Published in Cancer Res on July 03, 2014
BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages. Nat Commun (2015) 1.16
Hsp70 in cancer: back to the future. Oncogene (2014) 1.03
BAG3: a new player in the heart failure paradigm. Heart Fail Rev (2015) 0.98
The human HSP70 family of chaperones: where do we stand? Cell Stress Chaperones (2016) 0.95
Chemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease. Cell Chem Biol (2016) 0.92
Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther (2015) 0.90
A Synthetic Cell-Penetrating Dominant-Negative ATF5 Peptide Exerts Anticancer Activity against a Broad Spectrum of Treatment-Resistant Cancers. Clin Cancer Res (2016) 0.85
Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis. Oncogene (2015) 0.84
Estrogen receptor α regulates non-canonical autophagy that provides stress resistance to neuroblastoma and breast cancer cells and involves BAG3 function. Cell Death Dis (2015) 0.83
Dynamical Structures of Hsp70 and Hsp70-Hsp40 Complexes. Structure (2016) 0.81
Heat Shock Proteins Promote Cancer: It's a Protection Racket. Trends Biochem Sci (2016) 0.80
The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics. Hum Mol Genet (2015) 0.80
HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors. Cancer Res (2016) 0.79
BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins. J Mol Biol (2016) 0.79
A Role for the Chaperone Complex BAG3-HSPB8 in Actin Dynamics, Spindle Orientation and Proper Chromosome Segregation during Mitosis. PLoS Genet (2015) 0.79
Hallmarks of therapeutic management of the cystic fibrosis functional landscape. J Cyst Fibros (2015) 0.79
Characterization of three human cell line models for high-throughput neuronal cytotoxicity screening. J Appl Toxicol (2016) 0.77
Heat shock proteins and cancer: intracellular chaperones or extracellular signalling ligands? Philos Trans R Soc Lond B Biol Sci (2018) 0.76
Expression of TMEM207 in Colorectal Cancer: Relation between TMEM207 and Intelectin-1. J Cancer (2016) 0.76
Molecular Chaperone Accumulation in Cancer and Decrease in Alzheimer's Disease: The Potential Roles of HSF1. Front Neurosci (2017) 0.75
Knockdown of BAG3 sensitizes bladder cancer cells to treatment with the BH3 mimetic ABT-737. World J Urol (2015) 0.75
Fine-tuning of actin dynamics by the HSPB8-BAG3 chaperone complex facilitates cytokinesis and contributes to its impact on cell division. Cell Stress Chaperones (2017) 0.75
Allosteric heat shock protein 70 inhibitors block hepatitis C virus assembly. Int J Antimicrob Agents (2016) 0.75
Heat shock protein 70 regulates platelet integrin activation, granule secretion and aggregation. Am J Physiol Cell Physiol (2016) 0.75
Anticancer Effects of Targeting Hsp70 in Tumor Stromal Cells. Cancer Res (2016) 0.75
Therapeutic Strategies for Restoring Tau Homeostasis. Cold Spring Harb Perspect Med (2017) 0.75
The Role of the Multifunctional BAG3 Protein in Cellular Protein Quality Control and in Disease. Front Mol Neurosci (2017) 0.75
Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach. Int J Mol Sci (2017) 0.75
Hallmarks of cancer: the next generation. Cell (2011) 140.01
Principles of cancer therapy: oncogene and non-oncogene addiction. Cell (2009) 10.96
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol (2000) 5.24
Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones (2005) 5.22
Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase. Mol Cell Biol (2005) 4.80
Heat shock proteins in cancer: chaperones of tumorigenesis. Trends Biochem Sci (2006) 4.04
Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties. Cell Cycle (2006) 3.21
Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene (2004) 2.81
Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transduction. Biochem J (2005) 2.79
A small molecule inhibitor of inducible heat shock protein 70. Mol Cell (2009) 2.63
Molecular chaperone targeting and regulation by BAG family proteins. Nat Cell Biol (2001) 2.61
Posttranscriptional regulation of cancer traits by HuR. Wiley Interdiscip Rev RNA (2010) 2.59
Molecular chaperones and the stress of oncogenesis. Oncogene (2004) 2.51
Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat Chem Biol (2006) 2.47
Genomic instability and enhanced radiosensitivity in Hsp70.1- and Hsp70.3-deficient mice. Mol Cell Biol (2004) 2.05
HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy. J Biol Chem (2007) 2.02
WW domains provide a platform for the assembly of multiprotein networks. Mol Cell Biol (2005) 1.97
Chemical screens against a reconstituted multiprotein complex: myricetin blocks DnaJ regulation of DnaK through an allosteric mechanism. Chem Biol (2011) 1.89
Mechanisms of cellular senescence in human and mouse cells. Biogerontology (2004) 1.76
BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins. EMBO Rep (2011) 1.73
A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells. Cancer Chemother Pharmacol (2009) 1.72
Anoikis resistance: an essential prerequisite for tumor metastasis. Int J Cell Biol (2012) 1.67
FOX(M1) news--it is cancer. Mol Cancer Ther (2013) 1.64
Hsp70 and Hsp40 chaperone activities in the cytoplasm and the nucleus of mammalian cells. J Biol Chem (1997) 1.63
Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones. J Mol Biol (2011) 1.49
BAG3 regulates motility and adhesion of epithelial cancer cells. Cancer Res (2007) 1.49
CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70. Oncogene (2000) 1.47
Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy. Curr Biol (2013) 1.43
Heat shock protein Hsp72 controls oncogene-induced senescence pathways in cancer cells. Mol Cell Biol (2008) 1.37
Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Nat Chem Biol (2012) 1.37
IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth. Proc Natl Acad Sci U S A (2010) 1.36
Peptides and aptamers targeting HSP70: a novel approach for anticancer chemotherapy. Cancer Res (2011) 1.32
High levels of heat shock protein Hsp72 in cancer cells suppress default senescence pathways. Cancer Res (2007) 1.24
Induction of heat shock protein 70 inhibits ischemic renal injury. Kidney Int (2011) 1.22
HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells. Mol Cancer Res (2011) 1.21
CAIR-1/BAG-3 modulates cell adhesion and migration by downregulating activity of focal adhesion proteins. Exp Cell Res (2006) 1.14
Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein. Chem Biol (2013) 1.12
Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70. Chem Biol (2012) 1.10
Activation of nuclear factor kappaB in radioresistance of TP53-inactive human keratinocytes. Cancer Res (2002) 1.08
Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis. Oncogene (2011) 1.06
Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators. Proc Natl Acad Sci U S A (2011) 1.02
On the role of hsp72 in heat-induced intranuclear protein aggregation. Int J Hyperthermia (1995) 1.01
Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR. Mol Cell Biol (2012) 0.98
The role of heat shock protein 70 in mediating age-dependent mortality in sepsis. J Immunol (2011) 0.98
BAG3 (BCL2-associated athanogene 3) interacts with MMP-2 to positively regulate invasion by ovarian carcinoma cells. Cancer Lett (2011) 0.98
Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. Mol Cell Proteomics (2013) 0.98
The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype. Aging Cell (2012) 0.96
BAG3 expression in glioblastoma cells promotes accumulation of ubiquitinated clients in an Hsp70-dependent manner. J Biol Chem (2011) 0.95
c-Abl tyrosine kinase in the DNA damage response: cell death and more. Cell Death Differ (2011) 0.95