The roles of microRNAs and protein components of the microRNA pathway in lung development and diseases.

PubWeight™: 0.76‹?›

🔗 View Article (PMID 25211015)

Published in Am J Respir Cell Mol Biol on April 01, 2015

Authors

Leah Cushing1, Zhihua Jiang, Pingping Kuang, Jining Lü

Author Affiliations

1: Columbia Center for Human Development, Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Columbia University, College of Physicians & Surgeons, New York, New York.

Articles cited by this

(truncated to the top 100)

MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59

MicroRNAs: target recognition and regulatory functions. Cell (2009) 92.17

MicroRNA expression profiles classify human cancers. Nature (2005) 69.12

The functions of animal microRNAs. Nature (2004) 64.85

A microRNA polycistron as a potential human oncogene. Nature (2005) 40.21

MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet (2004) 37.83

c-Myc-regulated microRNAs modulate E2F1 expression. Nature (2005) 31.81

Argonaute2 is the catalytic engine of mammalian RNAi. Science (2004) 22.86

MicroRNA genes are transcribed by RNA polymerase II. EMBO J (2004) 20.65

A microRNA component of the p53 tumour suppressor network. Nature (2007) 19.25

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev (2003) 17.64

Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature (2005) 17.17

Dicer is essential for mouse development. Nat Genet (2003) 15.87

The diverse functions of microRNAs in animal development and disease. Dev Cell (2006) 15.62

Identification of mammalian microRNA host genes and transcription units. Genome Res (2004) 14.63

Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA (2005) 14.14

Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways. Cell (2004) 13.51

Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell (2008) 12.29

Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA (2004) 11.52

A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res (2005) 10.46

miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature (2009) 10.26

SMAD proteins control DROSHA-mediated microRNA maturation. Nature (2008) 9.67

DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet (2007) 9.25

Dicer, Drosha, and outcomes in patients with ovarian cancer. N Engl J Med (2008) 8.77

MicroRNA functions in animal development and human disease. Development (2005) 8.41

MicroRNA function in animal development. FEBS Lett (2005) 6.93

p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol (2007) 6.87

Dicer1 functions as a haploinsufficient tumor suppressor. Genes Dev (2009) 5.21

MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science (2009) 5.17

The Hippo pathway and human cancer. Nat Rev Cancer (2013) 5.17

Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci U S A (2006) 4.87

Preparing for the first breath: genetic and cellular mechanisms in lung development. Dev Cell (2010) 4.78

MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell (2008) 4.70

Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation. Nature (2006) 4.68

MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. Genes Dev (2009) 4.62

Regulation of early lung morphogenesis: questions, facts and controversies. Development (2006) 4.59

Reduced expression of Dicer associated with poor prognosis in lung cancer patients. Cancer Sci (2005) 4.55

Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer. Cell Cycle (2008) 4.35

Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. Dev Biol (2007) 4.16

Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. J Clin Invest (2009) 4.12

Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling. Cell (2009) 3.90

DICER1 mutations in familial pleuropulmonary blastoma. Science (2009) 3.82

Transcriptional control of lung morphogenesis. Physiol Rev (2007) 3.58

Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha. Mol Cell (2010) 3.12

Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92. Oncogene (2007) 3.11

Inhibition and role of let-7d in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2010) 3.02

Evolution of microRNA diversity and regulation in animals. Nat Rev Genet (2011) 2.92

miR-29 is a major regulator of genes associated with pulmonary fibrosis. Am J Respir Cell Mol Biol (2010) 2.87

DICER1 syndrome: clarifying the diagnosis, clinical features and management implications of a pleiotropic tumour predisposition syndrome. J Med Genet (2011) 2.52

Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer. Cell (2014) 2.47

Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline. Arterioscler Thromb Vasc Biol (2010) 2.44

miR-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer. Carcinogenesis (2009) 2.41

Lung organogenesis. Curr Top Dev Biol (2010) 2.30

MicroRNA-17-92 down-regulates expression of distinct targets in different B-cell lymphoma subtypes. Blood (2008) 2.29

Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells. EMBO J (2008) 2.25

miRNA-34 prevents cancer initiation and progression in a therapeutically resistant K-ras and p53-induced mouse model of lung adenocarcinoma. Cancer Res (2012) 2.13

Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development (2009) 2.10

MicroRNAs in idiopathic pulmonary fibrosis. Transl Res (2011) 2.10

Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway. Nat Cell Biol (2011) 2.09

MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function. Arterioscler Thromb Vasc Biol (2010) 2.00

MicroRNA in lung cancer. Br J Cancer (2010) 1.97

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease. Development (2014) 1.96

Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo. Cell Death Differ (2009) 1.92

miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. Genes Dev (2009) 1.91

TAZ is a novel oncogene in non-small cell lung cancer. Oncogene (2011) 1.85

The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy. Kidney Int (2011) 1.82

MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts. Circ Res (2013) 1.80

down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4. J Biol Chem (2011) 1.79

MicroRNAs and the regulation of fibrosis. FEBS J (2010) 1.79

LATS tumor suppressor: a new governor of cellular homeostasis. Cell Cycle (2010) 1.78

Role of Sonic Hedgehog in idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2012) 1.71

MicroRNA-127 modulates fetal lung development. Physiol Genomics (2009) 1.68

miRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-Myc. J Exp Clin Cancer Res (2010) 1.67

MicroRNA-133 controls vascular smooth muscle cell phenotypic switch in vitro and vascular remodeling in vivo. Circ Res (2011) 1.67

E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis. Cell Death Differ (2009) 1.66

Lung development: orchestrating the generation and regeneration of a complex organ. Development (2014) 1.66

let-7 and miR-17-92: small-sized major players in lung cancer development. Cancer Sci (2011) 1.65

Quantitative functions of Argonaute proteins in mammalian development. Genes Dev (2012) 1.64

Gene expression networks in COPD: microRNA and mRNA regulation. Thorax (2011) 1.62

A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples. Circ Res (2012) 1.61

Functionally diverse microRNA effector complexes are regulated by extracellular signaling. Mol Cell (2013) 1.60

Intact p53-dependent responses in miR-34-deficient mice. PLoS Genet (2012) 1.59

miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution. Dev Biol (2009) 1.56

The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors. Dev Cell (2014) 1.51

miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110. Nature (2014) 1.50

MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy. PLoS One (2009) 1.44

MiR-145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1. RNA Biol (2011) 1.42

Yap tunes airway epithelial size and architecture by regulating the identity, maintenance, and self-renewal of stem cells. Dev Cell (2014) 1.42

Airway epithelial miRNA expression is altered in asthma. Am J Respir Crit Care Med (2012) 1.42

Wnt signaling and pulmonary fibrosis. Am J Pathol (2003) 1.41

Branching morphogenesis of the lung: new molecular insights into an old problem. Trends Cell Biol (2003) 1.41

Epithelial/mesenchymal interactions and branching morphogenesis of the lung. Curr Opin Genet Dev (1998) 1.39

Mechanisms of lung development: contribution to adult lung disease and relevance to chronic obstructive pulmonary disease. Proc Am Thorac Soc (2009) 1.38

Wnt/beta-catenin signaling: a promising new target for fibrosis diseases. Physiol Res (2012) 1.37

Molecular signature of a right heart failure program in chronic severe pulmonary hypertension. Am J Respir Cell Mol Biol (2011) 1.36

Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function. PLoS One (2011) 1.33

mir-17-92: a polycistronic oncomir with pleiotropic functions. Immunol Rev (2013) 1.32

Comprehensive microRNA analysis in bleomycin-induced pulmonary fibrosis identifies multiple sites of molecular regulation. Physiol Genomics (2011) 1.32

Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2. Mol Cell Biol (2011) 1.32

MicroRNAs profiling in murine models of acute and chronic asthma: a relationship with mRNAs targets. PLoS One (2011) 1.31

Articles by these authors

Regulation of early lung morphogenesis: questions, facts and controversies. Development (2006) 4.59

A survey of ovary-, testis-, and soma-biased gene expression in Drosophila melanogaster adults. Genome Biol (2004) 3.21

miR-29 is a major regulator of genes associated with pulmonary fibrosis. Am J Respir Cell Mol Biol (2010) 2.87

Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis. J Cell Biol (2006) 2.24

Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction. Development (2007) 1.70

miR-129 regulates cell proliferation by downregulating Cdk6 expression. Cell Cycle (2010) 1.51

Advances in QTL mapping in pigs. Int J Biol Sci (2007) 1.42

Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis. Dev Biol (2006) 1.24

Allied industry approaches to alter intramuscular fat content and composition in beef animals. J Food Sci (2010) 1.22

Interferon induced IFIT family genes in host antiviral defense. Int J Biol Sci (2013) 1.13

Catalog of microRNA seed polymorphisms in vertebrates. PLoS One (2012) 1.13

Human amniotic epithelial cells ameliorate behavioral dysfunction and reduce infarct size in the rat middle cerebral artery occlusion model. Shock (2008) 1.05

A Shh/miR-206/BDNF cascade coordinates innervation and formation of airway smooth muscle. J Neurosci (2011) 1.03

Mapping quantitative trait loci affecting female reproductive traits on porcine chromosome 8. Biol Reprod (2003) 1.02

FlyGEM, a full transcriptome array platform for the Drosophila community. Genome Biol (2004) 1.00

Lipid metabolism, adipocyte depot physiology and utilization of meat animals as experimental models for metabolic research. Int J Biol Sci (2010) 1.00

An experiment-based model of vein graft remodeling induced by shear stress. Ann Biomed Eng (2008) 0.98

Emerging roles of zinc finger proteins in regulating adipogenesis. Cell Mol Life Sci (2013) 0.98

Genome assembly anchored QTL map of bovine chromosome 14. Int J Biol Sci (2008) 0.97

Lipoproteins, cholesterol homeostasis and cardiac health. Int J Biol Sci (2009) 0.97

Early differential MMP-2 and -9 dynamics during flow-induced arterial and vein graft adaptations. J Surg Res (2006) 0.97

Impact of shear stress on early vein graft remodeling: a biomechanical analysis. Ann Biomed Eng (2004) 0.95

Differential expression and activity of matrix metalloproteinases during flow-modulated vein graft remodeling. J Vasc Surg (2004) 0.95

Skeletal muscle stem cells from animals I. Basic cell biology. Int J Biol Sci (2010) 0.93

Two-dimensional liquid chromatography-tandem mass spectrometry coupled with isobaric tags for relative and absolute quantification (iTRAQ) labeling approach revealed first proteome profiles of pulmonary alveolar macrophages infected with porcine reproductive and respiratory syndrome virus. J Proteome Res (2012) 0.92

Cellular and molecular comparison of redifferentiation of intramuscular- and visceral-adipocyte derived progeny cells. Int J Biol Sci (2010) 0.91

Water buffalo genome science comes of age. Int J Biol Sci (2010) 0.89

Coordinated miRNA/mRNA expression profiles for understanding breed-specific metabolic characters of liver between Erhualian and large white pigs. PLoS One (2012) 0.88

Core promoter sequences contribute to ovo-B regulation in the Drosophila melanogaster germline. Genetics (2004) 0.88

Monocyte chemoattractant protein-1/CCR2 axis promotes vein graft neointimal hyperplasia through its signaling in graft-extrinsic cell populations. Arterioscler Thromb Vasc Biol (2012) 0.88

A global view of 54,001 single nucleotide polymorphisms (SNPs) on the Illumina BovineSNP50 BeadChip and their transferability to water buffalo. Int J Biol Sci (2010) 0.87

Swine genome science comes of age. Int J Biol Sci (2007) 0.87

Genome-wide genetic diversity and differentially selected regions among Suffolk, Rambouillet, Columbia, Polypay, and Targhee sheep. PLoS One (2013) 0.86

Rule-based model of vein graft remodeling. PLoS One (2013) 0.86

Hemodynamically driven vein graft remodeling: a systems biology approach. Vascular (2009) 0.85

Potential impact of mature adipocyte dedifferentiation in terms of cell numbers. Int J Stem Cells (2011) 0.85

The reverse cholesterol transport pathway improves understanding of genetic networks for fat deposition and muscle growth in beef cattle. PLoS One (2010) 0.85

c-Abl kinase regulates curcumin-induced cell death through activation of c-Jun N-terminal kinase. Mol Pharmacol (2006) 0.84

Functional UQCRC1 polymorphisms affect promoter activity and body lipid accumulation. Obesity (Silver Spring) (2007) 0.84

The role of miR-29 in pulmonary fibrosis. Biochem Cell Biol (2014) 0.83

A novel nuclear-encoded mitochondrial poly(A) polymerase PAPD1 is a potential candidate gene for the extreme obesity related phenotypes in mammals. Int J Biol Sci (2006) 0.83

Corticotropin releasing hormone is a promising candidate gene for marbling and subcutaneous fat depth in beef cattle. Genome (2007) 0.83

Evaluation of candidate gene effects for beef backfat via Bayesian model selection. Genetica (2005) 0.82

Differential display of expressed genes reveals a novel function of SFRS18 in regulation of intramuscular fat deposition. Int J Biol Sci (2008) 0.82

Hsp70 positively regulates porcine circovirus type 2 replication in vitro. Virology (2013) 0.82

Two-dimensional liquid chromatography-tandem mass spectrometry coupled with isobaric tags for relative and absolute quantification (iTRAQ) labeling approach revealed first proteome profiles of pulmonary alveolar macrophages infected with porcine circovirus type 2. J Proteomics (2012) 0.81

The glypican 3-hosted murine mir717 gene: sequence conservation, seed region polymorphisms and putative targets. Int J Biol Sci (2010) 0.81

miR-326 is downstream of Sonic hedgehog signaling and regulates the expression of Gli2 and smoothened. Am J Respir Cell Mol Biol (2014) 0.81

Molecular characterization of porcine SARM1 and its role in regulating TLRs signaling during highly pathogenic porcine reproductive and respiratory syndrome virus infection in vivo. Dev Comp Immunol (2012) 0.81

Bovine dedifferentiated adipose tissue (DFAT) cells: DFAT cell isolation. Adipocyte (2013) 0.80

Quantitative genomics of 30 complex phenotypes in Wagyu x Angus F₁ progeny. Int J Biol Sci (2012) 0.80

A simplified QTL mapping approach for screening and mapping of novel AFLP markers associated with beef marbling. J Biotechnol (2006) 0.79

Regulation of Fgf10 gene expression in murine mesenchymal cells. J Cell Biochem (2008) 0.79

Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm. J Biol Chem (2011) 0.78

Detection and identification of NAP-2 as a biomarker in hepatitis B-related hepatocellular carcinoma by proteomic approach. Proteome Sci (2008) 0.78

Census of orthologous genes and self-organizing maps of biologically relevant transcriptional patterns in chickens (Gallus gallus). Gene (2004) 0.77

A novel in vivo procedure for volumetric flow measurements. Ultrasound Med Biol (2004) 0.77

Like pigs, and unlike other breeds of cattle examined, mature Angus-derived adipocytes may extrude lipid prior to proliferation in vitro. Adipocyte (2012) 0.77

The pig p160 co-activator family: full length cDNA cloning, expression and effects on intramuscular fat content in Longissimus Dorsi muscle. Domest Anim Endocrinol (2008) 0.76

TNF-alpha and shear stress-induced large artery adaptations. J Surg Res (2007) 0.75

Molecular characterization of the porcine S100A6 gene and analysis of its expression in pigs infected with highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV). J Appl Genet (2014) 0.75

Protection of epidermal cells against UVB injury by the antioxidant selenium-containing single-chain Fv catalytic antibody. Arch Biochem Biophys (2003) 0.75