Published in Mol Cell Biol on January 03, 2012
Multiple functions of the RNA-binding protein HuR in cancer progression, treatment responses and prognosis. Int J Mol Sci (2013) 1.28
Hsp70-Bag3 interactions regulate cancer-related signaling networks. Cancer Res (2014) 1.06
Heat shock factor Hsf1 cooperates with ErbB2 (Her2/Neu) protein to promote mammary tumorigenesis and metastasis. J Biol Chem (2012) 1.05
HSF1: Guardian of Proteostasis in Cancer. Trends Cell Biol (2015) 0.94
Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells. Oncogene (2014) 0.93
HSF1 regulation of β-catenin in mammary cancer cells through control of HuR/elavL1 expression. Oncogene (2014) 0.92
Overexpression of Heat Shock Transcription Factor 1 enhances the resistance of melanoma cells to doxorubicin and paclitaxel. BMC Cancer (2013) 0.81
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HuR: a promising therapeutic target for angiogenesis. Gland Surg (2014) 0.80
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Withaferin a induces proteasome-dependent degradation of breast cancer susceptibility gene 1 and heat shock factor 1 proteins in breast cancer cells. ISRN Biochem (2012) 0.76
Defective heat shock factor 1 inhibits the growth of fibrosarcoma derived from simian virus 40/T antigen‑transformed MEF cells. Mol Med Rep (2015) 0.75
Heat shock factor 2 is associated with the occurrence of lung cancer by enhancing the expression of heat shock proteins. Oncol Lett (2016) 0.75
Overexpression of heat-shock factor 1 is associated with a poor prognosis in esophageal squamous cell carcinoma. Oncol Lett (2017) 0.75
Post-transcriptional regulation of cytokine and growth factor signaling in cancer. Cytokine Growth Factor Rev (2016) 0.75
Current Evidence and Future Perspectives on HuR and Breast Cancer Development, Prognosis, and Treatment. Neoplasia (2016) 0.75
Proteotoxicity is not the reason for the dependence of cancer cells on the major chaperone Hsp70. Cell Cycle (2014) 0.75
Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases. Mol Cell Biol (2016) 0.75
Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet (2009) 16.58
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell (2007) 8.84
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Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene (2009) 8.01
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The signals and pathways activating cellular senescence. Int J Biochem Cell Biol (2004) 5.00
Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J (2001) 4.74
Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol (2006) 4.71
Hypoxia-inducible factors: central regulators of the tumor phenotype. Curr Opin Genet Dev (2007) 4.46
Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis. J Biol Chem (1998) 4.15
HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice. EMBO J (1999) 3.80
Non-oncogene addiction and the stress phenotype of cancer cells. Cell (2007) 3.19
Role of the RNA-binding protein HuR in colon carcinogenesis. Oncogene (2003) 2.69
A microRNA component of the hypoxic response. Cell Death Differ (2008) 2.59
HuR: post-transcriptional paths to malignancy. RNA Biol (2005) 2.38
Posttranscriptional orchestration of an anti-apoptotic program by HuR. Cell Cycle (2007) 2.25
RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. Mol Cell Biol (2007) 2.20
Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways. J Clin Invest (2005) 2.06
Genomic instability and enhanced radiosensitivity in Hsp70.1- and Hsp70.3-deficient mice. Mol Cell Biol (2004) 2.05
Oncogene-induced senescence: putting the brakes on tumor development. Cancer Res (2006) 2.04
Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent. Proc Natl Acad Sci U S A (2001) 1.96
Selective suppression of lymphomas by functional loss of Hsf1 in a p53-deficient mouse model for spontaneous tumors. Oncogene (2007) 1.95
Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors. Cancer Res (2006) 1.64
Induction of heat shock proteins by heregulin beta1 leads to protection from apoptosis and anchorage-independent growth. Oncogene (2005) 1.64
HIF at a glance. J Cell Sci (2009) 1.55
Genome-wide analysis of human HSF1 signaling reveals a transcriptional program linked to cellular adaptation and survival. Mol Biosyst (2006) 1.47
Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis. Oncogene (2010) 1.45
Heat shock protein Hsp72 controls oncogene-induced senescence pathways in cancer cells. Mol Cell Biol (2008) 1.37
Synergistic interaction of the Neu proto-oncogene product and transforming growth factor alpha in the mammary epithelium of transgenic mice. Mol Cell Biol (1996) 1.36
Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosis. Mol Cell Biol (2002) 1.17
Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis. Oncogene (2011) 1.06
Induction of the heat shock pathway during hypoxia requires regulation of heat shock factor by hypoxia-inducible factor-1. J Biol Chem (2006) 1.02
Differential oncogenic Ras signaling and senescence in tumor cells. Cell Cycle (2004) 0.96
Role of the RNA-binding protein HuR in human renal cell carcinoma. Carcinogenesis (2010) 0.94
A novel mechanism for chaperone-mediated telomerase regulation during prostate cancer progression. Cancer Res (2001) 0.89
Regulation of transcription of hypoxia-inducible factor-1α (HIF-1α) by heat shock factors HSF2 and HSF4. Oncogene (2011) 0.87
Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice. Cell (2007) 3.54
Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1. J Cell Biol (2002) 2.76
Autophagy is an adaptive response in desmin-related cardiomyopathy. Proc Natl Acad Sci U S A (2008) 2.07
A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo. Proc Natl Acad Sci U S A (2005) 1.88
Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factor. Genes Dev (2008) 1.78
Modulation of prion formation, aggregation, and toxicity by the actin cytoskeleton in yeast. Mol Cell Biol (2006) 1.77
Abnormal proteins can form aggresome in yeast: aggresome-targeting signals and components of the machinery. FASEB J (2008) 1.74
Involvement of reductive stress in the cardiomyopathy in transgenic mice with cardiac-specific overexpression of heat shock protein 27. Hypertension (2010) 1.73
Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors. Cancer Res (2006) 1.64
Induction of heat shock proteins by heregulin beta1 leads to protection from apoptosis and anchorage-independent growth. Oncogene (2005) 1.64
Localized recruitment of a chromatin-remodeling activity by an activator in vivo drives transcriptional elongation. Genes Dev (2003) 1.61
Heat shock factor 1 and heat shock proteins: critical partners in protection against acute cell injury. Crit Care Med (2002) 1.58
Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage. EMBO J (2002) 1.58
Selective degradation of aggregate-prone CryAB mutants by HSPB1 is mediated by ubiquitin-proteasome pathways. J Mol Cell Cardiol (2010) 1.54
OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells. Mol Pharmacol (2008) 1.52
Malfolded protein structure and proteostasis in lung diseases. Am J Respir Crit Care Med (2014) 1.47
Modulation of prion-dependent polyglutamine aggregation and toxicity by chaperone proteins in the yeast model. J Biol Chem (2005) 1.46
Small heat shock proteins: a new classification scheme in mammals. J Mol Cell Cardiol (2005) 1.38
Heat shock protein Hsp72 controls oncogene-induced senescence pathways in cancer cells. Mol Cell Biol (2008) 1.37
Invited review: Interplay between molecular chaperones and signaling pathways in survival of heat shock. J Appl Physiol (1985) (2002) 1.32
Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1. J Immunol (2005) 1.28
Triggering aggresome formation. Dissecting aggresome-targeting and aggregation signals in synphilin 1. J Biol Chem (2008) 1.26
High levels of heat shock protein Hsp72 in cancer cells suppress default senescence pathways. Cancer Res (2007) 1.24
Hsp27 modulates p53 signaling and suppresses cellular senescence. Cancer Res (2007) 1.22
Induction of heat shock protein 70 inhibits ischemic renal injury. Kidney Int (2011) 1.22
Endocytosis machinery is involved in aggregation of proteins with expanded polyglutamine domains. FASEB J (2007) 1.22
Aggregation of expanded polyglutamine domain in yeast leads to defects in endocytosis. Mol Cell Biol (2003) 1.21
Increased expression of the major heat shock protein Hsp72 in human prostate carcinoma cells is dispensable for their viability but confers resistance to a variety of anticancer agents. Oncogene (2005) 1.18
Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosis. Mol Cell Biol (2002) 1.17
Glutathione-dependent reductive stress triggers mitochondrial oxidation and cytotoxicity. FASEB J (2011) 1.16
Heat shock transcription factor 2 is not essential for embryonic development, fertility, or adult cognitive and psychomotor function in mice. Mol Cell Biol (2002) 1.15
Heat shock co-activates interleukin-8 transcription. Am J Respir Cell Mol Biol (2008) 1.12
Immobilization of MP-11 into a mesoporous metal-organic framework, MP-11@mesoMOF: a new platform for enzymatic catalysis. J Am Chem Soc (2011) 1.11
Stereocontrolled synthesis of a complex library via elaboration of angular epoxyquinol scaffolds. J Org Chem (2005) 1.07
Characterization of proteins associated with polyglutamine aggregates: a novel approach towards isolation of aggregates from protein conformation disorders. Prion (2007) 1.06
Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice. Antioxid Redox Signal (2011) 1.06
Heat shock proteins in mammalian development. Semin Cell Dev Biol (2003) 1.04
Febrile-range temperature modifies cytokine gene expression in LPS-stimulated macrophages by differentially modifying NF-{kappa}B recruitment to cytokine gene promoters. Am J Physiol Cell Physiol (2009) 1.00
Molecular determinants of selective clearance of protein inclusions by autophagy. Nat Commun (2012) 1.00
Oncogenes induce senescence with incomplete growth arrest and suppress the DNA damage response in immortalized cells. Aging Cell (2011) 0.99
Small heat shock proteins in redox metabolism: implications for cardiovascular diseases. Int J Biochem Cell Biol (2012) 0.99
Persistence of the bacterial pathogen Granulibacter bethesdensis in chronic granulomatous disease monocytes and macrophages lacking a functional NADPH oxidase. J Immunol (2013) 0.98
Polyglutamine toxicity is controlled by prion composition and gene dosage in yeast. PLoS Genet (2012) 0.98
Induction of KLF4 in response to heat stress. Cell Stress Chaperones (2006) 0.97
HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway. Chem Biol (2011) 0.96
The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype. Aging Cell (2012) 0.96
CRYAB and HSPB2 deficiency increases myocyte mitochondrial permeability transition and mitochondrial calcium uptake. J Mol Cell Cardiol (2006) 0.96
Triggering senescence programs suppresses Chk1 kinase and sensitizes cells to genotoxic stresses. Cancer Res (2008) 0.95
Inactivation of dual-specificity phosphatases is involved in the regulation of extracellular signal-regulated kinases by heat shock and hsp72. Mol Cell Biol (2003) 0.94
Proteostasis and REDOX state in the heart. Am J Physiol Heart Circ Physiol (2011) 0.93
Proteasome failure promotes positioning of lysosomes around the aggresome via local block of microtubule-dependent transport. Mol Cell Biol (2014) 0.92
Heat shock transcription factor (HSF1) plays a critical role in cell migration via maintaining MAP kinase signaling. Cell Cycle (2006) 0.91
Unmasking different mechanical and energetic roles for the small heat shock proteins CryAB and HSPB2 using genetically modified mouse hearts. FASEB J (2007) 0.90
Regulation of necrosis of H9c2 myogenic cells upon transient energy deprivation. Rapid deenergization of mitochondria precedes necrosis and is controlled by reactive oxygen species, stress kinase JNK, HSP72 and ARC. J Biol Chem (2003) 0.90
Heat shock factor 1-deficient mice exhibit decreased recovery of hearing following noise overstimulation. J Neurosci Res (2005) 0.89
Targeting endoglin, an auxiliary transforming growth factor β coreceptor, to prevent fibrosis and heart failure. Circulation (2012) 0.88
Global expression profiling identifies a novel biosignature for protein aggregation R120GCryAB cardiomyopathy in mice. Physiol Genomics (2008) 0.87
Reductive stress linked to small HSPs, G6PD, and Nrf2 pathways in heart disease. Antioxid Redox Signal (2012) 0.87
Heat shock factor 1-independent activation of dendritic cells by heat shock: implication for the uncoupling of heat-mediated immunoregulation from the heat shock response. Eur J Immunol (2003) 0.87
Association of translation factor eEF1A with defective ribosomal products generates a signal for aggresome formation. J Cell Sci (2012) 0.85
Mouse HSF1 disruption perturbs redox state and increases mitochondrial oxidative stress in kidney. Antioxid Redox Signal (2005) 0.84
A novel approach to recovery of function of mutant proteins by slowing down translation. J Biol Chem (2012) 0.83
Stress pathways in the rat cochlea and potential for protection from acquired deafness. Audiol Neurootol (2002) 0.82
Use of Hsf1(-/-) mice reveals an essential role for HSF1 to protect lung against cadmium-induced injury. Toxicol Appl Pharmacol (2003) 0.82
HSPB2 is dispensable for the cardiac hypertrophic response but reduces mitochondrial energetics following pressure overload in mice. PLoS One (2012) 0.82
Molecular stress-inducing compounds increase osteoclast formation in a heat shock factor 1 protein-dependent manner. J Biol Chem (2014) 0.81
RANK ligand expression in heat shock factor-2 deficient mouse bone marrow stromal/preosteoblast cells. J Cell Biochem (2006) 0.81
Viewing a stressful episode of ER: is ATF6 the triage nurse? Circ Res (2006) 0.80
Reductive stress on life span extension in C. elegans. BMC Res Notes (2008) 0.79
Discovering the full spectrum of cardiovascular disease: Minority Health Summit 2003: report of the Basic Science Writing Group. Circulation (2005) 0.79
Aggregate-prone R120GCRYAB triggers multifaceted modifications of the thioredoxin system. Antioxid Redox Signal (2014) 0.79
Isolation of aggresomes and other large aggregates. Curr Protoc Cell Biol (2010) 0.79
Workflow for combined proteomics and glycomics profiling from histological tissues. Anal Chem (2014) 0.78
The stress or heat shock (HS) response: insights from transgenic mouse models. Methods (2004) 0.78
Proteotoxic stress targeted therapy (PSTT). Oncotarget (2011) 0.78
Exercise, estrogen, and ischemic cardioprotection by heat shock protein 70. Circ Res (2002) 0.78
Synchronous electrosynthesis of poly(xanthurenic acid)-reduced graphene oxide nanocomposite for highly sensitive impedimetric detection of DNA. ACS Appl Mater Interfaces (2013) 0.77
Graphene-based polyaniline arrays for deoxyribonucleic acid electrochemical sensor: effect of nanostructure on sensitivity. ACS Appl Mater Interfaces (2014) 0.77
Three-dimensional porous metal-metalloporphyrin framework consisting of nanoscopic polyhedral cages. J Am Chem Soc (2011) 0.77
Porous double-walled metal triazolate framework based upon a bifunctional ligand and a pentanuclear zinc cluster exhibiting selective CO2 uptake. Inorg Chem (2012) 0.76
Direct and freely switchable detection of target genes engineered by reduced graphene oxide-poly(m-aminobenzenesulfonic acid) nanocomposite via synchronous pulse electrosynthesis. Anal Chem (2013) 0.76
The NADPH metabolic network regulates human αB-crystallin cardiomyopathy and reductive stress in Drosophila melanogaster. PLoS Genet (2013) 0.76
A murine world without HSFs: meeting report. Cell Stress Chaperones (2005) 0.75
Direct electrochemical DNA detection originated from the self-redox signal of sulfonated polyaniline enhanced by graphene oxide in neutral solution. ACS Appl Mater Interfaces (2013) 0.75
Quest for a highly connected robust porous metal-organic framework on the basis of a bifunctional linear linker and a rare heptanuclear zinc cluster. Chem Commun (Camb) (2013) 0.75