Published in Biochemistry on April 25, 2011
Identification and characterization of second-generation invader locked nucleic acids (LNAs) for mixed-sequence recognition of double-stranded DNA. J Org Chem (2013) 0.91
Invaders: Recognition of Double-Stranded DNA by Using Duplexes Modified with Interstrand Zippers of 2'-O-(Pyren-1-yl)methyl-ribonucleotides. Chembiochem (2013) 0.87
γ Sulphate PNA (PNA S): highly selective DNA binding molecule showing promising antigene activity. PLoS One (2012) 0.86
Recognition of mixed-sequence DNA duplexes: design guidelines for invaders based on 2'-O-(pyren-1-yl)methyl-RNA monomers. J Org Chem (2013) 0.84
Recognition of double-stranded DNA using energetically activated duplexes with interstrand zippers of 1-, 2- or 4-pyrenyl-functionalized O2'-alkylated RNA monomers. Org Biomol Chem (2014) 0.83
Recent advances in chemical modification of Peptide nucleic acids. J Nucleic Acids (2012) 0.82
Evaluating the effect of ionic strength on duplex stability for PNA having negatively or positively charged side chains. PLoS One (2013) 0.81
Invader probes: Harnessing the energy of intercalation to facilitate recognition of chromosomal DNA for diagnostic applications. Chem Sci (2015) 0.80
Nanoparticle for delivery of antisense γPNA oligomers targeting CCR5. Artif DNA PNA XNA (2013) 0.80
Single-stranded γPNAs for in vivo site-specific genome editing via Watson-Crick recognition. Curr Gene Ther (2014) 0.79
Nanotechnology for delivery of peptide nucleic acids (PNAs). J Control Release (2016) 0.77
Cooperative hybridization of γPNA miniprobes to a repeating sequence motif and application to telomere analysis. Org Biomol Chem (2014) 0.77
Fluorescent intercalator displacement replacement (FIDR) assay: determination of relative thermodynamic and kinetic parameters in triplex formation--a case study using triplex-forming LNAs. Nucleic Acids Res (2012) 0.76
Targeted genome modification via triple helix formation. Methods Mol Biol (2014) 0.75
Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes. Nucleic Acids Res (2016) 0.75
Duplex DNA-Invading γ-Modified Peptide Nucleic Acids Enable Rapid Identification of Bloodstream Infections in Whole Blood. MBio (2016) 0.75
Effect of chirality in gamma-PNA: PNA interaction, another piece in the picture. Artif DNA PNA XNA (2014) 0.75
A system for stable expression of short interfering RNAs in mammalian cells. Science (2002) 35.21
Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide. Science (1991) 12.17
A general purpose RNA-cleaving DNA enzyme. Proc Natl Acad Sci U S A (1997) 6.02
A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites. Science (1997) 4.93
Engineering polydactyl zinc-finger transcription factors. Nat Biotechnol (2002) 4.40
Molecular recognition of DNA by small molecules. Bioorg Med Chem (2001) 3.69
A single mode of DNA base-pair opening drives imino proton exchange. Nature (1987) 3.13
Solid-phase synthesis of peptide nucleic acids. J Pept Sci (1997) 2.67
Drug discovery with engineered zinc-finger proteins. Nat Rev Drug Discov (2003) 2.63
Inhibiting transcription of chromosomal DNA with antigene peptide nucleic acids. Nat Chem Biol (2005) 2.00
Characterization of base-pair opening in deoxynucleotide duplexes using catalyzed exchange of the imino proton. J Mol Biol (1988) 1.89
Double duplex invasion by peptide nucleic acid: a general principle for sequence-specific targeting of double-stranded DNA. Proc Natl Acad Sci U S A (1999) 1.74
Highly selective chemical modification of cruciform loops by diethyl pyrocarbonate. Nucleic Acids Res (1986) 1.61
Enhanced peptide nucleic acid binding to supercoiled DNA: possible implications for DNA "breathing" dynamics. Biochemistry (1996) 1.39
A simple gamma-backbone modification preorganizes peptide nucleic acid into a helical structure. J Am Chem Soc (2006) 1.34
Strand invasion of mixed-sequence B-DNA by acridine-linked, gamma-peptide nucleic acid (gamma-PNA). J Am Chem Soc (2007) 1.34
Strand invasion of extended, mixed-sequence B-DNA by gammaPNAs. J Am Chem Soc (2009) 1.22
Extending recognition by peptide nucleic acids (PNAs): binding to duplex DNA and inhibition of transcription by tail-clamp PNA-peptide conjugates. Biochemistry (2003) 1.20
Strand invasion by mixed base PNAs and a PNA-peptide chimera. Nucleic Acids Res (2000) 1.19
Combined triplex/duplex invasion of double-stranded DNA by "tail-clamp" peptide nucleic acid. Biochemistry (2003) 1.14
A simple cytosine to G-clamp nucleobase substitution enables chiral gamma-PNAs to invade mixed-sequence double-helical B-form DNA. Chembiochem (2008) 1.04
DNA chemistry. How the double helix breathes. Nature (1987) 1.03
The design of functional DNA-binding proteins based on zinc finger domains. Chem Rev (2004) 1.02
Superior duplex DNA strand invasion by acridine conjugated peptide nucleic acids. J Am Chem Soc (2003) 0.96
End invasion of peptide nucleic acids (PNAs) with mixed-base composition into linear DNA duplexes. Nucleic Acids Res (2005) 0.90
Substituted 1,8-naphthyridin-2(1H)-ones are superior to thymine in the recognition of adenine in duplex as well as triplex structures. J Am Chem Soc (2002) 0.89
Sequence-selective DNA recognition by synthetic ligands. Bioconjug Chem (1991) 0.86
Binding affinities of oligonucleotides and PNAs containing phenoxazine and G-clamp cytosine analogues are unusually sequence-dependent. Org Lett (2007) 0.79
A simple gamma-backbone modification preorganizes peptide nucleic acid into a helical structure. J Am Chem Soc (2006) 1.34
Strand invasion of mixed-sequence B-DNA by acridine-linked, gamma-peptide nucleic acid (gamma-PNA). J Am Chem Soc (2007) 1.34
Strand invasion of extended, mixed-sequence B-DNA by gammaPNAs. J Am Chem Soc (2009) 1.22
Synthesis and characterization of conformationally preorganized, (R)-diethylene glycol-containing γ-peptide nucleic acids with superior hybridization properties and water solubility. J Org Chem (2011) 1.16
Novel binding and efficient cellular uptake of guanidine-based peptide nucleic acids (GPNA). J Am Chem Soc (2003) 1.12
A simple cytosine to G-clamp nucleobase substitution enables chiral gamma-PNAs to invade mixed-sequence double-helical B-form DNA. Chembiochem (2008) 1.04
Crystal structure of chiral gammaPNA with complementary DNA strand: insights into the stability and specificity of recognition and conformational preorganization. J Am Chem Soc (2010) 1.02
High-affinity homologous peptide nucleic acid probes for targeting a quadruplex-forming sequence from a MYC promoter element. Biochemistry (2007) 1.02
Electronic barcoding of a viral gene at the single-molecule level. Nano Lett (2012) 1.00
Sequence-unrestricted, Watson-Crick recognition of double helical B-DNA by (R)-miniPEG-γPNAs. Chembiochem (2011) 1.00
Cell-permeable GPNA with appropriate backbone stereochemistry and spacing binds sequence-specifically to RNA. Chem Commun (Camb) (2004) 0.98
Loop and backbone modifications of peptide nucleic acid improve g-quadruplex binding selectivity. J Am Chem Soc (2009) 0.96
Synthesis of cell-permeable peptide nucleic acids and characterization of their hybridization and uptake properties. Bioorg Med Chem Lett (2006) 0.95
Synthesis of conformationally preorganized and cell-permeable guanidine-based gamma-peptide nucleic acids (gammaGPNAs). J Org Chem (2009) 0.95
Cell-permeable peptide nucleic acid designed to bind to the 5'-untranslated region of E-cadherin transcript induces potent and sequence-specific antisense effects. J Am Chem Soc (2006) 0.93
β-Catenin knockdown in liver tumor cells by a cell permeable gamma guanidine-based peptide nucleic acid. Curr Cancer Drug Targets (2013) 0.87
The structure of a gamma-modified peptide nucleic acid duplex. Mol Biosyst (2010) 0.82
Sequence specificity at targeting double-stranded DNA with a γ-PNA oligomer modified with guanidinium G-clamp nucleobases. Artif DNA PNA XNA (2010) 0.81
Nanoparticle for delivery of antisense γPNA oligomers targeting CCR5. Artif DNA PNA XNA (2013) 0.80
Effect of Steric Constraint at the γ-Backbone Position on the Conformations and Hybridization Properties of PNAs. J Nucleic Acids (2011) 0.80
Effect of backbone flexibility on charge transfer rates in peptide nucleic acid duplexes. J Am Chem Soc (2012) 0.79
Modified poly(lactic-co-glycolic acid) nanoparticles for enhanced cellular uptake and gene editing in the lung. Adv Healthc Mater (2014) 0.79
Single-stranded γPNAs for in vivo site-specific genome editing via Watson-Crick recognition. Curr Gene Ther (2014) 0.79
Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes. Chem Commun (Camb) (2011) 0.79
Coordination-driven inversion of handedness in ligand-modified PNA. Inorg Chem (2011) 0.78
Antitumor effects of EGFR antisense guanidine-based peptide nucleic acids in cancer models. ACS Chem Biol (2012) 0.78
Strand invasion of DNA quadruplexes by PNA: comparison of homologous and complementary hybridization. Chembiochem (2013) 0.76
RTD-1mimic containing γPNA scaffold exhibits broad-spectrum antibacterial activities. J Am Chem Soc (2012) 0.76
High affinity γPNA sandwich hybridization assay for rapid detection of short nucleic acid targets with single mismatch discrimination. Biomacromolecules (2013) 0.75
MiniPEG-γPNA. Methods Mol Biol (2014) 0.75
Embryonic stem cells: a perfect marriage between gene regulation and regenerative medicine. Curr Top Med Chem (2003) 0.75