Published in J Immunol on July 18, 2014
Human thymic epithelial primary cells produce exosomes carrying tissue-restricted antigens. Immunol Cell Biol (2015) 0.86
The Thymic Orchestration Involving Aire, miRNAs, and Cell-Cell Interactions during the Induction of Central Tolerance. Front Immunol (2015) 0.82
Differential Expression of Inflammation-Related Genes in Children with Down Syndrome. Mediators Inflamm (2016) 0.75
Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem (1996) 45.70
Projection of an immunological self shadow within the thymus by the aire protein. Science (2002) 12.15
Towards a knowledge-based Human Protein Atlas. Nat Biotechnol (2010) 11.05
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat Immunol (2001) 7.30
Exosomes--vesicular carriers for intercellular communication. Curr Opin Cell Biol (2009) 6.96
Aire regulates negative selection of organ-specific T cells. Nat Immunol (2003) 5.85
The cellular mechanism of Aire control of T cell tolerance. Immunity (2005) 4.74
A central role for central tolerance. Annu Rev Immunol (2006) 4.31
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J Exp Med (2005) 4.06
Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med (2007) 2.84
Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance. Blood (2011) 2.25
Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters. J Exp Med (2004) 2.23
Clinical, immunological, and genetic features of autoimmune primary adrenal insufficiency: observations from a Norwegian registry. J Clin Endocrinol Metab (2009) 2.01
Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J Immunol (2005) 1.88
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J Exp Med (2011) 1.87
Thymus exosomes-like particles induce regulatory T cells. J Immunol (2008) 1.73
Highly variable expression of tissue-restricted self-antigens in human thymus: implications for self-tolerance and autoimmunity. Eur J Immunol (2007) 1.67
Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance. J Exp Med (2008) 1.63
Aire-dependent alterations in medullary thymic epithelium indicate a role for Aire in thymic epithelial differentiation. J Immunol (2007) 1.46
Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease. J Neurosci Res (1996) 1.43
A defect of regulatory T cells in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J Immunol (2007) 1.41
Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome. Neurosci Lett (2002) 1.33
Thymic deficiency in Down's syndrome. Pediatrics (1979) 1.23
Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes. J Immunol (2009) 1.13
Modulation of Aire regulates the expression of tissue-restricted antigens. Mol Immunol (2007) 1.07
Characterization of human thymic exosomes. PLoS One (2013) 1.05
Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens. Front Immunol (2012) 1.03
High frequency of celiac disease in Down syndrome. J Pediatr (1996) 1.03
Trisomy 21 (Down's syndrome): autoimmunity, aging and monoclonal antibody-defined T-cell abnormalities. J Autoimmun (1989) 1.02
Insulin alleles and autoimmune regulator (AIRE) gene expression both influence insulin expression in the thymus. J Autoimmun (2005) 0.97
Studies in mice deficient for the autoimmune regulator (Aire) and transgenic for the thyrotropin receptor reveal a role for Aire in tolerance for thyroid autoantigens. Endocrinology (2009) 0.96
Contrasting models for the roles of Aire in the differentiation program of epithelial cells in the thymic medulla. Eur J Immunol (2011) 0.95
Decreased AIRE expression and global thymic hypofunction in Down syndrome. J Immunol (2011) 0.94
Down syndrome, autoimmunity and T regulatory cells. Clin Exp Immunol (2012) 0.92
Impact of Down syndrome on the performance of neonatal screening assays for severe primary immunodeficiency diseases. J Allergy Clin Immunol (2013) 0.90
The impact of thyroid autoimmunity in children and adolescents with Down syndrome. Acta Paediatr (1997) 0.88
Alterations in thymocyte subpopulations in Down's syndrome (trisomy 21). Clin Immunol Immunopathol (1988) 0.84
Estimation of the frequency of self-reactive T cells in health and inflammatory diseases by limiting dilution analysis and single cell cloning. J Autoimmun (1996) 0.83
Down's syndrome, autoimmune hyperthyroidism, and hypoparathyroidism: a unique triad. Am J Dis Child (1987) 0.82
The Repertoires of Peptides Presented by MHC-II in the Thymus and in Peripheral Tissue: A Clue for Autoimmunity? Front Immunol (2013) 0.81
Thymic-thoracic ratio in fetuses with trisomy 21, 18 or 13. Ultrasound Obstet Gynecol (2012) 0.77
Autoantibodies linked to autoimmune polyendocrine syndrome type I are prevalent in Down syndrome. Acta Paediatr (2006) 0.77