IRE1 inhibition perturbs the unfolded protein response in a pancreatic β-cell line expressing mutant proinsulin, but does not sensitize the cells to apoptosis.

PubWeight™: 0.78‹?›

🔗 View Article (PMC 4118655)

Published in BMC Cell Biol on July 10, 2014

Authors

Liling Zhang, Courtney Nosak, Pietro Sollazzo, Tanya Odisho, Allen Volchuk1

Author Affiliations

1: Division of Advanced Diagnostics-Metabolism, Toronto General Research Institute, University Health Network, 101 College Street, TMDT 10-706, Toronto, ON, Canada. allen.volchuk@utoronto.ca.

Articles cited by this

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell (2001) 18.68

Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell (2000) 17.44

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature (1999) 16.97

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature (2002) 16.52

The unfolded protein response: from stress pathway to homeostatic regulation. Science (2011) 15.71

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science (2000) 13.62

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev (1998) 11.86

XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol (2003) 11.17

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol Biol Cell (1999) 9.05

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol (2011) 8.75

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol Cell (2001) 8.60

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol (2003) 7.06

Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion. Diabetes (2000) 6.27

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology (1992) 5.45

Biological and chemical approaches to diseases of proteostasis deficiency. Annu Rev Biochem (2009) 5.23

IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell (2009) 4.65

EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome. Nat Genet (2000) 4.48

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia (2007) 4.30

XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands. EMBO J (2005) 3.92

A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse. J Clin Invest (1999) 3.86

GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress. Cell Metab (2006) 3.28

Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc Natl Acad Sci U S A (2011) 3.20

IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab (2012) 2.80

The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Physiol Rev (2011) 2.50

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc Natl Acad Sci U S A (2012) 2.45

Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metab (2012) 2.39

The transcription factor XBP-1 is essential for the development and survival of dendritic cells. J Exp Med (2007) 2.12

The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology. Physiol Rev (2012) 1.95

Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress. Proc Natl Acad Sci U S A (2009) 1.84

Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma. Blood (2012) 1.81

Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide. Am J Physiol Endocrinol Metab (2007) 1.80

Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion. Proc Natl Acad Sci U S A (2011) 1.59

GRP78, but Not Protein-disulfide Isomerase, Partially Reverses Hyperglycemia-induced Inhibition of Insulin Synthesis and Secretion in Pancreatic {beta}-Cells. J Biol Chem (2008) 1.22

Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene. Rev Endocr Metab Disord (2010) 1.08

The mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseases. Endocr Rev (2012) 1.04

Endoplasmic reticulum stress response in an INS-1 pancreatic beta-cell line with inducible expression of a folding-deficient proinsulin. BMC Cell Biol (2010) 1.00

GRP78 overproduction in pancreatic beta cells protects against high-fat-diet-induced diabetes in mice. Diabetologia (2013) 0.84

Articles by these authors

Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis. Endocrinology (2006) 3.12

Detection and HER2 expression of circulating tumor cells: prospective monitoring in breast cancer patients treated in the neoadjuvant GeparQuattro trial. Clin Cancer Res (2010) 2.66

Pancreatic β-cells depend on basal expression of active ATF6α-p50 for cell survival even under nonstress conditions. Am J Physiol Cell Physiol (2011) 1.58

Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules. Mol Microbiol (2012) 1.05

Endoplasmic reticulum stress response in an INS-1 pancreatic beta-cell line with inducible expression of a folding-deficient proinsulin. BMC Cell Biol (2010) 1.00

Computational models for predicting substrates or inhibitors of P-glycoprotein. Drug Discov Today (2011) 0.98

OASIS/CREB3L1 induces expression of genes involved in extracellular matrix production but not classical endoplasmic reticulum stress response genes in pancreatic beta-cells. Endocrinology (2010) 0.97

Oleanolic acid enhances insulin secretion in pancreatic beta-cells. FEBS Lett (2008) 0.97

Ultrafast and sensitive room temperature NH3 gas sensors based on chemically reduced graphene oxide. Nanotechnology (2013) 0.93

ADMET evaluation in drug discovery. 12. Development of binary classification models for prediction of hERG potassium channel blockage. Mol Pharm (2012) 0.91

Theoretical studies on the susceptibility of oseltamivir against variants of 2009 A/H1N1 influenza neuraminidase. J Chem Inf Model (2012) 0.87

Clinical and prognostic significance of lost or decreased PDCD5 expression in human epithelial ovarian carcinomas. Oncol Rep (2010) 0.85

SDF2L1 interacts with the ER-associated degradation machinery and retards the degradation of mutant proinsulin in pancreatic β-cells. J Cell Sci (2013) 0.85

Discovery of Rho-kinase inhibitors by docking-based virtual screening. Mol Biosyst (2013) 0.84

Investigation of design space for freeze-drying: use of modeling for primary drying segment of a freeze-drying cycle. AAPS PharmSciTech (2011) 0.81

Discovery and optimization of triazine derivatives as ROCK1 inhibitors: molecular docking, molecular dynamics simulations and free energy calculations. Mol Biosyst (2013) 0.80

A novel mutation of RPGR gene in an X-linked Chinese family with retinitis pigmentosa. Mol Genet Metab (2010) 0.79

OASIS/CREB3L1 is induced by endoplasmic reticulum stress in human glioma cell lines and contributes to the unfolded protein response, extracellular matrix production and cell migration. PLoS One (2013) 0.79

Synthetic antibodies as tools to probe RNA-binding protein function. Mol Biosyst (2012) 0.79

Magnetic-field-induced diameter-selective synthesis of single-walled carbon nanotubes. Nanoscale (2012) 0.78

Pyrimidine benzamide-based thrombopoietin receptor agonists. Bioorg Med Chem Lett (2007) 0.77

Detection of circulating tumor cells by RT-PCR significantly associated with poor prognosis in breast cancer. Breast Cancer Res Treat (2011) 0.77

Endoplasmic reticulum redox state is not perturbed by pharmacological or pathological endoplasmic reticulum stress in live pancreatic β-cells. PLoS One (2012) 0.76

The mechanism of proton translocation in respiratory complex I from molecular dynamics. J Recept Signal Transduct Res (2014) 0.76

Depression of reactivity by the collision energy in the single barrier H + CD4 -> HD + CD3 reaction. Proc Natl Acad Sci U S A (2010) 0.75

A rule-based algorithm for automatic bond type perception. J Cheminform (2012) 0.75

Self-templated free-radical polymerization to form tactic chains in confined environment. J Phys Chem B (2013) 0.75

Development of a force field for zeolitic imidazolate framework-8 with structural flexibility. J Chem Phys (2012) 0.75

Rapid solid-phase microwave synthesis of highly photoluminescent nitrogen-doped carbon dots for Fe(3+) detection and cellular bioimaging. Nanotechnology (2016) 0.75

RhoA/ROCK pathway inhibition by fasudil suppresses the vasculogenic mimicry of U2OS osteosarcoma cells in vitro. Anticancer Drugs (2017) 0.75

Insight into the structural requirements of narlaprevir-type inhibitors of NS3/NS4A protease based on HQSAR and molecular field analyses. Comb Chem High Throughput Screen (2012) 0.75

Three-dimensional conductive networks based on stacked SiO2@graphene frameworks for enhanced gas sensing. Nanoscale (2016) 0.75

Controlled synthesis of different metal oxide nanostructures by direct current arc discharge. J Nanosci Nanotechnol (2013) 0.75

Hydrophilic and blue fluorescent N-doped carbon dots from tartaric acid and various alkylol amines under microwave irradiation. Nanoscale (2015) 0.75