Modulation of PPARγ provides new insights in a stress induced premature senescence model.

PubWeight™: 0.75‹?›

🔗 View Article (PMC 4125176)

Published in PLoS One on August 07, 2014

Authors

Stefania Briganti1, Enrica Flori1, Barbara Bellei1, Mauro Picardo1

Author Affiliations

1: Laboratory of Cutaneous Physiopathology, San Gallicano Dermatologic Institute, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.

Articles cited by this

A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A (1995) 32.89

Lipid rafts and signal transduction. Nat Rev Mol Cell Biol (2000) 25.87

Structure and function of sphingolipid- and cholesterol-rich membrane rafts. J Biol Chem (2000) 9.96

Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev (1999) 9.94

p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res (1995) 6.66

Cellular senescence in aging primates. Science (2006) 6.24

Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat Rev Drug Discov (2008) 5.78

FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J (2004) 4.57

Oxysterols: modulators of cholesterol metabolism and other processes. Physiol Rev (2000) 3.26

Sensing the environment: regulation of local and global homeostasis by the skin's neuroendocrine system. Adv Anat Embryol Cell Biol (2012) 2.99

Reactive oxygen species-induced activation of the MAP kinase signaling pathways. Antioxid Redox Signal (2006) 2.78

The autoxidation of human red cell lipids induced by hydrogen peroxide. Br J Haematol (1971) 2.77

DNA damage, cellular senescence and organismal ageing: causal or correlative? Nucleic Acids Res (2007) 2.09

A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity. Mol Cell (2001) 2.02

Cutaneous photodamage, oxidative stress, and topical antioxidant protection. J Am Acad Dermatol (2003) 2.00

Convergence of peroxisome proliferator-activated receptor gamma and Foxo1 signaling pathways. J Biol Chem (2003) 1.99

Reversal of HO-1 related cytoprotection with increased expression is due to reactive iron. FASEB J (1999) 1.82

Intrinsic aging vs. photoaging: a comparative histopathological, immunohistochemical, and ultrastructural study of skin. Exp Dermatol (2002) 1.75

Inflammation, gene mutation and photoimmunosuppression in response to UVR-induced oxidative damage contributes to photocarcinogenesis. Mutat Res (2005) 1.73

PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation. Biochim Biophys Acta (2011) 1.60

FOXO1 represses peroxisome proliferator-activated receptor-gamma1 and -gamma2 gene promoters in primary adipocytes. A novel paradigm to increase insulin sensitivity. J Biol Chem (2006) 1.56

Ultraviolet-B irradiation and matrix metalloproteinases: from induction via signaling to initial events. Ann N Y Acad Sci (2002) 1.56

Diverse actions of retinoid receptors in cancer prevention and treatment. Differentiation (2007) 1.48

Insulin-like growth factor 1/insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen receptor. J Biol Chem (2007) 1.43

Up-regulation of caveolin attenuates epidermal growth factor signaling in senescent cells. J Biol Chem (2000) 1.40

Membrane phospholipids, lipoxidative damage and molecular integrity: a causal role in aging and longevity. Biochim Biophys Acta (2008) 1.34

Dimethylfumarate induces immunosuppression via glutathione depletion and subsequent induction of heme oxygenase 1. J Invest Dermatol (2007) 1.32

Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion. J Biol Chem (1999) 1.31

The role of CYP26 enzymes in retinoic acid clearance. Expert Opin Drug Metab Toxicol (2009) 1.25

Photoaging of the skin from phenotype to mechanisms. Exp Gerontol (2000) 1.24

The chemical structure of the pigments in Ara macao plumage. Comp Biochem Physiol B Biochem Mol Biol (2001) 1.22

Free radical mediated peroxidative damage in systemic lupus erythematosus. Life Sci (2003) 1.17

NF-E2-related factor 2 regulates the stress response to UVA-1-oxidized phospholipids in skin cells. FASEB J (2009) 1.13

UVA radiation-induced oxidative damage to lipids and proteins in vitro and in human skin fibroblasts is dependent on iron and singlet oxygen. Free Radic Biol Med (1995) 1.09

Antagonistic control of cell fates by JNK and p38-MAPK signaling. Cell Death Differ (2007) 1.04

PPARγ and Oxidative Stress: Con(β) Catenating NRF2 and FOXO. PPAR Res (2012) 1.03

H2O2 accumulation by catalase reduction changes MAP kinase signaling in aged human skin in vivo. J Invest Dermatol (2005) 0.96

UV-induced oxidative stress and photoaging. Curr Probl Dermatol (2001) 0.95

The mechanism of retinol-induced irritation and its application to anti-irritant development. Toxicol Lett (2003) 0.95

Psoralen photoactivation promotes morphological and functional changes in fibroblasts in vitro reminiscent of cellular senescence. J Cell Sci (1998) 0.94

Effects of solar radiation on cutaneous detoxification pathways. J Photochem Photobiol B (2001) 0.93

The role of Nrf2 in ultraviolet A mediated heme oxygenase 1 induction in human skin fibroblasts. Photochem Photobiol Sci (2009) 0.92

Functional interplay between mitochondrial and proteasome activity in skin aging. J Invest Dermatol (2010) 0.91

Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression. J Nutr Biochem (2010) 0.91

Observation and quantification of ultraviolet-induced reactive oxygen species in ex vivo human skin. Photochem Photobiol (2002) 0.90

2,4,6-Octatrienoic acid is a novel promoter of melanogenesis and antioxidant defence in normal human melanocytes via PPAR-γ activation. Pigment Cell Melanoma Res (2011) 0.89

Transmission of UV-radiation through human epidermal layers as a factor influencing the minimal erythema dose. Photochem Photobiol (1984) 0.89

Topical tretinoin in the treatment of aging skin. J Am Acad Dermatol (1988) 0.89

PPAR gamma regulates MITF and beta-catenin expression and promotes a differentiated phenotype in mouse melanoma S91. Pigment Cell Melanoma Res (2008) 0.88

Small molecular antioxidants effectively protect from PUVA-induced oxidative stress responses underlying fibroblast senescence and photoaging. Free Radic Biol Med (2008) 0.87

p53 and Fas ligand are required for psoralen and UVA-induced apoptosis in mouse epidermal cells. Cell Death Differ (2002) 0.87

Functional changes induced by chronic UVA irradiation to cultured human dermal fibroblasts. Br J Dermatol (2005) 0.87

Superoxide anion is generated from cellular metabolites by solar radiation and its components. J Free Radic Biol Med (1985) 0.86

Age-dependent generation of reactive oxygen species in the skin of live hairless rats exposed to UVA light. Exp Dermatol (2003) 0.86

The role of Bach1 in ultraviolet A-mediated human heme oxygenase 1 regulation in human skin fibroblasts. Free Radic Biol Med (2011) 0.85

Heme oxygenase-1 induction by endogenous nitric oxide: influence of intracellular glutathione. FEBS Lett (2003) 0.85

Human catalase gene is regulated by peroxisome proliferator activated receptor-gamma through a response element distinct from that of mouse. Endocr J (2010) 0.85

PUVA-induced apoptosis involves mitochondrial dysfunction caused by the opening of the permeability transition pore. FEBS Lett (2002) 0.85

PPARδ inhibits UVB-induced secretion of MMP-1 through MKP-7-mediated suppression of JNK signaling. J Invest Dermatol (2013) 0.83

Regulation of fatty acid synthesis and Delta9-desaturation in senescence of human fibroblasts. Life Sci (2008) 0.83

Cultured murine dermal fibroblast-like cells from senescence-accelerated mice as in vitro models for higher oxidative stress due to mitochondrial alterations. J Gerontol A Biol Sci Med Sci (2005) 0.82

Imbalance in the antioxidant pool in melanoma cells and normal melanocytes from patients with melanoma. J Invest Dermatol (1996) 0.82

K6PC-5, a novel sphingosine kinase activator, improves long-term ultraviolet light-exposed aged murine skin. Exp Dermatol (2008) 0.82

Nrf2-mediated protection against UVA radiation in human skin keratinocytes. Biosci Trends (2011) 0.81

Cholesterol is more susceptible to oxidation than linoleates in cultured cells under oxidative stress induced by selenium deficiency and free radicals. FEBS Lett (2007) 0.81

Azelaic acid reduced senescence-like phenotype in photo-irradiated human dermal fibroblasts: possible implication of PPARγ. Exp Dermatol (2013) 0.79

The mechanisms by which lipids coordinately regulate the formation of the protein and lipid domains of the stratum corneum: Role of fatty acids, oxysterols, cholesterol sulfate and ceramides as signaling molecules. Dermatoendocrinol (2011) 0.79

The "rejuvenatory" impact of lipoic acid on mitochondrial function in aging rats may reflect induction and activation of PPAR-gamma coactivator-1alpha. Med Hypotheses (2008) 0.79

Simultaneous determination of reduced and oxidized glutathione in peripheral blood mononuclear cells by liquid chromatography-electrospray mass spectrometry. J Chromatogr B Biomed Sci Appl (2001) 0.79

Evaluation of the antioxidant activity of new carotenoid-like compounds by electron paramagnetic resonance. Drugs Exp Clin Res (2003) 0.78

Permeability of psoralen derivatives in lipid membranes. Biophys J (2006) 0.78

Biological activity of parrodienes, a new class of polyunsaturated linear aldehydes similar to carotenoids. Drugs Exp Clin Res (2004) 0.78

7-ketocholesterol and 5,6-secosterol modulate differently the stress-activated mitogen-activated protein kinases (MAPKs) in liver cells. J Cell Physiol (2010) 0.78

PPARgamma inhibits inflammatory reaction in oxidative stress induced human diploid fibloblast. Cell Biochem Funct (2010) 0.77

Fibroblasts in normal and pathological terminal differentiation, aging, apoptosis and transformation. Arch Gerontol Geriatr (1992) 0.77

Involvement of a forkhead transcription factor, FOXO1A, in UV-induced changes of collagen metabolism. J Investig Dermatol Symp Proc (2009) 0.77

The Role of PPARgamma Ligands as Regulators of the Immune Response. Drug News Perspect (2002) 0.77

Neuro-immune-endocrine functions of the skin: an overview. Expert Rev Dermatol (2013) 0.76

Influence of retinoids on skin fibroblasts metabolism in vitro. Acta Pol Pharm (2008) 0.76