Histones: annotating chromatin.

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet (2012) 7.61

Ribosome-mediated specificity in Hox mRNA translation and vertebrate tissue patterning. Cell (2011) 4.26

Chromatin structure and the inheritance of epigenetic information. Nat Rev Genet (2010) 4.03

Long noncoding RNAs: past, present, and future. Genetics (2013) 3.16

Effector T cell plasticity: flexibility in the face of changing circumstances. Nat Immunol (2010) 3.12

Epigenetic modifications in pluripotent and differentiated cells. Nat Biotechnol (2010) 3.02

Transcriptional regulation and its misregulation in disease. Cell (2013) 2.92

Asymmetrically modified nucleosomes. Cell (2012) 2.79

A double take on bivalent promoters. Genes Dev (2013) 2.79

H3K36 methylation antagonizes PRC2-mediated H3K27 methylation. J Biol Chem (2011) 2.63

Inducible gene expression: diverse regulatory mechanisms. Nat Rev Genet (2010) 2.53

Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay. Cell (2010) 2.53

Cell-specific determinants of peroxisome proliferator-activated receptor gamma function in adipocytes and macrophages. Mol Cell Biol (2010) 2.47

Epigenetic mechanisms in cognition. Neuron (2011) 2.31

Maternal obesity and fetal metabolic programming: a fertile epigenetic soil. Am J Physiol Regul Integr Comp Physiol (2010) 2.28

Suppression of the antiviral response by an influenza histone mimic. Nature (2012) 2.18

Chromatin remodeling at DNA double-strand breaks. Cell (2013) 2.18

New insights into nucleosome and chromatin structure: an ordered state or a disordered affair? Nat Rev Mol Cell Biol (2012) 2.14

G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer. J Clin Invest (2012) 2.12

The chromatin signaling pathway: diverse mechanisms of recruitment of histone-modifying enzymes and varied biological outcomes. Mol Cell (2010) 2.06

PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway. Mol Cell (2010) 2.06

Tackling the epigenome: challenges and opportunities for collaboration. Nat Biotechnol (2010) 2.04

Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Mol Cell (2012) 2.02

H3K4me3 interactions with TAF3 regulate preinitiation complex assembly and selective gene activation. Cell (2013) 2.00

The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology. Physiol Rev (2012) 1.95

The histone shuffle: histone chaperones in an energetic dance. Trends Biochem Sci (2010) 1.89

PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription. Genes Dev (2012) 1.81

Brain function and chromatin plasticity. Nature (2010) 1.75

Structural insights into the assembly and function of the SAGA deubiquitinating module. Science (2010) 1.74

The program for processing newly synthesized histones H3.1 and H4. Nat Struct Mol Biol (2010) 1.71

Current chemical biology approaches to interrogate protein methyltransferases. ACS Chem Biol (2012) 1.70

Handpicking epigenetic marks with PHD fingers. Nucleic Acids Res (2011) 1.69

Changes in H2A.Z occupancy and DNA methylation during B-cell lymphomagenesis. Genome Res (2010) 1.69

A downstream intergenic cluster of regulatory enhancers contributes to the induction of CYP24A1 expression by 1alpha,25-dihydroxyvitamin D3. J Biol Chem (2010) 1.67

HMGB1 in health and disease. Mol Aspects Med (2014) 1.67

PARP1 ADP-ribosylates lysine residues of the core histone tails. Nucleic Acids Res (2010) 1.64

Histone chaperone FACT coordinates nucleosome interaction through multiple synergistic binding events. J Biol Chem (2011) 1.63

Control of B cell development by the histone H2A deubiquitinase MYSM1. Immunity (2011) 1.63

Chromatin dynamics and the repair of DNA double strand breaks. Cell Cycle (2011) 1.63

Comparative epigenomic annotation of regulatory DNA. Cell (2012) 1.62

Regulation of primary response genes. Mol Cell (2011) 1.56

RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation. Mol Cell (2012) 1.52

Tracking epigenetic histone modifications in single cells using Fab-based live endogenous modification labeling. Nucleic Acids Res (2011) 1.49

Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis. EMBO J (2010) 1.47

A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase. Cell Cycle (2012) 1.46

Transcriptional activity regulates alternative cleavage and polyadenylation. Mol Syst Biol (2011) 1.41

Retention of the Native Epigenome in Purified Mammalian Chromatin. PLoS One (2015) 1.40

Breaking the histone code with quantitative mass spectrometry. Expert Rev Proteomics (2011) 1.39

Acetylation of H2A.Z is a key epigenetic modification associated with gene deregulation and epigenetic remodeling in cancer. Genome Res (2011) 1.39

Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis. Cell (2013) 1.35

Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis. Immunity (2010) 1.35

Epigenetic mechanisms in inflammation. J Dent Res (2011) 1.35

The histone chaperone FACT: structural insights and mechanisms for nucleosome reorganization. J Biol Chem (2011) 1.34

Transgenerational analysis of transcriptional silencing in zebrafish. Dev Biol (2011) 1.34

L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure. Mol Cell (2011) 1.32

Epigenetic regulation of gene expression in keratinocytes. J Invest Dermatol (2012) 1.32

Nucleosome structural studies. Curr Opin Struct Biol (2010) 1.32

SCF(FBXO22) regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation. Mol Cell Biol (2011) 1.30

Elongator complex influences telomeric gene silencing and DNA damage response by its role in wobble uridine tRNA modification. PLoS Genet (2011) 1.30

The emerging field of neuroepigenetics. Neuron (2013) 1.28

Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46. J Biol Chem (2010) 1.28

Histone H2B ubiquitination and beyond: Regulation of nucleosome stability, chromatin dynamics and the trans-histone H3 methylation. Epigenetics (2010) 1.27

Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability. J Biol Chem (2013) 1.26

Histone H3 phosphorylation - a versatile chromatin modification for different occasions. Biochimie (2012) 1.23

PARP-1 and PARP-2: New players in tumour development. Am J Cancer Res (2011) 1.23

Chromatin signatures of cancer. Genes Dev (2015) 1.20

Epigenetic modifications: basic mechanisms and role in cardiovascular disease. Circulation (2011) 1.20

Modification of histones by sugar β-N-acetylglucosamine (GlcNAc) occurs on multiple residues, including histone H3 serine 10, and is cell cycle-regulated. J Biol Chem (2011) 1.20

Defining the budding yeast chromatin-associated interactome. Mol Syst Biol (2010) 1.19

Epigenetic plasticity: a central regulator of epithelial-to-mesenchymal transition in cancer. Oncotarget (2014) 1.19

Yeast CAF-1 assembles histone (H3-H4)2 tetramers prior to DNA deposition. Nucleic Acids Res (2012) 1.18

Identification of combinatorial patterns of post-translational modifications on individual histones in the mouse brain. PLoS One (2012) 1.15

Analysis of active and inactive X chromosome architecture reveals the independent organization of 30 nm and large-scale chromatin structures. Mol Cell (2010) 1.14

The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice. J Clin Invest (2011) 1.13

Site-specific incorporation of ε-N-crotonyllysine into histones. Angew Chem Int Ed Engl (2012) 1.13

NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions. PLoS Biol (2012) 1.12

Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human. FEBS J (2010) 1.12

Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription. Nucleic Acids Res (2013) 1.12

Chatting histone modifications in mammals. Brief Funct Genomics (2010) 1.10

Release and activity of histone in diseases. Cell Death Dis (2014) 1.10

The cell biology of disease: FSHD: copy number variations on the theme of muscular dystrophy. J Cell Biol (2010) 1.10

Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle. J Biol Chem (2011) 1.10

H3.3-H4 tetramer splitting events feature cell-type specific enhancers. PLoS Genet (2013) 1.09

Nucleosome eviction and activated transcription require p300 acetylation of histone H3 lysine 14. Proc Natl Acad Sci U S A (2010) 1.08

A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation. EMBO J (2013) 1.08

Torque modulates nucleosome stability and facilitates H2A/H2B dimer loss. Nat Commun (2013) 1.07

Sequential establishment of marks on soluble histones H3 and H4. J Biol Chem (2011) 1.07

Utx is required for proper induction of ectoderm and mesoderm during differentiation of embryonic stem cells. PLoS One (2013) 1.07

Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice. J Biol Chem (2010) 1.06

The myeloid transcription factor GATA-2 regulates the viral UL144 gene during human cytomegalovirus latency in an isolate-specific manner. J Virol (2013) 1.06

Methamphetamine causes differential alterations in gene expression and patterns of histone acetylation/hypoacetylation in the rat nucleus accumbens. PLoS One (2012) 1.06

Nucleosome positioning: bringing order to the eukaryotic genome. Trends Cell Biol (2012) 1.06

Insights into interphase large-scale chromatin structure from analysis of engineered chromosome regions. Cold Spring Harb Symp Quant Biol (2011) 1.05

Multivalent epigenetic marks confer microenvironment-responsive epigenetic plasticity to ovarian cancer cells. Epigenetics (2010) 1.05

Chromatin affinity purification and quantitative mass spectrometry defining the interactome of histone modification patterns. Mol Cell Proteomics (2011) 1.03

Reference gene selection for quantitative reverse transcription-polymerase chain reaction normalization during in vitro adventitious rooting in Eucalyptus globulus Labill. BMC Mol Biol (2010) 1.03

Epigenetic regulation of EMT: the Snail story. Curr Pharm Des (2014) 1.02

Profiles of epigenetic histone post-translational modifications at type 1 diabetes susceptible genes. J Biol Chem (2012) 1.02

Control of chromatin structure by spt6: different consequences in coding and regulatory regions. Mol Cell Biol (2010) 1.02

A role for WDR5 in integrating threonine 11 phosphorylation to lysine 4 methylation on histone H3 during androgen signaling and in prostate cancer. Mol Cell (2014) 1.02

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev (2002) 13.08

The Polycomb complex PRC2 and its mark in life. Nature (2011) 11.97

Elongation by RNA polymerase II: the short and long of it. Genes Dev (2004) 9.17

A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66

A unified theory of gene expression. Cell (2002) 7.61

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science (2007) 7.41

Suz12 binds to silenced regions of the genome in a cell-type-specific manner. Genome Res (2006) 6.75

Role of the polycomb protein EED in the propagation of repressive histone marks. Nature (2009) 6.62

Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. Genes Dev (2004) 6.19

FACT facilitates transcription-dependent nucleosome alteration. Science (2003) 5.83

Epigenetic dynamics of imprinted X inactivation during early mouse development. Science (2003) 5.80

Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. Mol Cell (2007) 5.78

Regulation of p53 activity through lysine methylation. Nature (2004) 5.78

PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol Cell (2002) 5.59

Histone lysine methylation: a signature for chromatin function. Trends Genet (2003) 5.55

Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev (2002) 5.43

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell (2004) 5.37

New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34

Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell (2006) 5.14

Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell (2004) 5.06

The key to development: interpreting the histone code? Curr Opin Genet Dev (2005) 4.96

Molecular signals of epigenetic states. Science (2010) 4.81

Jarid2 and PRC2, partners in regulating gene expression. Genes Dev (2010) 4.65

Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. Proc Natl Acad Sci U S A (2005) 4.57

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell (2008) 4.44

Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. J Biol Chem (2005) 4.20

Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol Cell (2005) 4.04

Chromatin structure and the inheritance of epigenetic information. Nat Rev Genet (2010) 4.03

Tails of intrigue: phosphorylation of RNA polymerase II mediates histone methylation. Cell (2003) 3.82

L3MBTL1, a histone-methylation-dependent chromatin lock. Cell (2007) 3.70

Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA. Genes Dev (2010) 3.49

Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. Genes Dev (2002) 3.37

PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Mol Cell (2012) 3.28

Tracking FACT and the RNA polymerase II elongation complex through chromatin in vivo. Science (2003) 3.22

SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev (2006) 3.12

Polycomb group protein ezh2 controls actin polymerization and cell signaling. Cell (2005) 3.01

Facultative heterochromatin: is there a distinctive molecular signature? Mol Cell (2007) 2.94

Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. Mol Cell Biol (2008) 2.93

Histone H3 Lys 4 methylation: caught in a bind? Genes Dev (2006) 2.86

Asymmetrically modified nucleosomes. Cell (2012) 2.79

A double take on bivalent promoters. Genes Dev (2013) 2.79

Genomic comparison of the ants Camponotus floridanus and Harpegnathos saltator. Science (2010) 2.78

SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress. Genes Dev (2007) 2.77

SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. Nature (2007) 2.76

The human PAF complex coordinates transcription with events downstream of RNA synthesis. Genes Dev (2005) 2.70

Is there a code embedded in proteins that is based on post-translational modifications? Nat Rev Mol Cell Biol (2008) 2.64

G9a and Glp methylate lysine 373 in the tumor suppressor p53. J Biol Chem (2010) 2.64

Histone lysine demethylases and their impact on epigenetics. Cell (2006) 2.54

PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis. Genes Dev (2005) 2.51

Specificity and mechanism of the histone methyltransferase Pr-Set7. Genes Dev (2005) 2.50

Genome-wide and caste-specific DNA methylomes of the ants Camponotus floridanus and Harpegnathos saltator. Curr Biol (2012) 2.50

Histone variants meet their match. Nat Rev Mol Cell Biol (2005) 2.47

Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development. Mol Cell Biol (2009) 2.47

PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Mol Cell (2005) 2.44

Differential histone H3 Lys-9 and Lys-27 methylation profiles on the X chromosome. Mol Cell Biol (2004) 2.43

Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage. Mol Cell (2010) 2.39

A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell (2004) 2.27

Drosophila Paf1 modulates chromatin structure at actively transcribed genes. Mol Cell Biol (2006) 2.16

Chromatin higher-order structures and gene regulation. Curr Opin Genet Dev (2011) 2.08

The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate. J Biol Chem (2009) 2.06

Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins. J Biol Chem (2009) 2.02

The constantly changing face of chromatin. Sci Aging Knowledge Environ (2003) 2.02

Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II. Proc Natl Acad Sci U S A (2004) 2.01

PRC2 binds active promoters and contacts nascent RNAs in embryonic stem cells. Nat Struct Mol Biol (2013) 2.01

Recent highlights of RNA-polymerase-II-mediated transcription. Curr Opin Cell Biol (2004) 1.91

PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription. Genes Dev (2012) 1.81

Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity. Cell (2012) 1.78

Human Elongator facilitates RNA polymerase II transcription through chromatin. Proc Natl Acad Sci U S A (2002) 1.75

Methylation-acetylation interplay activates p53 in response to DNA damage. Mol Cell Biol (2007) 1.75

The program for processing newly synthesized histones H3.1 and H4. Nat Struct Mol Biol (2010) 1.71

CTCF regulates the human p53 gene through direct interaction with its natural antisense transcript, Wrap53. Genes Dev (2014) 1.62

Functional analysis of the subunits of the chromatin assembly factor RSF. Mol Cell Biol (2003) 1.56

Functional characterization of core promoter elements: DPE-specific transcription requires the protein kinase CK2 and the PC4 coactivator. Mol Cell (2005) 1.52

MBT domain proteins in development and disease. Semin Cell Dev Biol (2009) 1.49

Functional characterization of core promoter elements: the downstream core element is recognized by TAF1. Mol Cell Biol (2005) 1.46

Social insect genomes exhibit dramatic evolution in gene composition and regulation while preserving regulatory features linked to sociality. Genome Res (2013) 1.45

Calorie restriction and the exercise of chromatin. Genes Dev (2009) 1.44

A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo. Genes Dev (2011) 1.43

The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation. J Biol Chem (2010) 1.41

The mediator coactivator complex: functional and physical roles in transcriptional regulation. J Cell Sci (2003) 1.41

Facts about FACT and transcript elongation through chromatin. Curr Opin Genet Dev (2004) 1.40

Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro. Mol Cell Biol (2004) 1.38

ASAP, a novel protein complex involved in RNA processing and apoptosis. Mol Cell Biol (2003) 1.34

L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure. Mol Cell (2011) 1.32

Histone chaperone FACT action during transcription through chromatin by RNA polymerase II. Proc Natl Acad Sci U S A (2013) 1.32

Methods and tips for the purification of human histone methyltransferases. Methods (2003) 1.31

Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo. J Biol Chem (2009) 1.28

Phylogenetic and transcriptomic analysis of chemosensory receptors in a pair of divergent ant species reveals sex-specific signatures of odor coding. PLoS Genet (2012) 1.27

FCP1, a phosphatase specific for the heptapeptide repeat of the largest subunit of RNA polymerase II, stimulates transcription elongation. Mol Cell Biol (2002) 1.26

The role of PR-Set7 in replication licensing depends on Suv4-20h. Genes Dev (2012) 1.22

Facile synthesis of site-specifically acetylated and methylated histone proteins: reagents for evaluation of the histone code hypothesis. Proc Natl Acad Sci U S A (2003) 1.20

Epigenetic inheritance: uncontested? Cell Res (2011) 1.19

Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4. Genes Dev (2012) 1.19

Transcription through chromatin: understanding a complex FACT. Biochim Biophys Acta (2004) 1.15

SIRT3 functions in the nucleus in the control of stress-related gene expression. Mol Cell Biol (2012) 1.12

Processing the H3K36me3 signature. Nat Genet (2009) 1.10

Highly compacted chromatin formed in vitro reflects the dynamics of transcription activation in vivo. Mol Cell (2010) 1.08

Beyond histone methyl-lysine binding: how malignant brain tumor (MBT) protein L3MBTL1 impacts chromatin structure. Cell Cycle (2008) 1.08

EZH2 couples pancreatic regeneration to neoplastic progression. Genes Dev (2012) 1.07

New chaps in the histone chaperone arena. Genes Dev (2010) 1.06