Published in EMBO J on November 11, 2004
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Retracted Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci U S A (2009) 4.37
Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation. Nature (2009) 4.26
FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal. J Exp Med (2006) 3.78
FoxO transcription factors in the maintenance of cellular homeostasis during aging. Curr Opin Cell Biol (2008) 3.70
The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev (2008) 3.56
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From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev (2010) 3.11
Regulation of oxidative stress by the anti-aging hormone klotho. J Biol Chem (2005) 2.94
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Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat Cell Biol (2010) 2.78
AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell (2011) 2.77
Insulin signaling and FOXO regulate the overwintering diapause of the mosquito Culex pipiens. Proc Natl Acad Sci U S A (2008) 2.16
The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis. Genes Dev (2005) 2.13
FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor. Dev Cell (2010) 2.11
Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia. Nat Genet (2009) 2.07
The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors. J Biol Chem (2009) 2.05
Forkhead box proteins: tuning forks for transcriptional harmony. Nat Rev Cancer (2013) 2.02
Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression. Mol Cell Biol (2007) 1.96
The cunning little vixen: Foxo and the cycle of life and death. Nat Immunol (2009) 1.91
The mutational landscape of adenoid cystic carcinoma. Nat Genet (2013) 1.83
Oxidative stress in the regulation of normal and neoplastic hematopoiesis. Antioxid Redox Signal (2008) 1.81
FOXO1 is an essential regulator of pluripotency in human embryonic stem cells. Nat Cell Biol (2011) 1.70
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MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation. J Biol Chem (2009) 1.63
Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation. EMBO J (2006) 1.63
Forkhead homeobox type O transcription factors in the responses to oxidative stress. Antioxid Redox Signal (2010) 1.59
Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity. Cell Metab (2012) 1.51
In control of biology: of mice, men and Foxes. Biochem J (2006) 1.50
Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway. Proc Natl Acad Sci U S A (2010) 1.45
Mutual dependence of Foxo3a and PGC-1alpha in the induction of oxidative stress genes. J Biol Chem (2009) 1.40
Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity. Nat Chem Biol (2009) 1.40
The FoxO family in cardiac function and dysfunction. Annu Rev Physiol (2010) 1.33
Glucocorticoids and tumor necrosis factor α increase oxidative stress and suppress Wnt protein signaling in osteoblasts. J Biol Chem (2011) 1.32
FOXO transcription factors: key regulators of cellular quality control. Trends Biochem Sci (2014) 1.32
The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression. Mol Cell Biol (2008) 1.31
Regulation of Drosophila lifespan by JNK signaling. Exp Gerontol (2010) 1.27
Role of forkhead transcription factors in diabetes-induced oxidative stress. Exp Diabetes Res (2012) 1.27
Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress. Diabetes (2008) 1.26
Changes in select redox proteins of the retinal pigment epithelium in age-related macular degeneration. Am J Ophthalmol (2007) 1.26
Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression. Proc Natl Acad Sci U S A (2011) 1.26
Control of metabolic homeostasis by stress signaling is mediated by the lipocalin NLaz. PLoS Genet (2009) 1.25
ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice. EMBO J (2010) 1.24
Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling. Mol Syst Biol (2013) 1.24
Mdm2 induces mono-ubiquitination of FOXO4. PLoS One (2008) 1.22
JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life span. J Biol Chem (2009) 1.21
FoxO4 regulates tumor necrosis factor alpha-directed smooth muscle cell migration by activating matrix metalloproteinase 9 gene transcription. Mol Cell Biol (2007) 1.21
High levels of tumor necrosis factor-alpha contribute to accelerated loss of cartilage in diabetic fracture healing. Am J Pathol (2009) 1.20
Transcriptional regulation of neuronal polarity and morphogenesis in the mammalian brain. Neuron (2011) 1.19
Insulin and JNK: optimizing metabolic homeostasis and lifespan. Trends Endocrinol Metab (2009) 1.19
TNF induction of atrogin-1/MAFbx mRNA depends on Foxo4 expression but not AKT-Foxo1/3 signaling. Am J Physiol Cell Physiol (2008) 1.18
Redox regulation of SIRT1 in inflammation and cellular senescence. Free Radic Biol Med (2013) 1.17
RUNX1 and its understudied role in breast cancer. Cell Cycle (2011) 1.16
Intrinsic apoptosis in mechanically ventilated human diaphragm: linkage to a novel Fos/FoxO1/Stat3-Bim axis. FASEB J (2011) 1.15
Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans. Aging (Albany NY) (2010) 1.15
Differentiation of human adipose-derived stem cells into fat involves reactive oxygen species and Forkhead box O1 mediated upregulation of antioxidant enzymes. Stem Cells Dev (2012) 1.12
Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO. Dev Dyn (2010) 1.12
FoxO3a regulates hematopoietic homeostasis through a negative feedback pathway in conditions of stress or aging. Blood (2008) 1.12
Kallistatin attenuates endothelial apoptosis through inhibition of oxidative stress and activation of Akt-eNOS signaling. Am J Physiol Heart Circ Physiol (2010) 1.11
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. Aging Cell (2015) 1.10
Maternal obesity is associated with a lipotoxic placental environment. Placenta (2014) 1.10
FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function. EMBO J (2011) 1.09
Hyperglycemia induces inducible nitric oxide synthase gene expression and consequent nitrosative stress via c-Jun N-terminal kinase activation. Am J Obstet Gynecol (2010) 1.09
Hepatitis C virus infection promotes hepatic gluconeogenesis through an NS5A-mediated, FoxO1-dependent pathway. J Virol (2011) 1.09
14-3-3 Epsilon antagonizes FoxO to control growth, apoptosis and longevity in Drosophila. Aging Cell (2008) 1.09
High dietary fat selectively increases catalase expression within cardiac mitochondria. J Biol Chem (2012) 1.09
Synaptic activity and nuclear calcium signaling protect hippocampal neurons from death signal-associated nuclear translocation of FoxO3a induced by extrasynaptic N-methyl-D-aspartate receptors. J Biol Chem (2010) 1.09
Highly specialized role of Forkhead box O transcription factors in the immune system. Antioxid Redox Signal (2010) 1.08
Regulation of the intracellular localization of Foxo3a by stress-activated protein kinase signaling pathways in skeletal muscle cells. Mol Cell Biol (2009) 1.07
PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4. Oncogene (2010) 1.06
FOXO3a mediates the cytotoxic effects of cisplatin in colon cancer cells. Mol Cancer Ther (2008) 1.06
JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila. Aging Cell (2009) 1.06
RalGDS couples growth factor signaling to Akt activation. Mol Cell Biol (2008) 1.05
Oxidative stress in the haematopoietic niche regulates the cellular immune response in Drosophila. EMBO Rep (2011) 1.05
Promoting longevity by maintaining metabolic and proliferative homeostasis. J Exp Biol (2014) 1.05
Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence. Cancer Res (2010) 1.05
KRIT1 regulates the homeostasis of intracellular reactive oxygen species. PLoS One (2010) 1.05
Maternal hyperglycemia activates an ASK1-FoxO3a-caspase 8 pathway that leads to embryonic neural tube defects. Sci Signal (2013) 1.04
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Neuronal death by oxidative stress involves activation of FOXO3 through a two-arm pathway that activates stress kinases and attenuates insulin-like growth factor I signaling. Mol Biol Cell (2008) 1.03
Mitochondria and FOXO3: breath or die. Front Physiol (2013) 1.03
PPARγ and Oxidative Stress: Con(β) Catenating NRF2 and FOXO. PPAR Res (2012) 1.03
SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells. Stem Cells Dev (2011) 1.02
Direct control of caveolin-1 expression by FOXO transcription factors. Biochem J (2005) 1.02
Redox regulation of FoxO transcription factors. Redox Biol (2015) 1.01
Induction of Sirt1 by mechanical stretch of skeletal muscle through the early response factor EGR1 triggers an antioxidative response. J Biol Chem (2010) 1.01
The Ral/exocyst effector complex counters c-Jun N-terminal kinase-dependent apoptosis in Drosophila melanogaster. Mol Cell Biol (2006) 1.01
An aqueous extract of Fagonia cretica induces DNA damage, cell cycle arrest and apoptosis in breast cancer cells via FOXO3a and p53 expression. PLoS One (2012) 1.01
Ros-mediated activation of NF-kappaB and Foxo during muscle disuse. Muscle Nerve (2010) 1.01
Involvement of the up-regulated FoxO1 expression in follicular granulosa cell apoptosis induced by oxidative stress. J Biol Chem (2012) 1.00
Bimodal regulation of FoxO3 by AKT and 14-3-3. Biochim Biophys Acta (2011) 0.98
Maintenance of manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by repeated administration of the free thiol form of amifostine. Radiat Res (2008) 0.98
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Resveratrol and red wine, healthy heart and longevity. Heart Fail Rev (2010) 0.96
Unraveling the role of FoxOs in bone--insights from mouse models. Bone (2011) 0.96
C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress. PLoS Genet (2012) 0.96
Regulation of FOXO3 by phosphorylation and methylation in hepatitis C virus infection and alcohol exposure. Hepatology (2013) 0.96
Development and maintenance of cancer stem cells under chronic inflammation. J Nippon Med Sch (2011) 0.95
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
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Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature (2002) 7.88
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Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature (1999) 7.66
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Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty. J Leukoc Biol (2003) 2.90
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The small GTPase Rap1 is required for Mn(2+)- and antibody-induced LFA-1- and VLA-4-mediated cell adhesion. J Biol Chem (2002) 1.39
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Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling. Mol Syst Biol (2013) 1.24
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TSPYL5 suppresses p53 levels and function by physical interaction with USP7. Nat Cell Biol (2010) 1.13
The PKB/FOXO switch in aging and cancer. Biochim Biophys Acta (2011) 1.12
Should I stay or should I go: beta-catenin decides under stress. Biochim Biophys Acta (2009) 1.12
The RapGEF PDZ-GEF2 is required for maturation of cell-cell junctions. Cell Signal (2008) 1.11
Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29. Proc Natl Acad Sci U S A (2013) 1.06
cAMP-induced Epac-Rap activation inhibits epithelial cell migration by modulating focal adhesion and leading edge dynamics. Cell Signal (2008) 1.06
Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence. Cancer Res (2010) 1.05
RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans. EMBO J (2007) 1.04
Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control. Cell Signal (2011) 1.03
Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2. Biochim Biophys Acta (2003) 1.02
Direct control of caveolin-1 expression by FOXO transcription factors. Biochem J (2005) 1.02
Rap1 signaling is required for suppression of Ras-generated reactive oxygen species and protection against oxidative stress in T lymphocytes. J Immunol (2004) 1.00
The peptidyl-isomerase Pin1 regulates p27kip1 expression through inhibition of Forkhead box O tumor suppressors. Cancer Res (2008) 1.00
Binding of protein kinase B to the plakin family member periplakin. J Cell Sci (2002) 0.98
Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins. Mol Cell Biol (2010) 0.98
The Caenorhabditis elegans nicotinamidase PNC-1 enhances survival. Mech Ageing Dev (2007) 0.98
Integrating opposing signals toward Forkhead box O. Antioxid Redox Signal (2010) 0.96
cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane. Proc Natl Acad Sci U S A (2012) 0.96
Structural dynamics in the activation of Epac. J Biol Chem (2007) 0.96
FoxO3a eggs on fertility and aging. Trends Mol Med (2003) 0.96
Pull-down assays for guanoside 5'-triphosphate-bound Ras-like guanosine 5'-triphosphatases. Methods Mol Biol (2004) 0.95
Evolution of the TOR pathway. J Mol Evol (2011) 0.95
Redox-dependent control of FOXO/DAF-16 by transportin-1. Mol Cell (2013) 0.95
UNC45A confers resistance to histone deacetylase inhibitors and retinoic acid. Mol Cancer Res (2009) 0.95
The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity. J Cell Biol (2011) 0.94
Stressed marrow: FoxOs stem tumour growth. Nat Cell Biol (2007) 0.94
Ezrin is required for efficient Rap1-induced cell spreading. J Cell Sci (2011) 0.93
Retracted Overexpression of caveolin-1 in adult T-cell leukemia. Blood (2010) 0.92
The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner. Cell Signal (2007) 0.92
The small GTPase Rap1 is activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes. J Biol Chem (2003) 0.92
Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop β-cell dysfunction and metabolic syndrome. FASEB J (2013) 0.91
Epac-Rap signaling reduces cellular stress and ischemia-induced kidney failure. J Am Soc Nephrol (2011) 0.91
Down-regulation of Rap1 activity is involved in ephrinB1-induced cell contraction. Biochem J (2005) 0.89
Regulation of sterol carrier protein gene expression by the forkhead transcription factor FOXO3a. J Lipid Res (2003) 0.88
Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner. J Cell Biol (2014) 0.87
The peroxide dilemma: opposing and mediating insulin action. Antioxid Redox Signal (2011) 0.87
The DNA damage repair protein Ku70 interacts with FOXO4 to coordinate a conserved cellular stress response. FASEB J (2010) 0.86
Activation of FoxO transcription factors contributes to the antiproliferative effect of cAMP. Oncogene (2005) 0.85
RAPL: taking the Rap in immunity. Nat Immunol (2004) 0.84
Rap1 and Rap2 antagonistically control endothelial barrier resistance. PLoS One (2013) 0.83
Alteration of SMRT tumor suppressor function in transformed non-Hodgkin lymphomas. Cancer Res (2005) 0.83
Rap1 can bypass the FAK-Src-Paxillin cascade to induce cell spreading and focal adhesion formation. PLoS One (2012) 0.82
Phylogeny of the CDC25 homology domain reveals rapid differentiation of Ras pathways between early animals and fungi. Cell Signal (2009) 0.82
The small GTPase RALA controls c-Jun N-terminal kinase-mediated FOXO activation by regulation of a JIP1 scaffold complex. J Biol Chem (2013) 0.81
Involvement of Rap-1 activation and early termination of immune synapse in CTLA-4-mediated negative signal. Hematology (2009) 0.80