Published in Adv Healthc Mater on August 25, 2014
Nanoparticles that deliver triplex-forming peptide nucleic acid molecules correct F508del CFTR in airway epithelium. Nat Commun (2015) 0.91
In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery. Nat Commun (2016) 0.86
Nanotechnology for delivery of peptide nucleic acids (PNAs). J Control Release (2016) 0.77
Recent trends on hydrogel based drug delivery systems for infectious diseases. Biomater Sci (2016) 0.75
Cystic fibrosis. N Engl J Med (2005) 8.09
CFTR regulates phagosome acidification in macrophages and alters bactericidal activity. Nat Cell Biol (2006) 3.60
Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA. Nat Mater (2009) 2.87
Polymers for gene delivery across length scales. Nat Mater (2006) 2.79
Solid-phase synthesis of peptide nucleic acids. J Pept Sci (1997) 2.67
A combinatorial polymer library approach yields insight into nonviral gene delivery. Acc Chem Res (2008) 2.63
Cystic fibrosis: a mucosal immunodeficiency syndrome. Nat Med (2012) 2.03
Synthesis of poly(beta-amino ester)s optimized for highly effective gene delivery. Bioconjug Chem (2003) 1.87
Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier. Proc Natl Acad Sci U S A (2009) 1.86
A new peptide vector for efficient delivery of oligonucleotides into mammalian cells. Nucleic Acids Res (1997) 1.67
Controlled surface modification with poly(ethylene)glycol enhances diffusion of PLGA nanoparticles in human cervical mucus. Mol Pharm (2009) 1.59
Macrophages directly contribute to the exaggerated inflammatory response in cystic fibrosis transmembrane conductance regulator-/- mice. Am J Respir Cell Mol Biol (2008) 1.57
Efficient and persistent splice switching by systemically delivered LNA oligonucleotides in mice. Mol Ther (2006) 1.42
Nano-carriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG-PEI. J Control Release (2005) 1.38
Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. J Immunol (2011) 1.31
Enhanced siRNA delivery into cells by exploiting the synergy between targeting ligands and cell-penetrating peptides. Biomaterials (2011) 1.24
In vivo distribution of surface-modified PLGA nanoparticles following intravaginal delivery. J Control Release (2011) 1.20
In vitro and in vivo mRNA delivery using lipid-enveloped pH-responsive polymer nanoparticles. Mol Pharm (2011) 1.17
Nanoparticles deliver triplex-forming PNAs for site-specific genomic recombination in CD34+ human hematopoietic progenitors. Mol Ther (2010) 1.13
Nonviral siRNA delivery to the lung: investigation of PEG-PEI polyplexes and their in vivo performance. Mol Pharm (2009) 1.12
In vivo SPECT and real-time gamma camera imaging of biodistribution and pharmacokinetics of siRNA delivery using an optimized radiolabeling and purification procedure. Bioconjug Chem (2009) 1.12
Nonviral pulmonary delivery of siRNA. Acc Chem Res (2011) 1.01
Surface modified poly(β amino ester)-containing nanoparticles for plasmid DNA delivery. J Control Release (2012) 0.97
Aerosolized nanogram quantities of plasmid DNA mediate highly efficient gene delivery to mouse airway epithelium. Mol Ther (2005) 0.94
Sustained delivery of proangiogenic microRNA-132 by nanoparticle transfection improves endothelial cell transplantation. FASEB J (2013) 0.94
Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities. Hum Mol Genet (2002) 0.91
Controlled pulmonary drug and gene delivery using polymeric nano-carriers. J Control Release (2011) 0.88
Polymer delivery systems for site-specific genome editing. J Control Release (2011) 0.82
Lung deposition and cellular uptake behavior of pathogen-mimicking nanovaccines in the first 48 hours. Adv Healthc Mater (2014) 0.82
Medical nanoparticles for next generation drug delivery to the lungs. Eur Respir J (2014) 0.78
Outcome of conservatively managed early-onset breast cancer by BRCA1/2 status. Lancet (2002) 3.04
MicroRNA regulation of DNA repair gene expression in hypoxic stress. Cancer Res (2009) 2.93
Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA. Nat Mater (2009) 2.87
Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodeling. Proc Natl Acad Sci U S A (2010) 2.49
Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. Mol Cell Biol (2003) 2.12
Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells. Mol Cell Biol (2004) 2.09
Hypoxia-induced down-regulation of BRCA1 expression by E2Fs. Cancer Res (2005) 2.02
Regulation of DNA repair in hypoxic cancer cells. Cancer Metastasis Rev (2007) 1.99
Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma. Proc Natl Acad Sci U S A (2013) 1.95
Enhanced and prolonged cross-presentation following endosomal escape of exogenous antigens encapsulated in biodegradable nanoparticles. Immunology (2006) 1.92
Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma. Proc Natl Acad Sci U S A (2012) 1.91
The uptake and intracellular fate of PLGA nanoparticles in epithelial cells. Biomaterials (2009) 1.82
PEGylated PLGA nanoparticles for the improved delivery of doxorubicin. Nanomedicine (2009) 1.70
Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance. Cancer Res (2008) 1.70
Hypoxia-induced genetic instability--a calculated mechanism underlying tumor progression. J Mol Med (Berl) (2006) 1.66
Controlled surface modification with poly(ethylene)glycol enhances diffusion of PLGA nanoparticles in human cervical mucus. Mol Pharm (2009) 1.59
Multiphoton microscopy guides neurotrophin modification with poly(ethylene glycol) to enhance interstitial diffusion. Nat Mater (2004) 1.59
Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302. Mol Cancer Ther (2011) 1.58
Macrophages directly contribute to the exaggerated inflammatory response in cystic fibrosis transmembrane conductance regulator-/- mice. Am J Respir Cell Mol Biol (2008) 1.57
Tissue-engineered vascular grafts form neovessels that arise from regeneration of the adjacent blood vessel. FASEB J (2011) 1.52
Pharmacokinetics of the carmustine implant. Clin Pharmacokinet (2002) 1.52
Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells. Cancer Biol Ther (2011) 1.50
Human XPA and RPA DNA repair proteins participate in specific recognition of triplex-induced helical distortions. Proc Natl Acad Sci U S A (2002) 1.49
Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130. Proc Natl Acad Sci U S A (2010) 1.47
The influence of microchannels on neurite growth and architecture. Biomaterials (2005) 1.47
Surface-mediated gene transfer from nanocomposites of controlled texture. Nat Mater (2004) 1.45
Genetic instability and the tumor microenvironment: towards the concept of microenvironment-induced mutagenesis. Mutat Res (2005) 1.37
Octa-functional PLGA nanoparticles for targeted and efficient siRNA delivery to tumors. Biomaterials (2011) 1.36
Repair of DNA lesions associated with triplex-forming oligonucleotides. Mol Carcinog (2009) 1.36
Therapeutic siRNA: principles, challenges, and strategies. Yale J Biol Med (2012) 1.35
Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery. Nat Mater (2011) 1.33
Site-directed recombination via bifunctional PNA-DNA conjugates. Proc Natl Acad Sci U S A (2002) 1.32
Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. J Immunol (2011) 1.31
Human aortic smooth muscle cells promote arteriole formation by coengrafted endothelial cells. Tissue Eng Part A (2009) 1.28
New methods for direct delivery of chemotherapy for treating brain tumors. Yale J Biol Med (2006) 1.26
Dilation and degradation of the brain extracellular matrix enhances penetration of infused polymer nanoparticles. Brain Res (2007) 1.25
Correction of a splice-site mutation in the beta-globin gene stimulated by triplex-forming peptide nucleic acids. Proc Natl Acad Sci U S A (2008) 1.25
Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner. Cancer Res (2005) 1.24
Enhanced siRNA delivery into cells by exploiting the synergy between targeting ligands and cell-penetrating peptides. Biomaterials (2011) 1.24
Controlled delivery of VEGF via modulation of alginate microparticle ionic crosslinking. J Control Release (2008) 1.23
Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells. Radiother Oncol (2005) 1.22
Strand invasion of extended, mixed-sequence B-DNA by gammaPNAs. J Am Chem Soc (2009) 1.22
In vivo distribution of surface-modified PLGA nanoparticles following intravaginal delivery. J Control Release (2011) 1.20
The potential for gene repair via triple helix formation. J Clin Invest (2003) 1.19
Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6. Carcinogenesis (2006) 1.19
High loading efficiency and tunable release of plasmid DNA encapsulated in submicron particles fabricated from PLGA conjugated with poly-L-lysine. J Control Release (2008) 1.19
Cellular fate of a modular DNA delivery system mediated by silica nanoparticles. Biotechnol Prog (2005) 1.19
Hypoxic tumor microenvironment and cancer cell differentiation. Curr Mol Med (2009) 1.19
Diffusion of nerve growth factor in rat striatum as determined by multiphoton microscopy. Biophys J (2003) 1.17
Fibronectin terminated multilayer films: protein adsorption and cell attachment studies. Biomaterials (2006) 1.16
Synthesis and characterization of conformationally preorganized, (R)-diethylene glycol-containing γ-peptide nucleic acids with superior hybridization properties and water solubility. J Org Chem (2011) 1.16
Assessment of cystic fibrosis transmembrane conductance regulator (CFTR) activity in CFTR-null mice after bone marrow transplantation. Proc Natl Acad Sci U S A (2006) 1.16
Site-specific gene modification by PNAs conjugated to psoralen. Biochemistry (2006) 1.16
Biomaterials with hierarchically defined micro- and nanoscale structure. Biomaterials (2004) 1.15
Emerging roles of microRNAs in the molecular responses to hypoxia. Curr Pharm Des (2009) 1.14
Co-repression of mismatch repair gene expression by hypoxia in cancer cells: role of the Myc/Max network. Cancer Lett (2007) 1.14
Hypoxia-induced epigenetic regulation and silencing of the BRCA1 promoter. Mol Cell Biol (2011) 1.13
Nanoparticles deliver triplex-forming PNAs for site-specific genomic recombination in CD34+ human hematopoietic progenitors. Mol Ther (2010) 1.13
Poly(omega-pentadecalactone-co-butylene-co-succinate) nanoparticles as biodegradable carriers for camptothecin delivery. Biomaterials (2009) 1.12
Centrifugal seeding increases seeding efficiency and cellular distribution of bone marrow stromal cells in porous biodegradable scaffolds. Tissue Eng (2007) 1.12
Engineering of multifunctional gels integrating highly efficient growth factor delivery with endothelial cell transplantation. FASEB J (2008) 1.11
Polymeric nanoparticles for drug delivery to the central nervous system. Adv Drug Deliv Rev (2011) 1.09
Basal repression of BRCA1 by multiple E2Fs and pocket proteins at adjacent E2F sites. Cancer Biol Ther (2006) 1.09
Triplex-forming oligonucleotides: principles and applications. Q Rev Biophys (2002) 1.09
Targeting cancer with a lupus autoantibody. Sci Transl Med (2012) 1.09
Improving the expansion and neuronal differentiation of mesenchymal stem cells through culture surface modification. Biomaterials (2003) 1.09
Triplex-forming oligonucleotides as potential tools for modulation of gene expression. Curr Med Chem Anticancer Agents (2005) 1.08
Convection-enhanced delivery of camptothecin-loaded polymer nanoparticles for treatment of intracranial tumors. Drug Deliv Transl Res (2011) 1.07
A self-assembled, modular DNA delivery system mediated by silica nanoparticles. J Control Release (2004) 1.07
Engraftment of donor-derived epithelial cells in multiple organs following bone marrow transplantation into newborn mice. Stem Cells (2006) 1.07
Development of a model system for preliminary evaluation of tissue-engineered vascular conduits. J Pediatr Surg (2006) 1.06
Targeted disruption of the CCR5 gene in human hematopoietic stem cells stimulated by peptide nucleic acids. Chem Biol (2011) 1.05
Repair and recombination induced by triple helix DNA. Front Biosci (2007) 1.04
Enhancement of surface ligand display on PLGA nanoparticles with amphiphilic ligand conjugates. J Control Release (2011) 1.03
Emergence of rationally designed therapeutic strategies for breast cancer targeting DNA repair mechanisms. Breast Cancer Res (2010) 1.03
Nanotechnology for delivery of drugs to the brain for epilepsy. Neurotherapeutics (2009) 1.03
Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions. Proc Natl Acad Sci U S A (2004) 1.03
Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation. Cancer Res (2009) 1.02
Repair of DNA interstrand cross-links: interactions between homology-dependent and homology-independent pathways. DNA Repair (Amst) (2006) 1.02
Strand invasion of mixed-sequence, double-helical B-DNA by γ-peptide nucleic acids containing G-clamp nucleobases under physiological conditions. Biochemistry (2011) 1.01
Gene expression and mucosal immune responses after vaginal DNA immunization in mice using a controlled delivery matrix. J Control Release (2003) 1.01
Novel delivery strategies for glioblastoma. Cancer J (2012) 1.01
Targeted gene modification of hematopoietic progenitor cells in mice following systemic administration of a PNA-peptide conjugate. Mol Ther (2011) 1.01
Dual delivery of VEGF and MCP-1 to support endothelial cell transplantation for therapeutic vascularization. Biomaterials (2010) 0.99
Partial correction of cystic fibrosis defects with PLGA nanoparticles encapsulating curcumin. Mol Pharm (2010) 0.99
Canonical and non-canonical barriers facing antimiR cancer therapeutics. Curr Med Chem (2013) 0.98
Nanosystems for simultaneous imaging and drug delivery to T cells. AAPS J (2007) 0.98
Peptide conjugates for chromosomal gene targeting by triplex-forming oligonucleotides. Nucleic Acids Res (2004) 0.98
Topographical control of human neutrophil motility on micropatterned materials with various surface chemistry. Biomaterials (2002) 0.98
In vitro evaluation of biodegradable microspheres with surface-bound ligands. J Control Release (2005) 0.97
Surface modified poly(β amino ester)-containing nanoparticles for plasmid DNA delivery. J Control Release (2012) 0.97
Functional and physical interaction between the mismatch repair and FA-BRCA pathways. Hum Mol Genet (2011) 0.97
CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney. J Clin Invest (2006) 0.97