal weight gain on insulin sensitivity index and transfer of traits to offspring of overweight females. Endocrinology (2009) 1.32

HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging. Aging Cell (2010) 1.16

Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter. Trends Endocrinol Metab (2011) 1.14

Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis. J Hepatol (2010) 1.13

Adaptive mechanisms to compensate for overnutrition-induced cardiovascular abnormalities. Am J Physiol Regul Integr Comp Physiol (2011) 1.12

Systems genetics of susceptibility to obesity-induced diabetes in mice. Physiol Genomics (2011) 1.10

Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis. PLoS One (2010) 1.09

Mechanisms and clinical implications of hepatocyte lipoapoptosis. Clin Lipidol (2010) 1.07

Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration. Elife (2014) 1.06

Elevated liver function enzymes are related to the development of prediabetes and type 2 diabetes in younger adults: the Bogalusa Heart Study. Diabetes Care (2011) 1.05

Stromal cell-derived factor-1 (SDF-1)/chemokine (C-X-C motif) receptor 4 (CXCR4) axis activation induces intra-islet glucagon-like peptide-1 (GLP-1) production and enhances beta cell survival. Diabetologia (2011) 1.05

Metabolically healthy and unhealthy obese--the 2013 Stock Conference report. Obes Rev (2014) 1.04

Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice. Proc Natl Acad Sci U S A (2013) 1.04

The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease. Cell Cycle (2012) 1.00

Cardiac dysfunction and oxidative stress in the metabolic syndrome: an update on antioxidant therapies. Curr Pharm Des (2013) 0.99

Prevention of diabetes with pioglitazone in ACT NOW: physiologic correlates. Diabetes (2013) 0.97

Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis. Liver Int (2013) 0.96

Usefulness of preclinical models for assessing the efficacy of late-life interventions for sarcopenia. J Gerontol A Biol Sci Med Sci (2011) 0.95

The effects of obesity on skeletal muscle regeneration. Front Physiol (2013) 0.93

Subcellular trafficking of the substrate transporters GLUT4 and CD36 in cardiomyocytes. Cell Mol Life Sci (2011) 0.92

miR-375 enhances palmitate-induced lipoapoptosis in insulin-secreting NIT-1 cells by repressing myotrophin (V1) protein expression. Int J Clin Exp Pathol (2010) 0.92

β-cell dysfunction: Its critical role in prevention and management of type 2 diabetes. World J Diabetes (2015) 0.92

Plasma phospholipid very-long-chain saturated fatty acids and incident diabetes in older adults: the Cardiovascular Health Study. Am J Clin Nutr (2015) 0.92

Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis. J Biol Chem (2013) 0.91

Hyperglycemia magnifies Schwann cell dysfunction and cell death triggered by PA-induced lipotoxicity. Brain Res (2010) 0.91

High-fat feeding does not induce an autophagic or apoptotic phenotype in female rat skeletal muscle. Exp Biol Med (Maywood) (2014) 0.89

A functional, genome-wide evaluation of liposensitive yeast identifies the "ARE2 required for viability" (ARV1) gene product as a major component of eukaryotic fatty acid resistance. J Biol Chem (2013) 0.86

Lipid storage by adipose tissue macrophages regulates systemic glucose tolerance. Am J Physiol Endocrinol Metab (2014) 0.85

Targeting adipose tissue in the treatment of obesity-associated diabetes. Nat Rev Drug Discov (2016) 0.83

The effects of α-lipoic acid on liver oxidative stress and free fatty acid composition in methionine-choline deficient diet-induced NAFLD. J Med Food (2013) 0.82

Protective Effects of Oleic Acid Against Palmitic Acid-Induced Apoptosis in Pancreatic AR42J Cells and Its Mechanisms. Korean J Physiol Pharmacol (2013) 0.82

Lipotoxicity and decreased islet graft survival. Diabetes Care (2009) 0.81

Reduction of connexin36 content by ICER-1 contributes to insulin-secreting cells apoptosis induced by oxidized LDL particles. PLoS One (2013) 0.80

Saturated free fatty acid sodium palmitate-induced lipoapoptosis by targeting glycogen synthase kinase-3β activation in human liver cells. Dig Dis Sci (2013) 0.80

Metabolomics in diabetic complications. Mol Biosyst (2016) 0.79

Hop and Acacia Phytochemicals Decreased Lipotoxicity in 3T3-L1 Adipocytes, db/db Mice, and Individuals with Metabolic Syndrome. J Nutr Metab (2010) 0.79

Mesenchymal Stem Cells Ameliorated Glucolipotoxicity in HUVECs through TSG-6. Int J Mol Sci (2016) 0.79

Six-minute walk test in non-insulin-dependent diabetes mellitus patients living in Northwest Africa. Diabetes Metab Syndr Obes (2012) 0.78

Sphingolipid and ceramide homeostasis: potential therapeutic targets. Biochem Res Int (2012) 0.77

Endogenous GLP-1 as a key self-defense molecule against lipotoxicity in pancreatic islets. Int J Mol Med (2015) 0.77

Unexpected severe consequences of Pikfyve deletion by aP2- or Aq-promoter-driven Cre expression for glucose homeostasis and mammary gland development. Physiol Rep (2016) 0.76

Lipid droplet-associated proteins in atherosclerosis (Review). Mol Med Rep (2016) 0.76

Fatty acid transport protein-2 inhibitor Grassofermata/CB5 protects cells against lipid accumulation and toxicity. Biochem Biophys Res Commun (2015) 0.76

Deciphering the Roles of Thiazolidinediones and PPARγ in Bladder Cancer. PPAR Res (2017) 0.75

Gender-specific differences in the development of sarcopenia in the rodent model of the ageing high-fat rat. J Cachexia Sarcopenia Muscle (2015) 0.75

Yap1 plays a protective role in suppressing free fatty acid-induced apoptosis and promoting beta-cell survival. Protein Cell (2016) 0.75

Bayesian parameter estimation for characterizing the cyclic variation of echocardiographic backscatter to assess the hearts of asymptomatic type 2 diabetes mellitus subjects. Ultrasound Med Biol (2011) 0.75

Antiresistin RNA Oligonucleotide Ameliorates Diet-Induced Nonalcoholic Fatty Liver Disease in Mice through Attenuating Proinflammatory Cytokines. Biomed Res Int (2015) 0.75

Differential Effects of Oral and Intravenous Lipid Administration on Key Molecules Related to Energy Homeostasis. J Clin Endocrinol Metab (2016) 0.75

Endotrophin, a multifaceted player in metabolic dysregulation and cancer progression, is a predictive biomarker for the response to PPARγ agonist treatment. Diabetologia (2016) 0.75

Muscle and liver-specific alterations in lipid and acylcarnitine metabolism after a single bout of exercise in mice. Sci Rep (2016) 0.75

Protection of Human Pancreatic Islets from Lipotoxicity by Modulation of the Translocon. PLoS One (2016) 0.75

Adipose tissue, inflammation, and cardiovascular disease. Circ Res (2005) 8.72

Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest (2007) 8.71

Adipose tissue remodeling and obesity. J Clin Invest (2011) 6.12

Bi-directional protein transport between the ER and Golgi. Annu Rev Cell Dev Biol (2004) 6.10

Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem (2003) 5.40

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nat Med (2010) 4.96

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature (2012) 4.84

Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol (2008) 4.75

ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab (2002) 4.64

Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J Biol Chem (2002) 4.60

Adiposity of the heart, revisited. Ann Intern Med (2006) 4.60

Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. J Biol Chem (2005) 4.32

Minireview: The adipocyte--at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology (2003) 4.28

Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes (2007) 4.28

Multiple cargo binding sites on the COPII subunit Sec24p ensure capture of diverse membrane proteins into transport vesicles. Cell (2003) 4.23

Sar1p N-terminal helix initiates membrane curvature and completes the fission of a COPII vesicle. Cell (2005) 3.96

Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Mol Cell Biol (2009) 3.96

Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat Med (2013) 3.86

Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities. J Biol Chem (2001) 3.54

Adiponectin acts in the brain to decrease body weight. Nat Med (2004) 3.47

The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. J Biol Chem (2004) 3.31

Leptin therapy in insulin-deficient type I diabetes. Proc Natl Acad Sci U S A (2010) 3.23

Adipose tissue-derived factors: impact on health and disease. Endocr Rev (2006) 3.16

Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production. J Clin Invest (2003) 3.11

A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology (2003) 3.04

Lipid homeostasis, lipotoxicity and the metabolic syndrome. Biochim Biophys Acta (2009) 2.84

Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy. Nat Med (2005) 2.78

Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization. Endocrinology (2002) 2.72

JNK1 but not JNK2 promotes the development of steatohepatitis in mice. Hepatology (2006) 2.70

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J Clin Invest (2011) 2.68

An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice. Cell Metab (2013) 2.62

Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab (2010) 2.58

Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity. Trends Endocrinol Metab (2010) 2.58

Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes (2003) 2.40

Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking. Nat Genet (2006) 2.39

Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment. J Clin Invest (2005) 2.38

Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion. J Biol Chem (2004) 2.37

Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention. Mol Cell Biol (2007) 2.27

Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization. Oncogene (2003) 2.27

Role of caveolin-1 in the modulation of lipolysis and lipid droplet formation. Diabetes (2004) 2.26

The genetic basis of a craniofacial disease provides insight into COPII coat assembly. Dev Cell (2007) 2.26

Dichotomous effects of VEGF-A on adipose tissue dysfunction. Proc Natl Acad Sci U S A (2012) 2.24

Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation. Mol Cell Biol (2003) 2.22

The adipocyte as an endocrine cell. Endocrinol Metab Clin North Am (2008) 2.20

Consuming fructose-sweetened beverages increases body adiposity in mice. Obes Res (2005) 2.18

Adipokines as novel biomarkers and regulators of the metabolic syndrome. Ann N Y Acad Sci (2010) 2.16

A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome. Diabetes (2002) 2.15

MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity. Nat Med (2012) 2.13

Making insulin-deficient type 1 diabetic rodents thrive without insulin. Proc Natl Acad Sci U S A (2008) 2.12

Lipoapoptosis: its mechanism and its diseases. Biochim Biophys Acta (2002) 2.10

Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice. Diabetes (2011) 2.08

Fibrosis and adipose tissue dysfunction. Cell Metab (2013) 2.07

Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue. Am J Physiol Cell Physiol (2003) 2.06

Rapid transformation of white adipocytes into fat-oxidizing machines. Proc Natl Acad Sci U S A (2004) 2.03

C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists. Mol Cell Biol (2009) 1.98

Forgotten but not gone: the rediscovery of fatty heart, the most common unrecognized disease in America. Circ Res (2007) 1.97

Plasma adiponectin complexes have distinct biochemical characteristics. Endocrinology (2008) 1.94

Targeted deletion of adipocytes by apoptosis leads to adipose tissue recruitment of alternatively activated M2 macrophages. Endocrinology (2011) 1.94

Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes. Diabetes Care (2007) 1.91

Adiponectin: systemic contributor to insulin sensitivity. Curr Diab Rep (2003) 1.90

The transcriptional response of the islet to pregnancy in mice. Mol Endocrinol (2009) 1.89

Adiponectin in health and disease: evaluation of adiponectin-targeted drug development strategies. Trends Pharmacol Sci (2009) 1.89

Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome. Proc Natl Acad Sci U S A (2008) 1.89

Myofibroblasts in murine cutaneous fibrosis originate from adiponectin-positive intradermal progenitors. Arthritis Rheumatol (2015) 1.85

Role of resistin in diet-induced hepatic insulin resistance. J Clin Invest (2004) 1.83

The adipocyte as an important target cell for Trypanosoma cruzi infection. J Biol Chem (2005) 1.82

Paracrinology of islets and the paracrinopathy of diabetes. Proc Natl Acad Sci U S A (2010) 1.79

Disulfide-dependent multimeric assembly of resistin family hormones. Science (2004) 1.76

Mechanisms of obesity and related pathologies: the macro- and microcirculation of adipose tissue. FEBS J (2009) 1.73

Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3. Proc Natl Acad Sci U S A (2002) 1.73

Enhanced metabolic flexibility associated with elevated adiponectin levels. Am J Pathol (2010) 1.72

Identification and characterization of a promoter cassette conferring adipocyte-specific gene expression. Endocrinology (2010) 1.71

Coordination of COPII vesicle trafficking by Sec23. Trends Cell Biol (2008) 1.70

Within-individual stability of obesity-related biomarkers among women. Cancer Epidemiol Biomarkers Prev (2007) 1.67

Adipocyte-derived factors potentiate nutrient-induced production of plasminogen activator inhibitor-1 by macrophages. Sci Transl Med (2010) 1.67

Role of caveolin and caveolae in insulin signaling and diabetes. Am J Physiol Endocrinol Metab (2003) 1.66

Paracrine and endocrine effects of adipose tissue on cancer development and progression. Endocr Rev (2011) 1.65

Systemic fate of the adipocyte-derived factor adiponectin. Diabetes (2009) 1.65

Selective downregulation of the high molecular weight form of adiponectin in hyperinsulinemia and in type 2 diabetes: differential regulation from nondiabetic subjects. Diabetes (2007) 1.63

ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity. Diabetes (2006) 1.62

Adipocyte metabolism and obesity. J Lipid Res (2008) 1.62

Adiponectin, cardiovascular function, and hypertension. Hypertension (2007) 1.61

ATR/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis' three sites of entry: implications for the pathogenesis of anthrax infection. Am J Physiol Cell Physiol (2005) 1.61

A proteomic approach for identification of secreted proteins during the differentiation of 3T3-L1 preadipocytes to adipocytes. Mol Cell Proteomics (2002) 1.61

Mechanisms of early insulin-sensitizing effects of thiazolidinediones in type 2 diabetes. Diabetes (2004) 1.60

Adiponectin, driver or passenger on the road to insulin sensitivity? Mol Metab (2013) 1.58

Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo. Clin Cancer Res (2009) 1.58

Sec16p potentiates the action of COPII proteins to bud transport vesicles. J Cell Biol (2002) 1.55

Adipocyte-derived endotrophin promotes malignant tumor progression. J Clin Invest (2012) 1.55

Uncoupled packaging of amyloid precursor protein and presenilin 1 into coat protein complex II vesicles. J Biol Chem (2004) 1.52

Exomer: A coat complex for transport of select membrane proteins from the trans-Golgi network to the plasma membrane in yeast. J Cell Biol (2006) 1.52

Fat storage in adipocytes requires inactivation of leptin's paracrine activity: implications for treatment of human obesity. Proc Natl Acad Sci U S A (2005) 1.52

Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: a new genetically tractable model for human cancer associated fibroblasts. Cancer Biol Ther (2011) 1.48

Iatrogenic hyperinsulinemia in type 1 diabetes: its effect on atherogenic risk markers. J Diabetes Complications (2012) 1.48

Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling. J Clin Invest (2011) 1.46

Weight loss and incretin responsiveness improve glucose control independently after gastric bypass surgery. J Diabetes (2010) 1.46