Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma.

PubWeight™: 4.04‹?› | Rank: Top 1%

🔗 View Article (PMC 3770275)

Published in Cell on September 14, 2012

Authors

Christine Guo Lian1, Yufei Xu, Craig Ceol, Feizhen Wu, Allison Larson, Karen Dresser, Wenqi Xu, Li Tan, Yeguang Hu, Qian Zhan, Chung-Wei Lee, Di Hu, Bill Q Lian, Sonja Kleffel, Yijun Yang, James Neiswender, Abraham J Khorasani, Rui Fang, Cecilia Lezcano, Lyn M Duncan, Richard A Scolyer, John F Thompson, Hojabr Kakavand, Yariv Houvras, Leonard I Zon, Martin C Mihm, Ursula B Kaiser, Tobias Schatton, Bruce A Woda, George F Murphy, Yujiang G Shi

Author Affiliations

1: Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Articles citing this

(truncated to the top 100)

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription. Nat Rev Mol Cell Biol (2013) 3.18

Reversing DNA methylation: mechanisms, genomics, and biological functions. Cell (2014) 3.17

Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming. Cell (2013) 3.13

Ten-eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity. Circulation (2013) 2.95

5-Hydroxymethylcytosine is a predominantly stable DNA modification. Nat Chem (2014) 2.54

Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host. Nat Rev Cancer (2013) 2.41

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell (2013) 2.17

Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor. Cancer Discov (2013) 2.11

Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development. Cell (2012) 1.76

Tet3-mediated hydroxymethylation of epigenetically silenced genes contributes to bone morphogenic protein 7-induced reversal of kidney fibrosis. J Am Soc Nephrol (2014) 1.71

HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis. Proc Natl Acad Sci U S A (2013) 1.70

Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. Nature (2013) 1.65

Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells. Proc Natl Acad Sci U S A (2014) 1.50

BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy. Cancer Res (2013) 1.43

Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine. J Biol Chem (2013) 1.43

Pathway, in silico and tissue-specific expression quantitative analyses of oesophageal squamous cell carcinoma genome-wide association studies data. Int J Epidemiol (2015) 1.41

Mechanism and function of oxidative reversal of DNA and RNA methylation. Annu Rev Biochem (2014) 1.36

DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia. Cell Rep (2014) 1.31

An extensive network of TET2-targeting MicroRNAs regulates malignant hematopoiesis. Cell Rep (2013) 1.29

TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway. Oncogene (2014) 1.26

Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1. PLoS One (2013) 1.26

Connections between TET proteins and aberrant DNA modification in cancer. Trends Genet (2014) 1.24

The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia. Annu Rev Pathol (2014) 1.22

Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells. Genome Biol (2013) 1.22

5-hydroxymethylcytosine and its potential roles in development and cancer. Epigenetics Chromatin (2013) 1.20

TET1 plays an essential oncogenic role in MLL-rearranged leukemia. Proc Natl Acad Sci U S A (2013) 1.19

Nanopores discriminate among five C5-cytosine variants in DNA. J Am Chem Soc (2014) 1.17

TET proteins and the control of cytosine demethylation in cancer. Genome Med (2015) 1.13

Genomic insights into cancer-associated aberrant CpG island hypermethylation. Brief Funct Genomics (2013) 1.11

The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases. Leukemia (2013) 1.11

Cancer development, progression, and therapy: an epigenetic overview. Int J Mol Sci (2013) 1.10

Role of TET enzymes in DNA methylation, development, and cancer. Genes Dev (2016) 1.08

Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver. Nucleic Acids Res (2013) 1.07

Playing TETris with DNA modifications. EMBO J (2014) 1.07

Epigenetic regulation of smooth muscle cell plasticity. Biochim Biophys Acta (2014) 1.05

Ontogeny, distribution and potential roles of 5-hydroxymethylcytosine in human liver function. Genome Biol (2013) 1.04

Loss of 5-hydroxymethylcytosine correlates with increasing morphologic dysplasia in melanocytic tumors. Mod Pathol (2014) 1.00

Modulation of ten-eleven translocation 1 (TET1), Isocitrate Dehydrogenase (IDH) expression, α-Ketoglutarate (α-KG), and DNA hydroxymethylation levels by interleukin-1β in primary human chondrocytes. J Biol Chem (2014) 0.99

Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes. J Biol Chem (2015) 0.99

Identification of a melanoma susceptibility locus and somatic mutation in TET2. Carcinogenesis (2014) 0.98

Driver mutations of cancer epigenomes. Protein Cell (2014) 0.98

Mechanisms of base substitution mutagenesis in cancer genomes. Genes (Basel) (2014) 0.98

Epigenetic regulation in human melanoma: past and future. Epigenetics (2015) 0.98

Defending the genome from the enemy within: mechanisms of retrotransposon suppression in the mouse germline. Cell Mol Life Sci (2013) 0.97

Perspectives of international human epigenome consortium. Genomics Inform (2013) 0.95

TET family proteins: oxidation activity, interacting molecules, and functions in diseases. Chem Rev (2015) 0.94

Targeted next-generation sequencing reveals high frequency of mutations in epigenetic regulators across treatment-naïve patient melanomas. Clin Epigenetics (2015) 0.93

Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells. Genome Biol (2014) 0.93

5-Hydroxymethylcytosine expression in metastatic melanoma versus nodal nevus in sentinel lymph node biopsies. Mod Pathol (2014) 0.93

5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer. Genome Biol (2015) 0.93

Hydroxymethylation as a Novel Environmental Biosensor. Curr Environ Health Rep (2014) 0.92

Clinical significance of DNA methylation mRNA levels of TET family members in colorectal cancer. J Cancer Res Clin Oncol (2015) 0.92

Ascorbate-induced generation of 5-hydroxymethylcytosine is unaffected by varying levels of iron and 2-oxoglutarate. Biochem Biophys Res Commun (2013) 0.92

Analysis of TET expression/activity and 5mC oxidation during normal and malignant germ cell development. PLoS One (2013) 0.92

Loss of 5-hydroxymethylcytosine in cancer: cause or consequence? Genomics (2014) 0.92

Suppression of TET1-dependent DNA demethylation is essential for KRAS-mediated transformation. Cell Rep (2014) 0.92

5-hydroxymethylcytosine: a new insight into epigenetics in cancer. Cancer Biol Ther (2013) 0.91

Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hMeDIP-seq method. Nucleic Acids Res (2013) 0.91

TET proteins: on the frenetic hunt for new cytosine modifications. Brief Funct Genomics (2013) 0.91

Stem cells and targeted approaches to melanoma cure. Mol Aspects Med (2013) 0.90

Comparative analysis of affinity-based 5-hydroxymethylation enrichment techniques. Nucleic Acids Res (2013) 0.90

Nucleic Acid Modifications in Regulation of Gene Expression. Cell Chem Biol (2016) 0.90

Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. Environ Health Perspect (2017) 0.90

Balance of DNA methylation and demethylation in cancer development. Genome Biol (2012) 0.90

Melanoma epigenetics: novel mechanisms, markers, and medicines. Lab Invest (2014) 0.89

Unlocking epigenetic codes in neurogenesis. Genes Dev (2014) 0.89

Interindividual Variability in Stress Susceptibility: A Role for Epigenetic Mechanisms in PTSD. Front Psychiatry (2013) 0.89

Dynamic switching of active promoter and enhancer domains regulates Tet1 and Tet2 expression during cell state transitions between pluripotency and differentiation. Mol Cell Biol (2015) 0.88

Genome-Wide DNA Methylation Analysis in Melanoma Reveals the Importance of CpG Methylation in MITF Regulation. J Invest Dermatol (2015) 0.88

Induction of active demethylation and 5hmC formation by 5-azacytidine is TET2 dependent and suggests new treatment strategies against hepatocellular carcinoma. Clin Epigenetics (2015) 0.88

Cancer epigenetics: new therapies and new challenges. J Drug Deliv (2013) 0.88

Epigenetic regulation in adult stem cells and cancers. Cell Biosci (2013) 0.88

TET family proteins and 5-hydroxymethylcytosine in esophageal squamous cell carcinoma. Oncotarget (2015) 0.88

Regulation of the Epigenome by Vitamin C. Annu Rev Nutr (2015) 0.87

Tight correlation of 5-hydroxymethylcytosine and Polycomb marks in health and disease. Cell Cycle (2013) 0.87

TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression. Nat Commun (2015) 0.86

Real-time dynamics of methyl-CpG-binding domain protein 3 and its role in DNA demethylation by fluorescence correlation spectroscopy. Epigenetics (2013) 0.86

Robust quantitative assessments of cytosine modifications and changes in the expressions of related enzymes in gastric cancer. Gastric Cancer (2014) 0.86

High expression of 5-hydroxymethylcytosine and isocitrate dehydrogenase 2 is associated with favorable prognosis after curative resection of hepatocellular carcinoma. J Exp Clin Cancer Res (2014) 0.86

Alterations of 5-hydroxymethylcytosine in human cancers. Cancers (Basel) (2013) 0.85

Methylation-dependent SOX9 expression mediates invasion in human melanoma cells and is a negative prognostic factor in advanced melanoma. Genome Biol (2015) 0.85

Epigenetics, TET proteins, and hypoxia in epithelial-mesenchymal transition and tumorigenesis. Biomedicine (Taipei) (2016) 0.84

TET proteins and 5-methylcytosine oxidation in the immune system. Cold Spring Harb Symp Quant Biol (2014) 0.84

DNA methylation characteristics of primary melanomas with distinct biological behaviour. PLoS One (2014) 0.84

TET-catalyzed 5-hydroxymethylcytosine regulates gene expression in differentiating colonocytes and colon cancer. Sci Rep (2015) 0.84

Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer. Cell Res (2015) 0.83

Repression of Hox genes by LMP1 in nasopharyngeal carcinoma and modulation of glycolytic pathway genes by HoxC8. Oncogene (2015) 0.83

A novel cancer-germline transcript carrying pro-metastatic miR-105 and TET-targeting miR-767 induced by DNA hypomethylation in tumors. Epigenetics (2014) 0.83

Poly(ADP-ribosyl)ation is involved in the epigenetic control of TET1 gene transcription. Oncotarget (2014) 0.83

Evaluation of stromal HGF immunoreactivity as a biomarker for melanoma response to RAF inhibitors. Mod Pathol (2014) 0.83

High levels of 5-hydroxymethylcytosine (5hmC) is an adverse predictor of biochemical recurrence after prostatectomy in ERG-negative prostate cancer. Clin Epigenetics (2015) 0.83

Decrease of 5hmC in gastric cancers is associated with TET1 silencing due to with DNA methylation and bivalent histone marks at TET1 CpG island 3'-shore. Oncotarget (2015) 0.83

The epigenetic role of vitamin C in health and disease. Cell Mol Life Sci (2016) 0.83

Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency. Brain (2015) 0.83

Epigenetic reprogramming of melanoma cells by vitamin C treatment. Clin Epigenetics (2015) 0.82

Cytosine 5-Hydroxymethylation of the LZTS1 Gene Is Reduced in Breast Cancer. Transl Oncol (2013) 0.82

The role of 5-hydroxymethylcytosine in human cancer. Cell Tissue Res (2014) 0.81

TET1 inhibits gastric cancer growth and metastasis by PTEN demethylation and re-expression. Oncotarget (2016) 0.81

Cytosine modifications in neurodevelopment and diseases. Cell Mol Life Sci (2013) 0.81

Epigenetic mechanisms of tumorigenicity manifesting in stem cells. Oncogene (2014) 0.81

Articles cited by this

Model-based analysis of ChIP-Seq (MACS). Genome Biol (2008) 51.63

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97

Cancer statistics, 2006. CA Cancer J Clin (2006) 30.71

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature (2010) 18.63

Mutation in TET2 in myeloid cancers. N Engl J Med (2009) 16.07

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell (2010) 13.13

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell (2011) 11.44

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. Nature (2011) 9.33

Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol (2010) 9.01

Identification of cells initiating human melanomas. Nature (2008) 8.28

Acquired mutations in TET2 are common in myelodysplastic syndromes. Nat Genet (2009) 8.03

Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. PLoS Genet (2007) 5.16

Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA. Nucleic Acids Res (2010) 4.91

Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells. Mol Cell (2011) 4.89

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep (2011) 4.89

Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev (2011) 4.09

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome. Proc Natl Acad Sci U S A (2011) 3.66

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. Nature (2011) 3.37

Novel genes associated with malignant melanoma but not benign melanocytic lesions. Clin Cancer Res (2005) 3.30

The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis. BMC Med Genomics (2008) 3.11

The gene expression signatures of melanoma progression. Proc Natl Acad Sci U S A (2005) 3.05

IDH mutations in glioma and acute myeloid leukemia. Trends Mol Med (2010) 2.83

Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene (2012) 2.82

Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers. Oncotarget (2011) 2.80

A systematic profile of DNA methylation in human cancer cell lines. Cancer Res (2003) 2.75

Recent trends in cutaneous melanoma incidence among whites in the United States. J Natl Cancer Inst (2001) 2.73

TET1 is a DNA-binding protein that modulates DNA methylation and gene transcription via hydroxylation of 5-methylcytosine. Cell Res (2010) 2.11

Integrative genome comparison of primary and metastatic melanomas. PLoS One (2010) 1.97

TET family proteins and their role in stem cell differentiation and transformation. Cell Stem Cell (2011) 1.87

Profiling epigenetic inactivation of tumor suppressor genes in tumors and plasma from cutaneous melanoma patients. Oncogene (2004) 1.81

Identification of novel epigenetically modified genes in human melanoma via promoter methylation gene profiling. Pigment Cell Melanoma Res (2007) 1.45

CpG island methylation profiling in human melanoma cell lines. Melanoma Res (2009) 1.35

Identification of tumor suppressors and oncogenes from genomic and epigenetic features in ovarian cancer. PLoS One (2011) 1.25

Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH mutations in glioblastoma. PLoS One (2011) 1.24

Epidemiology of melanoma. Clin Exp Dermatol (2000) 1.17

DNA-methylation profiling distinguishes malignant melanomas from benign nevi. Pigment Cell Melanoma Res (2011) 1.08

Articles by these authors

Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol (2009) 23.08

Sentinel-node biopsy or nodal observation in melanoma. N Engl J Med (2006) 15.64

New models of collaboration in genome-wide association studies: the Genetic Association Information Network. Nat Genet (2007) 13.76

WHO-EORTC classification for cutaneous lymphomas. Blood (2005) 12.14

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10

Hematopoiesis: an evolving paradigm for stem cell biology. Cell (2008) 11.95

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science (2005) 11.31

Final trial report of sentinel-node biopsy versus nodal observation in melanoma. N Engl J Med (2014) 10.69

The GPR54 gene as a regulator of puberty. N Engl J Med (2003) 9.54

Melanoma. N Engl J Med (2006) 8.80

The zebrafish reference genome sequence and its relationship to the human genome. Nature (2013) 8.52

Identification of cells initiating human melanomas. Nature (2008) 8.28

Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature (2007) 7.55

Electric-field control of local ferromagnetism using a magnetoelectric multiferroic. Nat Mater (2008) 7.23

Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma. J Clin Oncol (2011) 7.18

Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. Nat Genet (2008) 6.06

Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants. Nat Immunol (2003) 5.73

Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Proc Natl Acad Sci U S A (2003) 5.49

The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab (2005) 5.32

Transparent adult zebrafish as a tool for in vivo transplantation analysis. Cell Stem Cell (2008) 5.09

Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance. Nat Commun (2012) 4.94

Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells. Mol Cell (2011) 4.89

Selective BRAF inhibitors induce marked T-cell infiltration into human metastatic melanoma. Clin Cancer Res (2011) 4.70

Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell (2009) 4.69

Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell (2006) 4.68

A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention. N Engl J Med (2015) 4.64

Rate of growth in melanomas: characteristics and associations of rapidly growing melanomas. Arch Dermatol (2006) 4.51

Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients. Proc Natl Acad Sci U S A (2008) 4.43

The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science (2010) 4.37

Direct RNA sequencing. Nature (2009) 4.37

Sentinel node biopsy and standard of care for melanoma. J Am Acad Dermatol (2009) 4.32

BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma. Clin Cancer Res (2013) 4.28

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc Natl Acad Sci U S A (2005) 4.15

Cutaneous melanoma. Lancet (2005) 3.94

Quantification of the yeast transcriptome by single-molecule sequencing. Nat Biotechnol (2009) 3.86

Sentinel node biopsy for early-stage melanoma: accuracy and morbidity in MSLT-I, an international multicenter trial. Ann Surg (2005) 3.80

BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol (2005) 3.68

Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism. Nat Genet (2005) 3.66

Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. Cell (2008) 3.58

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. Nature (2007) 3.55

ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. Cancer Res (2005) 3.52

Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse. Nature (2013) 3.45

Effects of RAS on the genesis of embryonal rhabdomyosarcoma. Genes Dev (2007) 3.45

Variability in nomenclature used for nevi with architectural disorder and cytologic atypia (microscopically dysplastic nevi) by dermatologists and dermatopathologists. J Cutan Pathol (2004) 3.43

Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE). Nat Biotechnol (2008) 3.43

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. Nature (2011) 3.37

Hematopoietic stem cell fate is established by the Notch-Runx pathway. Genes Dev (2005) 3.27

The therapeutic promise of the cancer stem cell concept. J Clin Invest (2010) 3.26

Adjuvant radiotherapy versus observation alone for patients at risk of lymph-node field relapse after therapeutic lymphadenectomy for melanoma: a randomised trial. Lancet Oncol (2012) 3.24

Activation of CCR9/CCL25 in cutaneous melanoma mediates preferential metastasis to the small intestine. Clin Cancer Res (2008) 3.24

DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. J Clin Invest (2008) 3.17

Myc-induced T cell leukemia in transgenic zebrafish. Science (2003) 3.15

The use of zebrafish to understand immunity. Immunity (2004) 3.09

Central precocious puberty caused by mutations in the imprinted gene MKRN3. N Engl J Med (2013) 3.04

The impact on morbidity and length of stay of early versus delayed complete lymphadenectomy in melanoma: results of the Multicenter Selective Lymphadenectomy Trial (I). Ann Surg Oncol (2010) 3.02

The prognostic importance of tumor mitotic rate confirmed in 1317 patients with primary cutaneous melanoma and long follow-up. Ann Surg Oncol (2004) 2.99

Mitoferrin is essential for erythroid iron assimilation. Nature (2006) 2.99

Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease. Immunity (2012) 2.99

SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization. Mol Cell (2002) 2.93

What would you do if you could sequence everything? Nat Biotechnol (2008) 2.89

Virtual terminator nucleotides for next-generation DNA sequencing. Nat Methods (2009) 2.83

Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival. Am J Pathol (2003) 2.81

A Phase 3 Trial of Sebelipase Alfa in Lysosomal Acid Lipase Deficiency. N Engl J Med (2015) 2.77

Hematopoietic stem cell development is dependent on blood flow. Cell (2009) 2.77

Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis. Cancer Discov (2014) 2.74

Outcomes following isolated limb infusion for melanoma. A 14-year experience. Ann Surg Oncol (2008) 2.69

Analysis of thrombocyte development in CD41-GFP transgenic zebrafish. Blood (2005) 2.65

Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules. Nat Struct Mol Biol (2007) 2.62

Nevus/Melanocytoma/Melanoma: an emerging paradigm for classification of melanocytic neoplasms? Arch Pathol Lab Med (2011) 2.60

The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA. BMC Biol (2010) 2.59

Teratoma formation assays with human embryonic stem cells: a rationale for one type of human-animal chimera. Cell Stem Cell (2007) 2.56

The 'definitive' (and 'primitive') guide to zebrafish hematopoiesis. Oncogene (2004) 2.54

Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell (2011) 2.53

A GPR54-activating mutation in a patient with central precocious puberty. N Engl J Med (2008) 2.53

TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood. J Clin Endocrinol Metab (2010) 2.50

Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation. Blood (2004) 2.46

Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma. Clin Cancer Res (2012) 2.46

The risk of in-transit melanoma metastasis depends on tumor biology and not the surgical approach to regional lymph nodes. J Clin Oncol (2005) 2.41

Patterns of lymphatic drainage from the skin in patients with melanoma. J Nucl Med (2003) 2.41

De novo intraepidermal epithelioid melanocytic dysplasia as a marker of the atypical mole phenotype -- a clinical and pathological study of 75 patients. J Cutan Pathol (2005) 2.38

Keystone flap reconstruction of primary melanoma excision defects of the leg-the end of the skin graft? Ann Surg Oncol (2008) 2.36

An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature (2012) 2.35

TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell (2010) 2.33

Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. Genome Res (2008) 2.32

Androgen receptor mutations in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663. J Clin Oncol (2003) 2.32

Multivariate analysis of prognostic factors among 2,313 patients with stage III melanoma: comparison of nodal micrometastases versus macrometastases. J Clin Oncol (2010) 2.30