Published in World J Gastroenterol on August 14, 2014
Mitochondrial dysfunction in inflammatory bowel disease. Front Cell Dev Biol (2015) 0.83
Altered intestinal microbiota-host mitochondria crosstalk in new onset Crohn's disease. Nat Commun (2016) 0.82
Serum protein profiling of adults and children with Crohn disease. J Pediatr Gastroenterol Nutr (2015) 0.76
An Overview of Inflammatory Bowel Disease: General Consideration and Genetic Screening Approach in Diagnosis of Early Onset Subsets. Middle East J Dig Dis (2017) 0.75
MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59
Identification of tissue-specific microRNAs from mouse. Curr Biol (2002) 34.55
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature (2001) 33.12
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol (2001) 25.63
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res (2008) 20.59
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 19.08
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
The diverse functions of microRNAs in animal development and disease. Dev Cell (2006) 15.62
Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol (2007) 15.47
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet (2007) 13.74
IL-10 inhibits cytokine production by activated macrophages. J Immunol (1991) 13.13
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature (2008) 11.39
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science (2005) 11.31
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature (2008) 10.84
Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol (2005) 10.16
Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science (2006) 9.17
Making a definitive diagnosis: successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease. Genet Med (2011) 9.03
A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Nat Med (2007) 8.97
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98
Genetics and pathogenesis of inflammatory bowel disease. Nature (2011) 7.79
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med (2009) 7.53
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci U S A (2008) 7.43
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nat Genet (2008) 6.97
A simple classification of Crohn's disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998. Inflamm Bowel Dis (2000) 6.90
Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature (2011) 6.43
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol (2009) 5.83
NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med (2009) 5.43
A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon. Am J Hum Genet (2006) 5.10
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet (2008) 5.05
Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A (2005) 5.05
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet (2009) 4.61
Toll-like receptors in the pathogenesis of human disease. Nat Immunol (2004) 4.40
NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut (2004) 4.39
The molecular classification of the clinical manifestations of Crohn's disease. Gastroenterology (2002) 4.20
Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease. Gastroenterology (2008) 4.05
RTEL1 maintains genomic stability by suppressing homologous recombination. Cell (2008) 3.84
Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet (2009) 3.82
The epidemiology of inflammatory bowel disease in Canada: a population-based study. Am J Gastroenterol (2006) 3.76
CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells. Gastroenterology (2003) 3.70
Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis. Nature (2011) 3.61
A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease. Nat Genet (2011) 3.59
Pediatric modification of the Montreal classification for inflammatory bowel disease: the Paris classification. Inflamm Bowel Dis (2010) 3.55
Epidemiologic and clinical characteristics of children with newly diagnosed inflammatory bowel disease in Wisconsin: a statewide population-based study. J Pediatr (2003) 3.49
Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett (1996) 3.39
Children with early-onset inflammatory bowel disease (IBD): analysis of a pediatric IBD consortium registry. J Pediatr (2005) 3.37
Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. PLoS One (2008) 3.36
Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. Nat Genet (2008) 3.36
Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy. Gastroenterology (2012) 3.28
Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages. J Immunol (2004) 2.58
Overlap in the spectrum of non-specific inflammatory bowel disease--'colitis indeterminate'. J Clin Pathol (1978) 2.56
DAP1, a novel substrate of mTOR, negatively regulates autophagy. Curr Biol (2010) 2.50
Epidemiology of pediatric inflammatory bowel disease: a systematic review of international trends. Inflamm Bowel Dis (2011) 2.46
Enhancing immunity through autophagy. Annu Rev Immunol (2009) 2.30
Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver. Proc Natl Acad Sci U S A (2006) 2.25
Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly. Cell Microbiol (2009) 2.23
PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis. Gut (2005) 2.22
Recent insights into the genetics of inflammatory bowel disease. Gastroenterology (2011) 2.12
NOD proteins: regulators of inflammation in health and disease. Nat Rev Immunol (2013) 2.10
Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort. Gut (2008) 2.06
Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon. Gastroenterology (2006) 2.04
European evidence-based Consensus on the diagnosis and management of ulcerative colitis: Definitions and diagnosis. J Crohns Colitis (2008) 1.99
MicroRNAs control intestinal epithelial differentiation, architecture, and barrier function. Gastroenterology (2010) 1.95
Increasing incidence of paediatric inflammatory bowel disease in northern Stockholm County, 2002-2007. J Pediatr Gastroenterol Nutr (2013) 1.87
Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor alpha antibody treatment. Gut (2004) 1.82
Presenting features of inflammatory bowel disease in Great Britain and Ireland. Arch Dis Child (2003) 1.82
Characteristics of inflammatory bowel disease with onset during the first year of life. J Pediatr Gastroenterol Nutr (2006) 1.80
Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria. Nat Cell Biol (2010) 1.76
The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4. J Immunol (2007) 1.73
Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster. Proc Natl Acad Sci U S A (2000) 1.67
NOD2/CARD15 mutation analysis and genotype-phenotype correlation in Jewish pediatric patients compared with adults with Crohn's disease. J Pediatr (2004) 1.65
Characterization of the novel ST2/IL-33 system in patients with inflammatory bowel disease. Inflamm Bowel Dis (2010) 1.65
Paneth cell alpha-defensin synthesis and function. Curr Top Microbiol Immunol (2006) 1.60
NOD2/CARD15 variants are associated with lower weight at diagnosis in children with Crohn's disease. Am J Gastroenterol (2003) 1.59
IL-10R polymorphisms are associated with very-early-onset ulcerative colitis. Inflamm Bowel Dis (2013) 1.59
Human beta-defensin 2 but not beta-defensin 1 is expressed preferentially in colonic mucosa of inflammatory bowel disease. Eur J Gastroenterol Hepatol (2002) 1.59
Genotype-phenotype analysis in childhood-onset Crohn's disease: NOD2/CARD15 variants consistently predict phenotypic characteristics of severe disease. Inflamm Bowel Dis (2005) 1.55
Crohn's disease is associated with a toll-like receptor-9 polymorphism. Gastroenterology (2004) 1.55
European consensus on the histopathology of inflammatory bowel disease. J Crohns Colitis (2013) 1.53
Inflammatory bowel disease: review from the aspect of genetics. J Gastroenterol (2009) 1.51
Diagnosis and treatment of perianal Crohn disease: NASPGHAN clinical report and consensus statement. J Pediatr Gastroenterol Nutr (2013) 1.47
Pediatric ulcerative colitis associated with autoimmune diseases: a distinct form of inflammatory bowel disease? Inflamm Bowel Dis (2012) 1.46
Defective IL10 signaling defining a subgroup of patients with inflammatory bowel disease. Am J Gastroenterol (2011) 1.43
MicroRNA regulation of intestinal epithelial tight junction permeability. Gastroenterology (2011) 1.41
Galpha12 regulates protein interactions within the MDCK cell tight junction and inhibits tight-junction assembly. J Cell Sci (2008) 1.41
A clinical review of recent findings in the epidemiology of inflammatory bowel disease. Clin Epidemiol (2013) 1.40
IL-33 is upregulated in colonocytes of ulcerative colitis. Immunol Lett (2009) 1.33
Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis. Differentiation (2008) 1.30
Paneth's disease. J Crohns Colitis (2010) 1.29
Genetics in twins with Crohn's disease: less pronounced than previously believed? Inflamm Bowel Dis (2011) 1.29
Indeterminate colitis: a review of the concept--what's in a name? Inflamm Bowel Dis (2008) 1.28
Update on the heritability of inflammatory bowel disease: the importance of twin studies. Inflamm Bowel Dis (2011) 1.27
CARD15 gene mutations and risk for early surgery in pediatric-onset Crohn's disease. Clin Gastroenterol Hepatol (2004) 1.25
A characterization in childhood inflammatory bowel disease, a new population-based inception cohort from South-Eastern Norway, 2005-07, showing increased incidence in Crohn's disease. Scand J Gastroenterol (2009) 1.24
Inflammatory bowel disease: the difference between children and adults. Inflamm Bowel Dis (2008) 1.22
Inflammatory bowel disease-associated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts. Am J Pathol (2010) 1.21
Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease. Hum Mol Genet (2010) 1.21
Expression of catenins and E-cadherin during epithelial restitution in inflammatory bowel disease. J Pathol (1998) 1.19
Paneth cell granule depletion in the human small intestine under infective and nutritional stress. Clin Exp Immunol (2004) 1.18