Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection.

PubWeight™: 1.40‹?› | Rank: Top 5%

🔗 View Article (PMC 4144726)

Published in J Exp Med on August 11, 2014

Authors

Pablo Penaloza-MacMaster1, Alice O Kamphorst1, Andreas Wieland1, Koichi Araki1, Smita S Iyer1, Erin E West1, Leigh O'Mara1, Shu Yang2, Bogumila T Konieczny1, Arlene H Sharpe3, Gordon J Freeman3, Alexander Y Rudensky4, Rafi Ahmed5

Author Affiliations

1: Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322.
2: Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322 Xiangya School of Medicine, Central South University, Changsha, Hunan Province, 410013, China.
3: Department of Microbiology and Immunology, and Department of Medical Oncology and Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.
4: Howard Hughes Medical Institute, Immunology Program, Sloan-Kettering Institute for Cancer Research, and Ludwig Center at Memorial Sloan-Kettering Cancer Center, New York, NY 10065 Howard Hughes Medical Institute, Immunology Program, Sloan-Kettering Institute for Cancer Research, and Ludwig Center at Memorial Sloan-Kettering Cancer Center, New York, NY 10065 Howard Hughes Medical Institute, Immunology Program, Sloan-Kettering Institute for Cancer Research, and Ludwig Center at Memorial Sloan-Kettering Cancer Center, New York, NY 10065 rahmed@emory.edu rudenska@mskcc.org.
5: Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322 rahmed@emory.edu rudenska@mskcc.org.

Articles citing this

Molecular and cellular insights into T cell exhaustion. Nat Rev Immunol (2015) 2.74

PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing. PLoS Pathog (2015) 1.49

A Human Trypanosome Suppresses CD8+ T Cell Priming by Dendritic Cells through the Induction of Immune Regulatory CD4+ Foxp3+ T Cells. PLoS Pathog (2016) 1.40

T-cell exhaustion: understanding the interface of chronic viral and autoinflammatory diseases. Immunol Cell Biol (2016) 1.08

Confusing signals: recent progress in CTLA-4 biology. Trends Immunol (2015) 1.03

T cell exhaustion during persistent viral infections. Virology (2015) 1.00

TIGIT predominantly regulates the immune response via regulatory T cells. J Clin Invest (2015) 0.96

Interleukin-35 Limits Anti-Tumor Immunity. Immunity (2016) 0.93

The multifaceted role of CD4(+) T cells in CD8(+) T cell memory. Nat Rev Immunol (2016) 0.90

Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection. Science (2015) 0.90

Reservoir host immune responses to emerging zoonotic viruses. Cell (2014) 0.90

Innate and Adaptive Immune Regulation During Chronic Viral Infections. Annu Rev Virol (2015) 0.89

Reversing T-cell Dysfunction and Exhaustion in Cancer. Clin Cancer Res (2016) 0.88

Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease. Immunity (2016) 0.88

The Characterization of Varicella Zoster Virus-Specific T Cells in Skin and Blood during Aging. J Invest Dermatol (2015) 0.85

T-cell exhaustion in allograft rejection and tolerance. Curr Opin Organ Transplant (2015) 0.82

TGFβ1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer. Cancer Discov (2016) 0.82

T-cell responses against CD19+ pediatric acute lymphoblastic leukemia mediated by bispecific T-cell engager (BiTE) are regulated contrarily by PD-L1 and CD80/CD86 on leukemic blasts. Oncotarget (2016) 0.81

Regulatory T Cells in Autoimmune and Viral Chronic Hepatitis. J Immunol Res (2015) 0.81

Expanded regulatory T cells in chronically friend retrovirus-infected mice suppress immunity to a murine cytomegalovirus superinfection. J Virol (2014) 0.80

CD4 T Cell Depletion Substantially Augments the Rescue Potential of PD-L1 Blockade for Deeply Exhausted CD8 T Cells. J Immunol (2015) 0.80

Methamphetamine mediates immune dysregulation in a murine model of chronic viral infection. Front Microbiol (2015) 0.80

Immunotherapy: A promising approach to reverse sepsis-induced immunosuppression. Pharmacol Res (2016) 0.79

PD-L1 Blockade Differentially Impacts Regulatory T Cells from HIV-Infected Individuals Depending on Plasma Viremia. PLoS Pathog (2015) 0.79

Endothelial cell dysfunction in viral hemorrhage and edema. Front Microbiol (2015) 0.78

Programmed death-1/programmed death-L1 signaling pathway and its blockade in hepatitis C virus immunotherapy. World J Hepatol (2015) 0.78

Beyond adjuvants: immunomodulation strategies to enhance T cell immunity. Vaccine (2015) 0.77

A role for pre-mNK cells in tumor progression. J Immunother Cancer (2016) 0.77

Development of novel replication-defective lymphocytic choriomeningitis virus vectors expressing SIV antigens. Vaccine (2016) 0.77

A Review of the CD4+ T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population. EC Microbiol (2015) 0.77

Local Cellular and Cytokine Cues in the Spleen Regulate In Situ T Cell Receptor Affinity, Function, and Fate of CD8(+) T Cells. Immunity (2016) 0.76

T regulatory cells are critical for the maintenance, anamnestic expansion and protection elicited by vaccine-induced CD8 T cells. Immunology (2017) 0.76

ssTherapeutic Effect of Human Ghrelin and Growth Hormone: Attenuation of Immunosuppression in Septic Aged Rats. Biochim Biophys Acta (2017) 0.76

The Immune Fulcrum: Regulatory T Cells Tip the Balance Between Pro- and Anti-inflammatory Outcomes upon Infection. Prog Mol Biol Transl Sci (2015) 0.75

CD8 T-cell regulation by T regulatory cells and the programmed cell death protein 1 pathway. Immunology (2017) 0.75

Expression of Viral Antigen by the Liver Leads to Chronic Infection Through the Generation of Regulatory T Cells. Cell Mol Gastroenterol Hepatol (2015) 0.75

Subset- and Antigen-Specific Effects of Treg on CD8+ T Cell Responses in Chronic HIV Infection. PLoS Pathog (2016) 0.75

Modulation of SIV and HIV DNA vaccine immunity by Fas-FasL signaling. Viruses (2015) 0.75

The microRNA miR-31 inhibits CD8(+) T cell function in chronic viral infection. Nat Immunol (2017) 0.75

Transcriptomic Analysis of Persistent Infection with Foot-and-Mouth Disease Virus in Cattle Suggests Impairment of Apoptosis and Cell-Mediated Immunity in the Nasopharynx. PLoS One (2016) 0.75

Impaired Subset Progression and Polyfunctionality of T Cells in Mice Exposed to Methamphetamine during Chronic LCMV Infection. PLoS One (2016) 0.75

PD-1: Dual guard for immunopathology. Oncotarget (2015) 0.75

Roles of PD-1, Tim-3 and CTLA-4 in immunoregulation in regulatory T cells among patients with sepsis. Int J Clin Exp Med (2015) 0.75

New Insights into Regulatory T Cells: Exosome- and Non-Coding RNA-Mediated Regulation of Homeostasis and Resident Treg Cells. Front Immunol (2016) 0.75

Regulation of CD4 T cells and their effects on immunopathological inflammation following viral infection. Immunology (2017) 0.75

Transcriptomic Signatures of Tacaribe Virus-Infected Jamaican Fruit Bats. mSphere (2017) 0.75

Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4. Nat Med (2017) 0.75

Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8(+) T Cell Responses to Chronic Viral Infections and Cancer. Front Immunol (2017) 0.75

Articles cited by this

Restoring function in exhausted CD8 T cells during chronic viral infection. Nature (2005) 28.04

Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med (2002) 23.42

PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol (2008) 19.24

Regulatory T cells and immune tolerance. Cell (2008) 18.77

Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med (2013) 17.53

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol (2003) 15.51

Viral immune evasion due to persistence of activated T cells without effector function. J Exp Med (1998) 14.39

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol (2006) 14.33

Preferential localization of effector memory cells in nonlymphoid tissue. Science (2001) 14.22

CTLA-4 control over Foxp3+ regulatory T cell function. Science (2008) 12.67

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A (2002) 12.39

Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J Virol (2003) 11.48

T cell exhaustion. Nat Immunol (2011) 11.08

Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence. J Exp Med (1984) 10.66

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol (2008) 10.26

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection. J Virol (1994) 10.03

Effector and memory T-cell differentiation: implications for vaccine development. Nat Rev Immunol (2002) 9.45

Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol (2006) 9.42

Differential antigen processing by dendritic cell subsets in vivo. Science (2007) 8.42

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature (1989) 7.52

Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity. Curr Opin Immunol (2012) 7.26

Memory CD8 T-cell differentiation during viral infection. J Virol (2004) 6.75

Cytotoxic T-cell memory without antigen. Nature (1994) 6.55

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J Exp Med (2010) 6.24

Persistence of memory CD8 T cells in MHC class I-deficient mice. Science (1999) 6.20

Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood (2007) 6.03

Coordination of early protective immunity to viral infection by regulatory T cells. Science (2008) 5.33

Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science (2011) 4.96

IL-21 is required to control chronic viral infection. Science (2009) 4.80

Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients. J Exp Med (2010) 4.79

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc Natl Acad Sci U S A (2010) 4.56

A vital role for interleukin-21 in the control of a chronic viral infection. Science (2009) 4.55

Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells. J Exp Med (2004) 4.37

Persistent LCMV infection is controlled by blockade of type I interferon signaling. Science (2013) 4.18

Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science (2013) 4.14

Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism. J Immunol (2005) 3.95

IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. Science (2009) 3.90

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. J Exp Med (2013) 3.83

Regulatory T cells in the control of host-microorganism interactions (*). Annu Rev Immunol (2009) 3.82

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo. Nat Med (2003) 3.68

Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. Immunity (2007) 3.33

Functional impairment of CD8(+) T cells by regulatory T cells during persistent retroviral infection. Immunity (2004) 3.10

A role for CD103 in the retention of CD4+CD25+ Treg and control of Leishmania major infection. J Immunol (2005) 2.81

Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells. Cancer Immunol Res (2013) 2.76

Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection. Nat Immunol (2011) 2.54

Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans. Proc Natl Acad Sci U S A (2013) 2.47

Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. Proc Natl Acad Sci U S A (2007) 2.39

Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies. J Exp Med (2013) 1.96

Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory. Science (2012) 1.88

Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection. J Virol (2009) 1.77

Natural regulatory T cells and persistent viral infection. J Virol (2007) 1.62

Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection. Proc Natl Acad Sci U S A (2011) 1.62

Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon. J Virol (1994) 1.56

PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice. J Clin Invest (2010) 1.53

Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy. J Exp Med (2013) 1.47

PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells. J Clin Invest (2013) 1.42

Regulatory T-cell expansion during chronic viral infection is dependent on endogenous retroviral superantigens. Proc Natl Acad Sci U S A (2011) 1.41

Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth. J Exp Med (2012) 1.38

A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota. J Exp Med (2010) 1.32

Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice. J Exp Med (2012) 1.29

Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8+ T cells and reduces chronic retroviral set points. Proc Natl Acad Sci U S A (2011) 1.26

Viral infection of the thymus. J Virol (1992) 1.25

FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells. Proc Natl Acad Sci U S A (2009) 1.15

Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression. J Immunol (2012) 1.08

IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection. PLoS Pathog (2013) 1.03