Published in Cell Death Dis on August 14, 2014
Cell death and DAMPs in acute pancreatitis. Mol Med (2014) 0.86
Anaplasma phagocytophilum increases the levels of histone modifying enzymes to inhibit cell apoptosis and facilitate pathogen infection in the tick vector Ixodes scapularis. Epigenetics (2016) 0.85
Sepsis and ARDS: The Dark Side of Histones. Mediators Inflamm (2015) 0.83
DAMPs, ageing, and cancer: The 'DAMP Hypothesis'. Ageing Res Rev (2014) 0.81
Organ distribution of histones after intravenous infusion of FITC histones or after sepsis. Immunol Res (2015) 0.81
Lactoferrin Suppresses Neutrophil Extracellular Traps Release in Inflammation. EBioMedicine (2016) 0.79
Actin and DNA Protect Histones from Degradation by Bacterial Proteases but Inhibit Their Antimicrobial Activity. Front Microbiol (2016) 0.79
The Receptor for Advanced Glycation End Products Activates the AIM2 Inflammasome in Acute Pancreatitis. J Immunol (2016) 0.78
Nuclear DAMP complex-mediated RAGE-dependent macrophage cell death. Biochem Biophys Res Commun (2015) 0.78
Histones facilitate α-synuclein aggregation during neuronal apoptosis. Acta Neuropathol (2016) 0.78
Nuclear histones: major virulence factors or just additional early sepsis markers? A comment. Inflammopharmacology (2016) 0.76
The Role of Antimicrobial Peptides in Influenza Virus Infection and Their Potential as Antiviral and Immunomodulatory Therapy. Pharmaceuticals (Basel) (2016) 0.75
Neutrophil-mediated vascular barrier injury: Role of neutrophil extracellular traps. Microcirculation (2017) 0.75
Kinetics of Circulating Damage-Associated Molecular Patterns in Sepsis. J Immunol Res (2015) 0.75
Extracellular histones, cell-free DNA, or nucleosomes: differences in immunostimulation. Cell Death Dis (2016) 0.75
Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth. Nat Commun (2017) 0.75
Neutrophil extracellular trap formation and circulating nucleosomes in patients with chronic myeloproliferative neoplasms. Sci Rep (2016) 0.75
NETosis in Alzheimer's Disease. Front Immunol (2017) 0.75
Evaluation of dynamic changes in interstitial fluid proteome following microdialysis probe insertion trauma in trapezius muscle of healthy women. Sci Rep (2017) 0.75
Histones and Neutrophil Extracellular Traps Enhance Tubular Necrosis and Remote Organ Injury in Ischemic AKI. J Am Soc Nephrol (2017) 0.75
Novel chemokine-like activities of histones in tumor metastasis. Oncotarget (2016) 0.75
Chronological Profiling of Plasma Native Peptides after Hepatectomy in Pigs: Toward the Discovery of Human Biomarkers for Liver Regeneration. PLoS One (2017) 0.75
A novel method to detect articular chondrocyte death during early stages of osteoarthritis using a non-invasive ApoPep-1 probe. Arthritis Res Ther (2015) 0.75
Influence of Arsenic on Global Levels of Histone Posttranslational Modifications: a Review of the Literature and Challenges in the Field. Curr Environ Health Rep (2016) 0.75
Complement and sepsis-induced heart dysfunction. Mol Immunol (2016) 0.75
Identification and Characterization of Switchgrass Histone H3 and CENH3 Genes. Front Plant Sci (2016) 0.75
A novel method for isolation of histones from serum and its implications in therapeutics and prognosis of solid tumours. Clin Epigenetics (2017) 0.75
From amino acids polymers, antimicrobial peptides, and histones, to their possible role in the pathogenesis of septic shock: a historical perspective. J Inflamm Res (2017) 0.75
Selective Biological Responses of Phagocytes and Lungs to Purified Histones. J Innate Immun (2017) 0.75
A Review of Radiation-Induced Coagulopathy and New Findings to Support Potential Prevention Strategies and Treatments. Radiat Res (2016) 0.75
Skin mucus proteins of lumpsucker (Cyclopterus lumpus). Biochem Biophys Rep (2017) 0.75
Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer. Cell Res (2017) 0.75
The language of covalent histone modifications. Nature (2000) 44.92
Neutrophil extracellular traps kill bacteria. Science (2004) 23.64
Perceptions of epigenetics. Nature (2007) 8.43
Protein arginine methylation in mammals: who, what, and why. Mol Cell (2009) 7.44
Epigenetic modifications and human disease. Nat Biotechnol (2010) 7.29
Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med (2009) 6.72
Bactericidal action of histone. J Exp Med (1958) 6.58
Extracellular histones are major mediators of death in sepsis. Nat Med (2009) 6.55
Nucleosome positioning and gene regulation: advances through genomics. Nat Rev Genet (2009) 6.50
Histones: annotating chromatin. Annu Rev Genet (2009) 5.93
Extracellular DNA traps promote thrombosis. Proc Natl Acad Sci U S A (2010) 5.69
DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res (2001) 5.45
Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis. Proc Natl Acad Sci U S A (2010) 5.05
Therapeutic application of histone deacetylase inhibitors for central nervous system disorders. Nat Rev Drug Discov (2008) 4.43
Covalent modifications of histones during development and disease pathogenesis. Nat Struct Mol Biol (2007) 4.17
Neutrophil extracellular traps promote deep vein thrombosis in mice. J Thromb Haemost (2012) 3.39
Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation. Blood (2008) 3.32
Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4. Blood (2011) 3.25
Cross-regulation of histone modifications. Nat Struct Mol Biol (2007) 3.09
Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE. J Exp Med (2008) 2.97
Elevated nucleosome levels in systemic inflammation and sepsis. Crit Care Med (2003) 2.76
Regulation of nucleosome dynamics by histone modifications. Nat Struct Mol Biol (2013) 2.71
Histones induce rapid and profound thrombocytopenia in mice. Blood (2011) 2.66
Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation. J Thromb Haemost (2011) 2.51
Circulating histones are mediators of trauma-associated lung injury. Am J Respir Crit Care Med (2012) 2.42
PAMPs and DAMPs: signal 0s that spur autophagy and immunity. Immunol Rev (2012) 2.24
Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury. J Immunol (2011) 2.09
Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice. Hepatology (2011) 1.94
Histones from dying renal cells aggravate kidney injury via TLR2 and TLR4. J Am Soc Nephrol (2012) 1.73
Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis. Blood (2013) 1.69
Histones trigger sterile inflammation by activating the NLRP3 inflammasome. Eur J Immunol (2013) 1.65
Histones have high affinity for the glomerular basement membrane. Relevance for immune complex formation in lupus nephritis. J Exp Med (1989) 1.48
Nucleosome structure(s) and stability: variations on a theme. Annu Rev Biophys (2011) 1.43
Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice. Gastroenterology (2013) 1.40
Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: a role for intracellular high-mobility group box 1 in cellular protection. Hepatology (2014) 1.40
Lipid A binding sites in membranes of macrophage tumor cells. J Biol Chem (1988) 1.29
Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury. FASEB J (2013) 1.26
A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis. Proc Natl Acad Sci U S A (2009) 1.26
Strange attractors: DAMPs and autophagy link tumor cell death and immunity. Cell Death Dis (2013) 1.25
Mechanisms of disease: Histone modifications in Huntington's disease. Nat Clin Pract Neurol (2006) 1.23
Clinical relevance of circulating nucleosomes in cancer. Ann N Y Acad Sci (2008) 1.23
Extracellular chromatin is an important mediator of ischemic stroke in mice. Arterioscler Thromb Vasc Biol (2012) 1.17
Extracellular histones in tissue injury and inflammation. J Mol Med (Berl) (2014) 1.17
Nucleosomal DNA fragments in autoimmune diseases. Ann N Y Acad Sci (2006) 1.16
Nephritogenic potential of anti-DNA antibodies against necrotic nucleosomes. J Am Soc Nephrol (2009) 1.14
Apoptotic release of histones from nucleosomes. J Biol Chem (2002) 1.14
Nucleosomes in serum of patients with benign and malignant diseases. Int J Cancer (2001) 1.13
Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury. J Immunol (2013) 1.11
Circulating nucleosomes predict the response to chemotherapy in patients with advanced non-small cell lung cancer. Clin Cancer Res (2004) 1.08
Identification of citrullinated histone H3 as a potential serum protein biomarker in a lethal model of lipopolysaccharide-induced shock. Surgery (2011) 1.07
Nucleosomes and DNA bind to specific cell-surface molecules on murine cells and induce cytokine production. Clin Immunol Immunopathol (1992) 1.04
DAMPs and autophagy: cellular adaptation to injury and unscheduled cell death. Autophagy (2013) 1.02
Human recombinant activated protein C for severe sepsis. Cochrane Database Syst Rev (2012) 1.02
Extracellular matrix histone H1 binds to perlecan, is present in regenerating skeletal muscle and stimulates myoblast proliferation. J Cell Sci (2002) 1.01
Circulating nucleosomes in serum. Ann N Y Acad Sci (2001) 0.99
Citrullination of autoantigens implicates NETosis in the induction of autoimmunity. Ann Rheum Dis (2013) 0.98
Extra-nuclear location of histones in activated human peripheral blood lymphocytes and cultured T-cells. Biochem Pharmacol (1995) 0.98
Functional role of the interaction between polysialic acid and extracellular histone H1. J Neurosci (2010) 0.98
Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism. PLoS One (2013) 0.98
Histone 3.3 participates in a self-sustaining cascade of apoptosis that contributes to the progression of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2013) 0.97
Extracellularly occurring histone H1 mediates the binding of thyroglobulin to the cell surface of mouse macrophages. J Clin Invest (1998) 0.94
Apoptosis in serum of patients with solid tumours. Anticancer Res (1999) 0.94
Predictive and prognostic value of circulating nucleosomes and serum biomarkers in patients with metastasized colorectal cancer undergoing Selective Internal Radiation Therapy. BMC Cancer (2012) 0.94
Histone induced platelet aggregation is inhibited by normal albumin. Thromb Res (2013) 0.94
Extranuclear detection of histones and nucleosomes in activated human lymphoblasts as an early event in apoptosis. Ann Rheum Dis (2004) 0.92
Nucleosomes in serum of patients with early cerebral stroke. Cerebrovasc Dis (2005) 0.92
Toxic effects of extracellular histones and their neutralization by vitreous in retinal detachment. Lab Invest (2014) 0.91
Linker histone H1 binds to disease associated amyloid-like fibrils. J Mol Biol (2006) 0.90
Nucleosomes in pancreatic cancer patients during radiochemotherapy. Tumour Biol (2005) 0.88
Functional responses and molecular mechanisms involved in histone-mediated platelet activation. Thromb Haemost (2013) 0.88
Histone H1; a neuronal protein that binds bacterial lipopolysaccharide. J Neurocytol (1997) 0.87
Blood levels of histone-complexed DNA fragments are associated with coagulopathy, inflammation and endothelial damage early after trauma. J Emerg Trauma Shock (2013) 0.87
Neutrophils release extracellular DNA traps during storage of red blood cell units. Transfusion (2013) 0.87
Circulating histones exacerbate inflammation in mice with acute liver failure. J Cell Biochem (2013) 0.87
Nucleosomes as a new prognostic marker in early cerebral stroke. J Neurol (2007) 0.87
Citrullinated histone H3: a novel target for the treatment of sepsis. Surgery (2014) 0.86
Plasma Nucleosome Levels in Node-Negative Breast Cancer Patients. Breast Cancer (1999) 0.85
In vitro interactions of extracellular histones with LDL suggest a potential pro-atherogenic role. PLoS One (2010) 0.83
Extracellular histone H1 is neurotoxic and drives a pro-inflammatory response in microglia. F1000Res (2013) 0.80
Stability of nucleosomal DNA fragments in serum. Clin Chem (2005) 0.78
Early prediction of therapy response in patients with acute myeloid leukemia by nucleosomal DNA fragments. BMC Cancer (2006) 0.76
From the nucleus to the plasma membrane: translocation of the nuclear proteins histone H3 and lamin B1 in apoptotic microglia. Apoptosis (2014) 0.76
Reduction of histone cytotoxicity by the Alzheimer beta-amyloid peptide precursor. Biochim Biophys Acta (1997) 0.76
Extracellular histones inhibit hair shaft elongation in cultured human hair follicles and promote regression of hair follicles in mice. Exp Dermatol (2012) 0.76