Published in Trends Genet on August 14, 2014
TET proteins and 5-methylcytosine oxidation in hematological cancers. Immunol Rev (2015) 1.18
Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex. Nat Commun (2015) 1.01
Control of Foxp3 stability through modulation of TET activity. J Exp Med (2016) 0.99
Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes. Mol Cell (2016) 0.93
Induction of active demethylation and 5hmC formation by 5-azacytidine is TET2 dependent and suggests new treatment strategies against hepatocellular carcinoma. Clin Epigenetics (2015) 0.88
Acute loss of TET function results in aggressive myeloid cancer in mice. Nat Commun (2015) 0.88
DNA methylation and hydroxymethylation in hematologic differentiation and transformation. Curr Opin Cell Biol (2015) 0.86
A Fluorescence Polarization Biophysical Assay for the Naegleria DNA Hydroxylase Tet1. ACS Med Chem Lett (2015) 0.85
The role of enhancers in cancer. Nat Rev Cancer (2016) 0.84
Recent Molecular Advances in Our Understanding of Glioma. Cureus (2015) 0.82
ALS and FTD: an epigenetic perspective. Acta Neuropathol (2016) 0.81
Tet2 and Tet3 cooperate with B-lineage transcription factors to regulate DNA modification and chromatin accessibility. Elife (2016) 0.80
Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome. Mol Cell (2016) 0.80
Epigenetics of Peripheral B-Cell Differentiation and the Antibody Response. Front Immunol (2015) 0.80
Tet1 and Tet2 Protect DNA Methylation Canyons against Hypermethylation. Mol Cell Biol (2015) 0.80
5-Hydroxymethylcytosine discriminates between parathyroid adenoma and carcinoma. Clin Epigenetics (2016) 0.79
Epigenetic function of activation-induced cytidine deaminase and its link to lymphomagenesis. Front Immunol (2014) 0.79
Enhanced MAPK signaling drives ETS1-mediated induction of miR-29b leading to downregulation of TET1 and changes in epigenetic modifications in a subset of lung SCC. Oncogene (2016) 0.78
DNA Methylation Affects the SP1-regulated Transcription of FOXF2 in Breast Cancer Cells. J Biol Chem (2015) 0.78
O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling. J Mol Biol (2016) 0.77
The expanding scope and impact of epigenetic cytosine modifications. Curr Opin Chem Biol (2016) 0.77
Functions of TET Proteins in Hematopoietic Transformation. Mol Cells (2015) 0.77
TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities. Cell Rep (2016) 0.76
Developmental exposure to endocrine disrupting chemicals alters the epigenome: Identification of reprogrammed targets. Gynecol Obstet Res (2016) 0.76
Increased N(6)-methyladenosine in Human Sperm RNA as a Risk Factor for Asthenozoospermia. Sci Rep (2016) 0.75
The emerging insights into catalytic or non-catalytic roles of TET proteins in tumors and neural development. Oncotarget (2016) 0.75
Simultaneous single-molecule epigenetic imaging of DNA methylation and hydroxymethylation. Proc Natl Acad Sci U S A (2016) 0.75
TET family dioxygenases and DNA demethylation in stem cells and cancers. Exp Mol Med (2017) 0.75
Epigenetic inactivation of the CpG demethylase TET1 as a DNA methylation feedback loop in human cancers. Sci Rep (2016) 0.75
Urinary Measurement of Epigenetic DNA Modifications: A Non-Invasive Assessment of the Whole-Body Epigenetic Status in Healthy Subjects and Colorectal Cancer Patients. ChemistryOpen (2016) 0.75
Ascorbate induces apoptosis in melanoma cells by suppressing Clusterin expression. Sci Rep (2017) 0.75
Molecular basis for the substrate specificity and catalytic mechanism of thymine-7-hydroxylase in fungi. Nucleic Acids Res (2015) 0.75
TET Methylcytosine Oxidases in T Cell and B Cell Development and Function. Front Immunol (2017) 0.75
SET oncoprotein accumulation regulates transcription through DNA demethylation and histone hypoacetylation. Oncotarget (2017) 0.75
Hinokitiol induces DNA demethylation via DNMT1 and UHRF1 inhibition in colon cancer cells. BMC Cell Biol (2017) 0.75
Epigenetic Modulators of Monocytic Function: Implication for Steady State and Disease in the CNS. Front Immunol (2016) 0.75
Engineered Split-TET2 Enzyme for Inducible Epigenetic Remodeling. J Am Chem Soc (2017) 0.75
5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages. Cell Res (2017) 0.75
Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition. Nat Commun (2017) 0.75
Epigenetic inactivation of tumour suppressor coding and non-coding genes in human cancer: an update. Open Biol (2017) 0.75
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97
The fundamental role of epigenetic events in cancer. Nat Rev Genet (2002) 30.05
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature (2010) 18.63
Mutation in TET2 in myeloid cancers. N Engl J Med (2009) 16.07
DNA methylation landscapes: provocative insights from epigenomics. Nat Rev Genet (2008) 15.45
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell (2010) 15.20
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science (2011) 14.29
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science (2011) 13.16
DNA methylation and human disease. Nat Rev Genet (2005) 12.00
Frequent pathway mutations of splicing machinery in myelodysplasia. Nature (2011) 11.44
A decade of exploring the cancer epigenome - biological and translational implications. Nat Rev Cancer (2011) 11.33
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med (2012) 10.20
Clinical effect of point mutations in myelodysplastic syndromes. N Engl J Med (2011) 9.90
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature (2010) 8.87
The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA. Nature (2007) 8.17
Acquired mutations in TET2 are common in myelodysplastic syndromes. Nat Genet (2009) 8.03
IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature (2012) 7.95
UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science (2007) 7.90
Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N Engl J Med (2011) 7.89
THE METABOLISM OF TUMORS IN THE BODY. J Gen Physiol (1927) 7.64
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell (2011) 7.41
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell (2011) 7.37
Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell (2011) 6.80
Clinical and biological implications of driver mutations in myelodysplastic syndromes. Blood (2013) 6.50
Global epigenomic reconfiguration during mammalian brain development. Science (2013) 6.14
Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. Blood (2009) 5.72
Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains. Nat Genet (2011) 5.70
TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis. Cancer Cell (2011) 5.28
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature (2010) 5.23
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science (2013) 5.10
Recurrent R-spondin fusions in colon cancer. Nature (2012) 5.10
(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science (2013) 4.88
Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites. J Biol Chem (2011) 4.64
Integrated molecular analysis of clear-cell renal cell carcinoma. Nat Genet (2013) 4.61
Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development. Cell Stem Cell (2011) 4.52
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature (2012) 4.37
Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies. Blood (2011) 4.35
The hexosamine signaling pathway: deciphering the "O-GlcNAc code". Sci STKE (2005) 4.20
TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23). Leukemia (2003) 4.17
Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids. Cell Cycle (2009) 4.14
New insights to the MLL recombinome of acute leukemias. Leukemia (2009) 4.07
IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature (2012) 4.04
Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell (2012) 4.04
Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes. Nat Genet (2011) 4.02
Landscape of genetic lesions in 944 patients with myelodysplastic syndromes. Leukemia (2013) 3.93
LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23). Cancer Res (2002) 3.73
Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science (2013) 3.72
On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs. Cell (1983) 3.56
Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Mol Cell (2013) 3.50
TET enzymes, TDG and the dynamics of DNA demethylation. Nature (2013) 3.49
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis. Nat Genet (2012) 3.33
Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development. Dev Cell (2013) 3.31
Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML. Leukemia (2009) 3.23
TETonic shift: biological roles of TET proteins in DNA demethylation and transcription. Nat Rev Mol Cell Biol (2013) 3.18
Reversing DNA methylation: mechanisms, genomics, and biological functions. Cell (2014) 3.17
Prognostic score including gene mutations in chronic myelomonocytic leukemia. J Clin Oncol (2013) 3.10
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice. Proc Natl Acad Sci U S A (2011) 3.07
MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling. Cell (2013) 2.92
TET2 promotes histone O-GlcNAcylation during gene transcription. Nature (2012) 2.92
Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability. Nat Cell Biol (2006) 2.90
IDH mutations in glioma and acute myeloid leukemia. Trends Mol Med (2010) 2.83
Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene (2012) 2.82
FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency. Cell Stem Cell (2013) 2.79
Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature (2013) 2.76
TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS. EMBO J (2013) 2.70
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev (2012) 2.70
Unraveling the molecular pathophysiology of myelodysplastic syndromes. J Clin Oncol (2011) 2.69
Beta-N-acetylglucosamine (O-GlcNAc) is part of the histone code. Proc Natl Acad Sci U S A (2010) 2.47
Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA. Nat Chem Biol (2012) 2.45
Mammalian cytosine methylation at a glance. J Cell Sci (2009) 2.43
5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations. Cancer Res (2011) 2.36
Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas. Nat Genet (2014) 2.34
Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation. Genes Cells (2002) 2.28
TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases. Cell Rep (2012) 2.20
TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs). Blood (2009) 2.18
Somatic RHOA mutation in angioimmunoblastic T cell lymphoma. Nat Genet (2014) 2.14
A targeted mutational landscape of angioimmunoblastic T-cell lymphoma. Blood (2013) 2.14
GlcNAcylation of histone H2B facilitates its monoubiquitination. Nature (2011) 2.14
Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases. Trends Biochem Sci (2010) 2.12
The calpain system and cancer. Nat Rev Cancer (2011) 2.10
Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA. Nat Chem Biol (2014) 2.05
TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia. Haematologica (2009) 1.95
Tet and TDG mediate DNA demethylation essential for mesenchymal-to-epithelial transition in somatic cell reprogramming. Cell Stem Cell (2014) 1.94
TET2 and DNMT3A mutations in human T-cell lymphoma. N Engl J Med (2012) 1.93
Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals. J Am Chem Soc (2013) 1.90
SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML). Blood (2012) 1.85
Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases. Cold Spring Harb Symp Quant Biol (2011) 1.81
Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells. Mol Cell (2013) 1.78
Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo. J Exp Med (2013) 1.71
ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia. Br J Haematol (2010) 1.71
HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis. Proc Natl Acad Sci U S A (2013) 1.70
Vitamin C is dispensable for oxygen sensing in vivo. Blood (2011) 1.68
The biochemical functions of ascorbic acid. Annu Rev Nutr (1986) 1.68
Clonal architecture of chronic myelomonocytic leukemias. Blood (2013) 1.67
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. Nature (2013) 1.65
A mitotic GlcNAcylation/phosphorylation signaling complex alters the posttranslational state of the cytoskeletal protein vimentin. Mol Biol Cell (2008) 1.64
Crystal structure of TET2-DNA complex: insight into TET-mediated 5mC oxidation. Cell (2013) 1.63
Targeting DNA methylation for epigenetic therapy. Trends Pharmacol Sci (2010) 1.61