Published in Int J Mol Sci on July 08, 2014
Therapies targeting cancer stem cells: Current trends and future challenges. World J Stem Cells (2015) 0.82
Correlation of GOLPH3 Gene with Wnt Signaling Pathway in Human Colon Cancer Cells. J Cancer (2016) 0.80
Let-7c blocks estrogen-activated Wnt signaling in induction of self-renewal of breast cancer stem cells. Cancer Gene Ther (2016) 0.80
Subpathway Analysis based on Signaling-Pathway Impact Analysis of Signaling Pathway. PLoS One (2015) 0.77
Derricin and derricidin inhibit Wnt/β-catenin signaling and suppress colon cancer cell growth in vitro. PLoS One (2015) 0.77
Filtered selection coupled with support vector machines generate a functionally relevant prediction model for colorectal cancer. Onco Targets Ther (2016) 0.75
AZ1366: An inhibitor of tankyrase and the canonical Wnt pathway that limits the persistence of non-small cell lung cancer cells following EGFR inhibition. Clin Cancer Res (2016) 0.75
The Effect of (1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-Olide (LS-1) from Lobophyyum sp. on the Apoptosis Induction of SNU-C5 Human Colorectal Cancer Cells. Biomol Ther (Seoul) (2016) 0.75
Triphala Extract Suppresses Proliferation and Induces Apoptosis in Human Colon Cancer Stem Cells via Suppressing c-Myc/Cyclin D1 and Elevation of Bax/Bcl-2 Ratio. Biomed Res Int (2015) 0.75
Comprehensive molecular characterization of human colon and rectal cancer. Nature (2012) 34.13
The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol (2004) 24.63
Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell (2009) 18.31
Identification and characterization of the familial adenomatous polyposis coli gene. Cell (1991) 14.46
Molecular origins of cancer: Molecular basis of colorectal cancer. N Engl J Med (2009) 10.01
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature (2009) 9.15
Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer (2003) 8.06
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell (2003) 7.93
Advances in flavonoid research since 1992. Phytochemistry (2000) 7.78
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol (2010) 7.73
The evolving role of natural products in drug discovery. Nat Rev Drug Discov (2005) 7.18
Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem (2006) 6.32
Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. Cancer Res (1998) 5.80
Flavonoids: a review of probable mechanisms of action and potential applications. Am J Clin Nutr (2001) 5.17
Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Cancer Cell (2004) 4.98
Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol (2006) 4.69
Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr (2003) 4.15
A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]. Proc Natl Acad Sci U S A (2004) 3.95
Lessons from natural molecules. Nature (2004) 3.95
Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat Rev Cancer (2009) 3.90
The diagnostic value of symptoms for colorectal cancer in primary care: a systematic review. Br J Gen Pract (2011) 3.79
The Wnts. Genome Biol (2001) 2.90
4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1. J Med Chem (2008) 2.89
Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α. Nat Chem Biol (2010) 2.71
The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history. Proc Natl Acad Sci U S A (1998) 2.27
Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas. Cancer Res (1999) 2.09
Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer. Cancer Res (2004) 2.09
A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Res (2010) 2.05
Cancer prevention with natural compounds. Semin Oncol (2010) 1.98
Identification of a specific inhibitor of the dishevelled PDZ domain. Biochemistry (2005) 1.92
An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc Natl Acad Sci U S A (2011) 1.92
Cancer preventive effects of flavonoids--a review. Biomed Pharmacother (2002) 1.90
Types of alternative medicine used by patients with breast, colon, or prostate cancer: predictors, motives, and costs. J Altern Complement Med (2002) 1.85
Multitargeted cancer prevention by quercetin. Cancer Lett (2008) 1.79
Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells. Biochem Biophys Res Commun (2005) 1.78
An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth. Cancer Res (2007) 1.73
Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea. Cancer Res (2005) 1.72
A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res (2012) 1.70
Inhibition of Wnt signaling by Dishevelled PDZ peptides. Nat Chem Biol (2009) 1.65
The APC gene in colorectal cancer. Eur J Cancer (2002) 1.55
Mutations in beta-catenin are uncommon in colorectal cancer occurring in occasional replication error-positive tumors. Cancer Res (1997) 1.52
Retracted Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia. Blood (2006) 1.49
Frequent frameshift mutations of the TCF-4 gene in colorectal cancers with microsatellite instability. Cancer Res (1999) 1.46
Wnt/beta-catenin signaling and small molecule inhibitors. Curr Pharm Des (2013) 1.44
Herb-drug interactions in oncology: focus on mechanisms of induction. Oncologist (2006) 1.43
A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth. Cancer Res (2013) 1.38
Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled. J Biol Chem (2009) 1.34
Potential synergism of natural products in the treatment of cancer. Phytother Res (2006) 1.32
Suppression of Wnt signaling by the green tea compound (-)-epigallocatechin 3-gallate (EGCG) in invasive breast cancer cells. Requirement of the transcriptional repressor HBP1. J Biol Chem (2006) 1.28
A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesis. Cell Res (2011) 1.27
Structural basis of selective inhibition of human tankyrases. J Med Chem (2012) 1.25
Cell signaling pathways altered by natural chemopreventive agents. Mutat Res (2004) 1.23
Efficacy of selected natural products as therapeutic agents against cancer. J Nat Prod (2008) 1.17
Cancer prevention -- the potential for diet to modulate molecular signalling. Trends Mol Med (2003) 1.13
Silibinin suppresses growth of human colorectal carcinoma SW480 cells in culture and xenograft through down-regulation of beta-catenin-dependent signaling. Neoplasia (2010) 1.12
Hepatitis B viral X protein interacts with tumor suppressor adenomatous polyposis coli to activate Wnt/β-catenin signaling. Cancer Lett (2010) 1.07
Promoter demethylation of WIF-1 by epigallocatechin-3-gallate in lung cancer cells. Anticancer Res (2009) 1.02
Impact of quercetin and EGCG on key elements of the Wnt pathway in human colon carcinoma cells. J Agric Food Chem (2006) 1.02
Structure-based discovery of a novel inhibitor targeting the β-catenin/Tcf4 interaction. Biochemistry (2012) 1.00
Cyclopamine and quercetin suppress the growth of leukemia and lymphoma cells. Anticancer Res (2009) 0.99
Phytochemicals and cancer. Proc Nutr Soc (2007) 0.98
Chemistry and utilization of phenylpropanoids including flavonoids, coumarins, and lignans. J Agric Food Chem (1980) 0.97
Dietary flavonoids as cancer prevention agents. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (2011) 0.96
[1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding. J Med Chem (2012) 0.95
Flavonoids: potential Wnt/beta-catenin signaling modulators in cancer. Life Sci (2011) 0.94
Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells. Toxicology (2013) 0.92
Selective small molecule targeting β-catenin function discovered by in vivo chemical genetic screen. Cell Rep (2013) 0.92
The case for population-based screening for colorectal cancer. Nat Rev Cancer (2002) 0.91
Isoquercitrin isolated from Hyptis fasciculata reduces glioblastoma cell proliferation and changes beta-catenin cellular localization. Anticancer Drugs (2009) 0.91
Potential targets for colorectal cancer prevention. Int J Mol Sci (2013) 0.89
Inhibition of beta-catenin/Tcf signaling by flavonoids. J Cell Biochem (2010) 0.88
Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem (2013) 0.88
Citrus flavonoids luteolin, apigenin, and quercetin inhibit glycogen synthase kinase-3β enzymatic activity by lowering the interaction energy within the binding cavity. J Med Food (2011) 0.86
WIF-1 promoter region hypermethylation as an adjuvant diagnostic marker for non-small cell lung cancer-related malignant pleural effusions. J Cancer Res Clin Oncol (2008) 0.85
Effects of natural compounds on Xenopus embryogenesis: a potential read out for functional drug discovery targeting Wnt/β-catenin signaling. Curr Top Med Chem (2012) 0.85
Inhibition of tumorigenesis in ApcMin/+ mice by a combination of (-)-epigallocatechin-3-gallate and fish oil. J Agric Food Chem (2007) 0.83
Effects of combination of notch inhibitor plus hedgehog inhibitor or Wnt inhibitor on growth of leukemia cells. Anticancer Res (2011) 0.83
Targeting the Tcf4 G13ANDE17 binding site to selectively disrupt β-catenin/T-cell factor protein-protein interactions. ACS Chem Biol (2013) 0.80
Epigallocatechin-3-gallate inhibits hepatoblastoma growth by reactivating the Wnt inhibitor SFRP1. Nutr Cancer (2013) 0.76