Published in Nat Genet on August 31, 2008
Inflammatory bowel disease. N Engl J Med (2009) 8.62
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98
Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nat Rev Genet (2009) 4.79
Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet (2010) 4.65
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet (2009) 4.61
Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet (2009) 3.82
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Nat Genet (2009) 3.65
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Nat Genet (2010) 3.58
Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease. Am J Hum Genet (2009) 3.19
Phasing of many thousands of genotyped samples. Am J Hum Genet (2012) 2.47
CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. J Exp Med (2014) 2.09
Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes. Hum Mol Genet (2010) 1.89
Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. Hum Mol Genet (2010) 1.81
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. Nat Med (2015) 1.66
The diagnostic approach to monogenic very early onset inflammatory bowel disease. Gastroenterology (2014) 1.63
IL-10R polymorphisms are associated with very-early-onset ulcerative colitis. Inflamm Bowel Dis (2013) 1.59
Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease. PLoS One (2010) 1.54
Inflammatory bowel disease: review from the aspect of genetics. J Gastroenterol (2009) 1.51
Incidence and paris classification of pediatric inflammatory bowel disease. Gastroenterol Res Pract (2014) 1.45
Alterations in the gut microbiome of children with severe ulcerative colitis. Inflamm Bowel Dis (2011) 1.42
Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans. Adv Immunol (2014) 1.38
Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain. Neurobiol Dis (2012) 1.35
IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases. Nat Med (2015) 1.32
Improved risk prediction for Crohn's disease with a multi-locus approach. Hum Mol Genet (2011) 1.28
Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease. Inflamm Bowel Dis (2010) 1.27
Genetics of spondyloarthritis--beyond the MHC. Nat Rev Rheumatol (2012) 1.26
Distinct and overlapping genetic loci in Crohn's disease and ulcerative colitis: correlations with pathogenesis. Inflamm Bowel Dis (2010) 1.22
Pathogenesis of immunoglobulin A nephropathy: recent insight from genetic studies. Annu Rev Med (2012) 1.21
Genome-wide significant associations for variants with minor allele frequency of 5% or less--an overview: A HuGE review. Am J Epidemiol (2010) 1.21
Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state. J Exp Med (2012) 1.19
Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells. Eur J Immunol (2009) 1.18
Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population. Genes Immun (2011) 1.18
Autophagy and Crohn's disease: at the crossroads of infection, inflammation, immunity, and cancer. Curr Mol Med (2010) 1.17
High-density genotyping study identifies four new susceptibility loci for atopic dermatitis. Nat Genet (2013) 1.11
Evaluation of 22 genetic variants with Crohn's disease risk in the Ashkenazi Jewish population: a case-control study. BMC Med Genet (2011) 1.10
Decoy strategies: the structure of TL1A:DcR3 complex. Structure (2011) 1.10
The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation. Nature (2016) 1.08
Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study. Ann Hum Genet (2010) 1.01
Investigation of multiple susceptibility loci for inflammatory bowel disease in an Italian cohort of patients. PLoS One (2011) 1.00
The chromatin-binding protein HMGN1 regulates the expression of methyl CpG-binding protein 2 (MECP2) and affects the behavior of mice. J Biol Chem (2011) 0.98
Whole genome gene expression meta-analysis of inflammatory bowel disease colon mucosa demonstrates lack of major differences between Crohn's disease and ulcerative colitis. PLoS One (2013) 0.98
The ubiquitin ligase adaptor Ndfip1 regulates T cell-mediated gastrointestinal inflammation and inflammatory bowel disease susceptibility. Mucosal Immunol (2010) 0.97
Genomic alterations in biliary atresia suggest region of potential disease susceptibility in 2q37.3. Am J Med Genet A (2010) 0.97
Dissecting Allele Architecture of Early Onset IBD Using High-Density Genotyping. PLoS One (2015) 0.96
Genotype/phenotype analyses for 53 Crohn's disease associated genetic polymorphisms. PLoS One (2012) 0.93
Oncostatin M mediates STAT3-dependent intestinal epithelial restitution via increased cell proliferation, decreased apoptosis and upregulation of SERPIN family members. PLoS One (2014) 0.93
The history of genetics in inflammatory bowel disease. Ann Gastroenterol (2014) 0.92
Cytokine gene polymorphisms and human autoimmune disease in the era of genome-wide association studies. J Interferon Cytokine Res (2011) 0.90
Multiple sclerosis risk variant HLA-DRB1*1501 associates with high expression of DRB1 gene in different human populations. PLoS One (2012) 0.90
Genetic comorbidities in Parkinson's disease. Hum Mol Genet (2013) 0.89
Enteropathic spondyloarthropathy: a common genetic background with inflammatory bowel disease? World J Gastroenterol (2009) 0.89
Impact of exome sequencing in inflammatory bowel disease. World J Gastroenterol (2013) 0.88
T300A polymorphism of ATG16L1 and susceptibility to inflammatory bowel diseases: a meta-analysis. World J Gastroenterol (2010) 0.88
Genetic Epidemiology of Psoriasis. Curr Dermatol Rep (2014) 0.87
Early life factors and risk of inflammatory bowel disease in adulthood. Inflamm Bowel Dis (2013) 0.87
The impact of genomics on pediatric research and medicine. Pediatrics (2012) 0.87
Higher activity of the inducible nitric oxide synthase contributes to very early onset inflammatory bowel disease. Clin Transl Gastroenterol (2014) 0.87
Genetics of inflammatory bowel disease from multifactorial to monogenic forms. World J Gastroenterol (2015) 0.86
A TNFSF15 disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8-induced IL-1. Proc Natl Acad Sci U S A (2014) 0.86
Network-based SNP meta-analysis identifies joint and disjoint genetic features across common human diseases. BMC Genomics (2012) 0.85
Atherosclerosis susceptibility Loci identified in an extremely atherosclerosis-resistant mouse strain. J Am Heart Assoc (2013) 0.84
Interaction of Crohn's disease susceptibility genes in an Australian paediatric cohort. PLoS One (2010) 0.84
Association between genome-wide association studies reported SNPs and pediatric-onset Crohn's disease in Canadian children. Hum Genet (2010) 0.84
Central role of IL-17/Th17 immune responses and the gut microbiota in the pathogenesis of intestinal fibrosis. Curr Opin Gastroenterol (2014) 0.83
NOD2/CARD15, ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn's disease. World J Gastroenterol (2010) 0.83
Accurate measurement of gene copy number for human alpha-defensin DEFA1A3. BMC Genomics (2013) 0.83
High intestinal and systemic levels of interleukin-23/T-helper 17 pathway in Chinese patients with inflammatory bowel disease. Mediators Inflamm (2013) 0.82
Current issues of pediatric inflammatory bowel disease in Korea. Korean J Pediatr (2014) 0.82
Genes involved in the metabolism of poly-unsaturated fatty-acids (PUFA) and risk for Crohn's disease in children & young adults. PLoS One (2010) 0.82
Genetic evidence supporting the association of protease and protease inhibitor genes with inflammatory bowel disease: a systematic review. PLoS One (2011) 0.82
The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses. Immunity (2016) 0.81
Genetic variants associated with Crohn's disease. Appl Clin Genet (2013) 0.81
GWAS signals across the HLA regions: revealing a clue for common etiology underlying infectious tumors and other immunity diseases. Chin J Cancer (2011) 0.81
Development of biomarkers to optimize pediatric patient management: what makes children different? Biomark Med (2011) 0.81
The transition of acute to chronic bowel inflammation in spondyloarthritis. Nat Rev Rheumatol (2012) 0.81
Genetic sharing and heritability of paediatric age of onset autoimmune diseases. Nat Commun (2015) 0.81
Temporal genome expression profile analysis during t-cell-mediated colitis: identification of novel targets and pathways. Inflamm Bowel Dis (2011) 0.81
Epidemiology of pediatric inflammatory bowel diseases in southern iran. Middle East J Dig Dis (2012) 0.80
Advances and challenges in biomarker development for type 1 diabetes prediction and prevention using omic technologies. Expert Opin Med Diagn (2010) 0.79
The anatomical distribution of genetic associations. Nucleic Acids Res (2015) 0.78
Genome-wide association studies--a summary for the clinical gastroenterologist. World J Gastroenterol (2009) 0.78
Developmental origins of genotype-phenotype correlations in chronic diseases of old age. Aging Dis (2012) 0.78
Crohn's disease risk alleles on the NOD2 locus have been maintained by natural selection on standing variation. Mol Biol Evol (2012) 0.78
Role of genetics in pediatric inflammatory bowel disease. Inflamm Bowel Dis (2014) 0.78
Gene network analysis of small molecules with autoimmune disease associated genes predicts a novel strategy for drug efficacy. Autoimmun Rev (2012) 0.77
Gut inflammation and microbiome in spondyloarthritis. Rheumatol Int (2015) 0.77
The TNF-family cytokine TL1A: from lymphocyte costimulator to disease co-conspirator. J Leukoc Biol (2015) 0.77
Inflammatory bowel disease in pediatric and adolescent patients: a biomolecular and histopathological review. World J Gastroenterol (2014) 0.77
Role of defective autophagia and the intestinal flora in Crohn disease. Self Nonself (2012) 0.77
Systematic meta-analyses and field synopsis of genetic and epigenetic studies in paediatric inflammatory bowel disease. Sci Rep (2016) 0.77
Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo. Immunity (2016) 0.77
How does knowledge from translational research impact our clinical care of pediatric inflammatory bowel disease patients? Curr Gastroenterol Rep (2012) 0.77
Autophagy gene polymorphism is associated with susceptibility to leprosy by affecting inflammatory cytokines. Inflammation (2014) 0.76
Application of Comparative Transcriptional Genomics to Identify Molecular Targets for Pediatric IBD. Front Immunol (2015) 0.76
Genetics and Therapeutics in Pediatric Ulcerative Colitis: the Past, Present and Future. F1000Res (2016) 0.75
Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins. PLoS One (2016) 0.75
Exome Analysis of Rare and Common Variants within the NOD Signaling Pathway. Sci Rep (2017) 0.75
Genetic architecture differences between pediatric and adult-onset inflammatory bowel diseases in the Polish population. Sci Rep (2016) 0.75
The role of the innate and adaptive immune system in pediatric inflammatory bowel disease. Inflamm Bowel Dis (2013) 0.75
Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network. Genome Med (2016) 0.75
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Genetics (2003) 53.11
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49
Inflammatory bowel disease. N Engl J Med (2002) 21.17
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 19.08
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet (2006) 15.14
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature (2007) 14.43
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet (2007) 13.74
Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol (2005) 10.16
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet (2007) 8.63
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Nature (2007) 6.10
Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease. Lancet (1996) 4.33
Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum. Gastroenterology (1998) 4.08
Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's disease: A European multicenter trial. Gastroenterology (1999) 2.80
An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases. Hum Mol Genet (2007) 2.14
Resistance of Crohn's disease T cells to multiple apoptotic signals is associated with a Bcl-2/Bax mucosal imbalance. J Immunol (1999) 2.11
Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors. Hum Mol Genet (2002) 1.76
Genetics of inflammatory bowel disease: progress and prospects. Hum Mol Genet (2004) 1.44
Epigenetic control of MHC class II expression in tumor-associated macrophages by decoy receptor 3. Blood (2008) 1.28
Association of variants of the interleukin-23 receptor gene with susceptibility to pediatric Crohn's disease. Clin Gastroenterol Hepatol (2007) 1.26
Modulation of dendritic cell differentiation and maturation by decoy receptor 3. J Immunol (2002) 1.20
Increased expression of soluble decoy receptor 3 in acutely inflamed intestinal epithelia. Clin Immunol (2005) 1.16
Modulation of macrophage differentiation and activation by decoy receptor 3. J Leukoc Biol (2003) 1.15
Ileal involvement is age dependent in pediatric Crohn's disease. Inflamm Bowel Dis (2005) 1.14
Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease. Gut (2007) 1.08
Fas ligand-induced murine pulmonary inflammation is reduced by a stable decoy receptor 3 analogue. Immunology (2003) 1.03
Pediatric onset Crohn's colitis is characterized by genotype-dependent age-related susceptibility. Inflamm Bowel Dis (2007) 1.01
Apoptosis resistance in ulcerative colitis: high expression of decoy receptors by lamina propria T cells. Eur J Immunol (2006) 0.98
MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol (2011) 220.97
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res (2010) 43.51
Signatures of mutational processes in human cancer. Nature (2013) 21.63
Human gut microbiome viewed across age and geography. Nature (2012) 19.31
PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data. Genome Res (2007) 19.07
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66
Rare variants create synthetic genome-wide associations. PLoS Biol (2010) 14.43
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
A landscape of driver mutations in melanoma. Cell (2012) 12.61
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature (2009) 9.47
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet (2009) 9.45
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98
Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature (2009) 7.39
Identification of ALK as a major familial neuroblastoma predisposition gene. Nature (2008) 7.38
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16
Pneumatic dilation versus laparoscopic Heller's myotomy for idiopathic achalasia. N Engl J Med (2011) 6.76
Analysing biological pathways in genome-wide association studies. Nat Rev Genet (2010) 6.63
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Nature (2007) 6.10
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet (2007) 5.88
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet (2010) 5.52
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet (2004) 5.31
De novo mutations in histone-modifying genes in congenital heart disease. Nature (2013) 5.15
A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. Nat Genet (2010) 4.96
GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis. N Engl J Med (2007) 4.94
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet (2012) 4.87
Impact of in-scanner head motion on multiple measures of functional connectivity: relevance for studies of neurodevelopment in youth. Neuroimage (2012) 4.84
Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet (2010) 4.65
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet (2013) 4.62
A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction. Nat Genet (2005) 4.45
The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future. Genet Med (2013) 4.37
High-resolution mapping and analysis of copy number variations in the human genome: a data resource for clinical and research applications. Genome Res (2009) 4.32
An improved framework for confound regression and filtering for control of motion artifact in the preprocessing of resting-state functional connectivity data. Neuroimage (2012) 4.30
Copy number variants in schizophrenia: confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplications. Am J Psychiatry (2011) 4.29
Adjustment of genomic waves in signal intensities from whole-genome SNP genotyping platforms. Nucleic Acids Res (2008) 4.22
Variants of DENND1B associated with asthma in children. N Engl J Med (2009) 4.18